HMGL-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: TIM beta/alpha-barrel [ 51350] (33)
• Superfamily: Aldolase [ 51569] (8)
• Family: HMGL-like [ 89494] (3)

---

Family statistics

	Genomes (2,041)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	3,613	27,738	5
Proteins	3,613	27,734	5

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	(R)-citramalate synthase	0	2.44	--	DIRECT
Enzyme Commission (EC)	2-isopropylmalate synthase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Acyl groups converted into alkyl on transfer	0	1.787	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	0.8778	--	DIRECT
Enzyme Commission (EC)	Carbon-carbon lyases	0	0.9151	--	DIRECT
Enzyme Commission (EC)	4-hydroxy-2-oxovalerate aldolase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Forming carbon-carbon bonds	0.000000009032	1.896	--	DIRECT
Enzyme Commission (EC)	Hydroxymethylglutaryl-CoA lyase	0.00008591	2.741	--	DIRECT
Enzyme Commission (EC)	Ligases that form carbon-carbon bonds	1	1.896	--	INHERITED FROM: Pyruvate carboxylase
Enzyme Commission (EC)	Lyases	0	0.4956	Least Informative	DIRECT
Enzyme Commission (EC)	Ligases	1	0.7455	Least Informative	INHERITED FROM: Pyruvate carboxylase || Forming carbon-carbon bonds
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	1	1.001	Moderately Informative	INHERITED FROM: (R)-citramalate synthase
Enzyme Commission (EC)	Oxo-acid-lyases	0	1.741	Informative	DIRECT
Enzyme Commission (EC)	Pyruvate carboxylase	0	1.963	Highly Informative	DIRECT

---

Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.5999	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.437	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	cauline leaf	0	0.6042	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.4893	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.4385	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.5171	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.6432	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || root || sporophyll || flower || collective plant structure || leaf || shoot internode || phyllome || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || cauline leaf || reproductive shoot system || shoot apex || leaf apex || collective leaf structure || stem internode || shoot system || portion of plant tissue || stomatal complex || plant organ || stem || epidermis || root system || cardinal part of multi-tissue plant structure || vascular leaf || epidermal cell || shoot epidermal cell || corolla || plant axis || collective phyllome structure || petal || plant cell || shoot epidermis || phyllome apex || cotyledon || stamen || shoot axis || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: flower || sporophyll || root system || root || perianth || stem || leaf || phyllome || shoot internode || vascular leaf || petal || reproductive shoot system || shoot apex || leaf apex || collective phyllome structure || guard cell || cauline leaf || microsporophyll || shoot epidermal cell || corolla || androecium || stomatal complex || phyllome apex || cotyledon || stamen || stem internode || shoot axis || shoot system || collective leaf structure || shoot epidermis
Plant ANatomical entity (PAN)	vascular leaf	0	0.437	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot apex	0	0.481	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.4893	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.5153	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.5956	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.3879	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || 1 main shoot growth stage || LP.04 four leaves visible stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.3879	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.08 eight leaves visible stage || LP.06 six leaves visible stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.4268	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.4752	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.4234	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.3895	Least Informative	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	(R)-citramalate synthase	0	2.929	--	DIRECT
Enzyme Commission (EC)	2-isopropylmalate synthase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Carbon-carbon lyases	0	1.305	--	DIRECT
Enzyme Commission (EC)	4-hydroxy-2-oxovalerate aldolase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Forming carbon-carbon bonds	0	2.385	--	DIRECT
Enzyme Commission (EC)	Pyruvate carboxylase	0.000000000002226	2.929	--	DIRECT
Enzyme Commission (EC)	Oxaloacetate decarboxylase (Na(+) extruding)	0.0000000007839	2.929	--	DIRECT
Enzyme Commission (EC)	Linked to decarboxylation	0.000000005881	2.753	--	DIRECT
Enzyme Commission (EC)	Hydroxymethylglutaryl-CoA lyase	0.000004014	3.23	--	DIRECT
Enzyme Commission (EC)	Forming carbon-carbon bonds	1	2.929	--	INHERITED FROM: Pyruvate carboxylase
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	1.034	Moderately Informative	DIRECT
Enzyme Commission (EC)	Lyases	0	0.8775	Moderately Informative	DIRECT
Enzyme Commission (EC)	Ligases	1	1.14	Moderately Informative	INHERITED FROM: Forming carbon-carbon bonds || Pyruvate carboxylase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	1	1.321	Informative	INHERITED FROM: (R)-citramalate synthase
Enzyme Commission (EC)	Translocases	1	1.628	Informative	INHERITED FROM: Linked to decarboxylation || Oxaloacetate decarboxylase (Na(+) extruding)
Enzyme Commission (EC)	Acyl groups converted into alkyl groups on transfer	0	2.084	Highly Informative	DIRECT
Enzyme Commission (EC)	Oxo-acid-lyases	0	2.084	Highly Informative	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of inorganic cations	0.08608	2.116	Highly Informative	INHERITED FROM: Oxaloacetate decarboxylase (Na(+) extruding) || Linked to decarboxylation

---