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Integrin beta tail domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Integrin beta tail domain [ 69686]
Superfamily:   Integrin beta tail domain [ 69687]
Families:   Integrin beta tail domain [ 69688]

Superfamily statistics
Genomes (138) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 731 2,087 1
Proteins 729 2,081 1

Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5081Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0005741Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0008002Moderately InformativeDirect
Disease Ontology (DO)skin disease0.003951Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.000000216InformativeDirect
Disease Ontology (DO)bullous skin disease0.000001181InformativeDirect
Disease Ontology (DO)connective tissue cancer0.001096InformativeInherited
Disease Ontology (DO)osteosarcoma0.0002136Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin morphology0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.008139Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.01296Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01892Least InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.0000486Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.0002292Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0003631Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.000756Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.01561Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02363Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.105Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2893Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.000001408InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.000003118InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0008736InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.006344InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.009194InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.5408InformativeInherited
Mammalian Phenotype (MP)abnormal trophoblast layer morphology0.0001318Highly InformativeDirect
Mammalian Phenotype (MP)abnormal preimplantation embryo morphology0.000272Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hematocrit0.0005778Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair growth0.0008514Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR012896 SSF69687 Protein matches

This entry represents the tail domain of the integrin beta subunit. It forms a four-stranded beta-sheet that contains parallel and anttparallel strands and faces an alpha helix found at the N-terminus of this domain [PubMed11546839]. Interactions between the alpha-helix and the beta-sheet are mostly hydrophobic and involve a disulphide bond. The rear of the beta sheet is covered with a long A-B loop.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Integrin beta tail domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Integrin beta tail domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]