gamma-adaptin C-terminal appendage domain-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Immunoglobulin-like beta-sandwich [ 48725] (28)
• Superfamily: Clathrin adaptor appendage domain [ 49348] (3)
• Family: gamma-adaptin C-terminal appendage domain-like [ 74857] (3)

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Family statistics

	Genomes (103)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	450	1,171	9
Proteins	450	1,171	9

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3626	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood homeostasis	0	0.6893	--	DIRECT
Mammalian Phenotype (MP)	abnormal survival	0	0.6441	--	DIRECT
Mammalian Phenotype (MP)	preweaning lethality	0	0.7055	--	DIRECT
Mammalian Phenotype (MP)	abnormal birth weight	0.0000009101	1.904	--	DIRECT
Mammalian Phenotype (MP)	hypoglycemia	0.000001158	2.126	--	DIRECT
Mammalian Phenotype (MP)	slow postnatal weight gain	0.000007034	2.302	--	DIRECT
Mammalian Phenotype (MP)	decreased birth body size	0.00001086	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal birth body size	0.0001999	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal postnatal growth	0.001786	1.524	--	INHERITED FROM: slow postnatal weight gain
Mammalian Phenotype (MP)	neonatal lethality	0.001801	1.825	--	INHERITED FROM: neonatal lethality, incomplete penetrance
Mammalian Phenotype (MP)	abnormal fertility/fecundity	0.004354	1.302	--	INHERITED FROM: reduced fertility
Mammalian Phenotype (MP)	decreased body weight	0.01127	1.562	--	INHERITED FROM: slow postnatal weight gain
Mammalian Phenotype (MP)	reproductive system phenotype	0.01231	0.8397	--	INHERITED FROM: reduced fertility
Mammalian Phenotype (MP)	abnormal total tissue mass	0.01506	1.188	--	INHERITED FROM: slow postnatal weight gain
Mammalian Phenotype (MP)	abnormal body weight	0.01746	1.156	--	INHERITED FROM: slow postnatal weight gain
Mammalian Phenotype (MP)	abnormal glucose homeostasis	0.02914	1.261	--	INHERITED FROM: hypoglycemia || decreased circulating glucose level
Mammalian Phenotype (MP)	abnormal postnatal growth/weight/body size	0.5038	0.8956	--	INHERITED FROM: slow postnatal weight gain
Mammalian Phenotype (MP)	abnormal homeostasis	0	0.4926	Least Informative	DIRECT
Mammalian Phenotype (MP)	growth/size/body region phenotype	0	0.6254	Least Informative	DIRECT
Mammalian Phenotype (MP)	mortality/aging	0	0.5424	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal reproductive system physiology	0.006651	1.012	Moderately Informative	INHERITED FROM: reduced fertility
Mammalian Phenotype (MP)	abnormal body size	0.0347	1.001	Moderately Informative	INHERITED FROM: slow postnatal weight gain
Mammalian Phenotype (MP)	abnormal body composition	0.2176	1.112	Moderately Informative	INHERITED FROM: slow postnatal weight gain
Mammalian Phenotype (MP)	lethality during fetal growth through weaning	0.2571	1.035	Moderately Informative	INHERITED FROM: neonatal lethality, incomplete penetrance
Mammalian Phenotype (MP)	postnatal growth retardation	0.001621	1.524	Informative	INHERITED FROM: slow postnatal weight gain
Mammalian Phenotype (MP)	decreased total tissue mass	0.01127	1.524	Informative	INHERITED FROM: slow postnatal weight gain
Mammalian Phenotype (MP)	abnormal circulating glucose level	0.01838	1.562	Informative	INHERITED FROM: hypoglycemia || decreased circulating glucose level
Mammalian Phenotype (MP)	decreased body size	0.02478	1.281	Informative	INHERITED FROM: slow postnatal weight gain
Mammalian Phenotype (MP)	perinatal lethality	0.03932	1.603	Informative	INHERITED FROM: neonatal lethality, incomplete penetrance
Mammalian Phenotype (MP)	decreased birth weight	0.0000008737	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	neonatal lethality, incomplete penetrance	0.0001023	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased circulating glucose level	0.0001077	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	reduced fertility	0.0003792	1.825	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	intestine	0	1.242	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.7579	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: testis || alimentary system || urogenital system || intestine || nervous system || brain || genital system || musculoskeletal system || male genitalia || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || head region || genital system || brain || intestine || nervous system || alimentary system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || compound organ || trunk || tissue || anatomical region || central nervous system || male genitalia || trunk region || anatomical cluster || viscus || male organism || musculoskeletal system || organism subdivision || head
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.7859	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.7647	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	musculoskeletal system	0	1.087	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.8828	Moderately Informative	DIRECT

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