Extended AAA-ATPase domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: P-loop containing nucleoside triphosphate hydrolases [ 52539]
• Superfamily: P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
• Family: Extended AAA-ATPase domain [ 81269] (28)

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Family statistics

	Genomes (3,262)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	69,729	444,459	60
Proteins	59,159	380,602	56

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Forming nitrogen-metal bonds	0	2.741	--	DIRECT
Enzyme Commission (EC)	Endopeptidase La	0	2.264	--	DIRECT
Enzyme Commission (EC)	Microtubule-severing ATPase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Adenosinetriphosphatase	0	2.741	--	DIRECT
Enzyme Commission (EC)	DNA helicase	0	1.223	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Vesicle-fusing ATPase	0.00002638	2.264	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: DNA-directed DNA polymerase
Enzyme Commission (EC)	Transferring phosphorous-containing groups	1	0.2728	--	INHERITED FROM: DNA-directed DNA polymerase
Enzyme Commission (EC)	Acting on acid anhydrides	0	0.7283	Least Informative	DIRECT
Enzyme Commission (EC)	Ligases	1	0.7455	Least Informative	INHERITED FROM: Forming nitrogen-metal bonds
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	1	0.5709	Least Informative	INHERITED FROM: Endopeptidase La || Serine endopeptidases
Enzyme Commission (EC)	Nucleotidyltransferases	1	0.6958	Least Informative	INHERITED FROM: DNA-directed DNA polymerase
Enzyme Commission (EC)	Acting on acid anhydrides; involved in cellular an	0	1.001	Moderately Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	0	1.139	Moderately Informative	DIRECT
Enzyme Commission (EC)	In phosphorous-containing anhydrides	1	1.098	Moderately Informative	INHERITED FROM: Adenosinetriphosphatase
Enzyme Commission (EC)	DNA-directed DNA polymerase	0.0000000001761	1.31	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.04347	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Phenotypic Abnormality (PA)	Pili torti	0.00001177	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal size of the clitoris	0.00003168	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal tissue metabolite concentration	0.0000469	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Spasticity	0.00005094	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the clitoris	0.0001225	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Ataxia	0.0001582	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal hair laboratory examination	0.0002296	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Impaired vibration sensation in the lower limbs	0.0002628	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the corticospinal tract	0.0003386	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0.0004646	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal ear physiology	0.0005451	1.462	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.0006364	0.533	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the pyramidal tract	0.005286	2.462	--	INHERITED FROM: Abnormality of the corticospinal tract
Phenotypic Abnormality (PA)	Abnormality of eye movement	0.009825	1.286	--	INHERITED FROM: Nystagmus
Phenotypic Abnormality (PA)	Abnormality of the female genitalia	0.01509	1.207	--	INHERITED FROM: Abnormality of the clitoris || Abnormal size of the clitoris
Phenotypic Abnormality (PA)	Abnormal external genitalia	0.04298	1.421	--	INHERITED FROM: Abnormal size of the clitoris || Abnormality of the clitoris
Phenotypic Abnormality (PA)	Impaired vibratory sensation	0.0449	2.462	--	INHERITED FROM: Impaired vibration sensation in the lower limbs
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.08626	0.2371	--	INHERITED FROM: Abnormality of the corticospinal tract || Neurodevelopmental abnormality || Spasticity || Ataxia || Impaired vibration sensation in the lower limbs || Morphological abnormality of the central nervous system || Abnormality of higher mental function
Phenotypic Abnormality (PA)	Upper motor neuron dysfunction	0.1001	1.286	--	INHERITED FROM: Spasticity
Phenotypic Abnormality (PA)	Abnormal muscle tone	0.1218	0.8942	--	INHERITED FROM: Spasticity
Phenotypic Abnormality (PA)	Sensory impairment	0.158	1.86	--	INHERITED FROM: Impaired vibration sensation in the lower limbs
