Frizzled cysteine-rich domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Frizzled cysteine-rich domain [ 63500]
• Superfamily: Frizzled cysteine-rich domain [ 63501]
• Family: Frizzled cysteine-rich domain [ 63502] (2)

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Family statistics

	Genomes (143)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,243	3,133	2
Proteins	1,242	3,103	2

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	bone marrow cancer	0.005374	1.399	--	INHERITED FROM: myeloid neoplasm || multiple myeloma
Disease Ontology (DO)	disease of cellular proliferation	0.03863	0.2322	--	INHERITED FROM: multiple myeloma || myeloid leukemia || myeloid neoplasm
Disease Ontology (DO)	immune system cancer	0.06406	0.89	--	INHERITED FROM: multiple myeloma || myeloid leukemia || myeloid neoplasm
Disease Ontology (DO)	leukemia	0.784	1.151	--	INHERITED FROM: myeloid leukemia
Disease Ontology (DO)	cancer	0.9064	0.2555	--	INHERITED FROM: myeloid leukemia || multiple myeloma || myeloid neoplasm
Disease Ontology (DO)	organ system cancer	0.06379	0.4879	Least Informative	INHERITED FROM: myeloid neoplasm || multiple myeloma || myeloid leukemia
Disease Ontology (DO)	hematologic cancer	0.007722	0.89	Moderately Informative	INHERITED FROM: myeloid neoplasm || myeloid leukemia || multiple myeloma
Disease Ontology (DO)	myeloid neoplasm	0.000163	1.399	Informative	DIRECT
Disease Ontology (DO)	myeloid leukemia	0.0009999	1.472	Informative	DIRECT
Disease Ontology (DO)	multiple myeloma	0.00001376	1.814	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	open neural tube	0.000000001648	2.603	--	DIRECT
Mammalian Phenotype (MP)	incomplete embryo turning	0.0000005043	2.603	--	DIRECT
Mammalian Phenotype (MP)	fused somites	0.000001909	2.603	--	DIRECT
Mammalian Phenotype (MP)	diluted coat color	0.000001948	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal cochlear outer hair cell morphology	0.000009744	1.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal hair cell morphology	0.00003054	1.524	--	DIRECT
Mammalian Phenotype (MP)	abnormal cochlear sensory epithelium morphology	0.00003054	1.524	--	DIRECT
Mammalian Phenotype (MP)	abnormal organ of Corti morphology	0.00003168	1.524	--	DIRECT
Mammalian Phenotype (MP)	decreased somite size	0.00003276	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.00003812	0.5861	--	DIRECT
Mammalian Phenotype (MP)	abnormal scala media morphology	0.00005552	1.524	--	DIRECT
Mammalian Phenotype (MP)	abnormal cochlear labyrinth morphology	0.00005552	1.524	--	DIRECT
Mammalian Phenotype (MP)	abnormal embryo turning	0.00006726	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal cochlea morphology	0.00008353	1.457	--	DIRECT
Mammalian Phenotype (MP)	abnormal somite size	0.00008611	2.302	--	DIRECT
Mammalian Phenotype (MP)	incomplete somite formation	0.000109	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal membranous labyrinth morphology	0.0001205	1.457	--	DIRECT
Mammalian Phenotype (MP)	embryonic growth retardation	0.0001428	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal embryonic tissue morphology	0.000184	1.281	--	DIRECT
Mammalian Phenotype (MP)	abnormal ear morphology	0.0003147	1.281	--	DIRECT
Mammalian Phenotype (MP)	prenatal growth retardation	0.0003312	2.603	--	DIRECT
Mammalian Phenotype (MP)	embryo phenotype	0.0004741	0.8708	--	DIRECT
Mammalian Phenotype (MP)	disorganized yolk sac vascular plexus	0.0005579	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal rostral-caudal body axis extension	0.0008508	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal mechanoreceptor morphology	0.01509	1.524	--	INHERITED FROM: abnormal orientation of cochlear hair cell stereociliary bundles || abnormal hair cell morphology || abnormal cochlear outer hair cell morphology || abnormal cochlear hair cell morphology
Mammalian Phenotype (MP)	abnormal coat/hair pigmentation	0.02833	2.126	--	INHERITED FROM: diluted coat color
Mammalian Phenotype (MP)	abnormal prenatal growth/weight/body size	0.03195	1.348	--	INHERITED FROM: prenatal growth retardation || embryonic growth retardation
Mammalian Phenotype (MP)	abnormal cochlear hair cell stereociliary bundle morphology	0.06951	1.758	--	INHERITED FROM: abnormal orientation of cochlear hair cell stereociliary bundles
Mammalian Phenotype (MP)	abnormal vascular development	0.07288	1.223	--	INHERITED FROM: disorganized yolk sac vascular plexus
