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Voltage-gated potassium channels family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Voltage-gated potassium channels [ 81325]
Superfamily:   Voltage-gated potassium channels [ 81324]
Family:   Voltage-gated potassium channels [ 81323] (5)

Family statistics
Genomes (183) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 191 1,150 18
Proteins 191 1,150 18

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)heart disease0.1178InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00002841Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.01807Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.4858Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.9841Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9867Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3051Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.4042Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.7091Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.8374Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.8547Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.8984Moderately InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.0007316InformativeDirect
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.005606InformativeInherited
Phenotypic Abnormality (PA)Encephalopathy0.01776InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.08646InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.6856InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac test0.0000001047Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal atrioventricular conduction0.0000001139Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.0000002134Highly InformativeDirect
Phenotypic Abnormality (PA)Syncope0.000002349Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.000002883Highly InformativeDirect
Phenotypic Abnormality (PA)Epileptic encephalopathy0.00003239Highly InformativeDirect
Phenotypic Abnormality (PA)Metabolic alkalosis0.000171Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0003027Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0003027Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0003027Highly InformativeDirect
Phenotypic Abnormality (PA)Ventricular arrhythmia0.0008734Highly InformativeDirect
Phenotypic Abnormality (PA)Tachycardia0.001519Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal urine output0.00975Highly InformativeInherited
Phenotypic Abnormality (PA)Atrial arrhythmia0.4683Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.004647Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.00315Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2236Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.2927Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6622Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.000000001688InformativeDirect
Mammalian Phenotype (MP)seizures0.0001085InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.001478InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.03513InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to pharmacologically induced seizures0.000002365Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.005906Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.03508Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.7834Least InformativeInherited
Worm Phenotype (WP)cell development variant0.8487Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.9774Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)cell physiology variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.1341Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.137Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.42Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.4502Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.6687Moderately InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.0000192InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.00012InformativeDirect
Worm Phenotype (WP)body posture variant0.0006286InformativeDirect
Worm Phenotype (WP)head movement variant0.0006558InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0007394InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.01009InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.02905InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.03194InformativeInherited
Worm Phenotype (WP)defecation variant0.04591InformativeInherited
Worm Phenotype (WP)egg laying variant0.04755InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.05112InformativeInherited
Worm Phenotype (WP)drug resistant0.07691InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.1701InformativeInherited
Worm Phenotype (WP)chemical resistant0.1896InformativeInherited
Worm Phenotype (WP)small0.3385InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.000001392Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.000002182Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00002639Highly InformativeDirect
Worm Phenotype (WP)coiling frequency variant0.00006315Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.00006355Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.0001558Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001583Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.0001986Highly InformativeDirect
Worm Phenotype (WP)serotonin response variant0.0005221Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0005598Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.0006191Highly InformativeDirect
Worm Phenotype (WP)short0.0008465Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.003134Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.0001176InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.000466InformativeDirect
Fly Phenotype (FP)behavior defective0.00195InformativeInherited
Fly Phenotype (FP)chemosensitive behavior defective0.00002398Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.09615Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.1829Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.6477Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.5098Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.5236Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.8084InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.00003673Highly InformativeDirect
Xenopus ANatomical entity (XAN)cell part0.002765Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0001737Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Voltage-gated potassium channels domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]