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  Home > SCOP hierarchy > SNARE fusion complex superfamily


SNARE fusion complex superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   SNARE fusion complex [ 58038]
Families:   SNARE fusion complex [ 58039] (11)

Superfamily statistics
Genomes (515) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,593 30,487 29
Proteins 10,536 27,745 29

 Functional annotation
General category coiled coil
Detailed category The code refers to 4-helix bundles. These are a type of structure which frequently contain coiled-coils.

Document: Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.0422Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.002863InformativeInherited
Disease Ontology (DO)endocrine organ benign neoplasm0.00009375Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the head0.2095Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.229Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1109Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1812Moderately InformativeInherited
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the synovia0.001333InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.002077InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.00249InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.004291InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.007172InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.009124InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.02377InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.07819InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.1842InformativeInherited
Phenotypic Abnormality (PA)Areflexia0.00001345Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.0002887Highly InformativeDirect
Phenotypic Abnormality (PA)Dysarthria0.0004026Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1911Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8686Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.04937Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3801Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.4498Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.06472InformativeInherited
Mammalian Phenotype (MP)enhanced paired-pulse facilitation0.00006378Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0004585Least InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.003864Least InformativeInherited
Fly Phenotype (FP)behavior defective0.4601Moderately InformativeInherited
Fly Phenotype (FP)neurophysiology defective0.0006937InformativeDirect
Fly Phenotype (FP)locomotor behavior defective0.1743Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0000001036InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00000189Moderately InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SNARE fusion complex domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the SNARE fusion complex superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.