Mammalian Phenotype (MP)	abnormal inner ear morphology	0.1146	1.427	--	INHERITED FROM: abnormal orientation of cochlear hair cell stereociliary bundles || abnormal cochlear outer hair cell morphology || abnormal membranous labyrinth morphology || abnormal organ of Corti morphology || abnormal cochlear hair cell morphology || abnormal cochlear sensory epithelium morphology || abnormal scala media morphology || abnormal hair cell morphology || abnormal cochlear labyrinth morphology || abnormal cochlea morphology
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.1499	0.7902	--	INHERITED FROM: disorganized yolk sac vascular plexus
Mammalian Phenotype (MP)	abnormal coat/ hair morphology	0.1678	1.649	--	INHERITED FROM: diluted coat color
Mammalian Phenotype (MP)	integument phenotype	0.1789	0.797	--	INHERITED FROM: diluted coat color
Mammalian Phenotype (MP)	abnormal somite development	0.2373	1.904	--	INHERITED FROM: fused somites || decreased somite size || incomplete somite formation || abnormal somite size
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.2471	0.931	--	INHERITED FROM: abnormal hair cell morphology || abnormal cochlear hair cell morphology || abnormal somatic sensory system morphology || abnormal cochlear outer hair cell morphology || abnormal orientation of cochlear hair cell stereociliary bundles
Mammalian Phenotype (MP)	abnormal embryo development	0.351	1.427	--	INHERITED FROM: abnormal embryo turning || embryonic growth retardation || incomplete embryo turning || abnormal rostral-caudal body axis extension
Mammalian Phenotype (MP)	abnormal extraembryonic tissue morphology	0.5927	1.348	--	INHERITED FROM: disorganized yolk sac vascular plexus
Mammalian Phenotype (MP)	nervous system phenotype	0.0004267	0.4959	Least Informative	DIRECT
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.01033	0.6737	Least Informative	INHERITED FROM: disorganized yolk sac vascular plexus
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.08279	0.6254	Least Informative	INHERITED FROM: embryonic growth retardation || prenatal growth retardation
Mammalian Phenotype (MP)	limbs/digits/tail phenotype	0.0001474	1.188	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal somatic sensory system morphology	0.0008394	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	hearing/vestibular/ear phenotype	0.003338	1.223	Moderately Informative	INHERITED FROM: abnormal organ of Corti morphology || abnormal membranous labyrinth morphology || abnormal scala media morphology || abnormal cochlear sensory epithelium morphology || abnormal ear morphology || abnormal orientation of cochlear hair cell stereociliary bundles || abnormal cochlear outer hair cell morphology || abnormal cochlear hair cell morphology || abnormal hair cell morphology || abnormal cochlea morphology || abnormal cochlear labyrinth morphology
Mammalian Phenotype (MP)	abnormal nervous system development	0.03391	1.112	Moderately Informative	INHERITED FROM: abnormal neural tube closure || open neural tube
Mammalian Phenotype (MP)	abnormal skin adnexa morphology	0.08853	1.156	Moderately Informative	INHERITED FROM: diluted coat color
Mammalian Phenotype (MP)	abnormal cardiovascular development	0.3153	1.059	Moderately Informative	INHERITED FROM: disorganized yolk sac vascular plexus
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.343	1.023	Moderately Informative	INHERITED FROM: disorganized yolk sac vascular plexus
Mammalian Phenotype (MP)	abnormal embryo morphology	0.4176	1.112	Moderately Informative	INHERITED FROM: abnormal embryonic tissue morphology || abnormal neural tube closure || open neural tube || abnormal somite size || fused somites || incomplete somite formation || decreased somite size
Mammalian Phenotype (MP)	abnormal cochlear hair cell morphology	0.00002433	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neural tube morphology	0.003595	1.7	Informative	INHERITED FROM: open neural tube || abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal embryonic growth/weight/body size	0.003967	1.489	Informative	INHERITED FROM: embryonic growth retardation
Mammalian Phenotype (MP)	abnormal developmental patterning	0.02359	1.524	Informative	INHERITED FROM: incomplete embryo turning || abnormal rostral-caudal body axis extension || abnormal embryo turning
Mammalian Phenotype (MP)	abnormal coat appearance	0.03013	1.649	Informative	INHERITED FROM: diluted coat color
Mammalian Phenotype (MP)	abnormal neural tube closure	0.00000005619	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal orientation of cochlear hair cell stereociliary bundles	0.000001182	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	pigmentation phenotype	0.0004009	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	impaired somite development	0.001171	2.001	Highly Informative	INHERITED FROM: incomplete somite formation
