Cysteine-rich DNA binding domain, (DM domain) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: Cysteine-rich DNA binding domain, (DM domain) [ 82926]
• Superfamily: Cysteine-rich DNA binding domain, (DM domain) [ 82927]
• Family: Cysteine-rich DNA binding domain, (DM domain) [ 82928]

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Family statistics

	Genomes (21)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	34	302	1
Proteins	34	302	1

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal meiosis	0.00007316	1.904	--	DIRECT
Mammalian Phenotype (MP)	reproductive system phenotype	0.004442	0.8397	--	INHERITED FROM: abnormal seminiferous tubule morphology || abnormal reproductive system morphology || abnormal meiosis || abnormal male meiosis
Mammalian Phenotype (MP)	abnormal internal male genitalia morphology	0.009708	1.373	--	INHERITED FROM: abnormal seminiferous tubule morphology
Mammalian Phenotype (MP)	abnormal sex gland morphology	0.03251	1.141	--	INHERITED FROM: abnormal seminiferous tubule morphology
Mammalian Phenotype (MP)	abnormal gland morphology	0.03683	0.7519	--	INHERITED FROM: abnormal seminiferous tubule morphology
Mammalian Phenotype (MP)	abnormal gametogenesis	0.4335	1.324	--	INHERITED FROM: abnormal meiosis || abnormal male meiosis
Mammalian Phenotype (MP)	abnormal male reproductive system morphology	0.5341	1.348	--	INHERITED FROM: abnormal seminiferous tubule morphology
Mammalian Phenotype (MP)	abnormal male reproductive gland morphology	0.6033	1.427	--	INHERITED FROM: abnormal seminiferous tubule morphology
Mammalian Phenotype (MP)	abnormal male genitalia morphology	1	1.348	--	INHERITED FROM: abnormal seminiferous tubule morphology
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.04769	0.6947	Least Informative	INHERITED FROM: abnormal seminiferous tubule morphology
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0.0005584	0.9404	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal spermatogenesis	0.004061	1.489	Informative	INHERITED FROM: abnormal male meiosis
Mammalian Phenotype (MP)	abnormal testis morphology	0.005744	1.427	Informative	INHERITED FROM: abnormal seminiferous tubule morphology
Mammalian Phenotype (MP)	abnormal male meiosis	0.00003883	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal seminiferous tubule morphology	0.0009195	1.904	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	hermaphrodite morphology variant	0.00000000262	2.769	--	DIRECT
Worm Phenotype (WP)	cell fusion variant	0.000005535	2.292	--	DIRECT
Worm Phenotype (WP)	male tail morphology variant	0.000007873	2.167	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic morphology variant	0.0002059	1.655	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || cell fusion variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	cell development variant	0.3804	0.6752	Least Informative	INHERITED FROM: cell fusion variant
Worm Phenotype (WP)	organism segment morphology variant	0.09412	1.087	Moderately Informative	INHERITED FROM: male tail morphology variant || tail morphology variant
Worm Phenotype (WP)	body region morphology variant	0.09498	1.087	Moderately Informative	INHERITED FROM: tail morphology variant || male tail morphology variant
Worm Phenotype (WP)	male morphology variant	0.0001529	1.655	Informative	DIRECT
Worm Phenotype (WP)	tail morphology variant	0.000118	1.866	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	visible	0	1.239	Moderately Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	thorax	0	0.912	--	DIRECT
Fly Anatomy (FA)	thoracic segment	0	0.912	--	DIRECT
Fly Anatomy (FA)	mesothoracic segment	0	0.9578	--	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.6649	--	DIRECT
Fly Anatomy (FA)	adult segment	0	0.821	--	DIRECT
Fly Anatomy (FA)	adult thorax	0	0.942	--	DIRECT
Fly Anatomy (FA)	adult thoracic segment	0	0.942	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	integumentary system	0	0.8094	--	DIRECT
Fly Anatomy (FA)	adult integumentary system	0	0.9578	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	region of integument	0	0.884	--	DIRECT
Fly Anatomy (FA)	tagmatic subdivision of integument	0	0.9742	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: adult external thorax || organism || mesothoracic segment || adult mesothoracic segment || adult || segment || thoracic segment || tagmatic subdivision of integument || adult thorax || appendage || region of integument || adult tagma || adult segment || tagma || organ system subdivision || thorax || adult integumentary system || adult thoracic segment || organ system || organism subdivision || integumentary system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: adult thoracic segment || organ system || organism subdivision || integumentary system || multicellular structure || thorax || adult integumentary system || adult tagma || adult segment || tagma || organ system subdivision || adult thorax || appendage || region of integument || tagmatic subdivision of integument || segment || thoracic segment || adult mesothoracic segment || adult || adult external thorax || organism || mesothoracic segment
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: mesothoracic segment || adult external thorax || adult thorax || tagma || adult segment || adult tagma || adult mesothoracic segment || thorax || thoracic segment || segment || adult thoracic segment
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	segment	0	0.6568	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	adult mesothoracic segment	0	0.9912	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult external thorax	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	appendage	0	1.047	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: portion of tissue || whole organism
Zebrafish Anatomy (ZA)	portion of tissue	0	0.7637	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: nervous system || brain || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: head region || brain || nervous system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || tissue || anatomical region || central nervous system || organism subdivision || embryonic structure || head || primary germ layer
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.7859	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryonic structure	0	1.149	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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