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  Home > SCOP hierarchy > Voltage-gated potassium channels superfamily


Voltage-gated potassium channels superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Voltage-gated potassium channels [ 81325]
Superfamily:   Voltage-gated potassium channels [ 81324]
Families:   Voltage-gated potassium channels [ 81323] (5)

Superfamily statistics
Genomes (2,257) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 39,381 135,221 19
Proteins 26,941 98,698 19

 Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0001335Least InformativeDirect
Disease Ontology (DO)disease of mental health0.000001921Moderately InformativeDirect
Disease Ontology (DO)brain disease0.00002964Moderately InformativeDirect
Disease Ontology (DO)syndrome0.02291Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.745Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.000007842InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.0001547InformativeDirect
Disease Ontology (DO)peripheral nervous system disease0.5014InformativeInherited
Disease Ontology (DO)focal epilepsy0.6793InformativeInherited
Disease Ontology (DO)temporal lobe epilepsy0.00001515Highly InformativeDirect
Disease Ontology (DO)metal metabolism disorder0.003508Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00000002421Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.004214Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.02802Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1759Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5816Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.6739Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.6897Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.9481Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9555Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.03329Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1786Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1806Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.2246Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.3234Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.3543Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.371Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.8314Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.8658Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.9367Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.9877Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb1Moderately InformativeInherited
Phenotypic Abnormality (PA)Encephalopathy0.00002438InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.00009487InformativeDirect
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.0001019InformativeDirect
Phenotypic Abnormality (PA)Involuntary movements0.0002443InformativeDirect
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.001788InformativeInherited
Phenotypic Abnormality (PA)Seizures0.003931InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.0129InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.1894InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.453InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.6715InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.7453InformativeInherited
Phenotypic Abnormality (PA)Epileptic encephalopathy0.0000000000037Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.00000000002052Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.000000005829Highly InformativeDirect
Phenotypic Abnormality (PA)Arrhythmia0.000033Highly InformativeDirect
Phenotypic Abnormality (PA)Metabolic alkalosis0.00009126Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0001765Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0001765Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0002338Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal autonomic nervous system physiology0.0004111Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ankles0.06677Highly InformativeInherited
Phenotypic Abnormality (PA)Paralysis0.2924Highly InformativeInherited
Phenotypic Abnormality (PA)Sensory impairment0.4549Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00003887Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.204Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.00000006203Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0.001635Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.007605Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2935Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.3484Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.6881Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.0000003331InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000001777InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.00003046InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.00006582InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.02108InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.03755InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.08176InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2695InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.856InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission1InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.00000000000001742Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00000003176Highly InformativeDirect
Mammalian Phenotype (MP)muscle twitch0.00003417Highly InformativeDirect
Mammalian Phenotype (MP)decreased alcohol consumption0.0007655Highly InformativeDirect
Mammalian Phenotype (MP)abnormal exploration in a new environment0.0007926Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.005939Highly InformativeInherited
Mammalian Phenotype (MP)abnormal breathing pattern0.04097Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.109Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.7578Highly InformativeInherited
Mammalian Phenotype (MP)abnormal reflex0.8363Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.1367Least InformativeInherited
Worm Phenotype (WP)cell development variant0.4848Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.8841Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.9022Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.9552Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)cell morphology variant1Least InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.02294Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.04084Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.04209Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.1094Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.1287Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2344Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.6744Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.000000001592InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00004705InformativeDirect
Worm Phenotype (WP)body bend variant0.00005214InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00007763InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001704InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0002749InformativeDirect
Worm Phenotype (WP)localized movement variant0.0003287InformativeDirect
Worm Phenotype (WP)body posture variant0.0004321InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.001967InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.004898InformativeInherited
Worm Phenotype (WP)male mating variant0.01664InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.02486InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.04763InformativeInherited
Worm Phenotype (WP)egg laying variant0.04955InformativeInherited
Worm Phenotype (WP)defecation variant0.07837InformativeInherited
Worm Phenotype (WP)drug resistant0.1368InformativeInherited
Worm Phenotype (WP)directionality variant0.17InformativeInherited
Worm Phenotype (WP)chemical resistant0.21InformativeInherited
Worm Phenotype (WP)small0.2705InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.7117InformativeInherited
Worm Phenotype (WP)protein degradation variant0.0000001116Highly InformativeDirect
Worm Phenotype (WP)coiling frequency variant0.000003219Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.000003296Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000006783Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.000007875Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.00001074Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.000016Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001014Highly InformativeDirect
Worm Phenotype (WP)short0.0002907Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.0004281Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0007632Highly InformativeDirect
Worm Phenotype (WP)imipramine resistant0.0009173Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.003131Highly InformativeInherited
Worm Phenotype (WP)post hermaphrodite contact variant0.04077Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.5273Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.00003669Moderately InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.0001156InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.0001336InformativeDirect
Fly Phenotype (FP)chemical resistant0.0000711Highly InformativeDirect
Fly Phenotype (FP)chemical sensitive0.0009756Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1711Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.2921Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4963Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1857Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.327Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0002701InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.02276InformativeInherited
Xenopus ANatomical entity (XAN)eye0.5919InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.0001276Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal neural layer0.0002305Highly InformativeDirect
Xenopus ANatomical entity (XAN)cell part0.000446Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0000001956Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Voltage-gated potassium channels domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Voltage-gated potassium channels superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.