Integrin domains superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Immunoglobulin-like beta-sandwich [ 48725] (28)
• Superfamily: Integrin domains [ 69179]
• Families: Integrin domains [ 69180] (2)

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Superfamily statistics

	Genomes (146)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	5,686	14,943	5
Proteins	2,648	7,274	3

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Functional annotation

• General category: Processes_EC
• Detailed category: Cell adhesion

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	Glanzmann's thrombasthenia	0.0000342	2.371	--	DIRECT
Disease Ontology (DO)	blood platelet disease	0.00005045	1.769	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0.001167	0.2157	--	INHERITED FROM: blood platelet disease || Glanzmann's thrombasthenia || hemorrhagic disease || thrombocytopenia || bullous pemphigoid || infertility
Disease Ontology (DO)	blood coagulation disease	0.00148	1.167	--	INHERITED FROM: hemorrhagic disease || Glanzmann's thrombasthenia || thrombocytopenia || blood platelet disease
Disease Ontology (DO)	cancer	0.002054	0.3104	--	INHERITED FROM: multiple myeloma || breast cancer
Disease Ontology (DO)	autoimmune disease of skin and connective tissue	0.002186	1.371	--	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	disease of cellular proliferation	0.002616	0.2812	--	INHERITED FROM: multiple myeloma || breast cancer
Disease Ontology (DO)	thoracic cancer	0.003972	1.371	--	INHERITED FROM: breast cancer
Disease Ontology (DO)	reproductive system disease	0.008539	1.33	--	INHERITED FROM: infertility
Disease Ontology (DO)	immune system disease	0.01302	0.78	--	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	commensal bacterial infectious disease	0.01824	1.894	--	INHERITED FROM: pertussis
Disease Ontology (DO)	bone marrow cancer	0.07055	1.371	--	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	bacterial infectious disease	0.09172	1.225	--	INHERITED FROM: pertussis
Disease Ontology (DO)	immune system cancer	0.1369	0.8797	--	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	hypersensitivity reaction disease	0.6841	0.827	--	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	organ system cancer	0.2619	0.5515	Least Informative	INHERITED FROM: breast cancer || multiple myeloma
Disease Ontology (DO)	disease by infectious agent	0.00004165	0.8029	Moderately Informative	DIRECT
Disease Ontology (DO)	hematologic cancer	0.01292	0.8939	Moderately Informative	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	hematopoietic system disease	0.1406	0.9397	Moderately Informative	INHERITED FROM: Glanzmann's thrombasthenia || thrombocytopenia || hemorrhagic disease || blood platelet disease
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.5345	0.8526	Moderately Informative	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	bullous pemphigoid	0.00004891	1.526	Informative	DIRECT
Disease Ontology (DO)	breast cancer	0.0002872	1.371	Informative	DIRECT
Disease Ontology (DO)	hemorrhagic disease	0.0006067	1.468	Informative	DIRECT
Disease Ontology (DO)	inherited blood coagulation disease	0.004274	1.593	Informative	INHERITED FROM: Glanzmann's thrombasthenia
Disease Ontology (DO)	myeloid neoplasm	0.004564	1.371	Informative	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	infertility	0.000001999	2.07	Highly Informative	DIRECT
Disease Ontology (DO)	thrombocytopenia	0.000007924	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	pertussis	0.00007713	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	multiple myeloma	0.0007397	2.07	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Cephalohematoma	0.0000000911	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Neonatal alloimmune thrombocytopenia	0.0000005305	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Melena	0.000001013	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Spontaneous hematomas	0.000002812	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Subarachnoid hemorrhage	0.00001203	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Cerebral palsy	0.00004564	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Ecchymosis	0.00005038	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Petechiae	0.00008678	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Bilateral sensorineural hearing impairment	0.00008678	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Macular purpura	0.000231	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Bloody diarrhea	0.0008605	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Purpura	0.001229	2.407	--	INHERITED FROM: Petechiae || Ecchymosis || Macular purpura
Phenotypic Abnormality (PA)	Internal hemorrhage	0.01453	1.561	--	INHERITED FROM: Melena || Subarachnoid hemorrhage
Phenotypic Abnormality (PA)	Abnormal platelet count	0.02331	1.628	--	INHERITED FROM: Neonatal alloimmune thrombocytopenia
Phenotypic Abnormality (PA)	Abnormality of the skin	0.03197	0.8751	--	INHERITED FROM: Spontaneous hematomas || Macular purpura || Petechiae || Ecchymosis
Phenotypic Abnormality (PA)	Vascular skin abnormality	0.04272	1.628	--	INHERITED FROM: Spontaneous hematomas || Petechiae || Macular purpura || Ecchymosis
Phenotypic Abnormality (PA)	Abnormal delivery	0.0503	1.628	--	INHERITED FROM: Cephalohematoma
Phenotypic Abnormality (PA)	Subcutaneous hemorrhage	0.06154	2.407	--	INHERITED FROM: Petechiae || Spontaneous hematomas || Macular purpura || Ecchymosis
Phenotypic Abnormality (PA)	Abnormal ear morphology	0.07031	1.23	--	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Abdominal symptom	0.1191	1.176	--	INHERITED FROM: Bloody diarrhea || Melena
