SNARE fusion complex family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Coiled coil proteins [ 57942] (7)
• Fold: Parallel coiled-coil [ 57943] (34)
• Superfamily: SNARE fusion complex [ 58038]
• Family: SNARE fusion complex [ 58039] (11)

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Family statistics

	Genomes (276)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,390	3,536	27
Proteins	1,154	3,034	27

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	parathyroid adenoma	0.000000002954	2.513	--	DIRECT
Disease Ontology (DO)	disease of cellular proliferation	1	0.2322	--	INHERITED FROM: endocrine organ benign neoplasm || parathyroid adenoma
Disease Ontology (DO)	benign neoplasm	0.03736	1.191	Moderately Informative	INHERITED FROM: endocrine organ benign neoplasm || parathyroid adenoma
Disease Ontology (DO)	organ system benign neoplasm	0.002325	1.559	Informative	INHERITED FROM: parathyroid adenoma || endocrine organ benign neoplasm
Disease Ontology (DO)	endocrine organ benign neoplasm	0.00007859	2.212	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.6771	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Poor head control	0.00008751	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Long face	0.0001752	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Reduced tendon reflexes	0.0001776	1.985	--	DIRECT
Phenotypic Abnormality (PA)	Prenatal movement abnormality	0.0002076	1.86	--	DIRECT
Phenotypic Abnormality (PA)	EEG with generalized epileptiform discharges	0.0002377	1.559	--	DIRECT
Phenotypic Abnormality (PA)	Interictal EEG abnormality	0.0002924	1.559	--	DIRECT
Phenotypic Abnormality (PA)	Hip dislocation	0.0003222	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Lower extremity joint dislocation	0.0005906	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Gastroesophageal reflux	0.0007413	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the synovia	0.0007849	1.508	--	DIRECT
Phenotypic Abnormality (PA)	EEG abnormality	0.002414	1.559	--	INHERITED FROM: EEG with generalized epileptiform discharges || Interictal EEG abnormality || EEG with spike-wave complexes
Phenotypic Abnormality (PA)	Abnormality of the hip bone	0.002721	1.508	--	INHERITED FROM: Hip dislocation || Abnormality of the hip joint
Phenotypic Abnormality (PA)	Abnormality of pelvic girdle bone morphology	0.004652	1.462	--	INHERITED FROM: Abnormality of the hip joint || Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of lower limb joint	0.006138	1.348	--	INHERITED FROM: Abnormality of the hip joint || Hip dislocation
Phenotypic Abnormality (PA)	Large face	0.01497	2.462	--	INHERITED FROM: Long face
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0.04555	1.184	--	INHERITED FROM: Gastroesophageal reflux
Phenotypic Abnormality (PA)	Abnormality of the head	0.1754	0.4538	--	INHERITED FROM: Long face
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.1802	0.4454	--	INHERITED FROM: Long face
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.3785	0.8289	--	INHERITED FROM: Abnormality of the hip joint || Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of central nervous system electrophysiology	0.604	1.559	--	INHERITED FROM: EEG with spike-wave complexes || Interictal EEG abnormality || EEG with generalized epileptiform discharges
Phenotypic Abnormality (PA)	Interictal epileptiform activity	1	1.559	--	INHERITED FROM: EEG with generalized epileptiform discharges || EEG with spike-wave complexes
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0.1293	0.533	Least Informative	INHERITED FROM: Long face
Phenotypic Abnormality (PA)	Abnormality of limbs	0.1879	0.6429	Least Informative	INHERITED FROM: Abnormality of the hip joint || Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.3766	0.5759	Least Informative	INHERITED FROM: Gastroesophageal reflux
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8092	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of movement	0	1.064	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0.04555	1.184	Moderately Informative	INHERITED FROM: Gastroesophageal reflux
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.08849	0.9309	Moderately Informative	INHERITED FROM: Abnormality of the hip joint || Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.09887	1.031	Moderately Informative	INHERITED FROM: Gastroesophageal reflux
Phenotypic Abnormality (PA)	Abnormal joint morphology	0.1613	1.101	Moderately Informative	INHERITED FROM: Abnormality of the hip joint || Lower extremity joint dislocation || Hip dislocation || Abnormality of the synovia
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0.1802	0.9572	Moderately Informative	INHERITED FROM: Gastroesophageal reflux
Phenotypic Abnormality (PA)	Seizures	0	1.316	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the hip joint	0.0007028	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal nervous system electrophysiology	0.001064	1.462	Informative	INHERITED FROM: EEG with generalized epileptiform discharges || Interictal EEG abnormality || EEG with spike-wave complexes
Phenotypic Abnormality (PA)	Joint dislocation	0.001658	1.508	Informative	INHERITED FROM: Hip dislocation || Lower extremity joint dislocation
Phenotypic Abnormality (PA)	Abnormal facial shape	0.002752	1.508	Informative	INHERITED FROM: Long face
Phenotypic Abnormality (PA)	Abnormality of prenatal development or birth	0.01673	1.286	Informative	INHERITED FROM: Prenatal movement abnormality || Decreased fetal movement
Phenotypic Abnormality (PA)	Functional abnormality of the gastrointestinal tract	0.02458	1.421	Informative	INHERITED FROM: Gastroesophageal reflux
Phenotypic Abnormality (PA)	Neurological speech impairment	0.05604	1.508	Informative	INHERITED FROM: Dysarthria
Phenotypic Abnormality (PA)	Abnormal reflex	0.1519	1.508	Informative	INHERITED FROM: Reduced tendon reflexes || Areflexia
Phenotypic Abnormality (PA)	Muscle weakness	0.2045	1.316	Informative	INHERITED FROM: Poor head control
Phenotypic Abnormality (PA)	EEG with spike-wave complexes	0.000003502	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Areflexia	0.000005747	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Decreased fetal movement	0.0001752	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Dysarthria	0.0002044	1.763	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the stomach	0.005186	1.86	Highly Informative	INHERITED FROM: Gastroesophageal reflux
Phenotypic Abnormality (PA)	Abnormality of esophagus physiology	0.007073	2.161	Highly Informative	INHERITED FROM: Gastroesophageal reflux

