Clathrin coat assembly domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Profilin-like [ 55769] (10)
• Superfamily: SNARE-like [ 64356] (4)
• Family: Clathrin coat assembly domain [ 75521] (2)

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Family statistics

	Genomes (503)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,734	7,612	5
Proteins	2,731	7,609	5

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Short philtrum	0.0003626	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Poor speech	0.0005601	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of mouth size	0.003065	1.763	--	INHERITED FROM: Wide mouth
Phenotypic Abnormality (PA)	Abnormality of upper lip	0.02669	1.684	--	INHERITED FROM: Short philtrum
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.2926	0.7381	--	INHERITED FROM: Short philtrum || Wide mouth
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.2957	0.2371	--	INHERITED FROM: Poor speech
Phenotypic Abnormality (PA)	Abnormality of the head	0.3736	0.4538	--	INHERITED FROM: Short philtrum || Wide mouth || Coarse facial features
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.3819	0.4454	--	INHERITED FROM: Short philtrum || Wide mouth || Coarse facial features
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.4568	0.7065	--	INHERITED FROM: Wide mouth || Short philtrum
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.2166	0.3869	Least Informative	INHERITED FROM: Poor speech
Phenotypic Abnormality (PA)	Abnormality of the face	0.2915	0.533	Least Informative	INHERITED FROM: Coarse facial features || Short philtrum || Wide mouth
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0.3095	0.8092	Moderately Informative	INHERITED FROM: Poor speech
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: Wide mouth || Short philtrum
Phenotypic Abnormality (PA)	Abnormal lip morphology	0.05093	1.508	Informative	INHERITED FROM: Short philtrum
Phenotypic Abnormality (PA)	Abnormal facial shape	0.05903	1.508	Informative	INHERITED FROM: Coarse facial features
Phenotypic Abnormality (PA)	Neurological speech impairment	0.1004	1.508	Informative	INHERITED FROM: Poor speech
Phenotypic Abnormality (PA)	Wide mouth	0.0001991	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Coarse facial features	0.0007758	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the philtrum	0.01182	1.86	Highly Informative	INHERITED FROM: Short philtrum