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.3579	0.7731	--	INHERITED FROM: Subarachnoid hemorrhage
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.461	0.6284	--	INHERITED FROM: Subarachnoid hemorrhage || Abnormal subarachnoid space morphology
Phenotypic Abnormality (PA)	Abnormality of the inner ear	0.5503	1.628	--	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Abnormal ear physiology	0.5555	1.561	--	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.733	0.2543	--	INHERITED FROM: Abnormal subarachnoid space morphology || Subarachnoid hemorrhage || Cerebral palsy
Phenotypic Abnormality (PA)	Hearing abnormality	1	1.561	--	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Abnormality of the integument	0.08012	0.7253	Least Informative	INHERITED FROM: Petechiae || Ecchymosis || Macular purpura || Spontaneous hematomas
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.1156	0.5805	Least Informative	INHERITED FROM: Melena || Bloody diarrhea
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.2248	0.6284	Least Informative	INHERITED FROM: Macular purpura || Spontaneous hematomas || Melena || Ecchymosis || Petechiae || Subarachnoid hemorrhage
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.5713	0.5677	Least Informative	INHERITED FROM: Subarachnoid hemorrhage || Abnormal subarachnoid space morphology
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.8275	0.4022	Least Informative	INHERITED FROM: Cerebral palsy
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.02131	0.9441	Moderately Informative	INHERITED FROM: Macular purpura || Petechiae || Ecchymosis || Spontaneous hematomas
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.08566	1.026	Moderately Informative	INHERITED FROM: Melena
Phenotypic Abnormality (PA)	Abnormality of the ear	0.1097	1.176	Moderately Informative	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.1869	1.026	Moderately Informative	INHERITED FROM: Subarachnoid hemorrhage || Spontaneous hematomas || Cephalohematoma || Petechiae || Ecchymosis || Neonatal alloimmune thrombocytopenia || Macular purpura || Melena
Phenotypic Abnormality (PA)	Abnormal cardiovascular system physiology	0.2603	1.084	Moderately Informative	INHERITED FROM: Subarachnoid hemorrhage || Melena
Phenotypic Abnormality (PA)	Abnormality of movement	0.4503	1.045	Moderately Informative	INHERITED FROM: Cerebral palsy
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.5409	0.8625	Moderately Informative	INHERITED FROM: Subarachnoid hemorrhage || Spontaneous hematomas || Macular purpura || Ecchymosis || Petechiae
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0.5591	0.9441	Moderately Informative	INHERITED FROM: Melena || Bloody diarrhea
Phenotypic Abnormality (PA)	Abnormality of central motor function	0.5858	1.064	Moderately Informative	INHERITED FROM: Cerebral palsy
Phenotypic Abnormality (PA)	Abnormality of prenatal development or birth	0.0001156	1.407	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebral vasculature	0.01402	1.561	Informative	INHERITED FROM: Subarachnoid hemorrhage
Phenotypic Abnormality (PA)	Abnormality of blood circulation	0.03267	1.561	Informative	INHERITED FROM: Melena || Subarachnoid hemorrhage
Phenotypic Abnormality (PA)	Generalized abnormality of skin	0.045	1.503	Informative	INHERITED FROM: Ecchymosis || Macular purpura || Petechiae || Spontaneous hematomas
Phenotypic Abnormality (PA)	Abnormal thrombocyte morphology	0.04792	1.561	Informative	INHERITED FROM: Neonatal alloimmune thrombocytopenia
Phenotypic Abnormality (PA)	Abnormal bleeding	0.07621	1.503	Informative	INHERITED FROM: Petechiae || Macular purpura || Spontaneous hematomas || Cephalohematoma || Melena || Subarachnoid hemorrhage || Ecchymosis
Phenotypic Abnormality (PA)	Functional abnormality of the inner ear	0.1898	1.628	Informative	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Hearing impairment	0.1961	1.561	Informative	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Functional abnormality of the gastrointestinal tract	0.4606	1.407	Informative	INHERITED FROM: Melena
Phenotypic Abnormality (PA)	Abnormal subarachnoid space morphology	0.000231	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Intracranial hemorrhage	0.001147	1.929	Highly Informative	INHERITED FROM: Subarachnoid hemorrhage
Phenotypic Abnormality (PA)	Gastrointestinal hemorrhage	0.001998	1.929	Highly Informative	INHERITED FROM: Melena
Phenotypic Abnormality (PA)	Diarrhea	0.005707	2.106	Highly Informative	INHERITED FROM: Melena || Bloody diarrhea
Phenotypic Abnormality (PA)	Thrombocytopenia	0.01921	1.804	Highly Informative	INHERITED FROM: Neonatal alloimmune thrombocytopenia
Phenotypic Abnormality (PA)	Sensorineural hearing impairment	0.2397	1.804	Highly Informative	INHERITED FROM: Bilateral sensorineural hearing impairment

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	impaired lung lobe morphogenesis	0.0000001478	2.207	--	DIRECT
Mammalian Phenotype (MP)	absent ureter	0.00003292	2.207	--	DIRECT
Mammalian Phenotype (MP)	decreased keratinocyte proliferation	0.0001195	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal branching involved in lung morphogenesis	0.0001291	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell physiology	0.000136	0.6214	--	DIRECT
Mammalian Phenotype (MP)	abnormal lens epithelium morphology	0.0001414	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell migration	0.0003278	1.394	--	DIRECT
Mammalian Phenotype (MP)	abnormal sciatic nerve morphology	0.0004056	2.508	--	DIRECT
Mammalian Phenotype (MP)	decreased CD4-positive, alpha beta T cell number	0.0004272	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.0004505	0.9281	--	DIRECT
