SCF ubiquitin ligase complex WHB domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: DNA/RNA-binding 3-helical bundle [ 46688] (14)
• Superfamily: "Winged helix" DNA-binding domain [ 46785] (84)
• Family: SCF ubiquitin ligase complex WHB domain [ 74679] (3)

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Family statistics

	Genomes (262)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	741	1,931	6
Proteins	741	1,931	6

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal cell physiology	0	0.6209	--	DIRECT
Mammalian Phenotype (MP)	abnormal survival	0	0.6441	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality between implantation and somite formation	0.000104	1.825	--	DIRECT
Mammalian Phenotype (MP)	increased apoptosis	0.000135	1.241	--	DIRECT
Mammalian Phenotype (MP)	increased cell death	0.0001367	1.241	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality between implantation and placentation	0.0003602	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal apoptosis	0.0008205	1.023	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality	0.00226	1.126	--	INHERITED FROM: embryonic lethality between implantation and placentation || embryonic lethality between implantation and somite formation || embryonic lethality between implantation and somite formation, complete penetrance
Mammalian Phenotype (MP)	abnormal embryo development	0.004849	1.427	--	INHERITED FROM: abnormal developmental patterning || abnormal gastrulation
Mammalian Phenotype (MP)	embryo phenotype	0.02635	0.8708	--	INHERITED FROM: abnormal gastrulation || abnormal developmental patterning
Mammalian Phenotype (MP)	embryonic lethality prior to tooth bud stage	0.09897	1.457	--	INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and somite formation || embryonic lethality between implantation and placentation
Mammalian Phenotype (MP)	preweaning lethality	0.6399	0.7055	--	INHERITED FROM: embryonic lethality between implantation and placentation || embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and somite formation
Mammalian Phenotype (MP)	cellular phenotype	0	0.5387	Least Informative	DIRECT
Mammalian Phenotype (MP)	mortality/aging	0	0.5424	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cell death	0.06988	0.9904	Moderately Informative	INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis
Mammalian Phenotype (MP)	prenatal lethality	0.09977	0.9129	Moderately Informative	INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and placentation || embryonic lethality between implantation and somite formation
Mammalian Phenotype (MP)	abnormal developmental patterning	0.0004394	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	embryonic lethality prior to organogenesis	0.001514	1.457	Informative	INHERITED FROM: embryonic lethality between implantation and somite formation || embryonic lethality between implantation and placentation || embryonic lethality between implantation and somite formation, complete penetrance
Mammalian Phenotype (MP)	embryonic lethality between implantation and somite formation, complete penetrance	0.00007969	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal gastrulation	0.0002112	1.758	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	accumulated cell corpses	0	1.371	--	DIRECT
Worm Phenotype (WP)	protein subcellular localization variant	0	1.513	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	cell corpse number variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	apoptosis variant	0	1.125	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0	1.087	--	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0.00007454	1.156	--	DIRECT
Worm Phenotype (WP)	protein aggregation induced behavior variant	0.00008074	1.769	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.0002035	1.087	--	DIRECT
Worm Phenotype (WP)	protein interaction variant	0.0126	1.078	--	INHERITED FROM: protein aggregation induced behavior variant || protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: cell corpse number variant || organism metabolism processing variant || protein protein interaction variant || gene expression variant || pattern protein expression variant || chemical response variant || organism homeostasis metabolism variant || apoptosis variant || lethal || organism physiology variant || protein subcellular localization variant || protein aggregation induced behavior variant || life span variant || development variant || accumulated germline cell corpses || apoptosis increased || reproductive system development variant || cell physiology variant || organism environmental stimulus response variant || spontaneous mutation rate increased || cell death variant || accumulated cell corpses || embryonic development variant || embryonic lethal || protein aggregation variant || chemical hypersensitive || protein expression variant || organism development variant || programmed cell death variant
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	chemical response variant	0	0.9053	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell death variant	0	1.061	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0.0002287	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0.001104	0.9113	Moderately Informative	INHERITED FROM: reproductive system development variant
Worm Phenotype (WP)	life span variant	0	1.321	Informative	DIRECT
Worm Phenotype (WP)	accumulated germline cell corpses	0	1.513	Informative	DIRECT
Worm Phenotype (WP)	pattern protein expression variant	0	1.49	Informative	DIRECT
Worm Phenotype (WP)	chemical hypersensitive	0	1.388	Informative	DIRECT
Worm Phenotype (WP)	apoptosis increased	0	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	spontaneous mutation rate increased	0.0000002018	2.07	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	reproductive system	0	1.047	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	portion of tissue	0	0.7764	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	female organism	0.0007428	1.213	--	DIRECT
Fly Anatomy (FA)	germline cyst	0.009808	1.389	--	INHERITED FROM: female germline cyst
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || adult || female organism || female germline cyst || larva || somatic cell || gonad || portion of tissue || cell || multi-tissue structure || organ system subdivision || epithelial cell || female-specific anatomical entity || reproductive system || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: reproductive system || organ system || multicellular structure || developing material anatomical entity || epithelial cell || female-specific anatomical entity || organ system subdivision || cell || multi-tissue structure || gonad || portion of tissue || larva || female germline cyst || somatic cell || adult || female organism || organism
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	gonad	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	developing material anatomical entity	0	0.8329	Moderately Informative	DIRECT
Fly Anatomy (FA)	female-specific anatomical entity	0.0005615	1.213	Moderately Informative	DIRECT
Fly Anatomy (FA)	epithelium	0.07172	1.159	Moderately Informative	INHERITED FROM: epithelial cell
Fly Anatomy (FA)	female germline cyst	0.0001473	1.486	Informative	DIRECT
Fly Anatomy (FA)	epithelial cell	0.0006476	1.787	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.7579	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: testis || urogenital system || genital system || male genitalia
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || head region || genital system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || compound organ || trunk || anatomical region || male genitalia || trunk region || male organism || organism subdivision || head
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.7647	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: flower || collective plant structure || reproductive shoot system || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: flower || reproductive shoot system || shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || corolla development stage || plant organ development stage

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