Interleukin 17F, IL-17F family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: Cystine-knot cytokines [ 57500]
• Superfamily: Cystine-knot cytokines [ 57501] (7)
• Family: Interleukin 17F, IL-17F [ 69955]

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Family statistics

	Genomes (49)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	82	192	1
Proteins	82	192	1

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	dermatitis	0.00001788	1.283	--	DIRECT
Disease Ontology (DO)	demyelinating disease	0.00005245	1.367	--	DIRECT
Disease Ontology (DO)	bronchial disease	0.0001013	1.133	--	DIRECT
Disease Ontology (DO)	skin disease	0.0003666	1.022	--	DIRECT
Disease Ontology (DO)	vascular disease	0.003539	0.832	--	INHERITED FROM: vasculitis
Disease Ontology (DO)	central nervous system disease	0.004958	0.8698	--	INHERITED FROM: demyelinating disease || multiple sclerosis
Disease Ontology (DO)	respiratory system disease	0.005121	0.9334	--	INHERITED FROM: bronchial disease || lower respiratory tract disease || asthma
Disease Ontology (DO)	cardiovascular system disease	0.03378	0.7889	--	INHERITED FROM: vasculitis
Disease Ontology (DO)	nervous system disease	0.07985	0.7279	Least Informative	INHERITED FROM: demyelinating disease || multiple sclerosis
Disease Ontology (DO)	lower respiratory tract disease	0.0007261	0.9947	Moderately Informative	DIRECT
Disease Ontology (DO)	neurodegenerative disease	0.001986	1.022	Moderately Informative	INHERITED FROM: multiple sclerosis || demyelinating disease
Disease Ontology (DO)	integumentary system disease	0.002663	0.9817	Moderately Informative	INHERITED FROM: dermatitis || atopic dermatitis || skin disease
Disease Ontology (DO)	vasculitis	0.000002246	1.668	Informative	DIRECT
Disease Ontology (DO)	multiple sclerosis	0.00005036	1.399	Informative	DIRECT
Disease Ontology (DO)	asthma	0.00009631	1.258	Informative	DIRECT
Disease Ontology (DO)	atopic dermatitis	0.000003377	1.911	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0	0.9129	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system morphology	0	0.7223	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0	0.8038	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system physiology	0	0.6789	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0	0.6686	--	DIRECT
Mammalian Phenotype (MP)	abnormal effector T cell morphology	0	1.399	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0	0.9404	--	DIRECT
Mammalian Phenotype (MP)	abnormal cytokine secretion	0	1.085	--	DIRECT
Mammalian Phenotype (MP)	abnormal T cell number	0	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0	0.8108	--	DIRECT
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0	0.8473	--	DIRECT
Mammalian Phenotype (MP)	abnormal interleukin secretion	0	1.188	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0	0.8473	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0	0.7167	--	DIRECT
Mammalian Phenotype (MP)	abnormal susceptibility to induced colitis	0.0000000279	1.758	--	DIRECT
Mammalian Phenotype (MP)	decreased interleukin-17 secretion	0.00000004977	2.603	--	DIRECT
Mammalian Phenotype (MP)	colitis	0.0000001407	1.758	--	DIRECT
Mammalian Phenotype (MP)	large intestinal inflammation	0.0000001824	1.649	--	DIRECT
Mammalian Phenotype (MP)	intestinal inflammation	0.0000005376	1.649	--	DIRECT
Mammalian Phenotype (MP)	abnormal intestine physiology	0.000002366	1.603	--	DIRECT
Mammalian Phenotype (MP)	autoimmune response	0.00000727	1.324	--	DIRECT
Mammalian Phenotype (MP)	abnormal self tolerance	0.000007464	1.324	--	DIRECT
Mammalian Phenotype (MP)	abnormal CD4-positive, alpha beta T cell number	0.000008538	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal IgG2a level	0.000009997	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal IgG2 level	0.00002386	1.7	--	DIRECT
Mammalian Phenotype (MP)	increased immunoglobulin level	0.0001452	1.825	--	DIRECT
Mammalian Phenotype (MP)	decreased immunoglobulin level	0.0002041	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal IgG level	0.000407	1.562	--	DIRECT
Mammalian Phenotype (MP)	increased inflammatory response	0.0004645	1.059	--	DIRECT
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.0009958	0.9404	--	DIRECT
Mammalian Phenotype (MP)	abnormal B cell physiology	0.001668	1.172	--	INHERITED FROM: decreased immunoglobulin level || abnormal IgG2 level || abnormal IgG level || increased immunoglobulin level || decreased IgG level || abnormal IgG2a level
Mammalian Phenotype (MP)	abnormal immune tolerance	0.002231	1.324	--	INHERITED FROM: decreased susceptibility to experimental autoimmune encephalomyelitis || autoimmune response || abnormal self tolerance || altered susceptibility to autoimmune disorder
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.007216	1.112	--	INHERITED FROM: abnormal IgG level || abnormal IgG2 level || decreased immunoglobulin level || abnormal IgG2a level || decreased IgG level || increased immunoglobulin level
Mammalian Phenotype (MP)	abnormal response to infection	0.008645	1.112	--	INHERITED FROM: altered susceptibility to infection || increased susceptibility to infection || altered susceptibility to bacterial infection