Mammalian Phenotype (MP)	abnormal renal glomerulus basement membrane morphology	0.000527	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal glomerular capillary morphology	0.0005624	1.809	--	DIRECT
Mammalian Phenotype (MP)	abnormal podocyte foot process morphology	0.0008322	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal keratinocyte proliferation	0.0008322	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.0008554	0.8177	--	DIRECT
Mammalian Phenotype (MP)	alopecia	0.0009944	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal glomerular capsule visceral layer morphology	0.00165	2.207	--	INHERITED FROM: podocyte foot process effacement || abnormal podocyte foot process morphology
Mammalian Phenotype (MP)	abnormal T cell number	0.001736	1.605	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal platelet aggregation	0.002007	1.906	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal extracellular matrix morphology	0.002058	1.809	--	INHERITED FROM: abnormal basement membrane morphology
Mammalian Phenotype (MP)	abnormal CD4-positive, alpha beta T cell number	0.002856	2.508	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.002902	0.7444	--	INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number || abnormal hematopoietic cell morphology
Mammalian Phenotype (MP)	abnormal T cell morphology	0.002929	1.362	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal renal glomerular capsule morphology	0.00574	2.207	--	INHERITED FROM: abnormal podocyte foot process morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal capillary morphology	0.01197	1.809	--	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	abnormal platelet physiology	0.01561	1.809	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal hemostasis	0.01991	1.394	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal limb development	0.0203	2.207	--	INHERITED FROM: abnormal digit development
Mammalian Phenotype (MP)	abnormal kidney blood vessel morphology	0.02223	1.809	--	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	abnormal gut-associated lymphoid tissue morphology	0.02295	1.73	--	INHERITED FROM: abnormal Peyer's patch size
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.02574	0.9168	--	INHERITED FROM: abnormal blood cell physiology || abnormal leukocyte migration || decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal respiratory system development	0.04135	2.031	--	INHERITED FROM: abnormal branching involved in lung morphogenesis || impaired lung lobe morphogenesis
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.05725	0.8951	--	INHERITED FROM: absent ureter || abnormal podocyte foot process morphology || abnormal glomerular capillary morphology || abnormal renal glomerulus basement membrane morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal renal glomerulus morphology	0.06209	1.554	--	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.0845	1.304	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.0979	1.186	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal skin morphology	0.134	1.229	--	INHERITED FROM: blistering || abnormal epidermal layer morphology
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.1342	1.045	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	vision/eye phenotype	0.1434	0.8744	--	INHERITED FROM: abnormal lens epithelium morphology
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.1443	0.3617	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal kidney capillary morphology	0.1542	1.809	--	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.1809	0.9281	--	INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal immune system physiology	0.2018	0.737	--	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal coat/ hair morphology	0.2063	1.605	--	INHERITED FROM: alopecia
Mammalian Phenotype (MP)	limbs/digits/tail phenotype	0.2764	1.253	--	INHERITED FROM: abnormal digit development
Mammalian Phenotype (MP)	abnormal kidney cortex morphology	0.2978	1.508	--	INHERITED FROM: abnormal renal glomerulus basement membrane morphology || abnormal podocyte foot process morphology || abnormal glomerular capillary morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.3076	0.9638	--	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.3106	0.8266	--	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.3188	0.9638	--	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.3429	0.9516	--	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal respiratory system morphology	0.3969	1.165	--	INHERITED FROM: abnormal lung lobe morphology || abnormal branching involved in lung morphogenesis || abnormal right lung morphology || impaired lung lobe morphogenesis
Mammalian Phenotype (MP)	abnormal skin adnexa morphology	0.4022	1.186	--	INHERITED FROM: alopecia
Mammalian Phenotype (MP)	abnormal immune system morphology	0.409	0.8003	--	INHERITED FROM: decreased T cell number || abnormal Peyer's patch size || decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.4208	0.9397	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal alpha-beta T cell number	0.4425	2.031	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.479	1.277	--	INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal nephron morphology	0.4826	1.229	--	INHERITED FROM: abnormal renal glomerulus basement membrane morphology || abnormal podocyte foot process morphology || abnormal glomerular capillary morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal platelet activation	0.5232	1.809	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.5564	1.061	--	INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.5754	0.7085	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.5963	1.253	--	INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.6176	0.627	--	INHERITED FROM: abnormal sciatic nerve morphology
