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FAS1 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   FAS1 domain [ 82152]
Superfamily:   FAS1 domain [ 82153]
Families:   FAS1 domain [ 82154] (2)

Superfamily statistics
Genomes (924) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,120 34,681 3
Proteins 4,554 21,189 2

Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)carcinoma0InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.03694Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.0002859InformativeDirect

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect
Xenopus ANatomical entity (XAN)adipose tissue0Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR000782 SSF82153 Protein matches

The FAS1 or BIgH3 domain is an extracellular module of about 140 amino acid residues. It has been suggested that the FAS1 domain represents an ancient cell adhesion domain common to plants and animals [PubMed7925267]; related FAS1 domains are also found in bacteria [PubMed7822037]. Most FAS1 domain containing proteins are GPI anchored and contain two or four copies of the domain. FAS1 domains of BIgH3 protein mediate cell adhesion throught an interaction with alpha3/beta1 integrin. A short motif (EPDIM), located on the C-teminal side of the fourth domain, is essential for the binding to integrin [PubMed10906123]. The crystal structure of two FAS1 domains (FAS1 3-4) of a fas1 protein have been solved [PubMed12575939]. Each domain consists of seven-stranded wedge and at least five alpha helices. Two well-ordered N-acetylglucosamine moities attached to a conserved asparagine are located in the interface region between the two FAS1 domains.

Some of the proteins containing a FAS1 domain are listed below:
  • Drosophila fasciclin I (fas1) protein. A cell adhesion molecule involved in axon guidance. It is attached to the membrane by a GPI-anchor (4 copies).
  • Human TGF-beta induced Ig-H3 (BIgH3) protein. Mutation in its FAS1 domains result in corneal distrophy, due to the deposition of insoluble protein aggregates (4 copies).
  • Arabidopsis fasciclin-like arabinogalactan proteins (2 copies).
  • Volvox major cell adhesion protein (2 copies).
  • Bacterial immunogenic protein MPT70 (1 copy).
  • Human extracellular matrix protein periostin (4 copies).
  • Mammalian stabilin protein (7 copies).

  • InterPro database

    PDBeMotif information about ligands, sequence and structure motifs
    Cross references PDB entries
    Ligand binding statistics
    Nucleic-acid binding statistics
    Occurrence of secondary structure elements
    Occurrence of small 3D structural motifs

    PDBeMotif resource

    Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

    Internal database links

    Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

    Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

    Browse and view proteins in genomes which have different domain combinations including a FAS1 domain domain.

    Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

    Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

    There are 3 hidden Markov models representing the FAS1 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

    Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]