Thioesterase domain of polypeptide, polyketide and fatty acid synthases family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: alpha/beta-Hydrolases [ 53473]
• Superfamily: alpha/beta-Hydrolases [ 53474] (41)
• Family: Thioesterase domain of polypeptide, polyketide and fatty acid synthases [ 69584] (4)

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Family statistics

	Genomes (173)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	259	1,388	6
Proteins	259	1,387	6

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin	0	2.264	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.0000001023	0.8778	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.00000843	0.935	--	DIRECT
Enzyme Commission (EC)	Carbon-oxygen lyases	0.0000441	0.8221	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.01425	0.01852	--	INHERITED FROM: Acting on ester bonds || Thiolester hydrolases || Oleoyl-[acyl-carrier-protein] hydrolase
Enzyme Commission (EC)	Transferases	0.1381	0	--	INHERITED FROM: [Acyl-carrier-protein] S-malonyltransferase || Beta-ketoacyl-acyl-carrier-protein synthase I || Acyltransferases || Transferring groups other than amino-acyl groups || [Acyl-carrier-protein] S-acetyltransferase || Fatty-acid synthase
Enzyme Commission (EC)	Acting on ester bonds	0.000003809	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Ligases	0.006621	0.7455	Least Informative	INHERITED FROM: Forming carbon-nitrogen bonds || N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin || Acid--D-amino-acid ligases (peptide synthases)
Enzyme Commission (EC)	Lyases	0.001397	0.4956	Least Informative	INHERITED FROM: Carbon-oxygen lyases || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat || Hydro-lyases
Enzyme Commission (EC)	Oxidoreductases	0.006412	0.3212	Least Informative	INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0.000000004558	1.185	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.00000002418	1.001	Moderately Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.000006465	0.9853	Moderately Informative	DIRECT
Enzyme Commission (EC)	Hydro-lyases	0.00000849	0.9853	Moderately Informative	DIRECT
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	0.00003586	0.993	Moderately Informative	DIRECT
Enzyme Commission (EC)	Thiolester hydrolases	0.000000000000001037	1.595	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.0000000001222	1.399	Informative	DIRECT
Enzyme Commission (EC)	Acid--D-amino-acid ligases (peptide synthases)	0.0000001163	1.379	Informative	DIRECT
Enzyme Commission (EC)	Oleoyl-[acyl-carrier-protein] hydrolase	0	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Fatty-acid synthase	0	1.896	Highly Informative	DIRECT
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s	0	1.896	Highly Informative	DIRECT
Enzyme Commission (EC)	3-oxoacyl-[acyl-carrier-protein] reductase	0	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat	0	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	[Acyl-carrier-protein] S-acetyltransferase	3.476e-16	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	[Acyl-carrier-protein] S-malonyltransferase	0.0000000000004195	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Beta-ketoacyl-acyl-carrier-protein synthase I	0.000000006691	1.787	Highly Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)	0	2.327	--	DIRECT
Enzyme Commission (EC)	Oleoyl-[acyl-carrier-protein] hydrolase	0	2.23	--	DIRECT
Enzyme Commission (EC)	3-oxoacyl-[acyl-carrier-protein] reductase	0	2.385	--	DIRECT
Enzyme Commission (EC)	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Fatty-acid synthase system	3.693e-16	2.327	--	DIRECT
Enzyme Commission (EC)	[Acyl-carrier-protein] S-acetyltransferase	0.00000000000001226	2.275	--	DIRECT
Enzyme Commission (EC)	[Acyl-carrier-protein] S-malonyltransferase	0.000000000006202	2.327	--	DIRECT
Enzyme Commission (EC)	3-hydroxyacyl-[acyl-carrier-protein] dehydratase	0.000000000007928	2.385	--	DIRECT
Enzyme Commission (EC)	Beta-ketoacyl-[acyl-carrier-protein] synthase I	0.00000000002901	2.275	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.00001309	1.372	--	DIRECT
Enzyme Commission (EC)	Carbon-oxygen lyases	0.0001042	1.208	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0.01136	0.7328	Least Informative	INHERITED FROM: With NAD(+) or NADP(+) as acceptor || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || Acting on the CH-CH group of donors || Acting on the CH-OH group of donors
Enzyme Commission (EC)	Hydrolases	0.02246	0.4043	Least Informative	INHERITED FROM: Acting on ester bonds || Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases
Enzyme Commission (EC)	Transferases	0.0504	0.3972	Least Informative	INHERITED FROM: Fatty-acid synthase system || Transferring groups other than amino-acyl groups || [Acyl-carrier-protein] S-malonyltransferase || [Acyl-carrier-protein] S-acetyltransferase || Beta-ketoacyl-[acyl-carrier-protein] synthase I || Acyltransferases
Enzyme Commission (EC)	Acyltransferases	0.000000003952	1.034	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.00001313	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Lyases	0.005599	0.8775	Moderately Informative	INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase || Carbon-oxygen lyases || Hydro-lyases
Enzyme Commission (EC)	Ligases	0.01124	1.14	Moderately Informative	INHERITED FROM: Acid--amino-acid ligases (peptide synthases) || N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase || Forming carbon-nitrogen bonds
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.000000000149	1.321	Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0.00000002109	1.586	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.00001027	1.437	Informative	DIRECT
Enzyme Commission (EC)	Hydro-lyases	0.00001877	1.385	Informative	DIRECT
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	0.0001282	1.338	Informative	DIRECT
Enzyme Commission (EC)	Thiolester hydrolases	0.000000000000003456	1.951	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.0000000002434	1.783	Highly Informative	DIRECT
Enzyme Commission (EC)	Acid--amino-acid ligases (peptide synthases)	0.0000001963	1.832	Highly Informative	DIRECT

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