Integrin domains family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Immunoglobulin-like beta-sandwich [ 48725] (28)
• Superfamily: Integrin domains [ 69179]
• Family: Integrin domains [ 69180] (2)

---

Family statistics

	Genomes (68)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	997	2,361	5
Proteins	487	1,168	3

---

Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	Glanzmann's thrombasthenia	0.00002409	2.513	--	DIRECT
Disease Ontology (DO)	blood platelet disease	0.00004269	1.814	--	DIRECT
Disease Ontology (DO)	bullous pemphigoid	0.00004576	1.61	--	DIRECT
Disease Ontology (DO)	pertussis	0.00006478	2.513	--	DIRECT
Disease Ontology (DO)	breast cancer	0.0002808	1.283	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0.001083	0.2414	--	INHERITED FROM: blood platelet disease || Glanzmann's thrombasthenia || hemorrhagic disease || thrombocytopenia || bullous pemphigoid || infertility
Disease Ontology (DO)	blood coagulation disease	0.00136	1.258	--	INHERITED FROM: hemorrhagic disease || Glanzmann's thrombasthenia || thrombocytopenia || blood platelet disease
Disease Ontology (DO)	cancer	0.001552	0.2555	--	INHERITED FROM: multiple myeloma || breast cancer
Disease Ontology (DO)	disease of cellular proliferation	0.001986	0.2322	--	INHERITED FROM: multiple myeloma || breast cancer
Disease Ontology (DO)	thoracic cancer	0.003556	1.283	--	INHERITED FROM: breast cancer
Disease Ontology (DO)	reproductive system disease	0.007683	1.399	--	INHERITED FROM: infertility
Disease Ontology (DO)	immune system disease	0.01015	0.8411	--	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	commensal bacterial infectious disease	0.01431	2.513	--	INHERITED FROM: pertussis
Disease Ontology (DO)	bone marrow cancer	0.05824	1.399	--	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	bacterial infectious disease	0.07957	1.191	--	INHERITED FROM: pertussis
Disease Ontology (DO)	immune system cancer	0.1182	0.89	--	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	hypersensitivity reaction disease	0.6605	0.8505	--	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	organ system cancer	0.2441	0.4879	Least Informative	INHERITED FROM: breast cancer || multiple myeloma
Disease Ontology (DO)	disease by infectious agent	0.00004246	0.8142	Moderately Informative	DIRECT
Disease Ontology (DO)	hematologic cancer	0.01108	0.89	Moderately Informative	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	hematopoietic system disease	0.12	1.051	Moderately Informative	INHERITED FROM: Glanzmann's thrombasthenia || thrombocytopenia || hemorrhagic disease || blood platelet disease
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.4724	0.8797	Moderately Informative	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	hemorrhagic disease	0.0005409	1.513	Informative	DIRECT
Disease Ontology (DO)	autoimmune disease of skin and connective tissue	0.001873	1.472	Informative	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	inherited blood coagulation disease	0.00317	1.735	Informative	INHERITED FROM: Glanzmann's thrombasthenia
Disease Ontology (DO)	myeloid neoplasm	0.003709	1.399	Informative	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	infertility	0.000001774	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	thrombocytopenia	0.000006413	2.036	Highly Informative	DIRECT
Disease Ontology (DO)	multiple myeloma	0.0005397	1.814	Highly Informative	DIRECT

---

Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Cephalohematoma	0.00000007594	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Neonatal alloimmune thrombocytopenia	0.0000004454	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Melena	0.0000008489	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Subarachnoid hemorrhage	0.000008846	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Cerebral palsy	0.0000231	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Ecchymosis	0.000026	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Bilateral sensorineural hearing impairment	0.0000444	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Petechiae	0.00006472	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Macular purpura	0.0001419	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal subarachnoid space morphology	0.0001626	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Bloody diarrhea	0.0006763	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Purpura	0.0008169	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Intracranial hemorrhage	0.0008807	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Thrombocytopenia	0.01415	1.684	--	INHERITED FROM: Neonatal alloimmune thrombocytopenia
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.01691	0.7722	--	INHERITED FROM: Macular purpura || Petechiae || Purpura || Ecchymosis || Spontaneous hematomas
Phenotypic Abnormality (PA)	Abnormality of the skin	0.02586	0.722	--	INHERITED FROM: Spontaneous hematomas || Macular purpura || Petechiae || Purpura || Ecchymosis
Phenotypic Abnormality (PA)	Abnormality of blood circulation	0.02719	1.421	--	INHERITED FROM: Melena || Intracranial hemorrhage || Subarachnoid hemorrhage
Phenotypic Abnormality (PA)	Generalized abnormality of skin	0.03501	1.383	--	INHERITED FROM: Purpura || Ecchymosis || Macular purpura || Petechiae || Spontaneous hematomas
Phenotypic Abnormality (PA)	Abnormal thrombocyte morphology	0.03535	1.421	--	INHERITED FROM: Neonatal alloimmune thrombocytopenia
Phenotypic Abnormality (PA)	Abnormal delivery	0.03798	1.763	--	INHERITED FROM: Cephalohematoma
Phenotypic Abnormality (PA)	Subcutaneous hemorrhage	0.04646	1.763	--	INHERITED FROM: Petechiae || Spontaneous hematomas || Macular purpura || Ecchymosis || Purpura