Mammalian Phenotype (MP)	abnormal kidney morphology	0.7477	1.093	--	INHERITED FROM: abnormal podocyte foot process morphology || abnormal renal glomerulus basement membrane morphology || podocyte foot process effacement || abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	abnormal cell proliferation	0.8716	1.332	--	INHERITED FROM: abnormal keratinocyte proliferation || decreased keratinocyte proliferation
Mammalian Phenotype (MP)	abnormal podocyte morphology	1	2.207	--	INHERITED FROM: abnormal podocyte foot process morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	cellular phenotype	0.0008132	0.5301	Least Informative	DIRECT
Mammalian Phenotype (MP)	immune system phenotype	0.001251	0.627	Least Informative	INHERITED FROM: abnormal leukocyte migration || decreased T cell number || abnormal Peyer's patch size || decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.007877	0.6818	Least Informative	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.01072	0.6505	Least Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || abnormal blood cell physiology || abnormal hematopoietic cell morphology || decreased T cell number || decreased platelet aggregation || abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal homeostasis	0.2814	0.495	Least Informative	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	nervous system phenotype	0.4386	0.5166	Least Informative	INHERITED FROM: abnormal sciatic nerve morphology
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.02221	1.016	Moderately Informative	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	abnormal eye morphology	0.1104	0.9168	Moderately Informative	INHERITED FROM: abnormal lens epithelium morphology
Mammalian Phenotype (MP)	respiratory system phenotype	0.1117	0.9893	Moderately Informative	INHERITED FROM: abnormal lung lobe morphology || abnormal branching involved in lung morphogenesis || impaired lung lobe morphogenesis || abnormal right lung morphology
Mammalian Phenotype (MP)	integument phenotype	0.154	0.8451	Moderately Informative	INHERITED FROM: abnormal epidermal layer morphology || decreased keratinocyte proliferation || blistering || alopecia || abnormal keratinocyte proliferation
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.2501	0.9764	Moderately Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.2621	0.9764	Moderately Informative	INHERITED FROM: abnormal sciatic nerve morphology
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.3364	1.016	Moderately Informative	INHERITED FROM: abnormal podocyte foot process morphology || absent ureter || abnormal glomerular capillary morphology || abnormal renal glomerulus basement membrane morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.3371	1.186	Moderately Informative	INHERITED FROM: abnormal Peyer's patch size
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.6463	0.9764	Moderately Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.7205	0.9764	Moderately Informative	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal leukocyte migration	0.00002314	1.605	Informative	DIRECT
Mammalian Phenotype (MP)	decreased T cell number	0.0003343	1.605	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal epidermal layer morphology	0.0007994	1.554	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal Peyer's patch morphology	0.002328	1.73	Informative	INHERITED FROM: abnormal Peyer's patch size
Mammalian Phenotype (MP)	abnormal blood coagulation	0.009524	1.394	Informative	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal skin physiology	0.04692	1.73	Informative	INHERITED FROM: decreased keratinocyte proliferation || abnormal keratinocyte proliferation
Mammalian Phenotype (MP)	decreased cell proliferation	0.06476	1.663	Informative	INHERITED FROM: decreased keratinocyte proliferation
Mammalian Phenotype (MP)	abnormal renal corpuscle morphology	0.07428	1.508	Informative	INHERITED FROM: abnormal renal glomerulus basement membrane morphology || abnormal glomerular capillary morphology || abnormal podocyte foot process morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal coat appearance	0.08638	1.605	Informative	INHERITED FROM: alopecia
Mammalian Phenotype (MP)	abnormal limb morphology	0.1671	1.429	Informative	INHERITED FROM: abnormal digit development
Mammalian Phenotype (MP)	abnormal anterior eye segment morphology	0.1787	1.394	Informative	INHERITED FROM: abnormal lens epithelium morphology
Mammalian Phenotype (MP)	abnormal lung morphology	0.2842	1.332	Informative	INHERITED FROM: abnormal right lung morphology || impaired lung lobe morphogenesis || abnormal branching involved in lung morphogenesis || abnormal lung lobe morphology
Mammalian Phenotype (MP)	abnormal skin appearance	0.3203	1.663	Informative	INHERITED FROM: blistering
