Integrin beta tail domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Integrin beta tail domain [ 69686]
• Superfamily: Integrin beta tail domain [ 69687]
• Family: Integrin beta tail domain [ 69688]

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Family statistics

	Genomes (59)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	103	250	1
Proteins	103	250	1

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	dermatitis herpetiformis	0.000000001449	1.668	--	DIRECT
Disease Ontology (DO)	bullous pemphigoid	0.0000001884	1.61	--	DIRECT
Disease Ontology (DO)	dermatitis	0.000178	1.283	--	DIRECT
Disease Ontology (DO)	bone cancer	0.000198	1.61	--	DIRECT
Disease Ontology (DO)	connective tissue cancer	0.0007565	1.367	--	DIRECT
Disease Ontology (DO)	hypersensitivity reaction disease	0.001044	0.8505	--	INHERITED FROM: dermatitis herpetiformis || autoimmune disease of skin and connective tissue || bullous pemphigoid || hypersensitivity reaction type II disease
Disease Ontology (DO)	musculoskeletal system cancer	0.002307	1.283	--	INHERITED FROM: osteosarcoma || bone cancer || connective tissue cancer
Disease Ontology (DO)	skin disease	0.003148	1.022	--	INHERITED FROM: bullous skin disease || dermatitis herpetiformis || dermatitis
Disease Ontology (DO)	immune system disease	0.01705	0.8411	--	INHERITED FROM: bullous pemphigoid || autoimmune disease of skin and connective tissue || hypersensitivity reaction type II disease || dermatitis herpetiformis
Disease Ontology (DO)	organ system cancer	0.4774	0.4879	Least Informative	INHERITED FROM: osteosarcoma || bone cancer || connective tissue cancer
Disease Ontology (DO)	cell type cancer	0	0.9112	Moderately Informative	DIRECT
Disease Ontology (DO)	disease by infectious agent	0.0004569	0.8142	Moderately Informative	DIRECT
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.0005992	0.8797	Moderately Informative	DIRECT
Disease Ontology (DO)	integumentary system disease	0.01891	0.9817	Moderately Informative	INHERITED FROM: bullous skin disease || dermatitis herpetiformis || dermatitis
Disease Ontology (DO)	bullous skin disease	0.0000009604	1.472	Informative	DIRECT
Disease Ontology (DO)	autoimmune disease of skin and connective tissue	0.0001041	1.472	Informative	DIRECT
Disease Ontology (DO)	osteosarcoma	0.0001548	1.61	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the mouth	0	0.7065	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skin	0	0.722	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0	0.7722	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal oral morphology	0	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.533	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the integument	0	0.6235	Least Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal leukocyte migration	0.00000208	1.649	--	DIRECT
Mammalian Phenotype (MP)	increased inflammatory response	0.0000136	1.059	--	DIRECT
Mammalian Phenotype (MP)	alopecia	0.00006186	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal preimplantation embryo morphology	0.0001722	2.302	--	DIRECT
Mammalian Phenotype (MP)	integument phenotype	0.0002478	0.797	--	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton physiology	0.0004939	1.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.001511	0.7167	--	INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.002804	0.6686	--	INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.004962	0.7902	--	INHERITED FROM: abnormal blood vessel morphology
Mammalian Phenotype (MP)	abnormal cell physiology	0.004988	0.6209	--	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal extraembryonic tissue morphology	0.006973	1.348	--	INHERITED FROM: abnormal trophoblast layer morphology
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.0092	0.9404	--	INHERITED FROM: abnormal digestive system physiology
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.01581	0.8789	--	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	skeleton phenotype	0.03697	0.8038	--	INHERITED FROM: abnormal skeleton physiology
Mammalian Phenotype (MP)	embryo phenotype	0.08671	0.8708	--	INHERITED FROM: abnormal trophoblast layer morphology || abnormal preimplantation embryo morphology
Mammalian Phenotype (MP)	abnormal immune system physiology	0.2063	0.6789	--	INHERITED FROM: increased inflammatory response || abnormal leukocyte migration || abnormal inflammatory response
Mammalian Phenotype (MP)	abnormal coat/ hair morphology	0.2399	1.649	--	INHERITED FROM: abnormal hair growth || alopecia
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.2585	0.8789	--	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.4316	0.9219	--	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.4397	0.9219	--	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.4577	0.9219	--	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal erythroid lineage cell morphology	0.5107	1.457	--	INHERITED FROM: abnormal hematocrit
Mammalian Phenotype (MP)	immune system phenotype	0	0.5462	Least Informative	DIRECT
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.005847	0.5945	Least Informative	INHERITED FROM: abnormal myeloid cell morphology || abnormal hematocrit || abnormal leukocyte migration
Mammalian Phenotype (MP)	cellular phenotype	0.009722	0.5387	Least Informative	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.01483	0.6737	Least Informative	INHERITED FROM: abnormal blood vessel morphology
Mammalian Phenotype (MP)	abnormal inflammatory response	0.0000364	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.0001442	0.9904	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.0005412	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.01176	0.9219	Moderately Informative	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	neoplasm	0.01966	1.035	Moderately Informative	INHERITED FROM: altered tumor pathology || abnormal tumor morphology
Mammalian Phenotype (MP)	abnormal embryo morphology	0.04672	1.112	Moderately Informative	INHERITED FROM: abnormal preimplantation embryo morphology
Mammalian Phenotype (MP)	abnormal skin morphology	0.0594	1.188	Moderately Informative	INHERITED FROM: abnormal epidermal layer morphology
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.2613	0.9129	Moderately Informative	INHERITED FROM: abnormal hematocrit
Mammalian Phenotype (MP)	abnormal skin adnexa morphology	0.3028	1.156	Moderately Informative	INHERITED FROM: alopecia || abnormal hair growth
Mammalian Phenotype (MP)	abnormal epidermal layer morphology	0.000001089	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal digestive system physiology	0.0005791	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	altered tumor pathology	0.0006115	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal placenta morphology	0.00101	1.649	Informative	INHERITED FROM: abnormal trophoblast layer morphology
Mammalian Phenotype (MP)	abnormal coat appearance	0.004498	1.649	Informative	INHERITED FROM: abnormal hair growth || alopecia
Mammalian Phenotype (MP)	abnormal cell migration	0.006944	1.399	Informative	INHERITED FROM: abnormal leukocyte migration
Mammalian Phenotype (MP)	abnormal erythrocyte morphology	0.2314	1.524	Informative	INHERITED FROM: abnormal hematocrit
Mammalian Phenotype (MP)	abnormal trophoblast layer morphology	0.00008582	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal tumor morphology	0.000191	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal hematocrit	0.0004088	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal hair growth	0.0006366	2.001	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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