Phenotypic Abnormality (PA)	Abnormal ear morphology	0.05277	1.047	--	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Abnormal bleeding	0.0638	1.286	--	INHERITED FROM: Petechiae || Macular purpura || Intracranial hemorrhage || Spontaneous hematomas || Cephalohematoma || Melena || Subarachnoid hemorrhage || Ecchymosis || Purpura
Phenotypic Abnormality (PA)	Abdominal symptom	0.1007	1.161	--	INHERITED FROM: Bloody diarrhea || Melena
Phenotypic Abnormality (PA)	Functional abnormality of the inner ear	0.1632	1.684	--	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.3054	0.6631	--	INHERITED FROM: Subarachnoid hemorrhage || Intracranial hemorrhage
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.4102	0.533	--	INHERITED FROM: Subarachnoid hemorrhage || Intracranial hemorrhage || Abnormal subarachnoid space morphology
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.5069	0.7142	--	INHERITED FROM: Intracranial hemorrhage || Subarachnoid hemorrhage || Spontaneous hematomas || Macular purpura || Purpura || Ecchymosis || Petechiae
Phenotypic Abnormality (PA)	Abnormal ear physiology	0.5149	1.462	--	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.6974	0.2371	--	INHERITED FROM: Abnormal subarachnoid space morphology || Intracranial hemorrhage || Subarachnoid hemorrhage || Cerebral palsy
Phenotypic Abnormality (PA)	Hearing abnormality	1	1.462	--	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Abnormality of the integument	0.06718	0.6235	Least Informative	INHERITED FROM: Petechiae || Ecchymosis || Purpura || Macular purpura || Spontaneous hematomas
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.09797	0.5759	Least Informative	INHERITED FROM: Melena || Bloody diarrhea
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.1997	0.5179	Least Informative	INHERITED FROM: Macular purpura || Spontaneous hematomas || Melena || Purpura || Ecchymosis || Petechiae || Intracranial hemorrhage || Subarachnoid hemorrhage
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.5218	0.4756	Least Informative	INHERITED FROM: Intracranial hemorrhage || Subarachnoid hemorrhage || Abnormal subarachnoid space morphology
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.7975	0.3869	Least Informative	INHERITED FROM: Cerebral palsy
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.06784	1.031	Moderately Informative	INHERITED FROM: Melena
Phenotypic Abnormality (PA)	Abnormality of the ear	0.0841	0.9572	Moderately Informative	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.1718	0.9183	Moderately Informative	INHERITED FROM: Subarachnoid hemorrhage || Spontaneous hematomas || Intracranial hemorrhage || Cephalohematoma || Petechiae || Ecchymosis || Purpura || Neonatal alloimmune thrombocytopenia || Macular purpura || Melena
Phenotypic Abnormality (PA)	Abnormal cardiovascular system physiology	0.2387	0.9309	Moderately Informative	INHERITED FROM: Subarachnoid hemorrhage || Melena || Intracranial hemorrhage
Phenotypic Abnormality (PA)	Abnormality of movement	0.3893	1.064	Moderately Informative	INHERITED FROM: Cerebral palsy
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0.5267	0.9572	Moderately Informative	INHERITED FROM: Melena || Bloody diarrhea
Phenotypic Abnormality (PA)	Abnormality of central motor function	0.5304	1.047	Moderately Informative	INHERITED FROM: Cerebral palsy
Phenotypic Abnormality (PA)	Abnormality of prenatal development or birth	0.00005993	1.286	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebral vasculature	0.01201	1.462	Informative	INHERITED FROM: Subarachnoid hemorrhage || Intracranial hemorrhage
Phenotypic Abnormality (PA)	Internal hemorrhage	0.01233	1.421	Informative	INHERITED FROM: Melena || Intracranial hemorrhage || Subarachnoid hemorrhage
Phenotypic Abnormality (PA)	Abnormal platelet count	0.01766	1.559	Informative	INHERITED FROM: Neonatal alloimmune thrombocytopenia
Phenotypic Abnormality (PA)	Vascular skin abnormality	0.0338	1.462	Informative	INHERITED FROM: Spontaneous hematomas || Petechiae || Macular purpura || Ecchymosis || Purpura
Phenotypic Abnormality (PA)	Hearing impairment	0.1588	1.462	Informative	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Functional abnormality of the gastrointestinal tract	0.4306	1.421	Informative	INHERITED FROM: Melena
Phenotypic Abnormality (PA)	Abnormality of the inner ear	0.527	1.508	Informative	INHERITED FROM: Bilateral sensorineural hearing impairment
Phenotypic Abnormality (PA)	Spontaneous hematomas	0.000001881	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Gastrointestinal hemorrhage	0.001677	1.763	Highly Informative	INHERITED FROM: Melena
Phenotypic Abnormality (PA)	Diarrhea	0.004245	2.161	Highly Informative	INHERITED FROM: Melena || Bloody diarrhea
Phenotypic Abnormality (PA)	Sensorineural hearing impairment	0.2164	1.985	Highly Informative	INHERITED FROM: Bilateral sensorineural hearing impairment

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	impaired lung lobe morphogenesis	0.0000001219	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte migration	0.00001481	1.649	--	DIRECT
Mammalian Phenotype (MP)	absent ureter	0.00002365	2.302	--	DIRECT
Mammalian Phenotype (MP)	decreased keratinocyte proliferation	0.00007478	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal lens epithelium morphology	0.00009076	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal digit development	0.0001008	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell physiology	0.0001072	0.6209	--	DIRECT
Mammalian Phenotype (MP)	abnormal branching involved in lung morphogenesis	0.0001117	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal lung lobe morphology	0.0001576	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal right lung morphology	0.0001794	2.302	--	DIRECT