Mammalian Phenotype (MP)	abnormal vitelline vasculature morphology	0.004582	2.001	Highly Informative	INHERITED FROM: disorganized yolk sac vascular plexus
Mammalian Phenotype (MP)	abnormal visceral yolk sac morphology	0.05284	2.126	Highly Informative	INHERITED FROM: disorganized yolk sac vascular plexus
Mammalian Phenotype (MP)	abnormal gastrulation	0.4019	1.758	Highly Informative	INHERITED FROM: abnormal embryo turning || incomplete embryo turning

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	Q neuroblast lineage migration variant	0	1.689	--	DIRECT
Worm Phenotype (WP)	ALM migration variant	0	2.468	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	nerve ring development variant	0	2.769	--	DIRECT
Worm Phenotype (WP)	neuropil development variant	0	2.468	--	DIRECT
Worm Phenotype (WP)	neuron migration variant	0	1.623	--	DIRECT
Worm Phenotype (WP)	anterior neuron migration defective	0	2.468	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	posterior cell migration variant	0	2.468	--	DIRECT
Worm Phenotype (WP)	posterior neuron migration variant	0	2.468	--	DIRECT
Worm Phenotype (WP)	muscle dystrophy	0.000000000001172	2.167	--	DIRECT
Worm Phenotype (WP)	body behavior variant	0.000000000003723	2.167	--	DIRECT
Worm Phenotype (WP)	organism segment behavior variant	0.000000000006084	2.167	--	DIRECT
Worm Phenotype (WP)	organism region behavior variant	0.00000000001095	2.167	--	DIRECT
Worm Phenotype (WP)	cell division polarity variant	0.0000000002083	2.292	--	DIRECT
Worm Phenotype (WP)	excess seam cells	0.000000004285	2.167	--	DIRECT
Worm Phenotype (WP)	fewer seam cells	0.000000008057	2.167	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.00000004976	1.306	--	DIRECT
Worm Phenotype (WP)	neuronal outgrowth variant	0.0000000598	1.565	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic morphology variant	0.000003848	1.655	--	DIRECT
Worm Phenotype (WP)	cell number variant	0.00007715	1.371	--	DIRECT
Worm Phenotype (WP)	neuron development variant	0.001272	1.321	--	INHERITED FROM: neuronal outgrowth variant || axon guidance variant
Worm Phenotype (WP)	organ system morphology variant	0.001427	0.7516	--	INHERITED FROM: sensillum morphology variant
Worm Phenotype (WP)	behavior variant	0.006175	0.6859	--	INHERITED FROM: organism region behavior variant || body behavior variant || body muscle dystrophy || organism segment behavior variant
Worm Phenotype (WP)	transgene expression variant	0.0067	0.773	--	INHERITED FROM: transgene expression reduced
Worm Phenotype (WP)	gene expression variant	0.0129	0.6256	--	INHERITED FROM: antibody staining variant || transgene expression reduced
Worm Phenotype (WP)	nervous system morphology variant	0.02666	1.321	--	INHERITED FROM: sensillum morphology variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.6893	0.1444	--	INHERITED FROM: transgene expression reduced || antibody staining variant
Worm Phenotype (WP)	organism physiology variant	0.7034	0.1342	--	INHERITED FROM: transgene expression reduced || antibody staining variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: multiple anchor cells || neuron migration variant || nerve ring development variant || cell division polarity variant || muscle dystrophy || epithelial development variant || cell number decreased || reproductive system physiology variant || cell migration variant || organ system development variant || organism region behavior variant || axon guidance variant || body behavior variant || nervous system development variant || body muscle dystrophy || transgene expression reduced || lethal || antibody staining variant || posterior cell migration variant || posterior neuron migration variant || neuropil development variant || cell division variant || organism segment behavior variant || development variant || excess seam cells || embryonic development variant || embryonic lethal || Q neuroblast lineage migration variant || cell number variant || fertility variant || cell number increased || muscle system physiology variant || fewer seam cells || anterior neuron migration defective || neuronal outgrowth variant || organ system physiology variant || organism development variant || cell polarity variant || ALM migration variant || fertility reduced || cell development variant
Worm Phenotype (WP)	cell development variant	0	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.004736	0.5955	Least Informative	INHERITED FROM: cell division variant || cell division polarity variant
Worm Phenotype (WP)	organism behavior variant	0.006058	0.6859	Least Informative	INHERITED FROM: body muscle dystrophy || organism region behavior variant || body behavior variant || organism segment behavior variant
