Ubiquitin carboxyl-terminal hydrolase, UCH family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Cysteine proteinases [ 54000]
• Superfamily: Cysteine proteinases [ 54001] (22)
• Family: Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)

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Family statistics

	Genomes (506)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	7,918	21,955	6
Proteins	7,911	21,935	6

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Omega peptidases	0	1.294	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5709	Least Informative	DIRECT
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0	1.379	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.533	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.6771	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8092	Moderately Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	embryonic lethality between implantation and placentation, complete penetrance	0.0004241	2.603	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality prior to tooth bud stage	0.2514	1.457	--	INHERITED FROM: embryonic lethality between implantation and placentation, complete penetrance
Mammalian Phenotype (MP)	embryonic lethality between implantation and placentation	0.2935	1.7	--	INHERITED FROM: embryonic lethality between implantation and placentation, complete penetrance
Mammalian Phenotype (MP)	embryonic lethality	0.3974	1.126	--	INHERITED FROM: embryonic lethality between implantation and placentation, complete penetrance
Mammalian Phenotype (MP)	abnormal survival	0.5537	0.6441	--	INHERITED FROM: embryonic lethality between implantation and placentation, complete penetrance
Mammalian Phenotype (MP)	preweaning lethality	0.5573	0.7055	--	INHERITED FROM: embryonic lethality between implantation and placentation, complete penetrance
Mammalian Phenotype (MP)	mortality/aging	0.5658	0.5424	Least Informative	INHERITED FROM: embryonic lethality between implantation and placentation, complete penetrance
Mammalian Phenotype (MP)	prenatal lethality	0.75	0.9129	Moderately Informative	INHERITED FROM: embryonic lethality between implantation and placentation, complete penetrance
Mammalian Phenotype (MP)	embryonic lethality prior to organogenesis	0.1918	1.457	Informative	INHERITED FROM: embryonic lethality between implantation and placentation, complete penetrance

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	Q neuroblast lineage migration variant	0	1.689	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	neuron migration variant	0	1.623	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.00000000002346	1.087	--	DIRECT
Worm Phenotype (WP)	protein interaction variant	0.0000000077	1.078	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0.000007279	0.773	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.00006882	0.6256	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.6347	0.1444	--	INHERITED FROM: gene expression variant || transgene expression variant || protein interaction variant || pattern of transgene expression variant || organism metabolism processing variant || protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	organism physiology variant	0.6657	0.1342	--	INHERITED FROM: transgene expression variant || gene expression variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: neuron migration variant || organism metabolism processing variant || protein protein interaction variant || transgene expression variant || cell migration variant || gene expression variant || lethal || protein interaction variant || development variant || Q neuroblast lineage migration variant || pattern of transgene expression variant || protein aggregation variant || organism development variant || cell development variant
Worm Phenotype (WP)	cell development variant	0.000000006593	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.0006187	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0.00000000003499	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0.00000002626	0.9833	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell migration variant	0.00000000003449	1.407	Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	prion formation	0.0008398	2.444	--	DIRECT
Yeast Phenotype (YP)	prion state	0.0008964	2.444	--	DIRECT
Yeast Phenotype (YP)	cellular processes	0.9392	0.09186	--	INHERITED FROM: prion state || prion formation

