1gx1 A: PDB entry domain

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Bacillus chorismate mutase-like [ 55297] (9)
• Superfamily: IpsF-like [ 69765]
• Family: IpsF-like [ 69766] (2)
• Protein:
  • 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF [69767]
• PDB Entry Domain:
  • 1gx1 A: [ 70675]
  • SUPERFAMILY domain annotation for 1gx1a
  • PDB structure summary for 1gx1

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InterPro annotation

• Cross references: IPR003526 SSF69765 Protein matches
• Abstract:

  This entry represents MECDP (2-C-methyl-D-erythritol 2,4-cyclodiphosphate) synthetase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis, isoprenoids being essential in all organisms. Isoprenoids can also be synthesized through the mevalonate pathway. The non-mevolante route is used by many bacteria and human pathogens, including Mycobacterium tuberculosis and Plasmodium falciparum. This route appears to involve seven enzymes. MECDP synthetase catalyses the intramolecular attack by a phosphate group on a diphosphate, with cytidine monophosphate (CMP) acting as the leaving group to give the cyclic diphosphate product MEDCP. The enzyme is a trimer with three active sites shared between adjacent copies of the protein. The enzyme also has two metal binding sites, the metals playing key roles in catalysis[12499535].

  A number of proteins from eukaryotes and prokaryotes share this common N-terminal signature and appear to be involved in terpenoid biosynthesis. The ygbB protein is a putative enzyme of this type [10694574].

InterPro database

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