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  Home > SCOP hierarchy > Tropomyosin superfamily


Tropomyosin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Tropomyosin [ 57997]
Families:   Tropomyosin [ 57998]

 Superfamily statistics
Genomes (1,718) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,162 45,295 8
Proteins 10,221 42,225 8

 Functional annotation
General category Processes_IC
Detailed category Cell motility

Document: Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.02893Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.04297Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1652Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2644Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4452Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.5062Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0007411Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.003041Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.04838Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.05065Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.06677Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.09726Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.1254Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3727Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.4753Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.7295Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the shoulder girdle musculature0.0006158InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the synovia0.0009099InformativeDirect
Phenotypic Abnormality (PA)Joint dislocation0.001985InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.007169InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.009582InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.02448InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.02489InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.02566InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.03589InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.03741InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber morphology0.04078InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.05326InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.1059InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.156InformativeInherited
Phenotypic Abnormality (PA)Breech presentation0.00000128Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber inclusion bodies0.000009284Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.00014Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0002314Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic aneurysm0.0004866Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.0008638Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.00124Highly InformativeInherited
Phenotypic Abnormality (PA)Cardiomyopathy0.004363Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the elbow0.004586Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.00597Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the upper limbs0.00701Highly InformativeInherited
Phenotypic Abnormality (PA)Limitation of joint mobility0.02861Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00005946Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0005296Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0005794Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003351Least InformativeInherited
Worm Phenotype (WP)movement variant0.04457Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1428Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00007681InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001619InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0002096InformativeDirect
Worm Phenotype (WP)sluggish0.000002506Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.0005692Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.5203Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.7524Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1786Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.5165Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.1033InformativeInherited
Zebrafish Anatomy (ZA)heart0.01998Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.1616Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3201Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7397Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8591Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.07736Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.08916Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.3893Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.00512InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.02424InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.1115InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.1292InformativeInherited
Xenopus ANatomical entity (XAN)somite0.00695Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.6158Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.0001923Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details) Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tropomyosin domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Tropomyosin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.