Clc chloride channel superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Membrane and cell surface proteins and peptides [ 56835] (58)
• Fold: Clc chloride channel [ 81341]
• Superfamily: Clc chloride channel [ 81340]
• Families: Clc chloride channel [ 69912]

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Superfamily statistics

	Genomes (2,139)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,141	33,059	14
Proteins	6,044	32,847	14

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Functional annotation

• General category: Processes_IC
• Detailed category: Ion metabolism and transport

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal blood ion concentration	0.000008374	1.628	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal blood potassium concentration	0.00008628	1.804	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal urinary electrolyte concentration	0.0001422	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Premature birth	0.0005513	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of urine homeostasis	0.08311	1.176	--	INHERITED FROM: Abnormal urinary electrolyte concentration
Phenotypic Abnormality (PA)	Abnormal blood monovalent inorganic cation concentration	0.1069	1.708	--	INHERITED FROM: Abnormal blood potassium concentration || Hypokalemia
Phenotypic Abnormality (PA)	Abnormality of the urinary system	0.1846	0.8268	--	INHERITED FROM: Abnormal urinary electrolyte concentration
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.1524	0.5315	Least Informative	INHERITED FROM: Hypokalemia || Abnormal urinary electrolyte concentration || Abnormal blood ion concentration || Abnormal blood potassium concentration
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.3734	0.5432	Least Informative	INHERITED FROM: Abnormal urinary electrolyte concentration
Phenotypic Abnormality (PA)	Abnormal circulating metabolite concentration	0.009306	0.9294	Moderately Informative	INHERITED FROM: Hypokalemia || Abnormal blood ion concentration || Abnormal blood potassium concentration
Phenotypic Abnormality (PA)	Abnormality of the urinary system physiology	0.2317	1.045	Moderately Informative	INHERITED FROM: Abnormal urinary electrolyte concentration
Phenotypic Abnormality (PA)	Abnormality of prenatal development or birth	0.07321	1.407	Informative	INHERITED FROM: Premature birth
Phenotypic Abnormality (PA)	Abnormal blood cation concentration	0.7454	1.628	Informative	INHERITED FROM: Abnormal blood potassium concentration || Hypokalemia
Phenotypic Abnormality (PA)	Hypokalemia	0.00002095	1.804	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal renal reabsorbtion	0.0000007328	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal photoreceptor inner segment morphology	0.00000327	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal photoreceptor outer segment morphology	0.00004684	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal retinal photoreceptor layer morphology	0.0002966	1.906	--	DIRECT
Mammalian Phenotype (MP)	abnormal spine curvature	0.001669	2.031	--	INHERITED FROM: kyphosis
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.001838	0.8951	--	INHERITED FROM: abnormal renal reabsorbtion || abnormal renal protein reabsorption
Mammalian Phenotype (MP)	abnormal retinal layer morphology	0.004109	1.466	--	INHERITED FROM: abnormal photoreceptor inner segment morphology || abnormal photoreceptor outer segment morphology || abnormal retinal photoreceptor morphology || abnormal retinal photoreceptor layer morphology
Mammalian Phenotype (MP)	abnormal retina morphology	0.01494	1.229	--	INHERITED FROM: abnormal retinal photoreceptor layer morphology || abnormal photoreceptor outer segment morphology || abnormal retinal photoreceptor morphology || retinal degeneration || abnormal photoreceptor inner segment morphology
Mammalian Phenotype (MP)	abnormal ocular fundus morphology	0.01543	1.229	--	INHERITED FROM: abnormal photoreceptor inner segment morphology || retinal degeneration || abnormal retinal photoreceptor morphology || abnormal photoreceptor outer segment morphology || abnormal retinal photoreceptor layer morphology
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.01723	1.128	--	INHERITED FROM: kyphosis
Mammalian Phenotype (MP)	abnormal somatic sensory system morphology	0.01742	1.093	--	INHERITED FROM: abnormal retinal photoreceptor morphology || abnormal photoreceptor inner segment morphology || abnormal photoreceptor outer segment morphology
Mammalian Phenotype (MP)	abnormal posterior eye segment morphology	0.01932	1.186	--	INHERITED FROM: abnormal retinal photoreceptor layer morphology || abnormal retinal photoreceptor morphology || abnormal photoreceptor inner segment morphology || abnormal photoreceptor outer segment morphology || retinal degeneration
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.05398	0.627	--	INHERITED FROM: abnormal photoreceptor outer segment morphology || abnormal retinal photoreceptor morphology || abnormal photoreceptor inner segment morphology
Mammalian Phenotype (MP)	skeleton phenotype	0.07922	0.8451	--	INHERITED FROM: kyphosis
Mammalian Phenotype (MP)	vision/eye phenotype	0.1109	0.8744	--	INHERITED FROM: abnormal photoreceptor inner segment morphology || abnormal retinal photoreceptor layer morphology || retinal degeneration || abnormal retinal photoreceptor morphology || abnormal photoreceptor outer segment morphology
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.1131	0.3617	--	INHERITED FROM: abnormal renal protein reabsorption
Mammalian Phenotype (MP)	abnormal vertebral column morphology	0.2815	1.362	--	INHERITED FROM: kyphosis
Mammalian Phenotype (MP)	nervous system phenotype	0.1066	0.5166	Least Informative	INHERITED FROM: abnormal retinal photoreceptor morphology || abnormal photoreceptor outer segment morphology || abnormal photoreceptor inner segment morphology
Mammalian Phenotype (MP)	abnormal homeostasis	0.6323	0.495	Least Informative	INHERITED FROM: abnormal renal protein reabsorption
Mammalian Phenotype (MP)	abnormal protein level	0.0149	1.146	Moderately Informative	INHERITED FROM: abnormal renal protein reabsorption
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.06683	0.8951	Moderately Informative	INHERITED FROM: kyphosis