Worm Phenotype (WP)	organism metabolism processing variant	0.02517	0.4899	Least Informative	INHERITED FROM: transgene expression reduced || antibody staining variant
Worm Phenotype (WP)	organ system development variant	0	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0.00004846	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0.01159	1.125	Moderately Informative	INHERITED FROM: antibody staining variant
Worm Phenotype (WP)	level of transgene expression variant	0.1444	1.125	Moderately Informative	INHERITED FROM: transgene expression reduced
Worm Phenotype (WP)	cell migration variant	0	1.407	Informative	DIRECT
Worm Phenotype (WP)	male morphology variant	0.000002824	1.655	Informative	DIRECT
Worm Phenotype (WP)	cell number increased	0.00002749	1.446	Informative	DIRECT
Worm Phenotype (WP)	sensillum morphology variant	0.00006063	1.593	Informative	DIRECT
Worm Phenotype (WP)	transgene expression reduced	0.000891	1.623	Informative	DIRECT
Worm Phenotype (WP)	epithelial system development variant	0.0876	1.655	Informative	INHERITED FROM: fewer seam cells || excess seam cells || epithelial development variant
Worm Phenotype (WP)	axon outgrowth variant	0.9693	1.565	Informative	INHERITED FROM: axon guidance variant
Worm Phenotype (WP)	nervous system development variant	0	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	body muscle dystrophy	0.000000000000939	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	multiple anchor cells	0.00000005048	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	epithelial development variant	0.0000001116	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	cell polarity variant	0.0000001892	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	axon guidance variant	0.000001612	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	cell number decreased	0.000001762	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	antibody staining variant	0.000002541	2.07	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	head	0	0.912	--	DIRECT
Fly Anatomy (FA)	head segment	0	1.31	--	DIRECT
Fly Anatomy (FA)	procephalic segment	0	1.31	--	DIRECT
Fly Anatomy (FA)	thorax	0	0.912	--	DIRECT
Fly Anatomy (FA)	thoracic segment	0	0.912	--	DIRECT
Fly Anatomy (FA)	mesothoracic segment	0	0.9578	--	DIRECT
Fly Anatomy (FA)	embryo	0	0.8978	--	DIRECT
Fly Anatomy (FA)	larval imaginal tissue	0	1.435	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.7171	--	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.6649	--	DIRECT
Fly Anatomy (FA)	adult segment	0	0.821	--	DIRECT
Fly Anatomy (FA)	adult head segment	0	1.435	--	DIRECT
Fly Anatomy (FA)	adult thorax	0	0.942	--	DIRECT
Fly Anatomy (FA)	adult thoracic segment	0	0.942	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0	0.7764	--	DIRECT
Fly Anatomy (FA)	adult sense organ	0	1.243	--	DIRECT
Fly Anatomy (FA)	head sensillum	0	1.31	--	DIRECT
Fly Anatomy (FA)	retina	0	1.435	--	DIRECT
Fly Anatomy (FA)	developing embryonic structure	0	1.243	--	DIRECT
Fly Anatomy (FA)	eye	0	1.389	--	DIRECT
Fly Anatomy (FA)	wing	0	1.243	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	reproductive system	0	1.047	--	DIRECT
Fly Anatomy (FA)	female reproductive system	0	1.31	--	DIRECT
Fly Anatomy (FA)	ovary	0	1.31	--	DIRECT
Fly Anatomy (FA)	germline cyst	0	1.389	--	DIRECT
Fly Anatomy (FA)	egg chamber	0	1.69	--	DIRECT
Fly Anatomy (FA)	follicle cell	0	2.389	--	DIRECT
Fly Anatomy (FA)	integumentary system	0	0.8094	--	DIRECT
Fly Anatomy (FA)	epidermis	0	1.787	--	DIRECT
Fly Anatomy (FA)	sensory neuron	0	1.213	--	DIRECT
Fly Anatomy (FA)	mechanosensory sensory organ	0	1.787	--	DIRECT
Fly Anatomy (FA)	photoreceptor	0	1.348	--	DIRECT
Fly Anatomy (FA)	external sensory organ	0	1.088	--	DIRECT
Fly Anatomy (FA)	mechanosensory chaeta	0	1.787	--	DIRECT
Fly Anatomy (FA)	wing margin	0	2.389	--	DIRECT
Fly Anatomy (FA)	presumptive embryonic/larval integumentary system	0	1.787	--	DIRECT
Fly Anatomy (FA)	adult integumentary system	0	0.9578	--	DIRECT
Fly Anatomy (FA)	adult peripheral nervous system	0	1.435	--	DIRECT
Fly Anatomy (FA)	eye photoreceptor cell	0	1.611	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	portion of tissue	0	0.7764	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	female organism	0	1.213	--	DIRECT
Fly Anatomy (FA)	sensillum	0	1.134	--	DIRECT
Fly Anatomy (FA)	compound cell cluster organ	0	1.389	--	DIRECT
Fly Anatomy (FA)	external sensillum	0	1.159	--	DIRECT
Fly Anatomy (FA)	eo-type sensillum	0	1.486	--	DIRECT
Fly Anatomy (FA)	compound sense organ	0	1.389	--	DIRECT
Fly Anatomy (FA)	external compound sense organ	0	1.389	--	DIRECT
Fly Anatomy (FA)	adult sensillum	0	1.31	--	DIRECT
Fly Anatomy (FA)	adult head sensillum	0	1.348	--	DIRECT
