Filamin repeat (rod domain) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Immunoglobulin-like beta-sandwich [ 48725] (28)
• Superfamily: E set domains [ 81296] (23)
• Family: Filamin repeat (rod domain) [ 81290] (4)

---

Family statistics

	Genomes (136)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	4,517	14,608	30
Proteins	462	1,722	25

---

Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0	0.9183	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of lower limb joint	0	1.348	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature of the upper limbs	0.00002978	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal tracheobronchial morphology	0.0001485	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Talipes	0.0003571	1.86	--	DIRECT
Phenotypic Abnormality (PA)	Positional foot deformity	0.0003691	1.86	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.3741	0.9183	--	INHERITED FROM: Abnormality of the musculature of the upper limbs
Phenotypic Abnormality (PA)	Abnormality of the foot	0.6075	1.082	--	INHERITED FROM: Positional foot deformity || Talipes || Talipes equinovarus
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0	0.6429	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal joint morphology	0	1.101	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0	0.9309	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0	0.9061	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal respiratory system morphology	0.3113	1.064	Moderately Informative	INHERITED FROM: Abnormality of the upper respiratory tract || Abnormal trachea morphology || Abnormal tracheobronchial morphology
Phenotypic Abnormality (PA)	Functional respiratory abnormality	0	1.348	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the upper respiratory tract	0.0005891	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature of the limbs	0.007944	1.421	Informative	INHERITED FROM: Abnormality of the musculature of the upper limbs
Phenotypic Abnormality (PA)	Respiratory insufficiency	0	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the knee	0	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal trachea morphology	0.00001238	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Talipes equinovarus	0.0001893	1.985	Highly Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || organism physiology variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: cell || whole organism
Zebrafish Anatomy (ZA)	cell	0	0.6388	Least Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0	1.617	--	DIRECT
Enzyme Commission (EC)	Protein xylosyltransferase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Pentosyltransferases	0.0000001686	1.738	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.000000002533	1.034	Moderately Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0	1.391	Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0.003883	1.378	Informative	INHERITED FROM: Protein xylosyltransferase || Pentosyltransferases

---