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.2068	0.9309	--	INHERITED FROM: Abnormal size of the clitoris || Abnormality of the clitoris
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0.364	1.184	--	INHERITED FROM: Abnormality of the stomach
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0.4452	0.6915	--	INHERITED FROM: Spasticity
Phenotypic Abnormality (PA)	Abnormal hair morphology	0.6191	1.207	--	INHERITED FROM: Abnormal hair laboratory examination || Pili torti
Phenotypic Abnormality (PA)	Hearing abnormality	1	1.462	--	INHERITED FROM: Hearing impairment
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.001226	0.5433	Least Informative	INHERITED FROM: Spasticity
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.002533	0.4756	Least Informative	INHERITED FROM: Abnormality of the corticospinal tract || Impaired vibration sensation in the lower limbs || Morphological abnormality of the central nervous system
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.03696	0.3869	Least Informative	INHERITED FROM: Neurodevelopmental abnormality || Ataxia || Abnormality of higher mental function || Spasticity
Phenotypic Abnormality (PA)	Abnormality of the eye	0.05113	0.5703	Least Informative	INHERITED FROM: Nystagmus
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.07625	0.5759	Least Informative	INHERITED FROM: Abnormality of the stomach
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.1629	0.6051	Least Informative	INHERITED FROM: Abnormal size of the clitoris || Abnormality of the clitoris
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.5836	0.5486	Least Informative	INHERITED FROM: Abnormal tissue metabolite concentration
Phenotypic Abnormality (PA)	Abnormality of the integument	0.8882	0.6235	Least Informative	INHERITED FROM: Abnormal hair laboratory examination || Pili torti
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0.0004032	0.8092	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal eye physiology	0.005687	0.7903	Moderately Informative	INHERITED FROM: Nystagmus
Phenotypic Abnormality (PA)	Abnormality of central motor function	0.009813	1.047	Moderately Informative	INHERITED FROM: Spasticity || Ataxia
Phenotypic Abnormality (PA)	Abnormality of the ear	0.01985	0.9572	Moderately Informative	INHERITED FROM: Hearing impairment || Abnormal ear physiology
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system morphology	0.1612	1.232	Moderately Informative	INHERITED FROM: Impaired vibration sensation in the lower limbs
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0.1883	1.184	Moderately Informative	INHERITED FROM: Abnormality of the stomach
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.1887	1.031	Moderately Informative	INHERITED FROM: Abnormality of the stomach
Phenotypic Abnormality (PA)	Abnormality of skin adnexa morphology	0.4811	1.184	Moderately Informative	INHERITED FROM: Pili torti || Abnormal hair laboratory examination
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0.5124	1.031	Moderately Informative	INHERITED FROM: Abnormal size of the clitoris || Abnormality of the clitoris
Phenotypic Abnormality (PA)	Hearing impairment	0.0004456	1.462	Informative	DIRECT
Phenotypic Abnormality (PA)	Hypertonia	0.03078	1.508	Informative	INHERITED FROM: Spasticity
Phenotypic Abnormality (PA)	Peripheral neuropathy	0.1154	1.421	Informative	INHERITED FROM: Impaired vibration sensation in the lower limbs
Phenotypic Abnormality (PA)	Abnormal involuntary eye movements	0.1232	1.684	Informative	INHERITED FROM: Nystagmus
Phenotypic Abnormality (PA)	Nystagmus	0.0002438	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the stomach	0.0009221	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of female external genitalia	0.004263	2.161	Highly Informative	INHERITED FROM: Abnormal size of the clitoris || Abnormality of the clitoris
Phenotypic Abnormality (PA)	Abnormality of coordination	0.05911	1.985	Highly Informative	INHERITED FROM: Ataxia

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	embryonic lethality prior to tooth bud stage	0.0003503	1.457	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality before implantation, complete penetrance	0.0006454	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal survival	0.0022	0.6441	--	INHERITED FROM: embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage || embryonic lethality before implantation, complete penetrance
