Inositol polyphosphate 5-phosphatase (IPP5) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: DNase I-like [ 56218]
• Superfamily: DNase I-like [ 56219] (3)
• Family: Inositol polyphosphate 5-phosphatase (IPP5) [ 64422] (2)

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Family statistics

	Genomes (476)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,892	7,687	2
Proteins	2,890	7,680	2

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Phosphoinositide 5-phosphatase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Inositol-polyphosphate 5-phosphatase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-3,4,5-trisphosphate 5-phospha	3.476e-16	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	0.9703	Moderately Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal skull morphology	0	0.8826	--	DIRECT
Phenotypic Abnormality (PA)	Growth abnormality	0	0.7903	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle tone	0	0.8942	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.6771	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the curvature of the vertebral column	0	1.258	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal eye morphology	0	0.7812	--	DIRECT
Phenotypic Abnormality (PA)	Elevated serum creatine kinase	0.0005435	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal circulating creatine kinase concentration	0.0005787	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of circulating enzyme level	0.0006396	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the synovia	0.0007849	1.508	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the hip bone	0.002721	1.508	--	INHERITED FROM: Abnormality of the hip joint
Phenotypic Abnormality (PA)	Abnormality of pelvic girdle bone morphology	0.05076	1.462	--	INHERITED FROM: Abnormality of the hip joint
Phenotypic Abnormality (PA)	Abnormality of lower limb joint	0.112	1.348	--	INHERITED FROM: Abnormality of the hip joint
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.1208	0.8289	--	INHERITED FROM: Abnormality of epiphysis morphology || Abnormality of the hip joint
Phenotypic Abnormality (PA)	Abnormality of the eye	0	0.5703	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0	0.6429	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.08298	0.5486	Least Informative	INHERITED FROM: Abnormality of circulating enzyme level || Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration
Phenotypic Abnormality (PA)	Abnormality of the vertebral column	0	1.031	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Muscular hypotonia	0	1.031	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0	0.9309	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal circulating metabolite concentration	0.005275	0.971	Moderately Informative	INHERITED FROM: Abnormality of circulating enzyme level || Abnormal circulating creatine kinase concentration || Elevated serum creatine kinase
Phenotypic Abnormality (PA)	Abnormal joint morphology	0.1613	1.101	Moderately Informative	INHERITED FROM: Abnormality of the hip joint || Abnormality of the synovia
Phenotypic Abnormality (PA)	Scoliosis	0	1.383	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the hip joint	0.0007028	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of long bone morphology	0.07315	1.462	Informative	INHERITED FROM: Abnormality of epiphysis morphology
Phenotypic Abnormality (PA)	Abnormal circulating protein level	0.09498	1.508	Informative	INHERITED FROM: Abnormal circulating creatine kinase concentration || Elevated serum creatine kinase || Abnormality of circulating enzyme level
Phenotypic Abnormality (PA)	Abnormal vertebral morphology	0.1043	1.684	Informative	INHERITED FROM: Abnormal form of the vertebral bodies
Phenotypic Abnormality (PA)	Abnormality of epiphysis morphology	0.0003299	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal form of the vertebral bodies	0.0007707	1.86	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal postnatal growth/weight/body size	0	0.8956	--	DIRECT
Mammalian Phenotype (MP)	abnormal body weight	0.0001824	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal postnatal growth	0.07074	1.524	--	INHERITED FROM: postnatal growth retardation
Mammalian Phenotype (MP)	growth/size/body region phenotype	0	0.6254	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal body size	0.5325	1.001	Moderately Informative	INHERITED FROM: abnormal body weight
Mammalian Phenotype (MP)	postnatal growth retardation	0.0006044	1.524	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	behavior variant	0	0.6859	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0	0.7558	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7516	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || organism metabolism processing variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || gene expression variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || cell physiology variant || hermaphrodite sterile || organism environmental stimulus response variant || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || behavior variant || postembryonic development variant || larval arrest || organ system physiology variant || protein expression variant || organism behavior variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0	0.8878	Moderately Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	hyperosmotic stress resistance	0.00009737	2.143	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0.7673	0.1452	--	INHERITED FROM: osmotic stress resistance || hyperosmotic stress resistance
Yeast Phenotype (YP)	cellular processes	0.8217	0.09186	--	INHERITED FROM: hyperosmotic stress resistance || osmotic stress resistance
Yeast Phenotype (YP)	resistance to chemicals	0.5898	0.3202	Least Informative	INHERITED FROM: osmotic stress resistance || hyperosmotic stress resistance
Yeast Phenotype (YP)	development	0.04424	1.143	Moderately Informative	INHERITED FROM: replicative lifespan
Yeast Phenotype (YP)	lifespan	0.0181	1.403	Informative	INHERITED FROM: replicative lifespan
Yeast Phenotype (YP)	osmotic stress resistance	0.0001053	1.967	Highly Informative	DIRECT
Yeast Phenotype (YP)	replicative lifespan	0.0001826	2.143	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	viable	0	0.6613	Least Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.8451	--	DIRECT
Fly Anatomy (FA)	sensory system	0	0.8577	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || larva || somatic cell || cell || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: anatomical group || organ system || multicellular structure || sensory system || non-connected functional system || cell || larva || somatic cell || organism
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: urogenital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || trunk region || organism subdivision
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	trichoblast	0.00001073	2.6	--	DIRECT
Plant ANatomical entity (PAN)	root hair cell	0.00003923	2.299	--	DIRECT
Plant ANatomical entity (PAN)	root epidermis	0.0003247	1.947	--	DIRECT
Plant ANatomical entity (PAN)	root system	0.02393	0.4584	--	INHERITED FROM: root epidermis || root epidermal cell || root hair cell || trichoblast
Plant ANatomical entity (PAN)	portion of plant tissue	0.6549	0.1621	--	INHERITED FROM: root hair cell || root epidermal cell || root epidermis || trichoblast
Plant ANatomical entity (PAN)	plant cell	0.7709	0.1228	--	INHERITED FROM: trichoblast || root epidermal cell || root hair cell
Plant ANatomical entity (PAN)	epidermal cell	0.7881	0.2152	--	INHERITED FROM: root epidermal cell || trichoblast || root hair cell
Plant ANatomical entity (PAN)	epidermis	0.8374	0.2046	--	INHERITED FROM: trichoblast || root epidermis || root hair cell || root epidermal cell
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: root hair cell || collective plant structure || multi-tissue plant structure || root epidermal cell || trichoblast || plant organ || root epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: root hair cell || root epidermal cell || root epidermis || trichoblast
Plant ANatomical entity (PAN)	root epidermal cell	0.000129	1.998	Highly Informative	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0.9332	0.1593	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	whole plant development stage	0.9364	0.1547	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	seedling development stage	0.000352	1.721	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphoinositide 5-phosphatase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Inositol-polyphosphate 5-phosphatase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	1.338	Informative	DIRECT

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