SAP domain superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: LEM/SAP HeH motif [ 63450] (6)
• Superfamily: SAP domain [ 68906]
• Families: SAP domain [ 68907] (7)

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Superfamily statistics

	Genomes (552)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	5,016	14,681	8
Proteins	4,888	14,392	7

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Functional annotation

• General category: Regulation
• Detailed category: DNA-binding

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	DNA helicase	0	1.162	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.00001634	0.04271	--	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0.00000000002257	0.6408	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides; involved in cellular an	4.713e-16	0.8971	Moderately Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal striatum morphology	0.0002843	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal telencephalon morphology	0.1213	1.332	--	INHERITED FROM: abnormal striatum morphology
Mammalian Phenotype (MP)	abnormal forebrain morphology	0.1888	1.253	--	INHERITED FROM: abnormal basal ganglion morphology || abnormal striatum morphology
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.7674	0.627	--	INHERITED FROM: abnormal striatum morphology || abnormal basal ganglion morphology
Mammalian Phenotype (MP)	nervous system phenotype	0.8903	0.5166	Least Informative	INHERITED FROM: abnormal striatum morphology || abnormal basal ganglion morphology
Mammalian Phenotype (MP)	abnormal brain morphology	0.4307	1.11	Moderately Informative	INHERITED FROM: abnormal striatum morphology || abnormal basal ganglion morphology
Mammalian Phenotype (MP)	abnormal basal ganglion morphology	0.0009056	2.207	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5905	Least Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.05522	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	tagma	0	0.6478	--	DIRECT
Fly Anatomy (FA)	adult head	0	1.125	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0	0.8487	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.2279	--	DIRECT
Fly Anatomy (FA)	sense organ	0	1.101	--	DIRECT
Fly Anatomy (FA)	external sensory organ	0	1.15	--	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.7891	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.9652	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.5607	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: external sensory organ || organism || nervous system || adult || adult nervous system || larva || somatic cell || adult head || cell || multi-tissue structure || adult tagma || sense organ || tagma || head || organ system subdivision || organ system || organism subdivision || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: anatomical group || organ system || organism subdivision || multicellular structure || sensory system || adult tagma || non-connected functional system || tagma || sense organ || head || organ system subdivision || cell || multi-tissue structure || adult head || larva || somatic cell || adult || adult nervous system || external sensory organ || organism || nervous system
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.632	--	INHERITED FROM: head || tagma || adult tagma || adult head
Fly Anatomy (FA)	larva	0	0.4611	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.5607	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.7467	Least Informative	DIRECT
Fly Anatomy (FA)	cell	0	0.4937	Least Informative	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.6243	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.7081	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.5673	Least Informative	DIRECT
Fly Anatomy (FA)	head	0	1.058	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.7674	Moderately Informative	DIRECT
Fly Anatomy (FA)	sensory system	0	0.9652	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.4287	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0.000828	0.7974	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || tissue || anatomical region || trunk region || organism subdivision || cell
Xenopus ANatomical entity (XAN)	trunk	0	0.4308	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryo	0.0008311	0.6341	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: sporophyll || collective plant structure || phyllome || multi-tissue plant structure || microsporophyll || guard cell || shoot system || portion of plant tissue || stomatal complex || plant organ || whole plant || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: sporophyll || phyllome || guard cell || microsporophyll || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.5029	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on ATP; involved in cellular and subcellular movement	0.0000000000006622	1.196	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.0000000000715	0.8446	--	DIRECT
Enzyme Commission (EC)	Transferases	0.02264	0.3035	--	INHERITED FROM: NAD(+) ADP-ribosyltransferase || Aminoacyltransferases || Acyltransferases || RING-type E3 ubiquitin transferase
Enzyme Commission (EC)	Hydrolases	0.002998	0.3541	Least Informative	INHERITED FROM: DNA helicase || Acting on ATP; involved in cellular and subcellular movement || Acting on acid anhydrides
Enzyme Commission (EC)	Aminoacyltransferases	0	1.166	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0.000000007375	0.9562	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0.1066	1.204	Moderately Informative	INHERITED FROM: NAD(+) ADP-ribosyltransferase
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0	1.384	Informative	DIRECT
Enzyme Commission (EC)	DNA helicase	0.000000000000001017	1.475	Informative	DIRECT
Enzyme Commission (EC)	Pentosyltransferases	0.004645	1.447	Informative	INHERITED FROM: NAD(+) ADP-ribosyltransferase
Enzyme Commission (EC)	NAD(+) ADP-ribosyltransferase	0.00000000003583	2.049	Highly Informative	DIRECT

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