Fly Anatomy (FA)	rhabdomeric photoreceptor cell	0	1.611	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.8451	--	DIRECT
Fly Anatomy (FA)	region of integument	0	0.884	--	DIRECT
Fly Anatomy (FA)	tagmatic subdivision of integument	0	0.9742	--	DIRECT
Fly Anatomy (FA)	sensory system	0	0.8577	--	DIRECT
Fly Anatomy (FA)	sensory system neuron	0	1.213	--	DIRECT
Fly Anatomy (FA)	non-connected developing system	0	1.389	--	DIRECT
Fly Anatomy (FA)	imaginal tissue	0	1.435	--	DIRECT
Fly Anatomy (FA)	visual system	0	1.348	--	DIRECT
Fly Anatomy (FA)	visual system neuron	0	1.544	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: embryonic epidermis || sensory neuron || adult external thorax || external sensory organ || cuboidal/columnar epithelium || ovariole || organism || nervous system || mesothoracic segment || eye || presumptive embryonic/larval integumentary system || peripheral nervous system || follicle cell || female reproductive system || epithelium || adult mesothoracic segment || neuron || adult || epidermis || female organism || embryonic/larval nervous system || sensillum || adult nervous system || mechanosensory chaeta || ovary || eo-type sensillum || retina || visual system neuron || developing embryonic structure || segment || female germline cyst || larva || leg || thoracic segment || mechanosensory sensory organ || somatic cell || ommatidium || adult optic lobe neuron || wing || procephalic segment || adult head || tagmatic subdivision of integument || external compound sense organ || gonad || sensory organ cell || photoreceptor || somatic cell of ovariole || portion of tissue || histaminergic neuron || chaeta || adult procephalic segment || adult sense organ || cell || adult thorax || adult head sensillum || cell cluster organ || appendage || region of integument || multi-tissue structure || rhabdomeric photoreceptor cell || late embryo || presumptive embryonic/larval system || germline cyst || head segment || eye photoreceptor cell || adult tagma || adult segment || sense organ || tagma || head || organ system subdivision || photoreceptor cell || imaginal disc || larval imaginal tissue || adult peripheral nervous system || thorax || adult head segment || egg chamber || sensory system neuron || compound sense organ || epithelial cell || adult integumentary system || female-specific anatomical entity || adult sensillum || external sensillum || embryo || reproductive system || adult thoracic segment || organ system || wing margin || compound cell cluster organ || organism subdivision || integumentary system || head sensillum || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: external sensillum || embryo || anatomical group || adult thoracic segment || reproductive system || wing margin || organ system || compound cell cluster organ || organism subdivision || head sensillum || integumentary system || multicellular structure || developing material anatomical entity || thorax || adult peripheral nervous system || sensory system || adult head segment || egg chamber || sensory system neuron || compound sense organ || epithelial cell || female-specific anatomical entity || adult integumentary system || adult sensillum || head segment || germline cyst || eye photoreceptor cell || presumptive embryonic/larval system || adult tagma || non-connected functional system || adult segment || visual system || tagma || sense organ || head || organ system subdivision || photoreceptor cell || larval imaginal tissue || mechanosensory system || imaginal disc || adult sense organ || adult thorax || cell || adult head sensillum || non-connected developing system || cell cluster organ || appendage || region of integument || multi-tissue structure || late embryo || rhabdomeric photoreceptor cell || procephalic segment || adult head || gonad || external compound sense organ || tagmatic subdivision of integument || sensory organ cell || photoreceptor || somatic cell of ovariole || portion of tissue || histaminergic neuron || chaeta || imaginal tissue || adult procephalic segment || developing embryonic structure || segment || leg || larva || female germline cyst || thoracic segment || mechanosensory sensory organ || somatic cell || ommatidium || adult optic lobe neuron || wing || epithelium || adult mesothoracic segment || neuron || adult || epidermis || female organism || sensillum || embryonic/larval nervous system || adult nervous system || mechanosensory chaeta || ovary || eo-type sensillum || retina || visual system neuron || sensory neuron || embryonic epidermis || adult external thorax || external sensory organ || cuboidal/columnar epithelium || ovariole || organism || nervous system || mesothoracic segment || eye || presumptive embryonic/larval integumentary system || peripheral nervous system || female reproductive system || follicle cell