Mammalian Phenotype (MP)	abnormal effector T cell morphology	0.6903	1.663	Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal alpha-beta T cell morphology	0.7956	1.663	Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal cell adhesion	0.0000000007307	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal digit development	0.0001414	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal basement membrane morphology	0.0001712	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	podocyte foot process effacement	0.0002843	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal lung lobe morphology	0.000303	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal Peyer's patch size	0.0003071	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	blistering	0.0004597	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal right lung morphology	0.0005002	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased platelet aggregation	0.0007511	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal CD4-positive, alpha beta T cell morphology	0.005559	2.031	Highly Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal spinal nerve morphology	0.006157	2.031	Highly Informative	INHERITED FROM: abnormal sciatic nerve morphology
Mammalian Phenotype (MP)	abnormal hair growth	0.01211	2.031	Highly Informative	INHERITED FROM: alopecia
Mammalian Phenotype (MP)	abnormal lung development	0.02995	2.031	Highly Informative	INHERITED FROM: impaired lung lobe morphogenesis || abnormal branching involved in lung morphogenesis
Mammalian Phenotype (MP)	abnormal keratinocyte physiology	0.05263	2.207	Highly Informative	INHERITED FROM: abnormal keratinocyte proliferation || decreased keratinocyte proliferation
Mammalian Phenotype (MP)	abnormal ureter morphology	0.06357	1.906	Highly Informative	INHERITED FROM: absent ureter
Mammalian Phenotype (MP)	decreased alpha-beta T cell number	0.1821	2.031	Highly Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal lens morphology	0.2936	1.906	Highly Informative	INHERITED FROM: abnormal lens epithelium morphology

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.4022	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0	1.385	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	muscle cell morphology variant	0	1.346	--	DIRECT
Worm Phenotype (WP)	striated muscle morphology variant	0	1.407	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0	0.8211	--	DIRECT
Worm Phenotype (WP)	engulfment failure by killer cell	0.00000000007981	2.708	--	DIRECT
Worm Phenotype (WP)	engulfment variant	0.00000003624	2.708	--	DIRECT
Worm Phenotype (WP)	body wall muscle myosin organization defective	0.00000005133	2.106	--	DIRECT
Worm Phenotype (WP)	vulva uterus connection defective	0.00000005526	1.708	--	DIRECT
Worm Phenotype (WP)	accumulated cell corpses	0.000004006	1.327	--	DIRECT
Worm Phenotype (WP)	cell corpse number variant	0.000005656	1.245	--	DIRECT
Worm Phenotype (WP)	protein metabolism variant	0.00002315	1.23	--	DIRECT
Worm Phenotype (WP)	cell migration variant	0.00003745	1.327	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.000106	0.9594	--	DIRECT
Worm Phenotype (WP)	cell death variant	0.0001264	0.9441	--	DIRECT
Worm Phenotype (WP)	organ system development variant	0.0008775	0.8099	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.01142	0.632	--	INHERITED FROM: egg laying variant
Worm Phenotype (WP)	gene expression variant	0.02161	0.6038	--	INHERITED FROM: protein expression variant || level of protein expression variant || protein expression reduced
Worm Phenotype (WP)	cell component morphology variant	0.6167	0.7833	--	INHERITED FROM: mitochondria morphology variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: level of protein expression variant || cell corpse number variant || pericellular component development variant || hermaphrodite fertility variant || distal tip cell migration variant || reproductive system physiology variant || metabolic pathway variant || cell migration variant || egg laying variant || organ system development variant || organism homeostasis metabolism variant || protein degradation variant || apoptosis variant || lethal || basement membrane remodeling variant || organism physiology variant || anchor cell invasion variant || engulfment variant || engulfment failure by killer cell || cell homeostasis metabolism variant || development variant || reproductive system development variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || cell death variant || accumulated cell corpses || embryonic development variant || embryonic lethal || vulva uterus connection defective || fertility variant || protein expression reduced || protein metabolism variant || postembryonic development variant || organ system physiology variant || protein expression variant || maternal sterile || organism development variant || programmed cell death variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.429	--	INHERITED FROM: body wall muscle sarcomere morphology variant || body wall muscle myosin organization defective
Worm Phenotype (WP)	cell morphology variant	0	0.6905	Least Informative	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7119	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.005325	0.632	Least Informative	INHERITED FROM: cell migration variant || distal tip cell migration variant
Worm Phenotype (WP)	cell physiology variant	0.009835	0.5344	Least Informative	INHERITED FROM: protein degradation variant || engulfment variant || apoptosis variant || cell corpse number variant || cell homeostasis metabolism variant || engulfment failure by killer cell || cell death variant || protein metabolism variant || accumulated cell corpses || programmed cell death variant
Worm Phenotype (WP)	organism behavior variant	0.01112	0.632	Least Informative	INHERITED FROM: egg laying variant
Worm Phenotype (WP)	organism metabolism processing variant	0.05826	0.4572	Least Informative	INHERITED FROM: protein degradation variant || level of protein expression variant || protein metabolism variant || metabolic pathway variant || protein expression reduced || protein expression variant
Worm Phenotype (WP)	pericellular component development variant	0.000004115	1.216	Moderately Informative	DIRECT