Mammalian Phenotype (MP)	abnormal interleukin-17 secretion	0.01265	2.603	--	INHERITED FROM: decreased interleukin-17 secretion
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.02197	0.8789	--	INHERITED FROM: abnormal IgG2a level || decreased immunoglobulin level || increased immunoglobulin level || decreased IgG level || abnormal IgG2 level || abnormal IgG level
Mammalian Phenotype (MP)	abnormal humoral immune response	0.05785	1.457	--	INHERITED FROM: decreased immunoglobulin level || abnormal IgG2a level || decreased IgG level || increased immunoglobulin level || abnormal IgG level || abnormal IgG2 level
Mammalian Phenotype (MP)	abnormal myeloid leukocyte morphology	0.1741	1.223	--	INHERITED FROM: abnormal granulocyte morphology
Mammalian Phenotype (MP)	decreased susceptibility to autoimmune disorder	0.2744	1.758	--	INHERITED FROM: decreased susceptibility to experimental autoimmune encephalomyelitis
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.3622	0.8789	--	INHERITED FROM: abnormal IgG level || abnormal IgG2 level || decreased IgG level || increased immunoglobulin level || decreased immunoglobulin level || abnormal IgG2a level
Mammalian Phenotype (MP)	abnormal alpha-beta T cell morphology	0.4072	1.373	--	INHERITED FROM: abnormal CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.5365	0.9219	--	INHERITED FROM: abnormal IgG level || abnormal IgG2 level || increased immunoglobulin level || decreased IgG level || decreased immunoglobulin level || abnormal IgG2a level
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.5439	0.9219	--	INHERITED FROM: decreased IgG level || increased immunoglobulin level || abnormal IgG2 level || abnormal IgG level || abnormal IgG2a level || decreased immunoglobulin level
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.5609	0.9219	--	INHERITED FROM: abnormal IgG2 level || abnormal IgG level || decreased IgG level || increased immunoglobulin level || decreased immunoglobulin level || abnormal IgG2a level
Mammalian Phenotype (MP)	immune system phenotype	0	0.5462	Least Informative	DIRECT
Mammalian Phenotype (MP)	hematopoietic system phenotype	0	0.5945	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0	1.001	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal T cell morphology	0	1.205	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	altered susceptibility to infection	0.00002774	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.005943	1.098	Moderately Informative	INHERITED FROM: abnormal IgG level || abnormal IgG2 level || decreased immunoglobulin level || abnormal IgG2a level || decreased IgG level || increased immunoglobulin level
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.01726	0.9219	Moderately Informative	INHERITED FROM: abnormal IgG level || abnormal IgG2 level || increased immunoglobulin level || decreased IgG level || decreased immunoglobulin level || abnormal IgG2a level
Mammalian Phenotype (MP)	abnormal inflammatory response	0.1384	1.023	Moderately Informative	INHERITED FROM: increased inflammatory response || large intestinal inflammation || abnormal susceptibility to induced colitis || colitis || intestinal inflammation
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.4064	1.112	Moderately Informative	INHERITED FROM: abnormal lymph node morphology
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.5916	0.9904	Moderately Informative	INHERITED FROM: abnormal granulocyte morphology
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.6907	0.9129	Moderately Informative	INHERITED FROM: abnormal granulocyte morphology
Mammalian Phenotype (MP)	altered susceptibility to autoimmune disorder	0.00000261	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	altered susceptibility to bacterial infection	0.000003413	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	increased susceptibility to infection	0.00001214	1.324	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal digestive system physiology	0.00004813	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal lymph node morphology	0.0003419	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal granulocyte morphology	0.0009754	1.7	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal alpha-beta T cell number	0.1841	1.562	Informative	INHERITED FROM: abnormal CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	abnormal immunoglobulin level	0.2335	1.524	Informative	INHERITED FROM: decreased immunoglobulin level || abnormal IgG2 level || abnormal IgG level || increased immunoglobulin level || decreased IgG level || abnormal IgG2a level
Mammalian Phenotype (MP)	abnormal CD4-positive, alpha beta T cell morphology	0.2361	1.562	Informative	INHERITED FROM: abnormal CD4-positive, alpha beta T cell number
Mammalian Phenotype (MP)	decreased susceptibility to experimental autoimmune encephalomyelitis	0.000002955	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased IgG level	0.00009076	2.001	Highly Informative	DIRECT

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