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal axon extension	0.0003646	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal paired-pulse facilitation	0.007954	2.001	--	INHERITED FROM: enhanced paired-pulse facilitation
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.03676	0.825	--	INHERITED FROM: enhanced paired-pulse facilitation || abnormal neurotransmitter secretion
Mammalian Phenotype (MP)	abnormal cell differentiation	0.0595	1.373	--	INHERITED FROM: abnormal axon extension
Mammalian Phenotype (MP)	abnormal cell physiology	0.7561	0.6209	--	INHERITED FROM: abnormal axon extension
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.8678	0.5861	--	INHERITED FROM: abnormal axon extension
Mammalian Phenotype (MP)	nervous system phenotype	0.1808	0.4959	Least Informative	INHERITED FROM: enhanced paired-pulse facilitation || abnormal neurotransmitter secretion || abnormal axon extension
Mammalian Phenotype (MP)	cellular phenotype	0.8608	0.5387	Least Informative	INHERITED FROM: abnormal axon extension
Mammalian Phenotype (MP)	abnormal synaptic transmission	0.0344	1.156	Moderately Informative	INHERITED FROM: abnormal neurotransmitter secretion || enhanced paired-pulse facilitation
Mammalian Phenotype (MP)	abnormal neuron morphology	0.3542	0.8323	Moderately Informative	INHERITED FROM: abnormal axon extension
Mammalian Phenotype (MP)	abnormal nervous system development	0.4136	1.112	Moderately Informative	INHERITED FROM: abnormal axon extension
Mammalian Phenotype (MP)	abnormal neuron differentiation	0.03413	1.562	Informative	INHERITED FROM: abnormal axon extension
Mammalian Phenotype (MP)	abnormal neurotransmitter secretion	0.00004226	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	enhanced paired-pulse facilitation	0.00004488	2.001	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	lysosome morphology variant	0.0000000002506	2.468	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.003934	0.7558	--	INHERITED FROM: lysosome morphology variant
Worm Phenotype (WP)	cell component morphology variant	0.2698	0.8392	--	INHERITED FROM: lysosome morphology variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: reproductive system physiology variant || lethal || development variant || fertility variant || organ system physiology variant || organism development variant || fertility reduced

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || larva || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || larva || organism
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	brain	0	1.193	--	DIRECT
Zebrafish Anatomy (ZA)	hindbrain	0	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: hindbrain || brain || anatomical system || multi-tissue structure || anatomical group || whole organism || compound organ || central nervous system || cavitated compound organ || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.7079	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.5848	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	central nervous system	0	1.04	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0.05483	0.1228	--	INHERITED FROM: pollen tube cell
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: pollen tube cell
Plant ANatomical entity (PAN)	pollen tube cell	0.0000001325	1.454	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	pollen development stage	0.000002165	1.279	--	DIRECT
Plant structure DEvelopment stage (PDE)	androecium development stage	0.000006333	1.279	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: pollen development stage || floral organ differentiation stage || floral organ formation stage || androecium development stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || pollen development stage || plant organ development stage || androecium development stage

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