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: eye || mesothoracic segment || adult external thorax || adult thorax || adult head sensillum || head || tagma || adult segment || retina || adult tagma || adult mesothoracic segment || head segment || eye photoreceptor cell || ommatidium || wing || adult head segment || thorax || thoracic segment || leg || segment || head sensillum || adult procephalic segment || adult head || procephalic segment || wing margin || adult thoracic segment
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	segment	0	0.6568	Least Informative	DIRECT
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	adult head	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult mesothoracic segment	0	0.9912	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult external thorax	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	gonad	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	peripheral nervous system	0	0.8978	Moderately Informative	DIRECT
Fly Anatomy (FA)	neuron	0	0.8451	Moderately Informative	DIRECT
Fly Anatomy (FA)	sense organ	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	late embryo	0	1.088	Moderately Informative	DIRECT
Fly Anatomy (FA)	appendage	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	epithelium	0	1.159	Moderately Informative	DIRECT
Fly Anatomy (FA)	developing material anatomical entity	0	0.8329	Moderately Informative	DIRECT
Fly Anatomy (FA)	cell cluster organ	0	1.134	Moderately Informative	DIRECT
Fly Anatomy (FA)	female-specific anatomical entity	0	1.213	Moderately Informative	DIRECT
Fly Anatomy (FA)	imaginal disc	0	1.435	Informative	DIRECT
Fly Anatomy (FA)	adult procephalic segment	0	1.435	Informative	DIRECT
Fly Anatomy (FA)	adult optic lobe neuron	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	photoreceptor cell	0	1.544	Informative	DIRECT
Fly Anatomy (FA)	ommatidium	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	leg	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	ovariole	0	1.31	Informative	DIRECT
Fly Anatomy (FA)	sensory organ cell	0	1.31	Informative	DIRECT
Fly Anatomy (FA)	chaeta	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	cuboidal/columnar epithelium	0	1.544	Informative	DIRECT
Fly Anatomy (FA)	presumptive embryonic/larval system	0	1.389	Informative	DIRECT
Fly Anatomy (FA)	female germline cyst	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	histaminergic neuron	0	1.611	Informative	DIRECT
Fly Anatomy (FA)	mechanosensory system	0	1.611	Informative	DIRECT
Fly Anatomy (FA)	epithelial cell	0	1.787	Highly Informative	DIRECT
Fly Anatomy (FA)	embryonic epidermis	0	1.787	Highly Informative	DIRECT
Fly Anatomy (FA)	somatic cell of ovariole	0	1.912	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	stromal cell	0.0002443	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: mesenchyme || stromal cell || whole organism
Zebrafish Anatomy (ZA)	cell	0.7754	0.6388	Least Informative	INHERITED FROM: stromal cell
Zebrafish Anatomy (ZA)	portion of tissue	0.1065	0.7637	Moderately Informative	INHERITED FROM: mesenchyme
Zebrafish Anatomy (ZA)	mesenchyme	0.0009591	2.17	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	pre-chordal neural plate	0.00000000004921	1.824	--	DIRECT
Xenopus ANatomical entity (XAN)	neural plate	0.00000000009186	1.635	--	DIRECT
Xenopus ANatomical entity (XAN)	stomodeal-hypophyseal primordium	0.0000000001851	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	otic vesicle	0.0000000006011	1.719	--	DIRECT
Xenopus ANatomical entity (XAN)	prechordal plate	0.000000002919	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	axial mesoderm	0.000000312	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	neural fold	0.000003733	1.824	--	DIRECT
Xenopus ANatomical entity (XAN)	gall bladder	0.00001277	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	cardiac mesoderm	0.00001296	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical line	0.0000188	2.166	--	DIRECT
Xenopus ANatomical entity (XAN)	stomach	0.00003071	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	endoderm	0.00003332	1.751	--	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal arch	0.00003784	1.689	--	DIRECT
Xenopus ANatomical entity (XAN)	tail tip	0.00004034	2.087	--	DIRECT
Xenopus ANatomical entity (XAN)	hematological system	0.00005749	1.865	--	DIRECT
Xenopus ANatomical entity (XAN)	tail fin	0.00006319	2.087	--	DIRECT