Mammalian Phenotype (MP)	embryonic lethality before implantation	0.1246	2.603	--	INHERITED FROM: embryonic lethality before implantation, complete penetrance
Mammalian Phenotype (MP)	embryonic lethality	0.8071	1.126	--	INHERITED FROM: embryonic lethality before implantation, complete penetrance || embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage
Mammalian Phenotype (MP)	preweaning lethality	0.8273	0.7055	--	INHERITED FROM: embryonic lethality prior to tooth bud stage || embryonic lethality before implantation, complete penetrance || embryonic lethality prior to organogenesis
Mammalian Phenotype (MP)	mortality/aging	0.005727	0.5424	Least Informative	INHERITED FROM: embryonic lethality before implantation, complete penetrance || embryonic lethality prior to tooth bud stage || embryonic lethality prior to organogenesis
Mammalian Phenotype (MP)	prenatal lethality	0.1322	0.9129	Moderately Informative	INHERITED FROM: embryonic lethality before implantation, complete penetrance || embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage
Mammalian Phenotype (MP)	embryonic lethality prior to organogenesis	0.0001695	1.457	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	nuclear number variant	0.000000002184	1.866	--	DIRECT
Worm Phenotype (WP)	relative cell cycle timing defective early emb	0.00000001603	2.468	--	DIRECT
Worm Phenotype (WP)	passage through meiosis defective early emb	0.00000002197	2.292	--	DIRECT
Worm Phenotype (WP)	ectopic cleavage furrow early emb	0.0000002446	2.769	--	DIRECT
Worm Phenotype (WP)	cell cycle timing defective early emb	0.0000004908	2.468	--	DIRECT
Worm Phenotype (WP)	multiple cytoplasmic cavities early emb	0.0000009043	2.292	--	DIRECT
Worm Phenotype (WP)	cell cell contacts abnormal in four cell embryo	0.000001101	2.769	--	DIRECT
Worm Phenotype (WP)	excessive blebbing early emb	0.000002614	2.292	--	DIRECT
Worm Phenotype (WP)	nuclear division variant	0.000003504	1.866	--	DIRECT
Worm Phenotype (WP)	cytoplasmic streaming defective	0.000004636	2.292	--	DIRECT
Worm Phenotype (WP)	embryonic cell lineage variant	0.000004798	2.468	--	DIRECT
Worm Phenotype (WP)	nucleus reforms cell division remnant early emb	0.000005391	2.468	--	DIRECT
Worm Phenotype (WP)	pace of P lineage defective early emb	0.00002072	2.769	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0.00002532	1.321	--	DIRECT
Worm Phenotype (WP)	response to bacteria variant	0.00002728	1.426	--	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0.00002935	1.013	--	DIRECT
Worm Phenotype (WP)	cell cell contacts abnormal	0.00003056	2.769	--	DIRECT
Worm Phenotype (WP)	microtubule organization biogenesis variant	0.00003465	1.727	--	DIRECT
Worm Phenotype (WP)	meiotic spindle defective early emb	0.00003946	2.769	--	DIRECT
Worm Phenotype (WP)	cytoplasmic appearance variant	0.0002027	1.99	--	DIRECT
Worm Phenotype (WP)	germ cell compartment small	0.0002231	2.769	--	DIRECT
Worm Phenotype (WP)	protein expression increased	0.0002398	2.468	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0.0005249	0.8392	--	DIRECT
Worm Phenotype (WP)	embryonic cell physiology variant	0.0005353	1.538	--	DIRECT
Worm Phenotype (WP)	feeding behavior variant	0.0005368	1.25	--	DIRECT
Worm Phenotype (WP)	one cell arrest early emb	0.0005884	2.292	--	DIRECT
Worm Phenotype (WP)	meiotic spindle defective	0.001275	2.468	--	INHERITED FROM: meiotic spindle defective early emb
Worm Phenotype (WP)	nuclear position defective early emb	0.002403	2.468	--	INHERITED FROM: nucleus reforms cell division remnant early emb
Worm Phenotype (WP)	cell cell contacts abnormal early emb	0.002925	2.769	--	INHERITED FROM: cell cell contacts abnormal in four cell embryo
Worm Phenotype (WP)	cell cycle defective early emb	0.004455	2.468	--	INHERITED FROM: cell cycle timing defective early emb || relative cell cycle timing defective early emb
Worm Phenotype (WP)	cell morphology variant	0.004851	0.7558	--	INHERITED FROM: embryonic cell organization biogenesis variant || cell cell contacts abnormal || cell cell contacts abnormal in four cell embryo || germ cell compartment anucleate || nucleus reforms cell division remnant early emb || multiple cytoplasmic cavities early emb || embryonic cell morphology variant || meiotic spindle defective early emb || germ cell compartment small || cytoplasmic appearance variant || endoplasmic reticulum morphology variant || excessive blebbing early emb || microtubule organization biogenesis variant || cell component morphology variant
