SUPERFAMILY 1.75 HMM library and genome assignments server

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MMP N-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   PGBD-like [ 47089]
Superfamily:   PGBD-like [ 47090] (2)
Family:   MMP N-terminal domain [ 63427] (4)

Family statistics
Genomes (55) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 143 325 5
Proteins 143 325 5

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Gelatinase B0.00001043Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A0.00001043Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.006323Least InformativeInherited
Disease Ontology (DO)nervous system disease0.1015Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.000006449Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.00001315Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.0003793Moderately InformativeDirect
Disease Ontology (DO)artery disease0.001105Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.002424Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.005635Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.006781Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.02527Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.06233Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.1005Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.4037Moderately InformativeInherited
Disease Ontology (DO)female reproductive system disease0.00000004909InformativeDirect
Disease Ontology (DO)Kawasaki disease0.000004061InformativeDirect
Disease Ontology (DO)atherosclerosis0.00001173InformativeDirect
Disease Ontology (DO)scleroderma0.00003155InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.000163InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0003714InformativeDirect
Disease Ontology (DO)liver carcinoma0.0005618InformativeDirect
Disease Ontology (DO)arthritis0.0006345InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.0007457InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.001563InformativeInherited
Disease Ontology (DO)eye disease0.005596InformativeInherited
Disease Ontology (DO)malignant glioma0.009186InformativeInherited
Disease Ontology (DO)urinary system cancer0.01141InformativeInherited
Disease Ontology (DO)heart disease0.01375InformativeInherited
Disease Ontology (DO)male reproductive organ cancer0.05004InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.08876InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9101InformativeInherited
Disease Ontology (DO)myopathy1InformativeInherited
Disease Ontology (DO)adult astrocytic tumour0.0000001067Highly InformativeDirect
Disease Ontology (DO)chondrosarcoma0.0000001404Highly InformativeDirect
Disease Ontology (DO)myopia0.0000006948Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.000001204Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.000001747Highly InformativeDirect
Disease Ontology (DO)Barrett's esophagus0.00003077Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.00003269Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.0001184Highly InformativeDirect
Disease Ontology (DO)integumentary system cancer0.0001733Highly InformativeDirect
Disease Ontology (DO)bronchiectasis0.0002166Highly InformativeDirect
Disease Ontology (DO)pancreatic ductal adenocarcinoma0.0007561Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.129Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.511Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.8604Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.081Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1235Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.01775InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.07315InformativeInherited
Phenotypic Abnormality (PA)Metaphyseal widening0.00006748Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0041Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.05075Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.00001749Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.01246Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.02141Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.04212Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.05448Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.05958Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.07178Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.08587Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.1075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.3808Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.8977Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.0000004589InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0002182InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.001832InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.003562InformativeInherited
Mammalian Phenotype (MP)abnormal long bone morphology0.004636InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.00801InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.01029InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.01298InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.0443InformativeInherited
Mammalian Phenotype (MP)altered tumor pathology0.05139InformativeInherited
Mammalian Phenotype (MP)abnormal limb bone morphology0.07374InformativeInherited
Mammalian Phenotype (MP)aortic aneurysm0.0000108Highly InformativeDirect
Mammalian Phenotype (MP)decreased angiogenesis0.00005916Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.0002173Highly InformativeDirect
Mammalian Phenotype (MP)decreased length of long bones0.0003132Highly InformativeDirect
Mammalian Phenotype (MP)abnormal femur morphology0.0003997Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tumor morphology0.0007314Highly InformativeDirect
Mammalian Phenotype (MP)abnormal forelimb stylopod morphology0.000778Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.007038Highly InformativeInherited
Mammalian Phenotype (MP)abnormal long bone epiphyseal plate morphology0.01193Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.01553Highly InformativeInherited
Mammalian Phenotype (MP)abnormal maxilla morphology0.1577Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)skeletal system0.0002624InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.4736Least InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.0002921InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a PGBD-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]