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  Home > SCOP hierarchy > Calcium-dependent phosphotriesterase superfamily


Calcium-dependent phosphotriesterase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Calcium-dependent phosphotriesterase [ 63829] (3)
Families:   SGL-like [ 63830] (3)
  Serum paraoxonase/arylesterase 1, PON1 [ 101895]
  All0351-like [ 159252]

 Superfamily statistics
Genomes (1,934) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,812 103,058 6
Proteins 10,449 85,483 6

 Functional annotation
General category Metabolism
Detailed category Other enzymes

Document: Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00446Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000006457InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.09793Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.004274Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.008424Moderately InformativeInherited
Disease Ontology (DO)artery disease0.008727Moderately InformativeInherited
Disease Ontology (DO)motor neuron disease0.00004371InformativeDirect
Disease Ontology (DO)celiac disease0.000003917Highly InformativeDirect
Disease Ontology (DO)lateral sclerosis0.000007056Highly InformativeDirect
Disease Ontology (DO)amyotrophic lateral sclerosis0.00002519Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.2126Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.2874Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5017Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.07072Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.15Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.1911Moderately InformativeInherited
Phenotypic Abnormality (PA)Fatigable weakness0.00001745InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.001049InformativeInherited
Phenotypic Abnormality (PA)Impairment in personality functioning0.003188InformativeInherited
Phenotypic Abnormality (PA)Constitutional symptom0.01672InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.02777InformativeInherited
Phenotypic Abnormality (PA)Fatigable weakness of swallowing muscles0.0000002742Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal larynx physiology0.000001067Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness of respiratory muscles0.000002028Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal motor neuron morphology0.000002341Highly InformativeDirect
Phenotypic Abnormality (PA)Agitation0.000008605Highly InformativeDirect
Phenotypic Abnormality (PA)Emotional lability0.00001674Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0.00001972Highly InformativeDirect
Phenotypic Abnormality (PA)Paralysis0.00002839Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of salivation0.00004375Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal fear/anxiety-related behavior0.00044Highly InformativeDirect
Phenotypic Abnormality (PA)Depressivity0.0005405Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigue0.0009343Highly InformativeDirect
Phenotypic Abnormality (PA)Respiratory insufficiency0.002288Highly InformativeInherited
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the central nervous system0.006769Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.005526Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.02533Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0001678Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.01742Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.0002025InformativeDirect
Mammalian Phenotype (MP)abnormal redox activity0.00001687Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000000004556Least InformativeDirect
Enzyme Commission (EC)Lyases0.0207Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.9744Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.000000001251InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.001838InformativeInherited
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0.6692Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium-dependent phosphotriesterase domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Calcium-dependent phosphotriesterase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.