Worm Phenotype (WP)	meiosis variant	0.02354	1.263	--	INHERITED FROM: passage through meiosis defective early emb || meiosis defective early emb || meiotic spindle defective early emb
Worm Phenotype (WP)	behavior variant	0.02852	0.6859	--	INHERITED FROM: feeding behavior variant
Worm Phenotype (WP)	germ cell compartment morphology variant	0.04084	1.354	--	INHERITED FROM: germ cell compartment anucleate || germ cell compartment small
Worm Phenotype (WP)	germ cell morphology variant	0.04471	1.156	--	INHERITED FROM: germ cell compartment anucleate || germ cell compartment small
Worm Phenotype (WP)	cytokinesis defective early emb	0.06812	1.866	--	INHERITED FROM: ectopic cleavage furrow early emb
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.08921	0.1444	--	INHERITED FROM: spontaneous mutation rate increased || protein expression increased || sick || response to bacteria variant
Worm Phenotype (WP)	cytokinesis variant	0.09558	1.689	--	INHERITED FROM: cytokinesis variant emb || ectopic cleavage furrow early emb
Worm Phenotype (WP)	organism physiology variant	0.1044	0.1342	--	INHERITED FROM: spontaneous mutation rate increased || sick || protein expression increased || response to bacteria variant
Worm Phenotype (WP)	spindle variant	0.1619	1.727	--	INHERITED FROM: meiotic spindle defective early emb
Worm Phenotype (WP)	germ cell compartment nuclei number variant	0.1667	1.814	--	INHERITED FROM: germ cell compartment anucleate
Worm Phenotype (WP)	growth variant	0.1807	0.3438	--	INHERITED FROM: sick
Worm Phenotype (WP)	spindle defective early emb	0.2047	1.727	--	INHERITED FROM: meiotic spindle defective early emb
Worm Phenotype (WP)	gene expression variant	0.2296	0.6256	--	INHERITED FROM: protein expression increased
Worm Phenotype (WP)	cleavage furrow defective	0.3098	2.07	--	INHERITED FROM: ectopic cleavage furrow early emb
Worm Phenotype (WP)	cytoplasmic dynamics defective early emb	0.3383	2.292	--	INHERITED FROM: excessive blebbing early emb
Worm Phenotype (WP)	oogenesis variant	0.4835	1.237	--	INHERITED FROM: meiotic progression during oogenesis variant
Worm Phenotype (WP)	organelle organization biogenesis variant	0.5659	1.306	--	INHERITED FROM: meiotic spindle defective early emb || microtubule organization biogenesis variant || nucleus reforms cell division remnant early emb
Worm Phenotype (WP)	embryonic development variant	0.6431	0.04518	--	INHERITED FROM: excessive blebbing early emb || meiosis defective early emb || cell cell contacts abnormal in four cell embryo || relative cell cycle timing defective early emb || cytokinesis variant emb || cell cycle timing defective early emb || passage through meiosis defective early emb || ectopic cleavage furrow early emb || embryonic cell organization biogenesis variant || cytoplasmic streaming defective || multiple cytoplasmic cavities early emb || early embryonic lethal || nucleus reforms cell division remnant early emb || meiotic spindle defective early emb || one cell arrest early emb
Worm Phenotype (WP)	embryonic lethal	0.6625	0.046	--	INHERITED FROM: ectopic cleavage furrow early emb || excessive blebbing early emb || cell cell contacts abnormal in four cell embryo || multiple cytoplasmic cavities early emb || meiosis defective early emb || early embryonic lethal || relative cell cycle timing defective early emb || cell cycle timing defective early emb || cytokinesis variant emb || meiotic spindle defective early emb || one cell arrest early emb || passage through meiosis defective early emb
Worm Phenotype (WP)	cytoplasmic morphology defective early emb	0.6686	2.167	--	INHERITED FROM: multiple cytoplasmic cavities early emb
