Penta-EF-hand proteins family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: EF Hand-like [ 47472] (4)
• Superfamily: EF-hand [ 47473] (11)
• Family: Penta-EF-hand proteins [ 63550] (6)

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Family statistics

	Genomes (267)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,143	3,348	17
Proteins	1,143	3,348	16

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Calpain-2	0.000000000002832	2.264	--	DIRECT
Enzyme Commission (EC)	Calpain-1	0.0000000002435	2.264	--	DIRECT
Enzyme Commission (EC)	Calpain-3	0.000000002101	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5709	Least Informative	DIRECT
Enzyme Commission (EC)	Cysteine endopeptidases	0	1.326	Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	muscle tissue disease	0.0005458	1.434	--	DIRECT
Disease Ontology (DO)	muscular disease	0.0006371	1.399	--	DIRECT
Disease Ontology (DO)	musculoskeletal system disease	0.08148	0.89	--	INHERITED FROM: muscular dystrophy || muscle tissue disease || muscular disease
Disease Ontology (DO)	disease of anatomical entity	0.2274	0.2414	--	INHERITED FROM: muscle tissue disease || muscular dystrophy || muscular disease
Disease Ontology (DO)	myopathy	1	1.559	Informative	INHERITED FROM: muscular dystrophy
Disease Ontology (DO)	muscular dystrophy	0.0000132	1.911	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased susceptibility to injury	0.0001777	2.603	--	DIRECT
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.397	0.3626	--	INHERITED FROM: increased susceptibility to injury
Mammalian Phenotype (MP)	abnormal response to injury	0.01166	1.261	Informative	INHERITED FROM: increased susceptibility to injury

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || multi-tissue plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || plant organ || stem || epidermis || epidermal cell || shoot epidermal cell || plant axis || plant cell || shoot epidermis || shoot axis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: stem || guard cell || shoot epidermal cell || stomatal complex || shoot axis || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Cysteine endopeptidases	0	1.753	--	DIRECT
Enzyme Commission (EC)	Calpain-2	0.000000000003414	2.753	--	DIRECT
Enzyme Commission (EC)	Calpain-1	0.0000000002853	2.753	--	DIRECT
Enzyme Commission (EC)	Calpain-3	0.000000002437	2.753	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	1.004	Moderately Informative	DIRECT

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