SUPERFAMILY 1.75 HMM library and genome assignments server

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Interleukin 17F, IL-17F family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Family:   Interleukin 17F, IL-17F [ 69955]

Family statistics
Genomes (49) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 82 192 1
Proteins 82 192 1

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.07985Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.0007261Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.001986Moderately InformativeInherited
Disease Ontology (DO)integumentary system disease0.002663Moderately InformativeInherited
Disease Ontology (DO)vasculitis0.000002246InformativeDirect
Disease Ontology (DO)multiple sclerosis0.00005036InformativeDirect
Disease Ontology (DO)asthma0.00009631InformativeDirect
Disease Ontology (DO)atopic dermatitis0.000003377Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.00002774Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.005943Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.01726Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.4064Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.5916Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6907Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.00000261InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.000003413InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.00001214InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.00004813InformativeDirect
Mammalian Phenotype (MP)abnormal lymph node morphology0.0003419InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte morphology0.0009754InformativeDirect
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.1841InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.2335InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.2361InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to experimental autoimmune encephalomyelitis0.000002955Highly InformativeDirect
Mammalian Phenotype (MP)decreased IgG level0.00009076Highly InformativeDirect

Document: MP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cystine-knot cytokines domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Internal database links ]