Xenopus ANatomical entity (XAN)	small intestine	0.000198	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	liver primordium	0.00031	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	mouth primordium	0.0003422	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	presumptive paraxial mesoderm	0.0005652	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	embryonic kidney	0.0005904	1.719	--	DIRECT
Xenopus ANatomical entity (XAN)	larval alimentary system	0.0006234	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	coelom	0.0006482	1.661	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0.003239	0.5841	--	INHERITED FROM: hindbrain || midbrain-hindbrain boundary || midbrain || neural tube || eye || forebrain
Xenopus ANatomical entity (XAN)	circumblastoporal collar	0.007185	2.02	--	INHERITED FROM: involuted dorsal mesoderm
Xenopus ANatomical entity (XAN)	muscular system	0.007917	1.263	--	INHERITED FROM: presomitic mesoderm || somite
Xenopus ANatomical entity (XAN)	paraxial mesoderm	0.008337	1.911	--	INHERITED FROM: presomitic mesoderm
Xenopus ANatomical entity (XAN)	primary germ layer	0.06368	0.6748	--	INHERITED FROM: pre-chordal neural plate || neural plate || presumptive paraxial mesoderm || endoderm || tail fin || lateral plate mesoderm || tail tip || mouth primordium || anterior neural fold || midbrain-hindbrain boundary || presomitic mesoderm || neural fold || neuroectoderm || somite || optic field || stomodeal-hypophyseal primordium || mesoderm
Xenopus ANatomical entity (XAN)	head region	0.06981	0.4759	--	INHERITED FROM: midbrain-hindbrain boundary || eye || forebrain || hindbrain || midbrain || pharyngeal arch || pharyngeal region
Xenopus ANatomical entity (XAN)	kidney	0.253	1.564	--	INHERITED FROM: embryonic kidney
Xenopus ANatomical entity (XAN)	visual system	0.7925	1.321	--	INHERITED FROM: optic vesicle || eye
Xenopus ANatomical entity (XAN)	trunk region	1	0.388	--	INHERITED FROM: gall bladder || stomach || coelom || small intestine
Xenopus ANatomical entity (XAN)	intestine	1	1.242	--	INHERITED FROM: small intestine
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: mouth primordium || larval alimentary system || neural tube || hindbrain || small intestine || gall bladder || cardiovascular system || forebrain || midbrain-hindbrain boundary || presomitic mesoderm || optic vesicle || vestibuloauditory system || midbrain || stomach || sensory system || liver primordium || otic vesicle || embryonic kidney || eye || somite || foregut || hematological system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: cardiac mesoderm || optic field || neural plate || tail tip || prechordal plate || midbrain-hindbrain boundary || presomitic mesoderm || involuted dorsal mesoderm || forebrain || anterior neural fold || endoderm || tail fin || hindbrain || axial mesoderm || neural tube || anatomical group || cavitated compound organ || mouth primordium || multicellular anatomical structure || larval alimentary system || gall bladder || cardiovascular system || mesoderm || compound organ || anatomical region || coelom || small intestine || otic vesicle || stomodeal-hypophyseal primordium || liver primordium || pre-chordal neural plate || pharyngeal region || foregut || hematological system || anatomical space || neural fold || somite || eye || embryonic kidney || mesenchyme || sensory system || stomach || pharyngeal arch || midbrain || multi-tissue structure || neuroectoderm || primordium || vestibuloauditory system || organism subdivision || embryonic structure || optic vesicle || presumptive paraxial mesoderm || lateral plate mesoderm
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0.01101	0.5619	Least Informative	INHERITED FROM: midbrain-hindbrain boundary || forebrain || eye || otic vesicle || hindbrain || sensory system || neural tube || midbrain || vestibuloauditory system || optic vesicle
Xenopus ANatomical entity (XAN)	embryo	0.01416	0.5979	Least Informative	INHERITED FROM: embryonic structure || optic vesicle || mouth primordium || tail tip || neural plate || pre-chordal neural plate || liver primordium || stomodeal-hypophyseal primordium || stomach || optic field || neural tube || neuroectoderm || primordium || cardiac mesoderm || axial mesoderm || coelom || anterior neural fold || endoderm || presumptive paraxial mesoderm || lateral plate mesoderm || tail fin || mesoderm || somite || neural fold || involuted dorsal mesoderm || gall bladder || prechordal plate || presomitic mesoderm || midbrain-hindbrain boundary || foregut
Xenopus ANatomical entity (XAN)	head	0.05759	0.4777	Least Informative	INHERITED FROM: hindbrain || midbrain || pharyngeal arch || pharyngeal region || midbrain-hindbrain boundary || eye || forebrain