Worm Phenotype (WP)	metabolic pathway variant	0.00008175	1.117	Moderately Informative	DIRECT
Worm Phenotype (WP)	apoptosis variant	0.00008403	1	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0.0000992	1.026	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0.0001582	1.117	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.0005189	0.9294	Moderately Informative	DIRECT
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0	1.429	Informative	DIRECT
Worm Phenotype (WP)	anchor cell invasion variant	0.00000004084	1.708	Informative	DIRECT
Worm Phenotype (WP)	basement membrane remodeling variant	0.000001567	1.31	Informative	DIRECT
Worm Phenotype (WP)	mitochondria morphology variant	0.000003457	1.477	Informative	DIRECT
Worm Phenotype (WP)	level of protein expression variant	0.000005471	1.666	Informative	DIRECT
Worm Phenotype (WP)	egg laying variant	0.0001378	1.452	Informative	DIRECT
Worm Phenotype (WP)	distal tip cell migration variant	0.000000111	2.23	Highly Informative	DIRECT
Worm Phenotype (WP)	protein degradation variant	0.0000005923	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	protein expression reduced	0.000001905	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	body wall muscle thick filament variant	0.01962	2.009	Highly Informative	INHERITED FROM: body wall muscle myosin organization defective

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.05522	--	DIRECT
Fly Phenotype (FP)	viable	0	0.735	Least Informative	DIRECT
Fly Phenotype (FP)	fertile	0	0.981	Moderately Informative	DIRECT
Fly Phenotype (FP)	neuroanatomy defective	0	1.349	Informative	DIRECT
Fly Phenotype (FP)	cell number defective	0.003024	1.525	Informative	INHERITED FROM: decreased cell number
Fly Phenotype (FP)	decreased cell number	0.0002502	2.002	Highly Informative	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.812	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0	0.8487	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.2279	--	DIRECT
Fly Anatomy (FA)	late embryo	0	1.15	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.5607	--	DIRECT
Fly Anatomy (FA)	embryonic/larval visceral branch	0.000000003068	2.38	--	DIRECT
Fly Anatomy (FA)	salivary gland common duct primordium	0.000000003068	2.38	--	DIRECT
Fly Anatomy (FA)	anterior midgut primordium	0.000000004467	2.38	--	DIRECT
Fly Anatomy (FA)	anterior endoderm derivative	0.00000001533	2.38	--	DIRECT
Fly Anatomy (FA)	endodermal derivative	0.00000003171	2.38	--	DIRECT
Fly Anatomy (FA)	endocuticular specialization	0.0000003978	1.903	--	DIRECT
Fly Anatomy (FA)	endocuticle	0.0000004457	1.778	--	DIRECT
Fly Anatomy (FA)	procuticle	0.0000008355	1.778	--	DIRECT
Fly Anatomy (FA)	pupal cuticle	0.0000009165	1.778	--	DIRECT
Fly Anatomy (FA)	cuticle layer	0.0000009165	1.778	--	DIRECT
Fly Anatomy (FA)	prepupal integumentary system	0.000001005	1.778	--	DIRECT
Fly Anatomy (FA)	presumptive embryonic salivary gland	0.0000011	2.38	--	DIRECT
Fly Anatomy (FA)	prepupa	0.000001608	1.778	--	DIRECT
Fly Anatomy (FA)	mitotic domain 1	0.000002644	2.38	--	DIRECT
Fly Anatomy (FA)	embryonic midgut constriction	0.000002644	2.38	--	DIRECT
Fly Anatomy (FA)	mitotic domain	0.000002839	2.38	--	DIRECT
Fly Anatomy (FA)	stage 8 embryo	0.000003036	2.38	--	DIRECT
Fly Anatomy (FA)	fused midgut primordium	0.000003956	2.38	--	DIRECT
Fly Anatomy (FA)	embryonic/larval midgut primordium	0.00001034	2.38	--	DIRECT
Fly Anatomy (FA)	gut epithelial section	0.00002492	1.903	--	DIRECT
Fly Anatomy (FA)	gut epithelium	0.0000259	1.903	--	DIRECT
Fly Anatomy (FA)	trachea	0.00006476	1.778	--	DIRECT
Fly Anatomy (FA)	salivary gland	0.00008359	2.079	--	DIRECT
Fly Anatomy (FA)	presumptive embryonic/larval digestive system	0.00008604	1.903	--	DIRECT
Fly Anatomy (FA)	embryonic/larval gut	0.0001854	1.778	--	DIRECT
Fly Anatomy (FA)	embryonic/larval alimentary canal	0.0001896	1.778	--	DIRECT
Fly Anatomy (FA)	gland	0.0002869	1.778	--	DIRECT
Fly Anatomy (FA)	foregut	0.000366	1.778	--	DIRECT
Fly Anatomy (FA)	gamete	0.000366	2.079	--	DIRECT
Fly Anatomy (FA)	stage 16 embryo	0.000377	2.38	--	DIRECT
Fly Anatomy (FA)	midgut	0.0003796	1.681	--	DIRECT
Fly Anatomy (FA)	hemocoel	0.0004291	1.778	--	DIRECT
Fly Anatomy (FA)	immaterial anatomical entity	0.0006464	1.681	--	DIRECT
Fly Anatomy (FA)	embryonic/larval tracheal system	0.001073	1.681	--	INHERITED FROM: embryonic/larval trachea || embryonic/larval visceral branch
Fly Anatomy (FA)	non-connected developing system	0.003251	1.339	--	INHERITED FROM: embryonic foregut || embryonic/larval midgut primordium || fused midgut primordium || embryonic midgut constriction || presumptive embryonic/larval digestive system || presumptive embryonic salivary gland || anterior midgut primordium || salivary gland common duct primordium
Fly Anatomy (FA)	gut	0.003657	1.426	--	INHERITED FROM: embryonic/larval midgut || salivary gland || embryonic/larval gut || salivary gland common duct primordium || foregut || embryonic/larval salivary gland || embryonic foregut || gut epithelial section || gut epithelium || presumptive embryonic salivary gland || midgut
Fly Anatomy (FA)	alimentary canal	0.003689	1.426	--	INHERITED FROM: salivary gland || embryonic/larval midgut || embryonic/larval gut || embryonic/larval alimentary canal || salivary gland common duct primordium || foregut || embryonic/larval salivary gland || embryonic foregut || gut epithelium || gut epithelial section || presumptive embryonic salivary gland || midgut
Fly Anatomy (FA)	gastrula embryo	0.004387	1.778	--	INHERITED FROM: stage 7 embryo || stage 8 embryo || mitotic domain 1
Fly Anatomy (FA)	egg chamber	0.004655	1.602	--	INHERITED FROM: oocyte
