MIR domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: beta-Trefoil [ 50352] (8)
• Superfamily: MIR domain [ 82109]
• Family: MIR domain [ 82110] (2)

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Family statistics

	Genomes (254)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	736	2,072	2
Proteins	733	2,065	2

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Dolichyl-phosphate-mannose-protein mannosyltransfe	0	2.741	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0	0.993	Moderately Informative	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0	1.264	Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	muscle tissue disease	0.0009511	1.434	--	DIRECT
Disease Ontology (DO)	musculoskeletal system disease	0.004568	0.89	--	INHERITED FROM: muscle tissue disease
Disease Ontology (DO)	muscular disease	0.03137	1.399	--	INHERITED FROM: muscle tissue disease
Disease Ontology (DO)	disease of anatomical entity	0.1623	0.2414	--	INHERITED FROM: muscle tissue disease

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.04347	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Mode of Inheritance (MI)	Heterogeneous	0.0002301	1.419	Informative	DIRECT
Phenotypic Abnormality (PA)	Axial muscle weakness	0.0000008679	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Proximal amyotrophy	0.000003068	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Calf muscle hypertrophy	0.000005395	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Muscle hypertrophy of the lower extremities	0.000006951	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Multiple joint contractures	0.000008836	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Difficulty climbing stairs	0.00001235	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Left ventricular hypertrophy	0.00001832	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the calf musculature	0.00002187	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Lumbar hyperlordosis	0.00003064	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Bifid uvula	0.0001275	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal cardiac ventricular function	0.0001863	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Fatigable weakness	0.0002262	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Infantile muscular hypotonia	0.0002671	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal synaptic transmission	0.0004051	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Protruding ear	0.0005059	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal soft palate morphology	0.0005059	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature of the upper limbs	0.00068	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Cerebellar hypoplasia	0.0006993	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Respiratory failure	0.000719	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Skeletal muscle hypertrophy	0.0008061	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Hyperlordosis	0.0008536	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebellar vermis	0.001296	2.161	--	INHERITED FROM: Aplasia/Hypoplasia of the cerebellar vermis
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the cerebellum	0.002687	2.462	--	INHERITED FROM: Cerebellar hypoplasia
Phenotypic Abnormality (PA)	Cerebellar malformation	0.003005	2.161	--	INHERITED FROM: Aplasia/Hypoplasia of the cerebellar vermis
Phenotypic Abnormality (PA)	Functional motor deficit	0.008054	1.763	--	INHERITED FROM: Difficulty climbing stairs
Phenotypic Abnormality (PA)	Ventricular hypertrophy	0.0114	2.462	--	INHERITED FROM: Left ventricular hypertrophy
Phenotypic Abnormality (PA)	Abnormal tendon morphology	0.03908	1.462	--	INHERITED FROM: Multiple joint contractures
Phenotypic Abnormality (PA)	Abnormal cerebellum morphology	0.04198	1.763	--	INHERITED FROM: Aplasia/Hypoplasia of the cerebellar vermis || Cerebellar hypoplasia
Phenotypic Abnormality (PA)	Abnormality of hindbrain morphology	0.04276	1.763	--	INHERITED FROM: Aplasia/Hypoplasia of the cerebellar vermis || Cerebellar hypoplasia
Phenotypic Abnormality (PA)	Abnormality of the curvature of the vertebral column	0.1068	1.258	--	INHERITED FROM: Hyperlordosis || Lumbar hyperlordosis
Phenotypic Abnormality (PA)	Abnormality of joint mobility	0.129	1.14	--	INHERITED FROM: Multiple joint contractures
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0.1384	0.9183	--	INHERITED FROM: Respiratory failure
Phenotypic Abnormality (PA)	Abnormal muscle tone	0.1683	0.8942	--	INHERITED FROM: Infantile muscular hypotonia
