Proprotein convertase P-domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Galactose-binding domain-like [ 49784]
• Superfamily: Galactose-binding domain-like [ 49785] (32)
• Family: Proprotein convertase P-domain [ 89249] (3)

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Family statistics

	Genomes (242)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	515	1,482	5
Proteins	515	1,482	5

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Proprotein convertase 2	0.0000000000008374	2.264	--	DIRECT
Enzyme Commission (EC)	Proprotein convertase 1	0.00000000003766	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5709	Least Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	0	1.139	Moderately Informative	DIRECT
Enzyme Commission (EC)	Furin	3.476e-16	2.139	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal digit morphology	0.0002682	1.603	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality prior to tooth bud stage	0.0003109	1.457	--	DIRECT
Mammalian Phenotype (MP)	abnormal limb morphology	0.005347	1.281	--	INHERITED FROM: abnormal autopod morphology || abnormal digit morphology
Mammalian Phenotype (MP)	embryonic lethality	0.008236	1.126	--	INHERITED FROM: embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage
Mammalian Phenotype (MP)	preweaning lethality	0.1416	0.7055	--	INHERITED FROM: embryonic lethality prior to tooth bud stage || embryonic lethality prior to organogenesis
Mammalian Phenotype (MP)	abnormal survival	0.2119	0.6441	--	INHERITED FROM: embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage
Mammalian Phenotype (MP)	mortality/aging	0.2574	0.5424	Least Informative	INHERITED FROM: embryonic lethality prior to tooth bud stage || embryonic lethality prior to organogenesis
Mammalian Phenotype (MP)	limbs/digits/tail phenotype	0.01071	1.188	Moderately Informative	INHERITED FROM: abnormal digit morphology || abnormal autopod morphology
Mammalian Phenotype (MP)	prenatal lethality	0.02397	0.9129	Moderately Informative	INHERITED FROM: embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage
Mammalian Phenotype (MP)	embryonic lethality prior to organogenesis	0.0002074	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal autopod morphology	0.0005174	1.524	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7516	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	basement membrane remodeling variant	0	1.225	--	DIRECT
Worm Phenotype (WP)	body length variant	0.000151	1.292	--	DIRECT
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.0001548	1.426	--	DIRECT
Worm Phenotype (WP)	body width variant	0.0002175	1.237	--	DIRECT
Worm Phenotype (WP)	body size variant	0.0003429	1.189	--	DIRECT
Worm Phenotype (WP)	body morphology variant	0.0004572	1.145	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: pericellular component development variant || hermaphrodite fertility variant || developmental growth variant || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || basement membrane remodeling variant || organism physiology variant || development variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	pericellular component development variant	0	1.178	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0.0008675	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.0008786	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0.2106	1.078	Moderately Informative	INHERITED FROM: hermaphrodite reproductive system morphology variant || vulva morphology variant
Worm Phenotype (WP)	vulva morphology variant	0.0001529	1.426	Informative	DIRECT
Worm Phenotype (WP)	dumpy	0.000005692	1.814	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical cluster || anatomical group || whole organism || organism subdivision
Zebrafish Anatomy (ZA)	organism subdivision	0	0.614	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	anatomical cluster	0	0.7389	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: animal hemisphere || anatomical group || cavitated compound organ || multicellular anatomical structure || vegetal hemisphere || compound organ || anatomical region || notochord || organism subdivision
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryo	0.6292	0.5979	Least Informative	INHERITED FROM: vegetal hemisphere || animal hemisphere
Xenopus ANatomical entity (XAN)	tissue	0.9202	0.4672	Least Informative	INHERITED FROM: notochord
Xenopus ANatomical entity (XAN)	animal hemisphere	0.0004608	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	notochord	0.0007199	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	vegetal hemisphere	0.000002144	2.087	Highly Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Furin	0	2.628	--	DIRECT
Enzyme Commission (EC)	Proprotein convertase 2	0.00000000000004039	2.753	--	DIRECT
Enzyme Commission (EC)	Proprotein convertase 1	0.00000000006756	2.753	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	1.004	Moderately Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	0.0000000000006736	1.576	Informative	DIRECT

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