Fibrinogen coiled-coil and central regions family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Coiled coil proteins [ 57942] (7)
• Fold: Parallel coiled-coil [ 57943] (34)
• Superfamily: Fibrinogen coiled-coil and central regions [ 58010]
• Family: Fibrinogen coiled-coil and central regions [ 58011] (3)

---

Family statistics

	Genomes (66)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	247	515	29
Proteins	247	507	29

---

Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	acquired metabolic disease	0	1.191	--	DIRECT
Disease Ontology (DO)	blood coagulation disease	0	1.258	--	DIRECT
Disease Ontology (DO)	cardiovascular system disease	0	0.7889	--	DIRECT
Disease Ontology (DO)	vascular disease	0	0.832	--	DIRECT
Disease Ontology (DO)	myocardial infarction	0	1.559	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	disease of metabolism	0	0.9817	Moderately Informative	DIRECT
Disease Ontology (DO)	artery disease	0	0.9817	Moderately Informative	DIRECT
Disease Ontology (DO)	hematopoietic system disease	0	1.051	Moderately Informative	DIRECT
Disease Ontology (DO)	hypertension	0	1.434	Informative	DIRECT
Disease Ontology (DO)	inherited blood coagulation disease	0	1.735	Informative	DIRECT
Disease Ontology (DO)	coronary artery disease	0	1.472	Informative	DIRECT
Disease Ontology (DO)	congenital afibrinogenemia	0	2.212	Highly Informative	DIRECT

---

Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT
Phenotypic Abnormality (PA)	Intracranial hemorrhage	0	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the coagulation cascade	0	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Gingival bleeding	0	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Menstrual irregularities	0	1.559	--	DIRECT
Phenotypic Abnormality (PA)	Puberty and gonadal disorders	0	1.207	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal spleen morphology	0	1.348	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal thrombosis	0	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of fluid regulation	0	1.508	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal internal genitalia	0	1.232	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the spleen	0	1.316	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of blood circulation	0	1.421	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal oral mucosa morphology	0	1.258	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal oral morphology	0	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of female internal genitalia	0	1.258	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the mouth	0	0.7065	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.533	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of circulating fibrinogen	0	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the genital system	0	0.9309	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0	0.6631	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal bleeding	0	1.286	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0	0.7142	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal delivery	0	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Venous thrombosis	0	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the female genitalia	0	1.207	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0	0.6051	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0	0.5179	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0	0.5486	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.533	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the immune system	0	0.7464	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0	0.5759	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0	0.9183	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lymphatic system	0	1.184	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the abdominal organs	0	1.031	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the endocrine system	0	0.9183	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0	1.031	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal joint morphology	0	1.101	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal cardiovascular system physiology	0	0.9309	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal homeostasis	0	0.7903	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0	1.031	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0	0.9572	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: Abnormality of the gingiva || Gingival bleeding || Abnormal oral mucosa morphology
Phenotypic Abnormality (PA)	Internal hemorrhage	0	1.421	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the gingiva	0	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of prenatal development or birth	0	1.286	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the menstrual cycle	0	1.559	Informative	DIRECT
Phenotypic Abnormality (PA)	Edema	0	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebral vasculature	0	1.462	Informative	DIRECT
Phenotypic Abnormality (PA)	Functional abnormality of the gastrointestinal tract	0	1.421	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of coagulation	0	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nose	0	1.258	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the common coagulation pathway	0	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Epistaxis	0	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Cerebral hemorrhage	0	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Gastrointestinal hemorrhage	0	1.763	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Spontaneous abortion	0	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Menometrorrhagia	0	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Joint swelling	0	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Splenic rupture	0	2.161	Highly Informative	DIRECT

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	reproductive system phenotype	0	0.8397	--	DIRECT
Mammalian Phenotype (MP)	cardiovascular system phenotype	0	0.6737	Least Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: alimentary system || liver and biliary system || liver
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: liver || alimentary system || anatomical group || multicellular anatomical structure || adipose tissue || compound organ || trunk || tissue || anatomical region || liver and biliary system || solid compound organ || trunk region || anatomical cluster || viscus || organism subdivision
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.8828	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	liver and biliary system	0	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	solid compound organ	0	1.334	Informative	DIRECT
Xenopus ANatomical entity (XAN)	liver	0	1.786	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	adipose tissue	0	1.962	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7127	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	embryonic stage	0	1.006	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage 62	0	2.006	Highly Informative	DIRECT

---