PX domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: PX domain [ 64267]
• Superfamily: PX domain [ 64268]
• Family: PX domain [ 64269] (5)

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Family statistics

	Genomes (347)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	743	2,089	8
Proteins	743	2,089	8

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phospholipase D	0	2.44	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.0000000189	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0.0007616	0	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.08134	0.01852	--	INHERITED FROM: Phospholipase D || Acting on ester bonds || Phosphoric diester hydrolases
Enzyme Commission (EC)	Acting on ester bonds	0.0000178	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.0001282	1.042	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0.005228	0.8381	Moderately Informative	INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.379	Informative	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.0000000003043	1.279	Informative	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4-phosphate 3-kinase	0	2.139	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT
Phenotypic Abnormality (PA)	Delayed eruption of teeth	0.0006993	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal spleen morphology	0.002086	1.348	--	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of the spleen	0.002596	1.316	--	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Visceromegaly	0.006837	1.462	--	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.009375	0.7381	--	INHERITED FROM: Delayed eruption of teeth || Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.01314	0.7065	--	INHERITED FROM: Delayed eruption of teeth || Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormal oral mucosa morphology	0.02877	1.258	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of abdomen morphology	0.03751	1.462	--	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of the head	0.08725	0.4538	--	INHERITED FROM: Abnormality of the gingiva || Delayed eruption of teeth
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.09081	0.4454	--	INHERITED FROM: Delayed eruption of teeth || Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.1998	0.7142	--	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.03604	0.5179	Least Informative	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.04738	0.7464	Least Informative	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.05067	0.5759	Least Informative	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of the face	0.05659	0.533	Least Informative	INHERITED FROM: Delayed eruption of teeth || Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the lymphatic system	0.03742	1.184	Moderately Informative	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of the abdominal organs	0.1687	1.031	Moderately Informative	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: Delayed eruption of teeth || Abnormality of the gingiva
Phenotypic Abnormality (PA)	Splenomegaly	0.0008649	1.462	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the gingiva	0.0008993	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the dentition	0.1764	1.421	Informative	INHERITED FROM: Delayed eruption of teeth
Phenotypic Abnormality (PA)	Abnormality of dental eruption	0.02291	2.161	Highly Informative	INHERITED FROM: Delayed eruption of teeth

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	accumulated cell corpses	0	1.371	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	cell corpse number variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	apoptosis variant	0	1.125	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0	1.087	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	anterior neuron migration defective	0.000000399	2.468	--	DIRECT
Worm Phenotype (WP)	protein subcellular localization variant	0.000008131	1.513	--	DIRECT
Worm Phenotype (WP)	cell division polarity variant	0.000009222	2.292	--	DIRECT
Worm Phenotype (WP)	Q neuroblast lineage migration variant	0.0003864	1.689	--	DIRECT
Worm Phenotype (WP)	neuron migration variant	0.0005994	1.623	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.0599	0.6256	--	INHERITED FROM: protein subcellular localization variant || protein expression variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.3533	0.1444	--	INHERITED FROM: protein subcellular localization variant || protein expression variant
Worm Phenotype (WP)	organism physiology variant	0.3729	0.1342	--	INHERITED FROM: protein expression variant || protein subcellular localization variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: cell corpse number variant || neuron migration variant || hermaphrodite fertility variant || cell division polarity variant || reproductive system physiology variant || apoptosis variant || lethal || protein subcellular localization variant || development variant || accumulated germline cell corpses || cell physiology variant || hermaphrodite sterile || hermaphrodite fertility reduced || cell death variant || accumulated cell corpses || embryonic development variant || embryonic lethal || Q neuroblast lineage migration variant || fertility variant || anterior neuron migration defective || organ system physiology variant || protein expression variant || maternal sterile || organism development variant || programmed cell death variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.0836	0.6752	Least Informative	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant || anterior neuron migration defective
Worm Phenotype (WP)	organism metabolism processing variant	0.1345	0.4899	Least Informative	INHERITED FROM: protein subcellular localization variant || protein expression variant
Worm Phenotype (WP)	cell death variant	0	1.061	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0.0002994	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0.8615	1.036	Moderately Informative	INHERITED FROM: cell division polarity variant
Worm Phenotype (WP)	accumulated germline cell corpses	0	1.513	Informative	DIRECT
Worm Phenotype (WP)	pattern protein expression variant	0.01148	1.49	Informative	INHERITED FROM: protein subcellular localization variant
Worm Phenotype (WP)	cell migration variant	0.03529	1.407	Informative	INHERITED FROM: neuron migration variant || anterior neuron migration defective || Q neuroblast lineage migration variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	neuromuscular junction	0.0008727	1.787	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || adult || neuromuscular junction || organ system subdivision || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organ system subdivision || neuromuscular junction || adult || organism
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0.1929	0.6333	Least Informative	INHERITED FROM: neuromuscular junction
Fly Anatomy (FA)	peripheral nervous system	0.1366	0.8978	Moderately Informative	INHERITED FROM: neuromuscular junction
Fly Anatomy (FA)	cell component	0.008177	1.544	Informative	INHERITED FROM: neuromuscular junction

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.3879	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.3879	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.02 two leaves visible stage || LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.08 eight leaves visible stage || LP.06 six leaves visible stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: LP.08 eight leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.3895	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.4752	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.4603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.4234	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.4268	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphatidylinositol-4-phosphate 3-kinase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Phospholipase D	0	2.929	--	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.000000001029	1.639	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.000000006382	0.7021	--	DIRECT
Enzyme Commission (EC)	Transferases	0.001	0.3972	Least Informative	INHERITED FROM: directed
Enzyme Commission (EC)	Hydrolases	0.034	0.4043	Least Informative	INHERITED FROM: Acting on ester bonds || Phosphoric diester hydrolases || Phospholipase D
Enzyme Commission (EC)	Acting on ester bonds	0.000004169	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.002089	1.238	Moderately Informative	INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.0003633	1.437	Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.753	Highly Informative	DIRECT

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