Mammalian Phenotype (MP)	podocyte foot process effacement	0.0001966	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal sciatic nerve morphology	0.0002501	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal glomerular capillary morphology	0.000338	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.0003549	0.8789	--	DIRECT
Mammalian Phenotype (MP)	abnormal podocyte foot process morphology	0.0005679	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.000609	0.7167	--	DIRECT
Mammalian Phenotype (MP)	abnormal keratinocyte proliferation	0.0006359	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal eosinophil cell number	0.0007699	2.603	--	DIRECT
Mammalian Phenotype (MP)	alopecia	0.0008241	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal T cell number	0.001223	1.261	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal glomerular capsule visceral layer morphology	0.001237	2.302	--	INHERITED FROM: podocyte foot process effacement || abnormal podocyte foot process morphology
Mammalian Phenotype (MP)	abnormal extracellular matrix morphology	0.001563	1.904	--	INHERITED FROM: abnormal basement membrane morphology
Mammalian Phenotype (MP)	abnormal platelet aggregation	0.001668	1.7	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal Peyer's patch morphology	0.001952	1.758	--	INHERITED FROM: abnormal Peyer's patch size
Mammalian Phenotype (MP)	abnormal CD4-positive, alpha beta T cell number	0.001974	1.7	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.002097	0.6686	--	INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number || abnormal eosinophil cell number || abnormal hematopoietic cell morphology
Mammalian Phenotype (MP)	abnormal renal glomerular capsule morphology	0.004357	2.302	--	INHERITED FROM: abnormal podocyte foot process morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal capillary morphology	0.008321	1.904	--	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	abnormal eosinophil morphology	0.008493	2.603	--	INHERITED FROM: abnormal eosinophil cell number
Mammalian Phenotype (MP)	abnormal myeloblast morphology/development	0.01054	2.603	--	INHERITED FROM: abnormal eosinophil cell number
Mammalian Phenotype (MP)	abnormal platelet physiology	0.01352	1.7	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal kidney blood vessel morphology	0.01517	1.904	--	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	abnormal hemostasis	0.0152	1.399	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal gut-associated lymphoid tissue morphology	0.01983	1.758	--	INHERITED FROM: abnormal Peyer's patch size
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.02117	0.8789	--	INHERITED FROM: abnormal cellular extravasation || abnormal blood cell physiology || abnormal leukocyte migration || decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal lung development	0.02294	1.825	--	INHERITED FROM: impaired lung lobe morphogenesis || abnormal branching involved in lung morphogenesis
Mammalian Phenotype (MP)	abnormal respiratory system development	0.03359	1.758	--	INHERITED FROM: abnormal branching involved in lung morphogenesis || impaired lung lobe morphogenesis
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.04686	0.931	--	INHERITED FROM: absent ureter || abnormal podocyte foot process morphology || abnormal glomerular capillary morphology || abnormal renal glomerulus basement membrane morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal renal corpuscle morphology	0.06434	1.427	--	INHERITED FROM: abnormal renal glomerulus basement membrane morphology || abnormal glomerular capillary morphology || abnormal podocyte foot process morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.07219	1.156	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.1087	0.9129	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number || abnormal eosinophil cell number
Mammalian Phenotype (MP)	abnormal kidney capillary morphology	0.1138	1.904	--	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	vision/eye phenotype	0.1273	0.8789	--	INHERITED FROM: abnormal lens epithelium morphology
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.139	0.3626	--	INHERITED FROM: abnormal response to injury || decreased platelet aggregation
Mammalian Phenotype (MP)	integument phenotype	0.1432	0.797	--	INHERITED FROM: abnormal epidermal layer morphology || decreased keratinocyte proliferation || blistering || alopecia || abnormal keratinocyte proliferation
Mammalian Phenotype (MP)	abnormal limb morphology	0.1447	1.281	--	INHERITED FROM: abnormal digit development
Mammalian Phenotype (MP)	decreased alpha-beta T cell number	0.1486	1.825	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.1501	0.8038	--	INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number || abnormal eosinophil cell number
Mammalian Phenotype (MP)	abnormal coat/ hair morphology	0.1678	1.649	--	INHERITED FROM: alopecia
Mammalian Phenotype (MP)	abnormal immune system physiology	0.1856	0.6789	--	INHERITED FROM: abnormal cellular extravasation || abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.2165	0.8473	--	INHERITED FROM: abnormal eosinophil cell number || decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.2498	0.931	--	INHERITED FROM: abnormal sciatic nerve morphology
Mammalian Phenotype (MP)	abnormal lung morphology	0.2518	1.205	--	INHERITED FROM: abnormal right lung morphology || impaired lung lobe morphogenesis || abnormal branching involved in lung morphogenesis || abnormal lung lobe morphology
