Hypoxia-inducible factor HIF ihhibitor (FIH1) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Double-stranded beta-helix [ 51181] (7)
• Superfamily: Clavaminate synthase-like [ 51197] (13)
• Family: Hypoxia-inducible factor HIF ihhibitor (FIH1) [ 82194]

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Family statistics

	Genomes (89)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	107	263	3
Proteins	106	263	3

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	[Histone H3]-lysine-36 demethylase	0.00003444	2.44	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0	1.173	Moderately Informative	DIRECT
Enzyme Commission (EC)	With 2-oxoglutarate as one donor, and incorporatio	0	1.963	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0	0.8608	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: alimentary system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: alimentary system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || germ cell || trunk region || anatomical cluster || viscus || organism subdivision || cell
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	germ cell	0	1.08	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.8828	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: root || collective plant structure || multi-tissue plant structure || guard cell || shoot apex || shoot system || portion of plant tissue || stomatal complex || plant organ || epidermis || root system || epidermal cell || shoot epidermal cell || plant axis || plant cell || seed || shoot epidermis || shoot axis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: root system || root || shoot apex || guard cell || shoot epidermal cell || stomatal complex || shoot axis || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	shoot apex	0	0.481	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.5189	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || E expanded cotyledon stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: E expanded cotyledon stage || sporophyte vegetative stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase	0	2.929	--	DIRECT
Enzyme Commission (EC)	methoxycarbonyltransferase	0	2.929	--	DIRECT
Enzyme Commission (EC)	tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase	0.000007361	3.23	--	DIRECT
Enzyme Commission (EC)	Hypoxia-inducible factor-asparagine dioxygenase	0.0000602	3.23	--	DIRECT
Enzyme Commission (EC)	Ankyrin-repeat-histidine dioxagenase	0.0000602	3.23	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0.0000000263	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	0.5044	0.3972	Least Informative	INHERITED FROM: Transferring groups other than amino-acyl groups || Transferring one-carbon groups || Acyltransferases || Methyltransferases || methoxycarbonyltransferase || tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
Enzyme Commission (EC)	Acyltransferases	0.000009474	1.034	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	0.0001382	1.161	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0	1.514	Informative	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.0000008069	1.321	Informative	DIRECT
Enzyme Commission (EC)	Methyltransferases	0.000007371	1.257	Informative	DIRECT
Enzyme Commission (EC)	With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	0	2.188	Highly Informative	DIRECT

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