Mammalian Phenotype (MP)	abnormal eye morphology	0.0937	0.9168	Moderately Informative	INHERITED FROM: abnormal retinal photoreceptor layer morphology || retinal degeneration || abnormal retinal photoreceptor morphology || abnormal photoreceptor inner segment morphology || abnormal photoreceptor outer segment morphology
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.1658	0.9764	Moderately Informative	INHERITED FROM: abnormal photoreceptor inner segment morphology || abnormal retinal photoreceptor morphology || abnormal photoreceptor outer segment morphology
Mammalian Phenotype (MP)	abnormal neuron morphology	0.1854	0.9516	Moderately Informative	INHERITED FROM: abnormal photoreceptor outer segment morphology || abnormal photoreceptor inner segment morphology || abnormal retinal photoreceptor morphology
Mammalian Phenotype (MP)	abnormal renal/urinary system physiology	0.1985	1.207	Moderately Informative	INHERITED FROM: abnormal renal protein reabsorption || abnormal renal reabsorbtion
Mammalian Phenotype (MP)	abnormal retinal neuronal layer morphology	0.00205	1.466	Informative	INHERITED FROM: abnormal retinal photoreceptor layer morphology || abnormal photoreceptor inner segment morphology || abnormal retinal photoreceptor morphology || abnormal photoreceptor outer segment morphology
Mammalian Phenotype (MP)	abnormal sensory neuron morphology	0.04783	1.304	Informative	INHERITED FROM: abnormal photoreceptor inner segment morphology || abnormal retinal photoreceptor morphology || abnormal photoreceptor outer segment morphology
Mammalian Phenotype (MP)	abnormal kidney physiology	0.2826	1.429	Informative	INHERITED FROM: abnormal renal reabsorbtion || abnormal renal protein reabsorption
Mammalian Phenotype (MP)	abnormal renal protein reabsorption	0.0000001064	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	retinal degeneration	0.00004865	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal retinal photoreceptor morphology	0.0002615	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	kyphosis	0.0006225	2.031	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	amphid physiology variant	0	2.407	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	sensory system variant	8.972e-16	2.407	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || sensory system variant || organism physiology variant || electrophysiology variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || nervous system physiology variant || embryonic development variant || embryonic lethal || fertility variant || amphid physiology variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	electrophysiology variant	0	1.708	Informative	DIRECT
Worm Phenotype (WP)	nervous system physiology variant	0.0000000000701	1.666	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	cauline leaf	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot apex	0	0.5633	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.6463	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.5246	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.6087	--	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.577	--	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.6058	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.6495	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.51	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3881	--	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.55	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.4141	--	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: sporophyll || flower || collective plant structure || leaf || shoot internode || phyllome || cardinal organ part || multi-tissue plant structure || guard cell || megasporophyll || cauline leaf || reproductive shoot system || shoot apex || leaf apex || collective leaf structure || stem internode || shoot system || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || inflorescence meristem || epidermis || inflorescence || cardinal part of multi-tissue plant structure || gynoecium || vascular leaf || epidermal cell || shoot epidermal cell || plant axis || collective phyllome structure || plant cell || carpel || shoot epidermis || phyllome apex || cotyledon || shoot axis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: flower || sporophyll || inflorescence meristem || inflorescence || stem || leaf || phyllome || shoot internode || vascular leaf || gynoecium || reproductive shoot system || shoot apex || leaf apex || carpel || collective phyllome structure || guard cell || megasporophyll || cauline leaf || shoot epidermal cell || stomatal complex || phyllome apex || cotyledon || stem internode || shoot axis || shoot system || collective leaf structure || shoot epidermis
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.6838	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.4337	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.5969	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.4648	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.4735	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.5053	Least Informative	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.7789	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.7615	Moderately Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.4754	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.4754	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || LP.10 ten leaves visible stage || LP.12 twelve leaves visible stage || LP.04 four leaves visible stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || leaf production stage || 1 main shoot growth stage || LP.04 four leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.478	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.5666	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.586	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.513	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.4338	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.5243	Least Informative	DIRECT

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InterPro annotation

• Cross references: IPR014743 SSF81340 Protein matches
• Abstract:

  This entry represents the core domain of the cholide ion channel.

InterPro database

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