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.2663	0.9219	--	INHERITED FROM: abnormal cellular extravasation || abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal kidney cortex morphology	0.2737	1.399	--	INHERITED FROM: abnormal renal glomerulus basement membrane morphology || abnormal podocyte foot process morphology || abnormal glomerular capillary morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.274	0.7902	--	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.2766	0.9219	--	INHERITED FROM: abnormal cellular extravasation || abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.3001	0.9219	--	INHERITED FROM: abnormal cellular extravasation || abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal immune system morphology	0.3608	0.7223	--	INHERITED FROM: decreased T cell number || abnormal eosinophil cell number || abnormal Peyer's patch size || decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal respiratory system morphology	0.3612	1.072	--	INHERITED FROM: abnormal lung lobe morphology || abnormal branching involved in lung morphogenesis || abnormal right lung morphology || impaired lung lobe morphogenesis
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.3791	0.8108	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number || abnormal eosinophil cell number
Mammalian Phenotype (MP)	abnormal myeloid leukocyte morphology	0.3984	1.223	--	INHERITED FROM: abnormal eosinophil cell number
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.4444	1.156	--	INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal nephron morphology	0.4681	1.261	--	INHERITED FROM: abnormal renal glomerulus basement membrane morphology || abnormal podocyte foot process morphology || abnormal glomerular capillary morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal granulocyte number	0.4789	1.758	--	INHERITED FROM: abnormal eosinophil cell number
Mammalian Phenotype (MP)	abnormal platelet activation	0.4839	1.7	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.5382	0.6893	--	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.5417	0.9404	--	INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.5818	0.5861	--	INHERITED FROM: abnormal sciatic nerve morphology
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.615	0.8473	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal effector T cell morphology	0.646	1.399	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal kidney morphology	0.7134	1.156	--	INHERITED FROM: abnormal podocyte foot process morphology || abnormal renal glomerulus basement membrane morphology || podocyte foot process effacement || abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	abnormal alpha-beta T cell morphology	0.7559	1.373	--	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal cell proliferation	0.8599	1.324	--	INHERITED FROM: abnormal keratinocyte proliferation || decreased keratinocyte proliferation
Mammalian Phenotype (MP)	abnormal podocyte morphology	1	2.302	--	INHERITED FROM: abnormal podocyte foot process morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	cellular phenotype	0.000621	0.5387	Least Informative	DIRECT
Mammalian Phenotype (MP)	immune system phenotype	0.0009559	0.5462	Least Informative	DIRECT
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.006701	0.6737	Least Informative	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.008438	0.5945	Least Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || abnormal cellular extravasation || abnormal blood cell physiology || abnormal eosinophil cell number || abnormal hematopoietic cell morphology || decreased T cell number || decreased platelet aggregation || abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal homeostasis	0.2426	0.4926	Least Informative	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	nervous system phenotype	0.4365	0.4959	Least Informative	INHERITED FROM: abnormal sciatic nerve morphology
Mammalian Phenotype (MP)	abnormal T cell morphology	0.002165	1.205	Moderately Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.01783	1.023	Moderately Informative	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.08041	1.072	Moderately Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal eye morphology	0.09583	0.9129	Moderately Informative	INHERITED FROM: abnormal lens epithelium morphology
Mammalian Phenotype (MP)	respiratory system phenotype	0.1048	0.9404	Moderately Informative	INHERITED FROM: abnormal lung lobe morphology || abnormal branching involved in lung morphogenesis || impaired lung lobe morphogenesis || abnormal right lung morphology
Mammalian Phenotype (MP)	abnormal skin morphology	0.1076	1.188	Moderately Informative	INHERITED FROM: blistering || abnormal epidermal layer morphology
Mammalian Phenotype (MP)	limbs/digits/tail phenotype	0.2483	1.188	Moderately Informative	INHERITED FROM: abnormal digit development
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.3111	1.047	Moderately Informative	INHERITED FROM: abnormal podocyte foot process morphology || absent ureter || abnormal glomerular capillary morphology || abnormal renal glomerulus basement membrane morphology || podocyte foot process effacement
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.3133	1.112	Moderately Informative	INHERITED FROM: abnormal Peyer's patch size
Mammalian Phenotype (MP)	abnormal skin adnexa morphology	0.3735	1.156	Moderately Informative	INHERITED FROM: alopecia
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.4817	0.9904	Moderately Informative	INHERITED FROM: abnormal eosinophil cell number
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.5803	1.023	Moderately Informative	INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.6687	0.9219	Moderately Informative	INHERITED FROM: abnormal cellular extravasation || abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.8197	0.9129	Moderately Informative	INHERITED FROM: abnormal eosinophil cell number
