Amidase signature (AS) enzymes family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Amidase signature (AS) enzymes [ 75303]
• Superfamily: Amidase signature (AS) enzymes [ 75304]
• Family: Amidase signature (AS) enzymes [ 75305] (4)

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Family statistics

	Genomes (2,867)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	9,811	74,036	12
Proteins	9,793	73,936	12

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Amidase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Fatty acid amide hydrolase	0.000000000000001037	2.741	--	DIRECT
Enzyme Commission (EC)	In linear amides	0.000000000001634	1.21	--	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptid	0	0.8435	Moderately Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	intestine	0	1.242	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: alimentary system || intestine
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: intestine || alimentary system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || trunk region || anatomical cluster || viscus || organism subdivision
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.8828	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	flower bud	0.0000001487	2.299	--	DIRECT
Plant ANatomical entity (PAN)	reproductive bud	0.0000001572	2.299	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0.2073	0.4282	--	INHERITED FROM: rosette leaf
Plant ANatomical entity (PAN)	reproductive shoot system	0.4202	0.3304	--	INHERITED FROM: reproductive bud || flower bud
Plant ANatomical entity (PAN)	phyllome	0.4671	0.3234	--	INHERITED FROM: rosette leaf
Plant ANatomical entity (PAN)	shoot system	1	0.05272	--	INHERITED FROM: bud || rosette leaf || flower bud || reproductive bud
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: rosette leaf || root || collective plant structure || bud || multi-tissue plant structure || reproductive bud || plant organ || root system || flower bud || plant axis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: flower bud || root system || root || rosette leaf || bud || reproductive bud
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0.1965	0.437	Least Informative	INHERITED FROM: rosette leaf
Plant ANatomical entity (PAN)	rosette leaf	0.00003484	1.725	Informative	DIRECT
Plant ANatomical entity (PAN)	bud	0.0000002903	2.202	Highly Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.3879	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.3879	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.02 two leaves visible stage || LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || LP.06 six leaves visible stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.3895	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.4752	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.4603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.4234	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.4268	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Amidase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Fatty acid amide hydrolase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Glutaminyl-tRNA synthase (glutamine-hydrolyzing)	0	3.23	--	DIRECT
Enzyme Commission (EC)	Allophanate hydrolase	0.00000003864	3.23	--	DIRECT
Enzyme Commission (EC)	Hydrolases	1	0.4043	Least Informative	INHERITED FROM: In linear amides || Amidase || Fatty acid amide hydrolase || Allophanate hydrolase
Enzyme Commission (EC)	Ligases	0	1.14	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	0.01865	1.213	Moderately Informative	INHERITED FROM: In linear amides || Allophanate hydrolase || Amidase || Fatty acid amide hydrolase
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	0	1.338	Informative	DIRECT
Enzyme Commission (EC)	In linear amides	0.00000001943	1.539	Informative	DIRECT
Enzyme Commission (EC)	Carbon--nitrogen ligases with glutamine as amido-N-donor	0	1.999	Highly Informative	DIRECT

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	Hydrolase	0.0004636	0.4314	Least Informative	DIRECT

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