MBT repeat family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: SH3-like barrel [ 50036] (21)
• Superfamily: Tudor/PWWP/MBT [ 63748] (4)
• Family: MBT repeat [ 89299] (4)

---

Family statistics

	Genomes (130)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,451	3,978	10
Proteins	754	2,098	6

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal presacral vertebrae morphology	0.000005403	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal vertebrae morphology	0.00006386	1.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.01355	0.8323	--	INHERITED FROM: abnormal vertebral column morphology || abnormal presacral vertebrae morphology || abnormal vertebrae morphology
Mammalian Phenotype (MP)	skeleton phenotype	0.017	0.8038	--	INHERITED FROM: abnormal presacral vertebrae morphology || abnormal vertebrae morphology || abnormal vertebral column morphology
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.002794	1.001	Moderately Informative	INHERITED FROM: abnormal presacral vertebrae morphology || abnormal vertebral column morphology || abnormal vertebrae morphology
Mammalian Phenotype (MP)	abnormal vertebral column morphology	0.0003634	1.399	Informative	DIRECT

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	lethal	0	0.678	--	DIRECT
Fly Phenotype (FP)	increased cell number	0	1.908	--	DIRECT
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of larval stage	0	1.306	--	DIRECT
Fly Phenotype (FP)	increased mortality during development	0	0.6148	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of prepupal stage	0	1.306	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of pupal stage	0	1.239	--	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5343	Least Informative	DIRECT
Fly Phenotype (FP)	lethal - all die before end of P-stage	0	1.181	Moderately Informative	DIRECT
Fly Phenotype (FP)	size defective	0	1.541	Informative	DIRECT
Fly Phenotype (FP)	cell number defective	0	1.344	Informative	DIRECT
Fly Phenotype (FP)	neoplasia	0	1.908	Highly Informative	DIRECT
Fly Phenotype (FP)	some die during larval stage	0	2.085	Highly Informative	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	reproductive system	0	1.047	--	DIRECT
Fly Anatomy (FA)	female reproductive system	0	1.31	--	DIRECT
Fly Anatomy (FA)	ovary	0	1.31	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	portion of tissue	0	0.7764	--	DIRECT
Fly Anatomy (FA)	female organism	0	1.213	--	DIRECT
Fly Anatomy (FA)	stem cell	0	1.31	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: ovariole || organism || female reproductive system || female organism || ovary || larva || gonad || portion of tissue || cell || multi-tissue structure || stem cell || female-specific anatomical entity || reproductive system || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: reproductive system || organ system || multicellular structure || developing material anatomical entity || female-specific anatomical entity || stem cell || cell || multi-tissue structure || gonad || portion of tissue || larva || female organism || ovary || ovariole || organism || female reproductive system
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	gonad	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	developing material anatomical entity	0	0.8329	Moderately Informative	DIRECT
Fly Anatomy (FA)	female-specific anatomical entity	0	1.213	Moderately Informative	DIRECT
Fly Anatomy (FA)	ovariole	0	1.31	Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---