Mammalian Phenotype (MP)	decreased T cell number	0.0002236	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cell migration	0.0002777	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal epidermal layer morphology	0.0007079	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal response to injury	0.0007741	1.261	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal CD4-positive, alpha beta T cell morphology	0.004094	1.562	Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal blood coagulation	0.007543	1.399	Informative	INHERITED FROM: decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal skin physiology	0.0374	1.603	Informative	INHERITED FROM: decreased keratinocyte proliferation || abnormal keratinocyte proliferation
Mammalian Phenotype (MP)	abnormal renal glomerulus morphology	0.05379	1.457	Informative	INHERITED FROM: abnormal glomerular capillary morphology
Mammalian Phenotype (MP)	decreased cell proliferation	0.05574	1.603	Informative	INHERITED FROM: decreased keratinocyte proliferation
Mammalian Phenotype (MP)	abnormal coat appearance	0.07252	1.649	Informative	INHERITED FROM: alopecia
Mammalian Phenotype (MP)	abnormal bone marrow cell morphology/development	0.1059	1.7	Informative	INHERITED FROM: abnormal eosinophil cell number
Mammalian Phenotype (MP)	abnormal anterior eye segment morphology	0.15	1.489	Informative	INHERITED FROM: abnormal lens epithelium morphology
Mammalian Phenotype (MP)	abnormal granulocyte morphology	0.2987	1.7	Informative	INHERITED FROM: abnormal eosinophil cell number
Mammalian Phenotype (MP)	abnormal skin appearance	0.3018	1.524	Informative	INHERITED FROM: blistering
Mammalian Phenotype (MP)	abnormal alpha-beta T cell number	0.3962	1.562	Informative	INHERITED FROM: decreased CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal cell adhesion	0.0000000006703	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal basement membrane morphology	0.0001234	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal Peyer's patch size	0.0002314	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased CD4-positive, alpha beta T cell number	0.0002693	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	blistering	0.0003057	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal renal glomerulus basement membrane morphology	0.0003633	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased platelet aggregation	0.0006006	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cellular extravasation	0.0007515	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal spinal nerve morphology	0.004482	2.126	Highly Informative	INHERITED FROM: abnormal sciatic nerve morphology
Mammalian Phenotype (MP)	abnormal hair growth	0.01065	2.001	Highly Informative	INHERITED FROM: alopecia
Mammalian Phenotype (MP)	abnormal limb development	0.01598	2.126	Highly Informative	INHERITED FROM: abnormal digit development
Mammalian Phenotype (MP)	abnormal keratinocyte physiology	0.04051	2.126	Highly Informative	INHERITED FROM: abnormal keratinocyte proliferation || decreased keratinocyte proliferation
Mammalian Phenotype (MP)	abnormal ureter morphology	0.04683	1.904	Highly Informative	INHERITED FROM: absent ureter
Mammalian Phenotype (MP)	abnormal lens morphology	0.2641	1.825	Highly Informative	INHERITED FROM: abnormal lens epithelium morphology

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	distal tip cell migration variant	0	2.292	--	DIRECT
Worm Phenotype (WP)	accumulated cell corpses	0	1.371	--	DIRECT
Worm Phenotype (WP)	engulfment failure by killer cell	0	2.769	--	DIRECT
Worm Phenotype (WP)	vulva uterus connection defective	0	1.866	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	metabolic pathway variant	0	1.263	--	DIRECT
Worm Phenotype (WP)	behavior variant	0	0.6859	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0	0.7558	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7516	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	cell corpse number variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0	1.407	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0	1.156	--	DIRECT
Worm Phenotype (WP)	locomotion variant	0	1.053	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	apoptosis variant	0	1.125	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	engulfment variant	0	2.769	--	DIRECT
Worm Phenotype (WP)	muscle cell morphology variant	0	1.337	--	DIRECT
Worm Phenotype (WP)	striated muscle morphology variant	0	1.407	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0	1.087	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	basement membrane remodeling variant	0	1.225	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0	0.8392	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: level of protein expression variant || cell corpse number variant || pericellular component development variant || hermaphrodite fertility variant || organism metabolism processing variant || distal tip cell migration variant || reproductive system physiology variant || transgene expression variant || metabolic pathway variant || cell migration variant || egg laying variant || gene expression variant || organ system development variant || organism homeostasis metabolism variant || protein degradation variant || movement variant || apoptosis variant || lethal || basement membrane remodeling variant || organism physiology variant || anchor cell invasion variant || engulfment variant || engulfment failure by killer cell || cell homeostasis metabolism variant || development variant || reproductive system development variant || cell physiology variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || cell death variant || accumulated cell corpses || embryonic development variant || embryonic lethal || vulva uterus connection defective || fertility variant || behavior variant || protein expression reduced || protein metabolism variant || pattern of transgene expression variant || postembryonic development variant || organ system physiology variant || protein expression variant || organism behavior variant || maternal sterile || organism development variant || locomotion variant || programmed cell death variant || fertility reduced || cell development variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.446	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	pericellular component development variant	0	1.178	Moderately Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell homeostasis metabolism variant	0	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell death variant	0	1.061	Moderately Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0	0.9833	Moderately Informative	DIRECT
Worm Phenotype (WP)	movement variant	0	1.02	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0	0.8878	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell migration variant	0	1.407	Informative	DIRECT
Worm Phenotype (WP)	egg laying variant	0	1.513	Informative	DIRECT
Worm Phenotype (WP)	level of protein expression variant	0	1.689	Informative	DIRECT
Worm Phenotype (WP)	mitochondria morphology variant	0	1.513	Informative	DIRECT
Worm Phenotype (WP)	protein metabolism variant	0	1.354	Informative	DIRECT
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0	1.446	Informative	DIRECT
Worm Phenotype (WP)	protein expression reduced	0	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	protein degradation variant	0	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	anchor cell invasion variant	0	1.866	Highly Informative	DIRECT

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	lethal	0	0.678	--	DIRECT
Fly Phenotype (FP)	decreased cell number	0	1.687	--	DIRECT
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of larval stage	0	1.306	--	DIRECT
Fly Phenotype (FP)	increased mortality during development	0	0.6148	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of prepupal stage	0	1.306	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of pupal stage	0	1.239	--	DIRECT
Fly Phenotype (FP)	viable	0	0.6613	Least Informative	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5343	Least Informative	DIRECT
Fly Phenotype (FP)	visible	0	1.239	Moderately Informative	DIRECT
Fly Phenotype (FP)	fertile	0	0.8805	Moderately Informative	DIRECT
Fly Phenotype (FP)	lethal - all die before end of P-stage	0	1.181	Moderately Informative	DIRECT
Fly Phenotype (FP)	neuroanatomy defective	0	1.344	Informative	DIRECT
Fly Phenotype (FP)	cell number defective	0	1.344	Informative	DIRECT
Fly Phenotype (FP)	partially lethal	0	2.085	Highly Informative	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	head	0	0.912	--	DIRECT
Fly Anatomy (FA)	thorax	0	0.912	--	DIRECT
Fly Anatomy (FA)	thoracic segment	0	0.912	--	DIRECT
Fly Anatomy (FA)	mesothoracic segment	0	0.9578	--	DIRECT
Fly Anatomy (FA)	embryo	0	0.8978	--	DIRECT
Fly Anatomy (FA)	mitotic domain	0	2.389	--	DIRECT
Fly Anatomy (FA)	mitotic domain 1	0	2.389	--	DIRECT
Fly Anatomy (FA)	embryonic/larval visceral branch	0	2.389	--	DIRECT
Fly Anatomy (FA)	presumptive embryonic/larval digestive system	0	2.389	--	DIRECT
Fly Anatomy (FA)	anterior midgut primordium	0	2.389	--	DIRECT
Fly Anatomy (FA)	embryonic midgut constriction	0	2.389	--	DIRECT
Fly Anatomy (FA)	embryonic/larval salivary gland	0	2.088	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.7171	--	DIRECT
Fly Anatomy (FA)	prepupa	0	2.088	--	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.6649	--	DIRECT
Fly Anatomy (FA)	adult segment	0	0.821	--	DIRECT
Fly Anatomy (FA)	adult thorax	0	0.942	--	DIRECT
Fly Anatomy (FA)	adult thoracic segment	0	0.942	--	DIRECT
Fly Anatomy (FA)	alimentary canal	0	1.348	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0	0.7764	--	DIRECT
Fly Anatomy (FA)	adult sense organ	0	1.243	--	DIRECT
Fly Anatomy (FA)	retina	0	1.435	--	DIRECT
Fly Anatomy (FA)	developing embryonic structure	0	1.243	--	DIRECT
Fly Anatomy (FA)	eye	0	1.389	--	DIRECT
Fly Anatomy (FA)	wing	0	1.243	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	reproductive system	0	1.047	--	DIRECT
Fly Anatomy (FA)	female reproductive system	0	1.31	--	DIRECT
Fly Anatomy (FA)	ovary	0	1.31	--	DIRECT
Fly Anatomy (FA)	germline cyst	0	1.389	--	DIRECT
Fly Anatomy (FA)	egg chamber	0	1.69	--	DIRECT
Fly Anatomy (FA)	integumentary system	0	0.8094	--	DIRECT
Fly Anatomy (FA)	cuticle	0	1.31	--	DIRECT
Fly Anatomy (FA)	procuticle	0	2.088	--	DIRECT
Fly Anatomy (FA)	pupal cuticle	0	2.088	--	DIRECT
Fly Anatomy (FA)	tracheal system	0	1.611	--	DIRECT
Fly Anatomy (FA)	trachea	0	2.088	--	DIRECT
Fly Anatomy (FA)	muscle system	0	1.435	--	DIRECT
Fly Anatomy (FA)	muscle attachment site	0	2.389	--	DIRECT
Fly Anatomy (FA)	neuron projection bundle	0	1.243	--	DIRECT
Fly Anatomy (FA)	sensory neuron	0	1.213	--	DIRECT
Fly Anatomy (FA)	photoreceptor	0	1.348	--	DIRECT
Fly Anatomy (FA)	external sensory organ	0	1.088	--	DIRECT
Fly Anatomy (FA)	gastrula embryo	0	2.088	--	DIRECT
Fly Anatomy (FA)	stage 8 embryo	0	2.389	--	DIRECT
Fly Anatomy (FA)	stage 16 embryo	0	2.389	--	DIRECT
Fly Anatomy (FA)	foregut	0	1.787	--	DIRECT
Fly Anatomy (FA)	prepupal integumentary system	0	2.088	--	DIRECT
Fly Anatomy (FA)	adult integumentary system	0	0.9578	--	DIRECT
Fly Anatomy (FA)	gamete	0	1.912	--	DIRECT
Fly Anatomy (FA)	embryonic foregut	0	2.389	--	DIRECT
Fly Anatomy (FA)	presumptive embryonic salivary gland	0	2.389	--	DIRECT
Fly Anatomy (FA)	embryonic/larval midgut primordium	0	2.389	--	DIRECT
