F1F0 ATP synthase subunit C superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Membrane and cell surface proteins and peptides [ 56835] (58)
• Fold: Transmembrane helix hairpin [ 81334] (5)
• Superfamily: F1F0 ATP synthase subunit C [ 81333]
• Families: F1F0 ATP synthase subunit C [ 81332]

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Superfamily statistics

	Genomes (3,209)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	7,386	42,610	4
Proteins	5,690	37,043	4

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Functional annotation

• General category: Metabolism
• Detailed category: Energy

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.7938	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6038	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	heteroplasmy	0.00000000009604	2.407	--	DIRECT
Worm Phenotype (WP)	protein transport variant	0.000000008137	2.407	--	DIRECT
Worm Phenotype (WP)	diakinesis progression during oogenesis variant	0.0000001055	2.407	--	DIRECT
Worm Phenotype (WP)	oocytes lack nucleus	0.0000001318	2.407	--	DIRECT
Worm Phenotype (WP)	receptor mediated endocytosis defective	0.000001121	1.594	--	DIRECT
Worm Phenotype (WP)	recycling endosome localization variant	0.000001493	1.753	--	DIRECT
Worm Phenotype (WP)	endosome localization variant	0.000001562	1.753	--	DIRECT
Worm Phenotype (WP)	hermaphrodite physiology variant	0.000001627	1.365	--	DIRECT
Worm Phenotype (WP)	germ cell compartment nuclei number variant	0.000002359	1.929	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic physiology variant	0.000003215	1.31	--	DIRECT
Worm Phenotype (WP)	germ cell physiology variant	0.000004654	1.26	--	DIRECT
Worm Phenotype (WP)	vesicle trafficking variant	0.000005343	1.216	--	DIRECT
Worm Phenotype (WP)	recycling endosome morphology variant	0.000006243	1.666	--	DIRECT
Worm Phenotype (WP)	endosome morphology variant	0.000007192	1.628	--	DIRECT
Worm Phenotype (WP)	vesicle morphology variant	0.00001008	1.594	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	0.00001522	1.327	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0.00002757	1.293	--	DIRECT
Worm Phenotype (WP)	gonad development variant	0.00003834	1.407	--	DIRECT
Worm Phenotype (WP)	germ cell compartment morphology variant	0.00003834	1.31	--	DIRECT
Worm Phenotype (WP)	oogenesis variant	0.00007742	1.189	--	DIRECT
Worm Phenotype (WP)	protein metabolism variant	0.0001059	1.23	--	DIRECT
Worm Phenotype (WP)	meiosis variant	0.000185	1.176	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.0004671	0.9594	--	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0.001748	0.9517	--	INHERITED FROM: germ cell differentiation variant || meiotic progression prophase variant || oogenesis variant || meiotic chromosome organization variant || diakinesis progression during oogenesis variant || oocytes lack nucleus || meiotic progression during oogenesis variant || meiosis variant || chromosome condensation variant
Worm Phenotype (WP)	response to bacteria variant	0.00177	1.26	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	behavior variant	0.00332	0.632	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	organ system development variant	0.003596	0.8099	--	INHERITED FROM: somatic gonad development variant || oocyte septum formation variant || gonad development variant || reproductive system development variant
Worm Phenotype (WP)	cell type morphology variant	0.005316	0.8211	--	INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocytes lack nucleus || germ cell compartment anucleate || germ cell compartment nuclei number variant
Worm Phenotype (WP)	cell component morphology variant	0.007125	0.7833	--	INHERITED FROM: cell membrane organization biogenesis variant || cell organization biogenesis variant || recycling endosome morphology variant || lysosome-related organelle morphology variant || endosome morphology variant || vesicle organization variant || vesicle morphology variant || nuclear appearance variant
Worm Phenotype (WP)	cell death variant	0.02242	0.9441	--	INHERITED FROM: programmed cell death variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || meiotic progression during oogenesis variant || membrane trafficking variant || organism metabolism processing variant || somatic gonad development variant || vesicle morphology variant || reproductive system physiology variant || transgene expression variant || gene expression variant || endocytic transport variant || oogenesis variant || organism homeostasis metabolism variant || avoids bacterial lawn || lethal || larval development variant || chromosome condensation variant || meiotic chromosome organization variant || germ cell physiology variant || organism physiology variant || meiosis variant || oocyte physiology variant || germ cell differentiation variant || sexually dimorphic physiology variant || organism stress response variant || oocyte septum formation variant || protein transport variant || endocytic transport defect || development variant || reproductive system development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || vesicle organization variant || heteroplasmy || fertility variant || protein metabolism variant || pattern of transgene expression variant || recycling endosome morphology variant || meiotic progression prophase variant || oocytes lack nucleus || postembryonic development variant || gonad development variant || organ system physiology variant || maternal sterile || endosome morphology variant || mitosis variant || organism development variant || programmed cell death variant || vesicle trafficking variant || diakinesis progression during oogenesis variant || level of transgene expression variant || hermaphrodite physiology variant || receptor mediated endocytosis defective || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4572	Least Informative	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.5007	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.002737	0.5344	Least Informative	INHERITED FROM: membrane trafficking variant || endocytic transport defect || endocytic transport variant || oocyte physiology variant || mitosis variant || protein transport variant || meiosis variant || meiotic progression prophase variant || meiotic chromosome organization variant || germ cell physiology variant || protein metabolism variant || vesicle trafficking variant || programmed cell death variant || diakinesis progression during oogenesis variant || receptor mediated endocytosis defective || chromosome condensation variant