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.1883	0.8391	--	INHERITED FROM: Left ventricular hypertrophy
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.2106	0.9183	--	INHERITED FROM: Abnormality of the musculature of the upper limbs
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.2421	0.2371	--	INHERITED FROM: Aplasia/Hypoplasia of the cerebellar vermis || Abnormal synaptic transmission || Fatigable weakness || Cerebellar hypoplasia
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0.2922	0.6915	--	INHERITED FROM: Axial muscle weakness || Proximal muscle weakness || Limb-girdle muscle weakness || Generalized muscle weakness || Difficulty climbing stairs || Infantile muscular hypotonia || Fatigable weakness
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.4119	0.7381	--	INHERITED FROM: Abnormal soft palate morphology || Bifid uvula || Abnormality of the uvula
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.4608	0.7065	--	INHERITED FROM: Bifid uvula || Abnormality of the uvula || Abnormal soft palate morphology
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.5406	0.6631	--	INHERITED FROM: Cerebellar hypoplasia || Aplasia/Hypoplasia of the cerebellar vermis
Phenotypic Abnormality (PA)	Abnormality of the head	0.5575	0.4538	--	INHERITED FROM: Abnormality of the uvula || Bifid uvula || Abnormal soft palate morphology
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.5667	0.4454	--	INHERITED FROM: Bifid uvula || Abnormality of the uvula || Abnormal soft palate morphology
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.5736	0.6771	--	INHERITED FROM: Hyperlordosis || Lumbar hyperlordosis
Phenotypic Abnormality (PA)	Abnormal ear morphology	0.6849	1.047	--	INHERITED FROM: Protruding ear
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.765	0.533	--	INHERITED FROM: Aplasia/Hypoplasia of the cerebellar vermis || Cerebellar hypoplasia
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.7898	0.4712	--	INHERITED FROM: Hyperlordosis || Multiple joint contractures || Lumbar hyperlordosis
Phenotypic Abnormality (PA)	Abnormality of the metencephalon	1	1.763	--	INHERITED FROM: Aplasia/Hypoplasia of the cerebellar vermis || Cerebellar hypoplasia
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system synaptic transmission	1	1.684	--	INHERITED FROM: Fatigable weakness
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.1543	0.5179	Least Informative	INHERITED FROM: Abnormal cardiac ventricular function || Left ventricular dysfunction || Left ventricular hypertrophy
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.1683	0.3869	Least Informative	INHERITED FROM: Fatigable weakness || Abnormal synaptic transmission
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.4208	0.5433	Least Informative	INHERITED FROM: Fatigable weakness || Proximal amyotrophy || Muscle hypertrophy of the lower extremities || Muscular dystrophy || Proximal muscle weakness || Abnormality of the musculature of the upper limbs || Axial muscle weakness || Difficulty climbing stairs || Generalized muscle weakness || Limb-girdle muscle weakness || Skeletal muscle hypertrophy || Infantile muscular hypotonia || Abnormality of the calf musculature || Calf muscle hypertrophy || Multiple joint contractures || Abnormality of the musculature of the lower limbs
Phenotypic Abnormality (PA)	Abnormality of limbs	0.4306	0.6429	Least Informative	INHERITED FROM: Abnormality of the musculature of the lower limbs || Abnormality of the calf musculature || Abnormality of the musculature of the upper limbs || Muscle hypertrophy of the lower extremities || Limb-girdle muscle weakness || Calf muscle hypertrophy
Phenotypic Abnormality (PA)	Abnormality of the face	0.4592	0.533	Least Informative	INHERITED FROM: Bifid uvula || Abnormality of the uvula || Abnormal soft palate morphology
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.6537	0.4756	Least Informative	INHERITED FROM: Aplasia/Hypoplasia of the cerebellar vermis || Cerebellar hypoplasia
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.7524	0.513	Least Informative	INHERITED FROM: Lumbar hyperlordosis || Multiple joint contractures || Hyperlordosis
Phenotypic Abnormality (PA)	Abnormal heart morphology	0.04731	0.9183	Moderately Informative	INHERITED FROM: Left ventricular hypertrophy
Phenotypic Abnormality (PA)	Abnormality of the ear	0.06857	0.9572	Moderately Informative	INHERITED FROM: Protruding ear
