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Aquaporin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Families:   Aquaporin-like [ 56895] (4)

Superfamily statistics
Genomes (2,153) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,999 38,951 8
Proteins 8,878 38,688 8

Functional annotation
General category Processes_IC
Detailed category Transport

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1056Least InformativeInherited
Disease Ontology (DO)sensory system disease0.00004551Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.01019Moderately InformativeInherited
Disease Ontology (DO)female reproductive system disease0.0007506InformativeDirect
Disease Ontology (DO)inner ear disease0.0000005271Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.008046Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.04257Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.0721Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.00004051InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.006895InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.04505InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.1069InformativeInherited
Mammalian Phenotype (MP)polyuria0.00000005833Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000003383Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.0004233Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.01471Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.0003418Moderately InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.00002691InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0007987Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.6623Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.9354Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.000008208InformativeDirect
Plant ANatomical entity (PAN)portion of vascular tissue0.0003175InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.0008513InformativeDirect
Plant ANatomical entity (PAN)lateral root0.00001038Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.0001302Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05325Highly InformativeInherited

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR000425 SSF81338 Protein matches

A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities [PubMed8325040, PubMed2014003, PubMed1715617, PubMed7529436].

These include:

  • Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions.
  • Mammalian aquaporins [PubMed7529436]. These proteins form water- specific channels that provide the plasma membranes of red cells and kidney prox imal and collecting tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Soybean nodulin-26, a major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection.
  • Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP : alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins may allow the diffusion of water, amino acids and/or peptides from the tonoplas t interior to the cytoplasm..
  • Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo vement of glycerol across the cytoplasmic membrane.
  • Salmonella typhimurium propanediol diffusion fac ilitator (gene pduF).
  • Yeast FPS1, a glycerol uptake/efflux facilitator protein.
  • Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in tercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an ep idermoblast instead of a neuroblast.
  • Yeast hypothetical protein YFL054c.
  • A hypothetical protein from the pepX region of Lactococ cus lactis.

MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem, intragenic duplication from an ancestral protein that contained 3 TM domains [].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates a ttached to lipids or proteins [PubMed11845000]. Aquaporin-CHIP (Aquaporin 1) belo ngs to the Colton blood group system and is associated with Co(a/b) antigen.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]