Worm Phenotype (WP)	organism behavior variant	0.003208	0.632	Least Informative	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	organism environmental stimulus response variant	0.004107	0.5677	Least Informative	INHERITED FROM: avoids bacterial lawn || organism stress response variant
Worm Phenotype (WP)	cell morphology variant	0.01547	0.6905	Least Informative	INHERITED FROM: nuclear appearance variant || recycling endosome localization variant || germ cell compartment morphology variant || endosome morphology variant || germ cell morphology variant || lysosome-related organelle morphology variant || germ cell compartment nuclei number variant || oocyte morphology variant || cell membrane organization biogenesis variant || germ cell compartment anucleate || vesicle morphology variant || germ cell compartment expansion variant || vesicle organization variant || oocytes lack nucleus || cell component localization variant || recycling endosome morphology variant || endosome localization variant || cell organization biogenesis variant || RAB-11 recycling endosome localization variant
Worm Phenotype (WP)	cell development variant	0.01969	0.632	Least Informative	INHERITED FROM: germ cell differentiation variant || diakinesis progression during oogenesis variant || meiotic progression during oogenesis variant || meiosis variant || chromosome condensation variant || meiotic progression prophase variant || meiotic chromosome organization variant || oogenesis variant || oocytes lack nucleus
Worm Phenotype (WP)	pattern of transgene expression variant	0	1.017	Moderately Informative	DIRECT
Worm Phenotype (WP)	level of transgene expression variant	0	1.151	Moderately Informative	DIRECT
Worm Phenotype (WP)	endocytic transport variant	0.000005154	1.216	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism stress response variant	0.0002054	0.8325	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell differentiation variant	0.000281	1.128	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell organization biogenesis variant	0.0004248	1.106	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0.0004377	1.026	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0.0006954	1.064	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0.001632	0.9752	Moderately Informative	INHERITED FROM: meiotic progression during oogenesis variant || chromosome condensation variant || meiosis variant || diakinesis progression during oogenesis variant || oocytes lack nucleus || oogenesis variant || meiotic chromosome organization variant || meiotic progression prophase variant
Worm Phenotype (WP)	feeding behavior variant	0.006177	1.176	Moderately Informative	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	cell cycle variant	0.01231	1.164	Moderately Informative	INHERITED FROM: diakinesis progression during oogenesis variant || chromosome condensation variant || meiosis variant || meiotic progression prophase variant || meiotic chromosome organization variant
Worm Phenotype (WP)	metabolic pathway variant	0.01477	1.117	Moderately Informative	INHERITED FROM: protein metabolism variant || protein transport variant
Worm Phenotype (WP)	cell division variant	0.04456	1	Moderately Informative	INHERITED FROM: meiotic chromosome organization variant || meiotic progression prophase variant || mitosis variant || meiosis variant || chromosome condensation variant || diakinesis progression during oogenesis variant
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.08446	0.9294	Moderately Informative	INHERITED FROM: protein metabolism variant || protein transport variant
Worm Phenotype (WP)	oocyte physiology variant	0.000001325	1.531	Informative	DIRECT
Worm Phenotype (WP)	endocytic transport defect	0.000004692	1.327	Informative	DIRECT
Worm Phenotype (WP)	mitosis variant	0.000005047	1.708	Informative	DIRECT
Worm Phenotype (WP)	vesicle organization variant	0.00001126	1.531	Informative	DIRECT
Worm Phenotype (WP)	meiotic chromosome organization variant	0.00001641	1.503	Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment expansion variant	0.00001661	1.407	Informative	DIRECT
Worm Phenotype (WP)	cell component localization variant	0.00001766	1.365	Informative	DIRECT
Worm Phenotype (WP)	somatic gonad development variant	0.00001808	1.531	Informative	DIRECT
Worm Phenotype (WP)	avoids bacterial lawn	0.0000239	1.327	Informative	DIRECT
Worm Phenotype (WP)	oocyte morphology variant	0.00008393	1.276	Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment anucleate	0.0000001497	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	oocyte septum formation variant	0.000000488	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	RAB-11 recycling endosome localization variant	0.000001459	1.753	Highly Informative	DIRECT
Worm Phenotype (WP)	chromosome condensation variant	0.000001527	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	membrane trafficking variant	0.000002444	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	lysosome-related organelle morphology variant	0.00000464	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	cell membrane organization biogenesis variant	0.000005851	1.804	Highly Informative	DIRECT
Worm Phenotype (WP)	nuclear appearance variant	0.00002061	1.862	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	development	0	1.267	--	DIRECT
Yeast Phenotype (YP)	cellular morphology	0	1.216	--	DIRECT
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	oxidative stress resistance	0	2.471	--	DIRECT
Yeast Phenotype (YP)	utilization of carbon source	0	1.357	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	utilization of iron source	0	2.471	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.4182	Least Informative	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5905	Least Informative	DIRECT