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	transgene subcellular localization variant	0	1.125	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	gut granule biogenesis reduced	0.00000004343	2.292	--	DIRECT
Worm Phenotype (WP)	gut granule development variant	0.0000007981	2.292	--	DIRECT
Worm Phenotype (WP)	lysosome organization biogenesis variant	0.00001081	2.292	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0.0000222	0.8392	--	DIRECT
Worm Phenotype (WP)	aldicarb resistant	0.00003406	2.769	--	DIRECT
Worm Phenotype (WP)	acetylcholinesterase inhibitor resistant	0.00003635	2.468	--	DIRECT
Worm Phenotype (WP)	intestinal cell development variant	0.00003934	2.292	--	DIRECT
Worm Phenotype (WP)	body morphology variant	0.00004427	1.145	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.00009537	0.7558	--	DIRECT
Worm Phenotype (WP)	vesicle morphology variant	0.00009809	1.689	--	DIRECT
Worm Phenotype (WP)	aldicarb response variant	0.0001081	1.655	--	DIRECT
Worm Phenotype (WP)	protein subcellular localization variant	0.0001947	1.513	--	DIRECT
Worm Phenotype (WP)	body length variant	0.0002404	1.292	--	DIRECT
Worm Phenotype (WP)	body width variant	0.0003727	1.237	--	DIRECT
Worm Phenotype (WP)	locomotion variant	0.0006385	1.053	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.001837	0.7516	--	INHERITED FROM: sensillum morphology variant
Worm Phenotype (WP)	drug response variant	0.004988	1.135	--	INHERITED FROM: aldicarb resistant || acetylcholinesterase inhibitor response variant || drug resistant || aldicarb response variant || acetylcholinesterase inhibitor resistant
Worm Phenotype (WP)	alimentary system development variant	0.005095	1.814	--	INHERITED FROM: intestinal cell development variant || intestinal development variant || gut granule development variant || gut granule biogenesis reduced
Worm Phenotype (WP)	behavior variant	0.009703	0.6859	--	INHERITED FROM: movement variant || locomotion variant
Worm Phenotype (WP)	nervous system morphology variant	0.08708	1.321	--	INHERITED FROM: sensillum morphology variant
Worm Phenotype (WP)	body size variant	0.8097	1.189	--	INHERITED FROM: body width variant || body length variant || dumpy
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || chemical resistant || developmental growth variant || organism metabolism processing variant || larval lethal || vesicle morphology variant || reproductive system physiology variant || transgene expression variant || lysosome organization biogenesis variant || gene expression variant || pattern protein expression variant || gut granule biogenesis reduced || organism homeostasis metabolism variant || movement variant || lethal || larval development variant || aldicarb response variant || organism physiology variant || transgene subcellular localization variant || protein subcellular localization variant || intestinal development variant || intestinal cell development variant || development variant || aldicarb resistant || gut granule development variant || cell physiology variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || acetylcholinesterase inhibitor resistant || embryonic development variant || embryonic lethal || larval growth variant || vesicle organization variant || fertility variant || pattern of transgene expression variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || locomotion variant || drug resistant || acetylcholinesterase inhibitor response variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.002545	0.6752	Least Informative	INHERITED FROM: gut granule development variant || intestinal cell development variant || gut granule biogenesis reduced
Worm Phenotype (WP)	organism behavior variant	0.009493	0.6859	Least Informative	INHERITED FROM: movement variant || locomotion variant
Worm Phenotype (WP)	organism environmental stimulus response variant	0.2308	0.6614	Least Informative	INHERITED FROM: chemical resistant || acetylcholinesterase inhibitor resistant || drug resistant || aldicarb resistant || acetylcholinesterase inhibitor response variant || aldicarb response variant
Worm Phenotype (WP)	pattern of transgene expression variant	0	0.9833	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0.00001302	0.8878	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0.0001148	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.000117	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	movement variant	0.0007301	1.02	Moderately Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0.0032	0.9113	Moderately Informative	INHERITED FROM: intestinal development variant || gut granule development variant || gut granule biogenesis reduced || intestinal cell development variant
Worm Phenotype (WP)	chemical response variant	0.02925	0.9053	Moderately Informative	INHERITED FROM: acetylcholinesterase inhibitor resistant || chemical resistant || aldicarb response variant || acetylcholinesterase inhibitor response variant || aldicarb resistant || drug resistant
Worm Phenotype (WP)	protein expression variant	0.156	1.125	Moderately Informative	INHERITED FROM: pattern protein expression variant || protein subcellular localization variant
Worm Phenotype (WP)	vesicle organization variant	0.0001098	1.655	Informative	DIRECT
Worm Phenotype (WP)	acetylcholinesterase inhibitor response variant	0.0001134	1.623	Informative	DIRECT
Worm Phenotype (WP)	pattern protein expression variant	0.0002657	1.49	Informative	DIRECT
Worm Phenotype (WP)	drug resistant	0.0003581	1.689	Informative	DIRECT
Worm Phenotype (WP)	sensillum morphology variant	0.0003706	1.593	Informative	DIRECT
Worm Phenotype (WP)	chemical resistant	0.0009332	1.593	Informative	DIRECT
Worm Phenotype (WP)	dumpy	0.00000437	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	intestinal development variant	0.00003635	1.866	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	vacuolar transport	0.00000002314	2.444	--	DIRECT
Yeast Phenotype (YP)	protein transport	0.00007803	2.444	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT
Yeast Phenotype (YP)	intracellular transport	0.02104	1.666	Informative	INHERITED FROM: vacuolar transport || protein transport

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || larva || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || larva || organism
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism || organism subdivision
Zebrafish Anatomy (ZA)	organism subdivision	0	0.614	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.3879	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.3879	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.02 two leaves visible stage || LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || LP.06 six leaves visible stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || 1 main shoot growth stage || D bilateral stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.3895	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.4752	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.4603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.4234	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.4268	Least Informative	DIRECT

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