SUPERFAMILY 1.75 HMM library and genome assignments server

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YWTD domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   YWTD domain [ 63825]
Family:   YWTD domain [ 63826] (2)

Family statistics
Genomes (144) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,652 14,756 3
Proteins 1,928 6,636 3

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.2361Least InformativeInherited
Disease Ontology (DO)artery disease0.00008658Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.01589Moderately InformativeInherited
Disease Ontology (DO)Alzheimer's disease0.0004559InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.01098Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.07141Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.09924Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4968Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.003814Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.008838Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.01337Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.03744Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.04156Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.05312Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.1029Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.1082Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3772Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal sterol level0.0001496InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel physiology0.0004884InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.0006523InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.000727InformativeDirect
Mammalian Phenotype (MP)abnormal lipoprotein level0.0007763InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.003363InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.0358InformativeInherited
Mammalian Phenotype (MP)abnormal long bone morphology0.03752InformativeInherited
Mammalian Phenotype (MP)abnormal circulating triglyceride level0.04846InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol homeostasis0.05606InformativeInherited
Mammalian Phenotype (MP)abnormal limb bone morphology0.1256InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.1266InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1493InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7117InformativeInherited
Mammalian Phenotype (MP)increased circulating triglyceride level0.00008001Highly InformativeDirect
Mammalian Phenotype (MP)amyloidosis0.0001012Highly InformativeDirect
Mammalian Phenotype (MP)nervous system inclusion bodies0.001055Highly InformativeInherited
Mammalian Phenotype (MP)abnormal abdominal fat pad morphology0.0031Highly InformativeInherited
Mammalian Phenotype (MP)abnormal energy expenditure0.0031Highly InformativeInherited
Mammalian Phenotype (MP)abnormal long term potentiation0.004051Highly InformativeInherited
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.01126Highly InformativeInherited
Mammalian Phenotype (MP)pigmentation phenotype0.02264Highly InformativeInherited
Mammalian Phenotype (MP)decreased triglyceride level0.2313Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.2437Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.1108Least InformativeInherited
Worm Phenotype (WP)cell secretion variant0.00001878Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a YWTD domain domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]