Xenopus ANatomical entity (XAN)	tissue	0.3733	0.4672	Least Informative	INHERITED FROM: stomodeal-hypophyseal primordium || optic field || otic vesicle || tail tip || neural plate || pre-chordal neural plate || involuted dorsal mesoderm || neural fold || somite || presomitic mesoderm || midbrain-hindbrain boundary || anterior neural fold || tail fin || endoderm || neuroectoderm || mesenchyme || mouth primordium || mesoderm || lateral plate mesoderm || presumptive paraxial mesoderm
Xenopus ANatomical entity (XAN)	anatomical cluster	0.9022	0.7159	Least Informative	INHERITED FROM: gall bladder || small intestine || stomach
Xenopus ANatomical entity (XAN)	urogenital system	1	0.4777	Least Informative	INHERITED FROM: embryonic kidney
Xenopus ANatomical entity (XAN)	trunk	1	0.3894	Least Informative	INHERITED FROM: gall bladder || stomach || small intestine || coelom
Xenopus ANatomical entity (XAN)	sensory system	0.0000006083	1.158	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryonic structure	0.000001428	1.149	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.000001702	1.066	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0.00225	0.9357	Moderately Informative	INHERITED FROM: tail tip || tail fin || neuroectoderm || neural fold || anterior neural fold || mouth primordium || stomodeal-hypophyseal primordium || optic field || pre-chordal neural plate || midbrain-hindbrain boundary || neural plate
Xenopus ANatomical entity (XAN)	brain	0.01915	0.7859	Moderately Informative	INHERITED FROM: forebrain || midbrain-hindbrain boundary || hindbrain || midbrain
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.03545	1.087	Moderately Informative	INHERITED FROM: somite || presomitic mesoderm
Xenopus ANatomical entity (XAN)	alimentary system	0.1865	0.8739	Moderately Informative	INHERITED FROM: larval alimentary system || small intestine || mouth primordium || liver primordium || stomach || foregut || gall bladder
Xenopus ANatomical entity (XAN)	tail region	0.4823	1.242	Moderately Informative	INHERITED FROM: tail fin || tail tip
Xenopus ANatomical entity (XAN)	viscus	0.9899	0.8828	Moderately Informative	INHERITED FROM: gall bladder || small intestine || stomach
Xenopus ANatomical entity (XAN)	mesoderm	0.0000000001584	1.285	Informative	DIRECT
Xenopus ANatomical entity (XAN)	neuroectoderm	0.000000009083	1.374	Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical direction	0.00000005611	1.661	Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesenchyme	0.00000006889	1.586	Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0.00001309	1.467	Informative	DIRECT
Xenopus ANatomical entity (XAN)	eye	0.00001545	1.403	Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical space	0.00004771	1.503	Informative	DIRECT
Xenopus ANatomical entity (XAN)	cardiovascular system	0.0005332	1.586	Informative	DIRECT
Xenopus ANatomical entity (XAN)	vestibuloauditory system	0.0007431	1.543	Informative	DIRECT
Xenopus ANatomical entity (XAN)	surface structure	0.03255	1.418	Informative	INHERITED FROM: tail fin || tail tip
Xenopus ANatomical entity (XAN)	urinary system	0.1946	1.523	Informative	INHERITED FROM: embryonic kidney
Xenopus ANatomical entity (XAN)	tail	0.3696	1.334	Informative	INHERITED FROM: tail tip || tail fin
Xenopus ANatomical entity (XAN)	liver and biliary system	0.6813	1.689	Informative	INHERITED FROM: gall bladder
Xenopus ANatomical entity (XAN)	primordium	0.00000003102	1.751	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	foregut	0.000000783	1.962	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	optic field	0.000001615	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	anterior neural fold	0.00002191	1.911	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	midbrain	0.00008728	1.865	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	lateral plate mesoderm	0.000111	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	hindbrain	0.0001851	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	involuted dorsal mesoderm	0.0002047	2.02	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	midbrain-hindbrain boundary	0.0002119	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	forebrain	0.0002451	1.786	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	neural tube	0.0002584	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	optic vesicle	0.0002596	1.911	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	somite	0.0002657	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	presomitic mesoderm	0.000504	1.911	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	fin	0.003141	1.962	Highly Informative	INHERITED FROM: tail tip || tail fin

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