Phenotypic Abnormality (PA)	Muscular hypotonia	0.1009	1.031	Moderately Informative	INHERITED FROM: Infantile muscular hypotonia
Phenotypic Abnormality (PA)	Abnormal cardiovascular system physiology	0.1016	0.9309	Moderately Informative	INHERITED FROM: Left ventricular dysfunction || Abnormal cardiac ventricular function
Phenotypic Abnormality (PA)	Abnormality of the vertebral column	0.1796	1.031	Moderately Informative	INHERITED FROM: Lumbar hyperlordosis || Hyperlordosis
Phenotypic Abnormality (PA)	Abnormality of connective tissue	0.2002	1.031	Moderately Informative	INHERITED FROM: Multiple joint contractures
Phenotypic Abnormality (PA)	Abnormality of skeletal physiology	0.2209	1.101	Moderately Informative	INHERITED FROM: Multiple joint contractures
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.2357	0.9309	Moderately Informative	INHERITED FROM: Muscle hypertrophy of the lower extremities || Abnormality of the calf musculature || Abnormality of the musculature of the lower limbs || Calf muscle hypertrophy
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving the central nervous system	0.2364	1.047	Moderately Informative	INHERITED FROM: Cerebellar hypoplasia
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.3069	0.9061	Moderately Informative	INHERITED FROM: Limb-girdle muscle weakness || Proximal amyotrophy || Muscle hypertrophy of the lower extremities || Skeletal muscle hypertrophy || Abnormality of the calf musculature || Muscular dystrophy || Calf muscle hypertrophy || Multiple joint contractures || Abnormality of the musculature of the lower limbs || Abnormality of the musculature of the upper limbs
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: Bifid uvula || Abnormality of the uvula || Abnormal soft palate morphology
Phenotypic Abnormality (PA)	Abnormal cardiac ventricle morphology	0.001761	1.508	Informative	INHERITED FROM: Left ventricular hypertrophy
Phenotypic Abnormality (PA)	Abnormality of the musculature of the limbs	0.01207	1.421	Informative	INHERITED FROM: Limb-girdle muscle weakness || Abnormality of the musculature of the lower limbs || Muscle hypertrophy of the lower extremities || Abnormality of the calf musculature || Abnormality of the musculature of the upper limbs || Calf muscle hypertrophy
Phenotypic Abnormality (PA)	Abnormality of muscle size	0.03458	1.684	Informative	INHERITED FROM: Calf muscle hypertrophy || Proximal amyotrophy || Skeletal muscle hypertrophy || Muscle hypertrophy of the lower extremities
Phenotypic Abnormality (PA)	Flexion contracture	0.03569	1.462	Informative	INHERITED FROM: Multiple joint contractures
Phenotypic Abnormality (PA)	Muscle weakness	0.08882	1.316	Informative	INHERITED FROM: Axial muscle weakness || Fatigable weakness || Limb-girdle muscle weakness || Generalized muscle weakness || Proximal muscle weakness
Phenotypic Abnormality (PA)	Abnormal palate morphology	0.09731	1.348	Informative	INHERITED FROM: Bifid uvula || Abnormal soft palate morphology || Abnormality of the uvula
Phenotypic Abnormality (PA)	Abnormality of the outer ear	0.1982	1.617	Informative	INHERITED FROM: Protruding ear
Phenotypic Abnormality (PA)	Functional respiratory abnormality	0.3653	1.348	Informative	INHERITED FROM: Respiratory failure
Phenotypic Abnormality (PA)	Abnormal synaptic transmission at the neuromuscular junction	1	1.684	Informative	INHERITED FROM: Fatigable weakness
Phenotypic Abnormality (PA)	Left ventricular dysfunction	0.00001368	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Muscular dystrophy	0.00003866	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Limb-girdle muscle weakness	0.00005939	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature of the lower limbs	0.00009167	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the uvula	0.0002262	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Generalized muscle weakness	0.0002909	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the cerebellar vermis	0.0007853	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Proximal muscle weakness	0.0009798	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal left ventricle morphology	0.007033	2.161	Highly Informative	INHERITED FROM: Left ventricular hypertrophy
Phenotypic Abnormality (PA)	Skeletal muscle atrophy	0.01776	1.86	Highly Informative	INHERITED FROM: Proximal amyotrophy
Phenotypic Abnormality (PA)	Respiratory insufficiency	0.01808	1.86	Highly Informative	INHERITED FROM: Respiratory failure
Phenotypic Abnormality (PA)	Abnormality of the pinna	0.03041	1.985	Highly Informative	INHERITED FROM: Protruding ear