Fly Anatomy (FA)	circulatory system	0.005266	1.301	--	INHERITED FROM: hemocoel
Fly Anatomy (FA)	ovariole	0.008352	1.301	--	INHERITED FROM: oocyte
Fly Anatomy (FA)	digestive system	0.009396	1.426	--	INHERITED FROM: embryonic foregut || embryonic/larval salivary gland || presumptive embryonic salivary gland || midgut || gut epithelial section || gut epithelium || embryonic/larval gut || embryonic/larval alimentary canal || embryonic/larval midgut || salivary gland || salivary gland common duct primordium || foregut
Fly Anatomy (FA)	ovary	0.009496	1.301	--	INHERITED FROM: oocyte
Fly Anatomy (FA)	germline cyst	0.009896	1.339	--	INHERITED FROM: oocyte
Fly Anatomy (FA)	female reproductive system	0.009957	1.301	--	INHERITED FROM: oocyte
Fly Anatomy (FA)	female organism	0.01226	1.234	--	INHERITED FROM: oocyte
Fly Anatomy (FA)	cuticle	0.01948	1.266	--	INHERITED FROM: muscle attachment site || procuticle || cuticle layer || pupal cuticle || endocuticular specialization || endocuticle
Fly Anatomy (FA)	developing embryonic structure	0.0287	1.204	--	INHERITED FROM: mitotic domain 1 || anterior endoderm derivative || presumptive embryonic/larval digestive system || anterior midgut primordium || presumptive embryonic salivary gland || endodermal derivative || germ layer derivative || salivary gland common duct primordium || embryonic foregut || mitotic domain || embryonic midgut constriction || fused midgut primordium || embryonic/larval midgut primordium
Fly Anatomy (FA)	reproductive system	0.03455	1.101	--	INHERITED FROM: oocyte || gamete
Fly Anatomy (FA)	developing material anatomical entity	0.112	0.8487	--	INHERITED FROM: anterior midgut primordium || presumptive embryonic/larval digestive system || anterior endoderm derivative || mitotic domain 1 || germ layer derivative || endodermal derivative || mitotic domain || embryonic foregut || embryonic/larval midgut primordium || fused midgut primordium || embryonic midgut constriction || presumptive embryonic salivary gland || salivary gland common duct primordium || midgut primordium
Fly Anatomy (FA)	portion of tissue	0.1378	0.7782	--	INHERITED FROM: trachea || primary trachea || gut epithelium || gut epithelial section || embryonic/larval visceral branch || embryonic/larval trachea || mitotic domain 1 || mitotic domain
Fly Anatomy (FA)	integumentary system	0.1721	0.8617	--	INHERITED FROM: prepupal integumentary system || endocuticular specialization || endocuticle || procuticle || cuticle layer || integumentary specialisation || pupal cuticle || muscle attachment site
Fly Anatomy (FA)	anatomical group	0.182	0.7891	--	INHERITED FROM: embryonic/larval midgut primordium || presumptive embryonic/larval digestive system || anterior midgut primordium || presumptive embryonic salivary gland || embryonic foregut || embryonic midgut constriction || fused midgut primordium || salivary gland common duct primordium
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: embryonic/larval gut || stage 7 embryo || embryonic foregut || mitotic domain || endocuticular specialization || organism || nervous system || peripheral nervous system || embryonic/larval midgut primordium || neuron || adult || germ layer derivative || presumptive embryonic/larval digestive system || midgut || embryonic/larval nervous system || adult nervous system || muscle attachment site || procuticle || integumentary specialisation || endocuticle || oocyte || larva || somatic cell || hemocoel || embryonic/larval visceral branch || prepupa || endodermal derivative || mitotic domain 1 || anterior endoderm derivative || stage 8 embryo || embryonic/larval salivary gland || stage 16 embryo || cuticle layer || embryonic midgut constriction || cell || gland || salivary gland || late embryo || trachea || embryonic/larval midgut || anterior midgut primordium || organ system subdivision || gut epithelium || gut epithelial section || presumptive embryonic salivary gland || fused midgut primordium || embryonic/larval alimentary canal || prepupal integumentary system || salivary gland common duct primordium || embryo || gamete || organ system || embryonic/larval trachea || pupal cuticle || foregut || multicellular structure || primary trachea
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: gamete || embryo || organ system || embryonic/larval trachea || pupal cuticle || primary trachea || multicellular structure || foregut || embryonic/larval alimentary canal || fused midgut primordium || prepupal integumentary system || salivary gland common duct primordium || embryonic/larval midgut || anterior midgut primordium || midgut primordium || organ system subdivision || presumptive embryonic salivary gland || gut epithelium || gut epithelial section || embryonic midgut constriction || cell || gland || late embryo || salivary gland || trachea || endodermal derivative || anterior endoderm derivative || mitotic domain 1 || stage 8 embryo || embryonic/larval salivary gland || stage 16 embryo || cuticle layer || oocyte || endocuticle || larva || somatic cell || embryonic/larval visceral branch || hemocoel || prepupa || embryonic/larval midgut primordium || neuron || adult || germ layer derivative || presumptive embryonic/larval digestive system || midgut || embryonic/larval nervous system || muscle attachment site || adult nervous system || procuticle || integumentary specialisation || embryonic/larval gut || stage 7 embryo || embryonic foregut || mitotic domain || endocuticular specialization || organism || nervous system || peripheral nervous system
Fly Anatomy (FA)	larva	0	0.4611	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.5607	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.7467	Least Informative	DIRECT