Fly Anatomy (FA)	adult peripheral nervous system	0	1.435	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	portion of tissue	0	0.7764	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	female organism	0	1.213	--	DIRECT
Fly Anatomy (FA)	compound cell cluster organ	0	1.389	--	DIRECT
Fly Anatomy (FA)	compound sense organ	0	1.389	--	DIRECT
Fly Anatomy (FA)	external compound sense organ	0	1.389	--	DIRECT
Fly Anatomy (FA)	cuticle layer	0	2.088	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.8451	--	DIRECT
Fly Anatomy (FA)	region of integument	0	0.884	--	DIRECT
Fly Anatomy (FA)	tagmatic subdivision of integument	0	0.9742	--	DIRECT
Fly Anatomy (FA)	embryonic/larval gut	0	1.69	--	DIRECT
Fly Anatomy (FA)	fused midgut primordium	0	2.389	--	DIRECT
Fly Anatomy (FA)	sensory system	0	0.8577	--	DIRECT
Fly Anatomy (FA)	sensory system neuron	0	1.213	--	DIRECT
Fly Anatomy (FA)	salivary gland common duct primordium	0	2.389	--	DIRECT
Fly Anatomy (FA)	endodermal derivative	0	2.389	--	DIRECT
Fly Anatomy (FA)	anterior endoderm derivative	0	2.389	--	DIRECT
Fly Anatomy (FA)	non-connected developing system	0	1.389	--	DIRECT
Fly Anatomy (FA)	gut epithelial section	0	1.787	--	DIRECT
Fly Anatomy (FA)	gut	0	1.348	--	DIRECT
Fly Anatomy (FA)	gut epithelium	0	1.787	--	DIRECT
Fly Anatomy (FA)	visual system	0	1.348	--	DIRECT
Fly Anatomy (FA)	endocuticular specialization	0	2.389	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	gut section	0	1.348	--	DIRECT
Fly Anatomy (FA)	gland	0	1.787	--	DIRECT
Fly Anatomy (FA)	embryonic/larval alimentary canal	0	1.69	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: sensory neuron || embryonic/larval gut || stage 7 embryo || adult external thorax || embryonic foregut || mitotic domain || digestive system || external sensory organ || alimentary canal || endocuticular specialization || ovariole || organism || acellular anatomical structure || dorsal closure embryo || nervous system || mesothoracic segment || eye || cuticle || peripheral nervous system || wing blade || female reproductive system || epithelium || embryonic/larval midgut primordium || adult mesothoracic segment || neuron || adult || female organism || germ layer derivative || presumptive embryonic/larval digestive system || midgut || embryonic/larval nervous system || adult nervous system || muscle attachment site || gut || ovary || retina || procuticle || germline cell || integumentary specialisation || developing embryonic structure || endocuticle || oocyte || tracheal system || segment || embryonic/larval digestive system || female germline cyst || larva || thoracic segment || somatic cell || embryonic/larval neuron || embryonic/larval visceral branch || wing || prepupa || gastrula embryo || adult head || tagmatic subdivision of integument || external compound sense organ || gonad || endodermal derivative || mitotic domain 1 || anterior endoderm derivative || photoreceptor || stage 8 embryo || portion of tissue || embryonic/larval salivary gland || stage 16 embryo || cuticle layer || nerve || embryonic midgut constriction || adult sense organ || cell || adult thorax || appendage || region of integument || muscle system || multi-tissue structure || gland || salivary gland || late embryo || trachea || embryonic/larval midgut || presumptive embryonic/larval system || germline cyst || adult tagma || anterior midgut primordium || adult segment || sense organ || tagma || head || organ system subdivision || embryonic/larval tracheal system || multi-cell-component structure || gut epithelium || gut epithelial section || presumptive embryonic salivary gland || adult peripheral nervous system || fused midgut primordium || thorax || embryonic/larval alimentary canal || egg chamber || sensory system neuron || prepupal integumentary system || central nervous system || compound sense organ || salivary gland common duct primordium || neuron projection bundle || adult integumentary system || female-specific anatomical entity || extended germ band embryo || embryo || gamete || epithelial tube || reproductive system || adult thoracic segment || organ system || embryonic/larval trachea || compound cell cluster organ || pupal cuticle || organism subdivision || integumentary system || foregut || multicellular structure || primary trachea || gut section
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: extended germ band embryo || gamete || embryo || epithelial tube || anatomical group || adult thoracic segment || reproductive system || organ system || embryonic/larval trachea || pupal cuticle || compound cell cluster organ || organism subdivision || integumentary system || primary trachea || multicellular structure || foregut || developing material anatomical entity || gut section || thorax || embryonic/larval alimentary canal || adult peripheral nervous system || fused midgut primordium || sensory system || egg chamber || sensory system neuron || prepupal integumentary system || central nervous system || compound sense organ || salivary gland common duct primordium || female-specific anatomical entity || neuron projection bundle || adult integumentary system || embryonic/larval midgut || germline cyst || presumptive embryonic/larval system || adult tagma || non-connected functional system || anterior midgut primordium || midgut primordium || adult segment || visual system || tagma || sense organ || head || organ system subdivision || embryonic/larval tracheal system || multi-cell-component structure || presumptive embryonic salivary gland || gut epithelium || gut epithelial section || nerve || embryonic midgut constriction || adult sense organ || adult thorax || cell || non-connected developing system || appendage || region of integument || muscle system || gland || multi-tissue structure || late embryo || salivary gland || trachea || gastrula embryo || adult head || gonad || external compound sense organ || endodermal derivative || tagmatic subdivision of integument || primordium || anterior endoderm derivative || mitotic domain 1 || photoreceptor || stage 8 embryo || portion of tissue || embryonic/larval salivary gland || stage 16 embryo || cuticle layer || developing embryonic structure || oocyte || endocuticle || tracheal system || segment || embryonic/larval digestive system || larva || female germline cyst || thoracic segment || somatic cell || embryonic/larval visceral branch || embryonic/larval neuron || wing || prepupa || embryonic/larval midgut primordium || epithelium || adult mesothoracic segment || neuron || adult || female organism || germ layer derivative || presumptive embryonic/larval digestive system || midgut || embryonic/larval nervous system || muscle attachment site || adult nervous system || gut || ovary || procuticle || retina || integumentary specialisation || germline cell || sensory neuron || embryonic/larval gut || stage 7 embryo || adult external thorax || embryonic foregut || digestive system || external sensory organ || mitotic domain || alimentary canal || endocuticular specialization || ovariole || organism || nervous system || mesothoracic segment || acellular anatomical structure || dorsal closure embryo || eye || cuticle || peripheral nervous system || wing blade || female reproductive system
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: eye || mesothoracic segment || wing blade || adult external thorax || adult thorax || head || tagma || adult segment || retina || adult tagma || adult mesothoracic segment || wing || thorax || thoracic segment || segment || adult head || adult thoracic segment
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	segment	0	0.6568	Least Informative	DIRECT
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	adult head	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult mesothoracic segment	0	0.9912	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult external thorax	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	gonad	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	digestive system	0	1.243	Moderately Informative	DIRECT
Fly Anatomy (FA)	central nervous system	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	peripheral nervous system	0	0.8978	Moderately Informative	DIRECT
Fly Anatomy (FA)	neuron	0	0.8451	Moderately Informative	DIRECT
Fly Anatomy (FA)	sense organ	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	late embryo	0	1.088	Moderately Informative	DIRECT
Fly Anatomy (FA)	appendage	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	epithelium	0	1.159	Moderately Informative	DIRECT
Fly Anatomy (FA)	developing material anatomical entity	0	0.8329	Moderately Informative	DIRECT
Fly Anatomy (FA)	acellular anatomical structure	0	1.134	Moderately Informative	DIRECT
Fly Anatomy (FA)	multi-cell-component structure	0	1.088	Moderately Informative	DIRECT
Fly Anatomy (FA)	female-specific anatomical entity	0	1.213	Moderately Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval tracheal system	0	1.611	Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval neuron	0	1.389	Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval digestive system	0	1.544	Informative	DIRECT
Fly Anatomy (FA)	germline cell	0	1.389	Informative	DIRECT
Fly Anatomy (FA)	ovariole	0	1.31	Informative	DIRECT
Fly Anatomy (FA)	nerve	0	1.389	Informative	DIRECT
Fly Anatomy (FA)	extended germ band embryo	0	1.435	Informative	DIRECT
Fly Anatomy (FA)	dorsal closure embryo	0	1.611	Informative	DIRECT
Fly Anatomy (FA)	midgut	0	1.611	Informative	DIRECT
Fly Anatomy (FA)	primordium	0	1.435	Informative	DIRECT
Fly Anatomy (FA)	wing blade	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	presumptive embryonic/larval system	0	1.389	Informative	DIRECT
Fly Anatomy (FA)	female germline cyst	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	epithelial tube	0	1.544	Informative	DIRECT
Fly Anatomy (FA)	germ layer derivative	0	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval trachea	0	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval midgut	0	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	oocyte	0	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	endocuticle	0	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	midgut primordium	0	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	stage 7 embryo	0	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	salivary gland	0	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	integumentary specialisation	0	1.787	Highly Informative	DIRECT
Fly Anatomy (FA)	primary trachea	0	2.088	Highly Informative	DIRECT

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	fibroblast	0.0000002822	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	mesodermal cell	0.00000078	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0.9247	0.6748	--	INHERITED FROM: fibroblast || mesodermal cell
Xenopus ANatomical entity (XAN)	cell	0.9923	0.8608	--	INHERITED FROM: fibroblast || mesodermal cell
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: mesodermal cell || fibroblast
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	1	0.1131	--	INHERITED FROM: fibroblast || mesodermal cell
Xenopus ANatomical entity (XAN)	tissue	0.8385	0.4672	Least Informative	INHERITED FROM: mesodermal cell || fibroblast
Xenopus ANatomical entity (XAN)	embryo	0.8446	0.5979	Least Informative	INHERITED FROM: mesodermal cell || fibroblast
Xenopus ANatomical entity (XAN)	mesoderm	0.2672	1.285	Informative	INHERITED FROM: fibroblast || mesodermal cell
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---