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T-box family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Family:   T-box [ 81316] (2)

Family statistics
Genomes (149) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,006 5,179 2
Proteins 2,003 5,158 2

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)physical disorder0.00003327InformativeDirect
Disease Ontology (DO)heart disease0.0302InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2585Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2883Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.5423Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.1883Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.269Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.4794Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.000813InformativeDirect
Phenotypic Abnormality (PA)Abnormal palate morphology0.02325InformativeInherited
Phenotypic Abnormality (PA)Atrial septal defect0.0003467Highly InformativeDirect
Phenotypic Abnormality (PA)Cleft palate0.0007276Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.001953Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.002887Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01169Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3481Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.000339Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0007526Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0.0007699Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0.001409Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.02478Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.09588Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.1326Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1679Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.4156Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.0000689InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.002576InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.03121InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.03738InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.04333InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.1637InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.2732InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.2808InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.3227InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0000006418Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate morphology0.00001973Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00005169Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.00007597Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0001474Highly InformativeDirect
Mammalian Phenotype (MP)abnormal occipital bone morphology0.0002823Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.0003939Highly InformativeDirect
Mammalian Phenotype (MP)embryonic lethality during organogenesis, complete penetrance0.0005293Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart atrium morphology0.03397Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical vertebrae morphology0.0714Highly InformativeInherited
Mammalian Phenotype (MP)abnormal rib morphology0.6946Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.2343Least InformativeInherited
Fly Anatomy (FA)circulatory system0.03211Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.2272Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.01474InformativeInherited
Fly Anatomy (FA)embryonic/larval dorsal vessel0.00009398Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.02243Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.03557Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.23Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.3496Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.001437Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.01979Moderately InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.000283InformativeDirect
Zebrafish Anatomy (ZA)embryonic structure0.0007759InformativeDirect
Zebrafish Anatomy (ZA)pleuroperitoneal region0.02436InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.03687InformativeInherited
Zebrafish Anatomy (ZA)mesenchyme0.000005223Highly InformativeDirect
Zebrafish Anatomy (ZA)heart primordium0.0003221Highly InformativeDirect
Zebrafish Anatomy (ZA)pronephros0.0009971Highly InformativeDirect
Zebrafish Anatomy (ZA)heart0.001303Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.02836Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.04781Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1514Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.3241Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.6611Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.6889Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0002398Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0004228Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0008034Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.02141Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8822Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8981Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.9831Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.000002412InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00002368InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00002704InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00003522InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00005469InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0005213InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.005951InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.01701InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.4762InformativeInherited
Xenopus ANatomical entity (XAN)limb0.4789InformativeInherited
Xenopus ANatomical entity (XAN)foregut0.00001736Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00002533Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.00006622Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.000135Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.000269Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.00988Highly InformativeInherited
Xenopus ANatomical entity (XAN)blastopore lip0.7941Highly InformativeInherited
Xenopus ANatomical entity (XAN)pelvic appendage0.9506Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.7347Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.0007417Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.
   
Superfamily level     Family level

Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.
   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.