Choline/Carnitine O-acyltransferase family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: CoA-dependent acyltransferases [ 52776]
• Superfamily: CoA-dependent acyltransferases [ 52777] (3)
• Family: Choline/Carnitine O-acyltransferase [ 82424] (3)

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Family statistics

	Genomes (410)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	3,435	10,577	22
Proteins	1,883	5,981	11

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Choline O-acetyltransferase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	0.8778	--	DIRECT
Enzyme Commission (EC)	Carnitine O-acetyltransferase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Carnitine O-palmitoyltransferase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	1.001	Moderately Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle tone	0	0.8942	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3626	--	DIRECT
Mammalian Phenotype (MP)	abnormal homeostasis	0	0.4926	Least Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	lipid metabolism variant	0.000008873	1.337	--	DIRECT
Worm Phenotype (WP)	dauer development variant	0.0007833	1.769	--	DIRECT
Worm Phenotype (WP)	larval physiology variant	0.009891	1.593	--	INHERITED FROM: dauer development variant
Worm Phenotype (WP)	larval development variant	0.7889	0.4322	--	INHERITED FROM: dauer development variant
Worm Phenotype (WP)	postembryonic development variant	0.8069	0.269	--	INHERITED FROM: dauer development variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.9881	0.1444	--	INHERITED FROM: lipid metabolism variant || fat content variant
Worm Phenotype (WP)	organism physiology variant	0.9967	0.1342	--	INHERITED FROM: lipid metabolism variant || fat content variant || dauer development variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || fat content variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || lipid metabolism variant || embryonic development variant || embryonic lethal || fertility variant || dauer development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0.07165	0.4899	Least Informative	INHERITED FROM: lipid metabolism variant || fat content variant
Worm Phenotype (WP)	fat content variant	0.000003983	1.407	Informative	DIRECT
Worm Phenotype (WP)	dauer larva physiology variant	1	1.593	Informative	INHERITED FROM: dauer development variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	skeletal muscle of mesothorax	0.0000122	1.912	--	DIRECT
Fly Anatomy (FA)	skeletal muscle of thorax	0.00001555	1.912	--	DIRECT
Fly Anatomy (FA)	adult somatic muscle	0.00002535	1.912	--	DIRECT
Fly Anatomy (FA)	adult muscle system	0.00003613	1.912	--	DIRECT
Fly Anatomy (FA)	somatic muscle	0.0008984	1.544	--	DIRECT
Fly Anatomy (FA)	muscle system	0.002268	1.435	--	INHERITED FROM: skeletal muscle of thorax || adult muscle system || skeletal muscle of mesothorax || flight muscle || somatic muscle || adult somatic muscle
Fly Anatomy (FA)	adult thoracic segment	0.04442	0.942	--	INHERITED FROM: skeletal muscle of mesothorax || flight muscle
Fly Anatomy (FA)	adult thorax	0.04565	0.942	--	INHERITED FROM: skeletal muscle of thorax || flight muscle || skeletal muscle of mesothorax
Fly Anatomy (FA)	mesothoracic segment	0.05283	0.9578	--	INHERITED FROM: flight muscle || skeletal muscle of mesothorax
Fly Anatomy (FA)	thoracic segment	0.06295	0.912	--	INHERITED FROM: skeletal muscle of mesothorax || flight muscle
Fly Anatomy (FA)	thorax	0.06568	0.912	--	INHERITED FROM: flight muscle || skeletal muscle of mesothorax || skeletal muscle of thorax
Fly Anatomy (FA)	adult segment	0.07369	0.821	--	INHERITED FROM: skeletal muscle of mesothorax || flight muscle
Fly Anatomy (FA)	adult tagma	0.1533	0.6649	--	INHERITED FROM: skeletal muscle of thorax || skeletal muscle of mesothorax || flight muscle
Fly Anatomy (FA)	organism subdivision	0.2647	0.5027	--	INHERITED FROM: skeletal muscle of mesothorax || flight muscle || skeletal muscle of thorax
Fly Anatomy (FA)	cell	0.3532	0.4069	--	INHERITED FROM: skeletal muscle of mesothorax || flight muscle || somatic muscle || syncytium || skeletal muscle of thorax || adult somatic muscle
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: adult muscle system || organism || skeletal muscle of mesothorax || flight muscle || skeletal muscle of thorax || adult somatic muscle || somatic muscle || organ system || syncytium || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: somatic muscle || organ system || syncytium || multicellular structure || skeletal muscle of thorax || adult somatic muscle || flight muscle || adult muscle system || organism || skeletal muscle of mesothorax
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: skeletal muscle of mesothorax || skeletal muscle of thorax || flight muscle
Fly Anatomy (FA)	segment	0.1234	0.6568	Least Informative	INHERITED FROM: skeletal muscle of mesothorax || flight muscle
Fly Anatomy (FA)	somatic cell	0.2811	0.4861	Least Informative	INHERITED FROM: skeletal muscle of mesothorax || adult somatic muscle || skeletal muscle of thorax || somatic muscle || flight muscle
Fly Anatomy (FA)	tagma	0.2872	0.5027	Least Informative	INHERITED FROM: skeletal muscle of mesothorax || flight muscle || skeletal muscle of thorax
Fly Anatomy (FA)	adult	0.3096	0.4496	Least Informative	INHERITED FROM: adult muscle system || skeletal muscle of mesothorax || skeletal muscle of thorax || adult somatic muscle || flight muscle
Fly Anatomy (FA)	adult mesothoracic segment	0.03912	0.9912	Moderately Informative	INHERITED FROM: skeletal muscle of mesothorax || flight muscle
Fly Anatomy (FA)	syncytium	0.0008984	1.544	Informative	DIRECT
Fly Anatomy (FA)	muscle cell	0.001104	1.486	Informative	INHERITED FROM: flight muscle || somatic muscle || adult somatic muscle || skeletal muscle of mesothorax || skeletal muscle of thorax
Fly Anatomy (FA)	flight muscle	0.00001104	1.912	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || tissue || anatomical region || trunk region || anatomical cluster || organism subdivision
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Carnitine O-palmitoyltransferase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Choline O-acetyltransferase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Carnitine O-acetyltransferase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Carnitine O-octanoyltransferase	0.0000000002823	3.23	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	1.034	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	1.321	Informative	DIRECT

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