Worm Phenotype (WP)	morphology variant	0.8276	0.046	--	INHERITED FROM: embryonic cell organization biogenesis variant || embryonic cell morphology variant || multiple cytoplasmic cavities early emb || endoplasmic reticulum morphology variant || cell cell contacts abnormal || cell cell contacts abnormal in four cell embryo || germ cell compartment small || meiotic spindle defective early emb || germ cell compartment anucleate || nucleus reforms cell division remnant early emb || cell component morphology variant || excessive blebbing early emb || cytoplasmic appearance variant || microtubule organization biogenesis variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: multiple nuclei || nuclear division variant || meiotic progression during oogenesis variant || relative cell cycle timing defective early emb || meiotic spindle defective early emb || response to bacteria variant || early embryonic lethal || embryonic cell organization biogenesis variant || lethal || cell cycle timing defective early emb || excessive blebbing early emb || cytokinesis variant emb || germ cell development variant || embryonic cell physiology variant || multiple cytoplasmic cavities early emb || cell division variant || cytoplasmic streaming defective || passage through meiosis defective early emb || one cell arrest early emb || development variant || cell physiology variant || pace of P lineage defective early emb || ectopic cleavage furrow early emb || spontaneous mutation rate increased || sick || embryonic cell lineage variant || cell cell contacts abnormal in four cell embryo || meiosis defective early emb || gametogenesis variant || microtubule organization biogenesis variant || cell cycle variant || feeding behavior variant || nucleus reforms cell division remnant early emb || nuclear number variant || organism development variant || cell development variant || protein expression increased
Worm Phenotype (WP)	cell physiology variant	0.000001082	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.0001444	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.0273	0.6859	Least Informative	INHERITED FROM: feeding behavior variant
Worm Phenotype (WP)	organism metabolism processing variant	0.04952	0.4899	Least Informative	INHERITED FROM: protein expression increased
Worm Phenotype (WP)	organism environmental stimulus response variant	0.07909	0.6614	Least Informative	INHERITED FROM: response to bacteria variant
Worm Phenotype (WP)	early embryonic lethal	0.000000000005676	1.178	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0.00000002806	1.013	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell cycle variant	0.0000001427	1.225	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0.0000002346	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell organization biogenesis variant	0.001159	1.135	Moderately Informative	INHERITED FROM: meiotic spindle defective early emb || embryonic cell organization biogenesis variant || excessive blebbing early emb || cytoplasmic appearance variant || microtubule organization biogenesis variant || multiple cytoplasmic cavities early emb || nucleus reforms cell division remnant early emb
Worm Phenotype (WP)	protein expression variant	0.097	1.125	Moderately Informative	INHERITED FROM: protein expression increased
Worm Phenotype (WP)	cell type morphology variant	0.2964	0.8878	Moderately Informative	INHERITED FROM: germ cell compartment small || embryonic cell morphology variant || germ cell compartment anucleate
Worm Phenotype (WP)	germ cell differentiation variant	0.75	1.167	Moderately Informative	INHERITED FROM: meiotic progression during oogenesis variant
Worm Phenotype (WP)	cytokinesis variant emb	0.0000005794	1.689	Informative	DIRECT
Worm Phenotype (WP)	embryonic cell organization biogenesis variant	0.0000006236	1.538	Informative	DIRECT
Worm Phenotype (WP)	sick	0.0004758	1.727	Informative	DIRECT
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0.1069	1.623	Informative	INHERITED FROM: meiotic spindle defective early emb || microtubule organization biogenesis variant
Worm Phenotype (WP)	nuclear positioning variant	0.207	1.623	Informative	INHERITED FROM: nucleus reforms cell division remnant early emb
Worm Phenotype (WP)	level of protein expression variant	0.2094	1.689	Informative	INHERITED FROM: protein expression increased
Worm Phenotype (WP)	multiple nuclei	0.0000000001727	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	endoplasmic reticulum morphology variant	0.000008516	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	embryonic cell morphology variant	0.0000178	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment anucleate	0.00002203	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	spontaneous mutation rate increased	0.000734	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	meiosis defective early emb	0.0008909	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	cytoplasmic appearance defective early emb	0.007045	1.99	Highly Informative	INHERITED FROM: multiple cytoplasmic cavities early emb || excessive blebbing early emb