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal pancreas secretion	0.0002111	1.603	--	DIRECT
Mammalian Phenotype (MP)	muscle phenotype	0.0003109	0.8473	--	DIRECT
Mammalian Phenotype (MP)	abnormal gland physiology	0.04136	1.324	--	INHERITED FROM: abnormal pancreas secretion
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.08236	0.6947	Least Informative	INHERITED FROM: abnormal pancreas secretion
Mammalian Phenotype (MP)	abnormal muscle physiology	0.00003183	1.085	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal pancreas physiology	0.001163	1.524	Informative	INHERITED FROM: abnormal pancreas secretion

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || organism metabolism processing variant || retarded heterochronic variations || reproductive system physiology variant || transgene expression variant || gene expression variant || organism homeostasis metabolism variant || lethal || larval development variant || organism physiology variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || pattern of transgene expression variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0	0.9833	Moderately Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	embryo	0	0.8978	--	DIRECT
Fly Anatomy (FA)	embryonic/larval muscle system	0	1.787	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	muscle system	0	1.435	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || muscle cell || adult || larva || somatic cell || cell || muscle system || late embryo || tagma || organ system subdivision || embryonic/larval muscle system || embryo || organ system || organism subdivision || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: embryo || embryonic/larval muscle system || organ system || organism subdivision || multicellular structure || tagma || organ system subdivision || cell || muscle system || late embryo || larva || somatic cell || adult || organism || muscle cell
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: tagma
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	late embryo	0	1.088	Moderately Informative	DIRECT
Fly Anatomy (FA)	muscle cell	0	1.486	Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	skeletal muscle cell	0.0005335	1.693	--	DIRECT
Zebrafish Anatomy (ZA)	striated muscle cell	0.002734	1.568	--	INHERITED FROM: skeletal muscle cell
Zebrafish Anatomy (ZA)	musculature system	0.01765	1.325	--	INHERITED FROM: skeletal muscle cell
Zebrafish Anatomy (ZA)	muscle	0.04698	1.43	--	INHERITED FROM: skeletal muscle cell
Zebrafish Anatomy (ZA)	anatomical group	0.9741	0.1532	--	INHERITED FROM: skeletal muscle cell
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism || skeletal muscle cell
Zebrafish Anatomy (ZA)	anatomical system	1	0.1857	--	INHERITED FROM: skeletal muscle cell
Zebrafish Anatomy (ZA)	electrically responsive cell	1	1.216	--	INHERITED FROM: skeletal muscle cell
Zebrafish Anatomy (ZA)	cell	0.6711	0.6388	Least Informative	INHERITED FROM: skeletal muscle cell
Zebrafish Anatomy (ZA)	portion of tissue	0.07756	0.7637	Moderately Informative	INHERITED FROM: skeletal muscle cell
Zebrafish Anatomy (ZA)	electrically active cell	0.124	1.17	Moderately Informative	INHERITED FROM: skeletal muscle cell
Zebrafish Anatomy (ZA)	skeletal muscle	0.001028	1.626	Informative	INHERITED FROM: skeletal muscle cell
Zebrafish Anatomy (ZA)	muscle cell	0.00449	1.471	Informative	INHERITED FROM: skeletal muscle cell

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: head region || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || tissue || anatomical region || trunk region || organism subdivision || head
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hexosyltransferases	0	1.65	--	DIRECT
Enzyme Commission (EC)	Dolichyl-phosphate-mannose--protein mannosyltransferase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0	1.378	Informative	DIRECT

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