Metal cation-transporting ATPase, ATP-binding domain N family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Metal cation-transporting ATPase, ATP-binding domain N [ 81661]
• Superfamily: Metal cation-transporting ATPase, ATP-binding domain N [ 81660]
• Family: Metal cation-transporting ATPase, ATP-binding domain N [ 81659] (4)

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Family statistics

	Genomes (746)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,918	10,032	4
Proteins	1,917	10,022	4

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Phospholipid-translocating ATPase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	0.7283	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides; catalyzing transmembran	0	1.662	Informative	DIRECT
Enzyme Commission (EC)	Potassium-transporting ATPase	0	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Calcium-transporting ATPase	0	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Sodium/potassium-exchanging ATPase	0	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Hydrogen/potassium-exchanging ATPase	0.0000000000001005	2.139	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	muscle phenotype	0.004662	0.8473	--	INHERITED FROM: abnormal muscle physiology || impaired muscle contractility
Mammalian Phenotype (MP)	abnormal muscle contractility	0.05581	1.427	--	INHERITED FROM: impaired muscle contractility
Mammalian Phenotype (MP)	abnormal muscle physiology	0.0003939	1.085	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	impaired muscle contractility	0.00003742	1.457	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	nicotine response variant	0.002459	1.814	--	INHERITED FROM: nicotine hypersensitive
Worm Phenotype (WP)	cholinergic agonist hypersensitive	0.01522	2.167	--	INHERITED FROM: nicotine hypersensitive
Worm Phenotype (WP)	drug response variant	0.1118	1.135	--	INHERITED FROM: drug hypersensitive || nicotine hypersensitive
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.2358	0.1444	--	INHERITED FROM: organism environmental stimulus response variant || drug hypersensitive || nicotine hypersensitive
Worm Phenotype (WP)	organism physiology variant	0.2539	0.1342	--	INHERITED FROM: organism environmental stimulus response variant || drug hypersensitive || nicotine hypersensitive
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || drug hypersensitive || lethal || development variant || hermaphrodite sterile || organism environmental stimulus response variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || nicotine hypersensitive || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism environmental stimulus response variant	0.00004903	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	chemical response variant	0.08871	0.9053	Moderately Informative	INHERITED FROM: nicotine hypersensitive || drug hypersensitive
Worm Phenotype (WP)	drug hypersensitive	0.0005675	1.689	Informative	DIRECT
Worm Phenotype (WP)	chemical hypersensitive	0.2047	1.388	Informative	INHERITED FROM: nicotine hypersensitive
Worm Phenotype (WP)	nicotine hypersensitive	0.00000001062	2.167	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.7171	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0	0.7764	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.8451	--	DIRECT
Fly Anatomy (FA)	sensory system	0	0.8577	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || nervous system || peripheral nervous system || neuron || adult || embryonic/larval nervous system || adult nervous system || larva || somatic cell || cell || organ system subdivision || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: anatomical group || organ system || multicellular structure || sensory system || non-connected functional system || organ system subdivision || cell || larva || somatic cell || neuron || adult || embryonic/larval nervous system || adult nervous system || organism || nervous system || peripheral nervous system
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	peripheral nervous system	0	0.8978	Moderately Informative	DIRECT
Fly Anatomy (FA)	neuron	0	0.8451	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Linked to the hydrolysis of a nucleoside triphosphate	0	2.275	--	DIRECT
Enzyme Commission (EC)	P-type phospholipid transporter	0	2.929	--	DIRECT
Enzyme Commission (EC)	P-type Ca(2+) transporter	0.00000000003611	2.929	--	DIRECT
Enzyme Commission (EC)	Na(+)/K(+)-exchanging ATPase	0.000006404	2.929	--	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of other compounds	0.2993	2.452	--	INHERITED FROM: P-type phospholipid transporter
Enzyme Commission (EC)	Linked to the hydrolysis of a nucleoside triphosphate	1	2.531	--	INHERITED FROM: P-type phospholipid transporter
Enzyme Commission (EC)	Translocases	0	1.628	Informative	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of inorganic cations	0	2.116	Highly Informative	DIRECT

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