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	locomotor behavior defective	0.000000197	1.784	--	DIRECT
Fly Phenotype (FP)	behavior defective	0.000185	1.306	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.6649	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || adult || adult tagma || tagma || organ system subdivision || organ system || organism subdivision || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || organism subdivision || multicellular structure || adult tagma || tagma || organ system subdivision || adult || organism
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: tagma || adult tagma
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	ethmoid cartilage	0.0000002836	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	caudal fin upper lobe	0.000001245	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	somite	0.000004285	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	serous membrane	0.00000507	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	cranial cartilage	0.000005481	1.994	--	DIRECT
Zebrafish Anatomy (ZA)	caudal fin lower lobe	0.000006067	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	chondrocranium	0.000008122	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	cartilage element	0.00001118	1.994	--	DIRECT
Zebrafish Anatomy (ZA)	pharyngeal arch 1	0.00002779	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	mandibular arch skeleton	0.00003207	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	skeletal element	0.00006525	1.693	--	DIRECT
Zebrafish Anatomy (ZA)	splanchnocranium	0.0002881	1.869	--	DIRECT
Zebrafish Anatomy (ZA)	oral region	0.001268	2.17	--	INHERITED FROM: ventral mandibular arch
Zebrafish Anatomy (ZA)	cranium	0.002562	1.693	--	INHERITED FROM: splanchnocranium || olfactory region || mandibular arch skeleton || ventral mandibular arch || chondrocranium || neurocranium || ethmoid cartilage || cranial cartilage || pharyngeal arch cartilage
Zebrafish Anatomy (ZA)	median fin	0.1635	2.17	--	INHERITED FROM: caudal fin lower lobe || caudal fin upper lobe
Zebrafish Anatomy (ZA)	anatomical group	0.6578	0.1532	--	INHERITED FROM: cartilage element || splanchnocranium || olfactory region || ethmoid cartilage || pharyngeal arch cartilage || ventral mandibular arch || neurocranium || skeletal element || mandibular arch skeleton || pericardium || cranial cartilage || chondrocranium
Zebrafish Anatomy (ZA)	caudal fin	0.7583	2.471	--	INHERITED FROM: caudal fin lower lobe || caudal fin upper lobe
Zebrafish Anatomy (ZA)	compound organ	0.7947	0.4299	--	INHERITED FROM: skeletal element || cartilage element || cranial cartilage || ethmoid cartilage || pharyngeal arch cartilage
Zebrafish Anatomy (ZA)	anatomical system	0.8009	0.1857	--	INHERITED FROM: ethmoid cartilage || pharyngeal arch cartilage || olfactory region || splanchnocranium || cartilage element || cranial cartilage || chondrocranium || skeletal element || neurocranium || ventral mandibular arch || mandibular arch skeleton
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: ethmoid cartilage || pharyngeal arch 1 || pharyngeal arch cartilage || caudal fin lower lobe || splanchnocranium || olfactory region || cartilage element || cranial cartilage || somite || chondrocranium || whole organism || caudal fin upper lobe || pericardium || serous membrane || neurocranium || skeletal element || ventral mandibular arch || post-vent region || mandibular arch skeleton
Zebrafish Anatomy (ZA)	organism subdivision	0.001283	0.614	Least Informative	INHERITED FROM: post-vent region || neurocranium || ventral mandibular arch || mandibular arch skeleton || splanchnocranium || olfactory region || caudal fin upper lobe || pharyngeal arch 1 || cranial cartilage || ethmoid cartilage || caudal fin lower lobe || pharyngeal arch cartilage || chondrocranium || somite
Zebrafish Anatomy (ZA)	multi-tissue structure	0.1097	0.5848	Least Informative	INHERITED FROM: pharyngeal arch 1 || pericardium || serous membrane || ventral mandibular arch || mandibular arch skeleton
Zebrafish Anatomy (ZA)	anatomical cluster	0.1346	0.7389	Least Informative	INHERITED FROM: ethmoid cartilage || olfactory region || splanchnocranium || pharyngeal arch cartilage || pericardium || chondrocranium || neurocranium || ventral mandibular arch || mandibular arch skeleton
Zebrafish Anatomy (ZA)	head	0.5439	0.9398	Moderately Informative	INHERITED FROM: cranial cartilage || ethmoid cartilage || neurocranium || ventral mandibular arch || splanchnocranium || olfactory region || pharyngeal arch 1 || pharyngeal arch cartilage || chondrocranium || mandibular arch skeleton
Zebrafish Anatomy (ZA)	portion of tissue	0.6249	0.7637	Moderately Informative	INHERITED FROM: somite
Zebrafish Anatomy (ZA)	post-vent region	0.0000299	1.568	Informative	DIRECT
Zebrafish Anatomy (ZA)	skeletal system	0.001384	1.517	Informative	INHERITED FROM: cartilage element || mandibular arch skeleton || ventral mandibular arch || neurocranium || skeletal element || chondrocranium || pharyngeal arch cartilage || ethmoid cartilage || cranial cartilage || splanchnocranium || olfactory region
Zebrafish Anatomy (ZA)	pharyngeal arch	0.001402	1.693	Informative	INHERITED FROM: ventral mandibular arch || mandibular arch skeleton || pharyngeal arch 1
Zebrafish Anatomy (ZA)	pericardial region	0.003111	1.568	Informative	INHERITED FROM: pericardium
Zebrafish Anatomy (ZA)	trunk	0.02864	1.568	Informative	INHERITED FROM: somite
Zebrafish Anatomy (ZA)	surface structure	0.9949	1.626	Informative	INHERITED FROM: caudal fin lower lobe || caudal fin upper lobe
Zebrafish Anatomy (ZA)	pharyngeal arch cartilage	0.0000008726	1.994	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	pericardium	0.000002185	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	olfactory region	0.000002888	1.994	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	neurocranium	0.00002391	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	ventral mandibular arch	0.0002626	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	chondrocranium cartilage	0.02123	2.17	Highly Informative	INHERITED FROM: ethmoid cartilage
Zebrafish Anatomy (ZA)	fin	0.4359	1.994	Highly Informative	INHERITED FROM: caudal fin upper lobe || caudal fin lower lobe

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	gamete	0.001766	1.333	--	INHERITED FROM: plant sperm cell
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant sperm cell || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant ANatomical entity (PAN)	plant sperm cell	0.0003582	1.396	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	pollen development stage	0.0009433	1.279	--	DIRECT
Plant structure DEvelopment stage (PDE)	androecium development stage	0.001872	1.279	--	INHERITED FROM: pollen development stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: pollen development stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || pollen development stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Omega peptidases	0	1.753	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	1.004	Moderately Informative	DIRECT
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0	1.849	Highly Informative	DIRECT

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