Cullin repeat family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: alpha-alpha superhelix [ 48370] (24)
• Superfamily: Cullin repeat-like [ 74788] (2)
• Family: Cullin repeat [ 74789] (2)

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Family statistics

	Genomes (464)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,334	6,415	4
Proteins	2,318	6,384	4

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal apoptosis	0	1.023	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell physiology	0	0.6209	--	DIRECT
Mammalian Phenotype (MP)	increased apoptosis	0	1.241	--	DIRECT
Mammalian Phenotype (MP)	abnormal survival	0	0.6441	--	DIRECT
Mammalian Phenotype (MP)	increased cell death	0	1.241	--	DIRECT
Mammalian Phenotype (MP)	decreased embryo size	0.0003312	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal embryo size	0.0005237	1.562	--	DIRECT
Mammalian Phenotype (MP)	abnormal embryo development	0.001425	1.427	--	INHERITED FROM: abnormal developmental patterning || abnormal gastrulation
Mammalian Phenotype (MP)	embryo phenotype	0.008842	0.8708	--	INHERITED FROM: abnormal gastrulation || abnormal developmental patterning || abnormal embryo size || decreased embryo size
Mammalian Phenotype (MP)	abnormal prenatal growth/weight/body size	0.02985	1.348	--	INHERITED FROM: abnormal prenatal body size || abnormal embryo size || decreased embryo size
Mammalian Phenotype (MP)	growth/size/body region phenotype	0	0.6254	Least Informative	DIRECT
Mammalian Phenotype (MP)	cellular phenotype	0	0.5387	Least Informative	DIRECT
Mammalian Phenotype (MP)	mortality/aging	0	0.5424	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cell death	0	0.9904	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal embryo morphology	0.004138	1.112	Moderately Informative	INHERITED FROM: decreased embryo size || abnormal embryo size
Mammalian Phenotype (MP)	abnormal developmental patterning	0.0001155	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal prenatal body size	0.0009308	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal embryonic growth/weight/body size	0.001401	1.489	Informative	INHERITED FROM: decreased embryo size || abnormal embryo size
Mammalian Phenotype (MP)	abnormal gastrulation	0.0000541	1.758	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	accumulated cell corpses	0	1.371	--	DIRECT
Worm Phenotype (WP)	protein subcellular localization variant	0	1.513	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	cell corpse number variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	apoptosis variant	0	1.125	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0	1.087	--	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0.00007454	1.156	--	DIRECT
Worm Phenotype (WP)	protein aggregation induced behavior variant	0.00008074	1.769	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.0002035	1.087	--	DIRECT
Worm Phenotype (WP)	protein interaction variant	0.0126	1.078	--	INHERITED FROM: protein aggregation induced behavior variant || protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: cell corpse number variant || organism metabolism processing variant || protein protein interaction variant || gene expression variant || pattern protein expression variant || chemical response variant || organism homeostasis metabolism variant || apoptosis variant || lethal || organism physiology variant || protein subcellular localization variant || protein aggregation induced behavior variant || life span variant || development variant || accumulated germline cell corpses || apoptosis increased || reproductive system development variant || cell physiology variant || organism environmental stimulus response variant || spontaneous mutation rate increased || cell death variant || accumulated cell corpses || embryonic development variant || embryonic lethal || protein aggregation variant || chemical hypersensitive || protein expression variant || organism development variant || programmed cell death variant
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	chemical response variant	0	0.9053	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell death variant	0	1.061	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0.0002287	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0.001104	0.9113	Moderately Informative	INHERITED FROM: reproductive system development variant
Worm Phenotype (WP)	life span variant	0	1.321	Informative	DIRECT
Worm Phenotype (WP)	accumulated germline cell corpses	0	1.513	Informative	DIRECT
Worm Phenotype (WP)	pattern protein expression variant	0	1.49	Informative	DIRECT
Worm Phenotype (WP)	chemical hypersensitive	0	1.388	Informative	DIRECT
Worm Phenotype (WP)	apoptosis increased	0	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	spontaneous mutation rate increased	0.0000002018	2.07	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	reproductive system	0	1.047	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	portion of tissue	0	0.7764	--	DIRECT
Fly Anatomy (FA)	somatic precursor cell	0	1.185	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	germline cyst	0.02212	1.389	--	INHERITED FROM: female germline cyst
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || adult || female germline cyst || larva || somatic cell || gonad || portion of tissue || somatic precursor cell || cell || multi-tissue structure || organ system subdivision || reproductive system || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: reproductive system || organ system || multicellular structure || developing material anatomical entity || organ system subdivision || cell || multi-tissue structure || gonad || portion of tissue || somatic precursor cell || larva || female germline cyst || somatic cell || adult || organism
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	gonad	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	developing material anatomical entity	0	0.8329	Moderately Informative	DIRECT
Fly Anatomy (FA)	female germline cyst	0.0008149	1.486	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.7579	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: testis || urogenital system || nervous system || genital system || male genitalia || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || head region || genital system || nervous system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || compound organ || trunk || anatomical region || central nervous system || male genitalia || trunk region || anatomical cluster || male organism || organism subdivision || head
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.7647	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: flower || collective plant structure || reproductive shoot system || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: flower || reproductive shoot system || shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || corolla development stage || plant organ development stage

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