Fly Anatomy (FA)	cell	0	0.4937	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.5673	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0.2056	0.7081	Least Informative	INHERITED FROM: embryonic/larval gut || embryonic midgut constriction || embryonic foregut || salivary gland || embryonic/larval midgut || midgut || presumptive embryonic salivary gland || gut epithelium || gut epithelial section || oocyte || embryonic/larval alimentary canal || salivary gland common duct primordium || embryonic/larval salivary gland || foregut
Fly Anatomy (FA)	embryo	0	0.9178	Moderately Informative	DIRECT
Fly Anatomy (FA)	peripheral nervous system	0	0.9823	Moderately Informative	DIRECT
Fly Anatomy (FA)	neuron	0	0.9031	Moderately Informative	DIRECT
Fly Anatomy (FA)	female-specific anatomical entity	0.01047	1.234	Moderately Informative	INHERITED FROM: oocyte
Fly Anatomy (FA)	gonad	0.02104	1.101	Moderately Informative	INHERITED FROM: oocyte || gamete
Fly Anatomy (FA)	epithelium	0.02203	1.176	Moderately Informative	INHERITED FROM: trachea || primary trachea || gut epithelium || embryonic/larval trachea || gut epithelial section || embryonic/larval visceral branch
Fly Anatomy (FA)	acellular anatomical structure	0.02569	1.176	Moderately Informative	INHERITED FROM: cuticle layer || procuticle || muscle attachment site || endocuticle || endocuticular specialization || pupal cuticle
Fly Anatomy (FA)	region of integument	0.2105	1.038	Moderately Informative	INHERITED FROM: endocuticular specialization || muscle attachment site || integumentary specialisation
Fly Anatomy (FA)	integumentary specialisation	0.000198	1.681	Informative	DIRECT
Fly Anatomy (FA)	anatomical space	0.0006085	1.681	Informative	DIRECT
Fly Anatomy (FA)	tracheal system	0.001057	1.477	Informative	INHERITED FROM: primary trachea || trachea || embryonic/larval visceral branch || embryonic/larval trachea
Fly Anatomy (FA)	epithelial tube	0.001684	1.602	Informative	INHERITED FROM: embryonic/larval visceral branch || gut epithelium || embryonic/larval trachea || gut epithelial section || primary trachea || trachea
Fly Anatomy (FA)	primordium	0.001901	1.426	Informative	INHERITED FROM: anterior midgut primordium || salivary gland common duct primordium || embryonic/larval midgut primordium || midgut primordium || embryonic midgut constriction || fused midgut primordium
Fly Anatomy (FA)	muscle system	0.002625	1.477	Informative	INHERITED FROM: muscle attachment site
Fly Anatomy (FA)	presumptive embryonic/larval system	0.003251	1.339	Informative	INHERITED FROM: embryonic midgut constriction || fused midgut primordium || embryonic/larval midgut primordium || embryonic foregut || salivary gland common duct primordium || presumptive embryonic salivary gland || anterior midgut primordium || presumptive embryonic/larval digestive system
Fly Anatomy (FA)	embryonic/larval digestive system	0.004902	1.681	Informative	INHERITED FROM: embryonic/larval salivary gland || embryonic/larval midgut || embryonic/larval alimentary canal || embryonic/larval gut
Fly Anatomy (FA)	female germline cyst	0.004959	1.477	Informative	INHERITED FROM: oocyte
Fly Anatomy (FA)	gut section	0.01424	1.426	Informative	INHERITED FROM: embryonic/larval midgut || salivary gland || foregut || salivary gland common duct primordium || embryonic/larval salivary gland || embryonic foregut || midgut || presumptive embryonic salivary gland
Fly Anatomy (FA)	dorsal closure embryo	0.02146	1.477	Informative	INHERITED FROM: salivary gland common duct primordium || fused midgut primordium || embryonic midgut constriction
Fly Anatomy (FA)	germline cell	0.02244	1.38	Informative	INHERITED FROM: gamete || oocyte
Fly Anatomy (FA)	extended germ band embryo	0.02785	1.535	Informative	INHERITED FROM: anterior midgut primordium
Fly Anatomy (FA)	muscle attachment site	0.0000003978	2.079	Highly Informative	DIRECT
Fly Anatomy (FA)	embryonic foregut	0.00000155	2.079	Highly Informative	DIRECT
Fly Anatomy (FA)	stage 7 embryo	0.00000801	2.079	Highly Informative	DIRECT
Fly Anatomy (FA)	midgut primordium	0.00001257	2.079	Highly Informative	DIRECT
Fly Anatomy (FA)	germ layer derivative	0.00001441	2.079	Highly Informative	DIRECT
Fly Anatomy (FA)	primary trachea	0.00002037	1.778	Highly Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval salivary gland	0.00003351	2.079	Highly Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval trachea	0.00004124	2.079	Highly Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval midgut	0.00004262	2.079	Highly Informative	DIRECT
Fly Anatomy (FA)	oocyte	0.0001774	2.079	Highly Informative	DIRECT

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	fibroblast	0.0000001927	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	mesodermal cell	0.0000005331	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0.9292	0.7237	--	INHERITED FROM: fibroblast || mesodermal cell
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: mesodermal cell || fibroblast
Xenopus ANatomical entity (XAN)	cell	1	0.7974	--	INHERITED FROM: fibroblast || mesodermal cell
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	1	0.1217	--	INHERITED FROM: fibroblast || mesodermal cell
Xenopus ANatomical entity (XAN)	tissue	0.831	0.5011	Least Informative	INHERITED FROM: mesodermal cell || fibroblast
Xenopus ANatomical entity (XAN)	embryo	0.8491	0.6341	Least Informative	INHERITED FROM: mesodermal cell || fibroblast
Xenopus ANatomical entity (XAN)	mesoderm	0.2518	1.314	Informative	INHERITED FROM: fibroblast || mesodermal cell
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

---