SUPERFAMILY 1.75 HMM library and genome assignments server

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Integrin beta EGF-like domains family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Family:   Integrin beta EGF-like domains [ 69940]

Family statistics
Genomes (0) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 0 0 0
Proteins 0 0 0

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4774Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0004569Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0005992Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.01891Moderately InformativeInherited
Disease Ontology (DO)bullous skin disease0.0000009604InformativeDirect
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.0001041InformativeDirect
Disease Ontology (DO)osteosarcoma0.0001548InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.002974Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.004735Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.006207Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.02155Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.000114Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.0001955Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.0007111Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.02213Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.02263Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.03072Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.0594Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2613Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.3028Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.000003762InformativeDirect
Mammalian Phenotype (MP)abnormal placenta morphology0.0001038InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.0001812InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.001059InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.007436InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.01603InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.2314InformativeInherited
Mammalian Phenotype (MP)abnormal tumor morphology0.0003367Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hematocrit0.0007097Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair growth0.001103Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 83 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a EGF/Laminin domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]