Worm Phenotype (WP)	nucleus defective early emb	0.007849	2.167	Highly Informative	INHERITED FROM: nucleus reforms cell division remnant early emb
Worm Phenotype (WP)	lineage variant	0.02088	1.924	Highly Informative	INHERITED FROM: embryonic cell lineage variant || pace of P lineage defective early emb
Worm Phenotype (WP)	germ cell compartment size variant	0.4517	1.99	Highly Informative	INHERITED FROM: germ cell compartment small
Worm Phenotype (WP)	cleavage furrow defective early emb	0.4925	2.07	Highly Informative	INHERITED FROM: ectopic cleavage furrow early emb

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	bang sensitive	0.0001275	2.386	--	DIRECT
Fly Phenotype (FP)	paralytic	0.01073	2.386	--	INHERITED FROM: bang sensitive
Fly Phenotype (FP)	phenotype	0.3775	0.06546	--	INHERITED FROM: bang sensitive

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || organism

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0.0001745	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0.0001846	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0.0004271	0.7579	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0.03247	0.388	--	INHERITED FROM: gonad || testis
Xenopus ANatomical entity (XAN)	anatomical region	0.1153	0.1803	--	INHERITED FROM: gonad || testis
Xenopus ANatomical entity (XAN)	male genitalia	0.1266	0.7647	--	INHERITED FROM: testis
Xenopus ANatomical entity (XAN)	organism subdivision	0.1575	0.1679	--	INHERITED FROM: gonad || testis
Xenopus ANatomical entity (XAN)	compound organ	0.2048	0.2177	--	INHERITED FROM: gonad || testis
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.359	0.1131	--	INHERITED FROM: testis || gonad
Xenopus ANatomical entity (XAN)	anatomical group	0.517	0.1408	--	INHERITED FROM: testis || genital system
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: testis || genital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: genital system || testis || gonad || male organism
Xenopus ANatomical entity (XAN)	urogenital system	0.00208	0.4777	Least Informative	INHERITED FROM: genital system || testis
Xenopus ANatomical entity (XAN)	trunk	0.024	0.3894	Least Informative	INHERITED FROM: gonad || testis
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.08535	0.2685	Least Informative	INHERITED FROM: gonad || testis
Xenopus ANatomical entity (XAN)	testis	0.0001713	0.7647	Moderately Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Endopeptidase La	0	2.753	--	DIRECT
Enzyme Commission (EC)	Adenosinetriphosphatase	0	2.531	--	DIRECT
Enzyme Commission (EC)	DNA helicase	0	1.639	--	DIRECT
Enzyme Commission (EC)	Isomerases altering macromolecular conformation	0	1.907	--	DIRECT
Enzyme Commission (EC)	Enzymes altering polypeptide conformation or assembly	0	2.385	--	DIRECT
Enzyme Commission (EC)	Microtubule-severing ATPase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Forming nitrogen-metal bonds	0	3.23	--	DIRECT
Enzyme Commission (EC)	Vesicle-fusing ATPase	0.000000000002642	2.628	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.7021	--	INHERITED FROM: DNA-directed DNA polymerase
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: DNA-directed DNA polymerase
Enzyme Commission (EC)	Acting on acid anhydrides	0	1.133	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0.1306	1.004	Moderately Informative	INHERITED FROM: Serine endopeptidases || Endopeptidase La
Enzyme Commission (EC)	Nucleotidyltransferases	1	1.126	Moderately Informative	INHERITED FROM: DNA-directed DNA polymerase
Enzyme Commission (EC)	Isomerases	1	1.026	Moderately Informative	INHERITED FROM: Microtubule-severing ATPase || Enzymes altering polypeptide conformation or assembly || Isomerases altering macromolecular conformation
Enzyme Commission (EC)	Ligases	1	1.14	Moderately Informative	INHERITED FROM: Forming nitrogen-metal bonds
Enzyme Commission (EC)	Serine endopeptidases	0	1.576	Informative	DIRECT
Enzyme Commission (EC)	Acting on ATP; involved in cellular and subcellular movement	0	1.385	Informative	DIRECT
Enzyme Commission (EC)	DNA-directed DNA polymerase	0.0000000002377	1.725	Informative	DIRECT
Enzyme Commission (EC)	In phosphorus-containing anhydrides	1	1.452	Informative	INHERITED FROM: Adenosinetriphosphatase

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