Ferredoxin reductase FAD-binding domain-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Reductase/isomerase/elongation factor common domain [ 50412] (4)
• Superfamily: Riboflavin synthase domain-like [ 63380] (3)
• Family: Ferredoxin reductase FAD-binding domain-like [ 63381] (9)

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Family statistics

	Genomes (1,181)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,407	12,676	50
Proteins	2,406	12,672	50

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Cytochrome-b5 reductase	0	2.264	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.787	--	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0	1.31	--	DIRECT
Enzyme Commission (EC)	Acting on iron-sulfur proteins as donors	0	1.838	--	DIRECT
Enzyme Commission (EC)	Nitric oxide dioxygenase	0.000000000002318	2.264	--	DIRECT
Enzyme Commission (EC)	With a oxygen as acceptor	0.000001273	2.264	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0	1.173	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on other nitrogenous compounds as donors	0	1.486	Informative	DIRECT
Enzyme Commission (EC)	With a heme protein as acceptor	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Nitrate reductase (NADH)	0.00000000000006059	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	Nitrate reductase (NADPH)	0.000001957	2.042	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the mouth	0	0.7065	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal skull morphology	0	0.8826	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skin	0	0.722	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.533	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.6771	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0	0.7722	--	DIRECT
Phenotypic Abnormality (PA)	Generalized abnormality of skin	0	1.383	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal oral morphology	0	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.533	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the integument	0	0.6235	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3626	--	DIRECT
Mammalian Phenotype (MP)	abnormal homeostasis	0	0.4926	Least Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	recycling endosome morphology variant	0.000002017	1.727	--	DIRECT
Worm Phenotype (WP)	endosome morphology variant	0.000002345	1.727	--	DIRECT
Worm Phenotype (WP)	vesicle morphology variant	0.000003279	1.689	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0.002723	0.8392	--	INHERITED FROM: recycling endosome morphology variant || lysosome-related organelle morphology variant || endosome morphology variant || vesicle organization variant || vesicle morphology variant
Worm Phenotype (WP)	cell morphology variant	0.006115	0.7558	--	INHERITED FROM: endosome morphology variant || lysosome-related organelle morphology variant || vesicle morphology variant || vesicle organization variant || recycling endosome morphology variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || vesicle morphology variant || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || organism physiology variant || development variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || vesicle organization variant || fertility variant || recycling endosome morphology variant || postembryonic development variant || organ system physiology variant || maternal sterile || endosome morphology variant || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	vesicle organization variant	0.000003685	1.655	Informative	DIRECT
Worm Phenotype (WP)	lysosome-related organelle morphology variant	0.000001404	1.924	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || trunk region || organism subdivision
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	unspecified stage	0	1.131	Moderately Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || multi-tissue plant structure || plant organ
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor	0	2.452	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.327	--	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0	1.783	--	DIRECT
Enzyme Commission (EC)	With a heme protein as acceptor	0	2.327	--	DIRECT
Enzyme Commission (EC)	Cytochrome-b5 reductase	0	2.753	--	DIRECT
Enzyme Commission (EC)	NAD(P)H oxidase (H(2)O(2)-forming)	0	2.753	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.188	--	DIRECT
Enzyme Commission (EC)	Nitrate reductase (NADH)	0	2.531	--	DIRECT
Enzyme Commission (EC)	Linked to oxidoreductase reactions	0	3.23	--	DIRECT
Enzyme Commission (EC)	NADH:ubiquinone reductase (Na(+)-transporting)	0	3.23	--	DIRECT
Enzyme Commission (EC)	Nitric oxide dioxygenase	0.0000000000003155	2.753	--	DIRECT
Enzyme Commission (EC)	Acting on reduced flavodoxin as donor	0.000000000001214	2.929	--	DIRECT
Enzyme Commission (EC)	3-ketosteroid 9-alpha-monooxygenase	0.00000000003903	3.23	--	DIRECT
Enzyme Commission (EC)	Nitrate reductase (NADPH)	0.0000000009665	2.531	--	DIRECT
Enzyme Commission (EC)	Carnitine monooxygenase	0.0000639	2.628	--	DIRECT
Enzyme Commission (EC)	Nitrate reductase (NAD(P)H)	0.00008911	2.929	--	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0.003515	2.753	--	INHERITED FROM: NAD(P)H oxidase (H(2)O(2)-forming)
Enzyme Commission (EC)	With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	0.3642	2.452	--	INHERITED FROM: 3-ketosteroid 9-alpha-monooxygenase
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0	1.514	Informative	DIRECT
Enzyme Commission (EC)	Translocases	0	1.628	Informative	DIRECT
Enzyme Commission (EC)	Acting on iron-sulfur proteins as donors	0	2.23	Highly Informative	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of inorganic cations	0	2.116	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on other nitrogenous compounds as donors	0.000000000000666	1.849	Highly Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of one atom of oxygen	0.5276	2.026	Highly Informative	INHERITED FROM: Carnitine monooxygenase

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