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  Home > SCOP hierarchy > Family A G protein-coupled receptor-like superfamily


Family A G protein-coupled receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Families:   Bacteriorhodopsin-like [ 81319] (5)
  Rhodopsin-like [ 81320]

 Superfamily statistics
Genomes (556) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 79,708 220,865 43
Proteins 78,352 217,479 43

 Functional annotation
General category Regulation
Detailed category Signal transduction

Document: Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5999Least InformativeInherited
Disease Ontology (DO)disease of mental health0.0000009865Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0001812Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.006128Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.03056Moderately InformativeInherited
Disease Ontology (DO)brain disease0.07195Moderately InformativeInherited
Disease Ontology (DO)asthma0.0000003616InformativeDirect
Disease Ontology (DO)overnutrition0.000005413InformativeDirect
Disease Ontology (DO)migraine0.00002326InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2291InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.3292InformativeInherited
Disease Ontology (DO)anxiety disorder0.000008485Highly InformativeDirect
Disease Ontology (DO)eating disorder0.0000184Highly InformativeDirect
Disease Ontology (DO)endocrine organ benign neoplasm0.002836Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.8453Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye1Least InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.4029Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.526Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.9815Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.02434InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0.5855InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.8547InformativeInherited
Phenotypic Abnormality (PA)Decreased body weight0.9959InformativeInherited
Phenotypic Abnormality (PA)Color vision defect0.003131Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the penis0.3262Highly InformativeInherited
Phenotypic Abnormality (PA)Sensorineural hearing impairment0.5646Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.005558Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.02758Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.05643Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.06782Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4854Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9852Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.00000005529Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.000008051Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.05237Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.05619Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.06488Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.06922Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1902Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.2111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2643Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3728Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5562Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7506Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.8036Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.9512Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9637Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.000000005624InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000002767InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.000008934InformativeDirect
Mammalian Phenotype (MP)abnormal consumption behavior0.00001275InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.00006654InformativeDirect
Mammalian Phenotype (MP)increased body weight0.00006838InformativeDirect
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.0001446InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0003278InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0.003107InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.01031InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.05536InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.2054InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2424InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.497InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.5863InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.6471InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.8408InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8453InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.9426InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9801InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.000001493Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.000009702Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.00001317Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.00002193Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00002233Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gallbladder physiology0.0001362Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0002442Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.0002552Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.0004104Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.0004273Highly InformativeDirect
Mammalian Phenotype (MP)abnormal locomotor activation0.0007123Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.000757Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.0007891Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.002782Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgE level0.003146Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.08449Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nose morphology0.1234Highly InformativeInherited
Mammalian Phenotype (MP)decreased immunoglobulin level0.2422Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.3973Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)drug response variant1Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant1Moderately InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)chemical resistant1InformativeInherited
Worm Phenotype (WP)pharyngeal pumping rate variant0.2253Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0000001402Moderately InformativeDirect
Fly Phenotype (FP)hypoactive0.0000000000002044Highly InformativeDirect
Fly Phenotype (FP)mating defective0.000001358Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.8575Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.1562InformativeInherited
Xenopus ANatomical entity (XAN)dermal system1InformativeInherited
Xenopus ANatomical entity (XAN)surface structure1InformativeInherited
Xenopus ANatomical entity (XAN)neural nucleus0.000001918Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.8202Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0000009605Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Family A G protein-coupled receptor-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Family A G protein-coupled receptor-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.