Yeast Phenotype (YP)	morphology	0	1.11	Moderately Informative	DIRECT
Yeast Phenotype (YP)	nutrient utilization	0	1.149	Moderately Informative	DIRECT
Yeast Phenotype (YP)	lifespan	0	1.517	Informative	DIRECT
Yeast Phenotype (YP)	chemical compound accumulation	0	1.295	Informative	DIRECT
Yeast Phenotype (YP)	respiratory metabolism	0	1.626	Informative	DIRECT
Yeast Phenotype (YP)	vegetative growth	0	1.392	Informative	DIRECT
Yeast Phenotype (YP)	subcellular morphology	0	1.392	Informative	DIRECT
Yeast Phenotype (YP)	metal resistance	0	2.17	Highly Informative	DIRECT
Yeast Phenotype (YP)	protein/peptide modification	0	2.17	Highly Informative	DIRECT
Yeast Phenotype (YP)	alkaline pH resistance	0	1.869	Highly Informative	DIRECT
Yeast Phenotype (YP)	respiratory growth	0	1.772	Highly Informative	DIRECT
Yeast Phenotype (YP)	chronological lifespan	0	1.869	Highly Informative	DIRECT
Yeast Phenotype (YP)	desiccation resistance	0	1.772	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.5108	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.4287	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5909	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.6506	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.7237	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7974	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	skeletal element	0	1.682	--	DIRECT
Xenopus ANatomical entity (XAN)	skeletal tissue	0	1.72	--	DIRECT
Xenopus ANatomical entity (XAN)	skeleton	0	1.647	--	DIRECT
Xenopus ANatomical entity (XAN)	bone element	0	1.761	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: testis || alimentary system || urogenital system || bone tissue || nervous system || skeletal element || brain || genital system || skeleton || musculoskeletal system || bone element || skeletal tissue || skeletal system || male genitalia || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: urogenital system || head region || genital system || brain || skeletal element || nervous system || bone tissue || alimentary system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || ectoderm || compound organ || trunk || tissue || anatomical region || solid compound organ || limb || central nervous system || skeletal system || male genitalia || connective tissue || trunk region || anatomical cluster || viscus || male organism || endomesoderm || skeletal tissue || musculoskeletal system || bone element || organism subdivision || skeleton || head || primary germ layer
Xenopus ANatomical entity (XAN)	embryo	0	0.6341	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.6341	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.5108	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.4308	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9688	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.8635	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.955	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.8318	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	musculoskeletal system	0	1.118	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.9618	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	connective tissue	0	1.72	Informative	DIRECT
Xenopus ANatomical entity (XAN)	limb	0	1.615	Informative	DIRECT
Xenopus ANatomical entity (XAN)	endomesoderm	0	1.256	Informative	DIRECT
Xenopus ANatomical entity (XAN)	skeletal system	0	1.531	Informative	DIRECT
Xenopus ANatomical entity (XAN)	solid compound organ	0	1.399	Informative	DIRECT
Xenopus ANatomical entity (XAN)	bone tissue	0	1.807	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5946	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6715	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5693	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7597	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage 66	0	1.384	Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	androecium development stage	0	1.135	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: pollen development stage || L mature pollen stage || floral organ differentiation stage || floral organ formation stage || M germinated pollen stage || androecium development stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || L mature pollen stage || floral organ formation stage || floral organ differentiation stage || pollen development stage || M germinated pollen stage || plant organ development stage || androecium development stage
Plant structure DEvelopment stage (PDE)	pollen development stage	0	1.135	Moderately Informative	DIRECT
Plant structure DEvelopment stage (PDE)	L mature pollen stage	0	1.527	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	M germinated pollen stage	0	1.425	Informative	DIRECT

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InterPro annotation

• Cross references: IPR002379 SSF81333 Protein matches
• Abstract:

  The F-ATPases (or F1F0-ATPases) and V-ATPases (or V1V0-ATPases) are each composed of two linked complexes: the F1 or V1 complex contains the catalytic core that synthesizes/hydrolyses ATP, and the F0 or V0 complex that forms the membrane-spanning pore. The F- and V-ATPases all contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [11309608, 15629643].

  This entry represents subunit C (also called subunit 9, or proteolipid in F-ATPases, or the 16 kDa proteolipid in V-ATPases) found in the F0 or V0 complex of F- and V-ATPases, respectively. In F-ATPases, ten C subunits form an oligomeric ring that makes up the F0 rotor. The flux of protons through the ATPase channel drives the rotation of the C subunit ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the C subunit ring of F0. The sequential protonation and deprotonation of Asp61 of subunit C is coupled to the stepwise movement of the rotor [14630314].

  In V-ATPases, there are three proteolipid subunits (c, c¿ and c¿¿) that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane [15951435, 14635779].

  More information about this protein can be found at Protein of the Month: ATP Synthases.

InterPro database

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