SUPERFAMILY 1.75 HMM library and genome assignments server

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Sir2 family of transcriptional regulators family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   DHS-like NAD/FAD-binding domain [ 52466]
Superfamily:   DHS-like NAD/FAD-binding domain [ 52467] (6)
Family:   Sir2 family of transcriptional regulators [ 63984] (7)


Family statistics
Genomes (2,121) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,755 23,214 15
Proteins 3,754 23,202 15


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)lower respiratory tract disease0.00258Moderately InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.06074Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005994Moderately InformativeDirect
Mammalian Phenotype (MP)adipose tissue phenotype0.001966Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.06988Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.0005877InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0.2361InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol homeostasis0.3226InformativeInherited
Mammalian Phenotype (MP)abnormal sterol level0.3745InformativeInherited
Mammalian Phenotype (MP)hepatic steatosis0.000006511Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.00009052Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)protein expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0Moderately InformativeDirect
Worm Phenotype (WP)life span variant0InformativeDirect
Worm Phenotype (WP)protein metabolism variant0InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a DHS-like NAD/FAD-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]