SUPERFAMILY 1.75 HMM library and genome assignments server

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CCCH zinc finger family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   CCCH zinc finger [ 90228]
Superfamily:   CCCH zinc finger [ 90229]
Family:   CCCH zinc finger [ 90230] (4)


Family statistics
Genomes (46) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 60 127 2
Proteins 60 127 2


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Muscular hypotonia0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental delay0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Generalized hypotonia0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.2059Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2195Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.2835Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7731Least InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.02929Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.08724Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.09941Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1302Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1491Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.3043Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.0001405InformativeDirect
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.004436InformativeInherited
Mammalian Phenotype (MP)increased gland tumor incidence0.004547InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.007274InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.007672InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell number0.008056InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.01087InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.1405InformativeInherited
Mammalian Phenotype (MP)enlarged lymph nodes0.000005481Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0.0001522Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus development0.0001853Highly InformativeDirect
Mammalian Phenotype (MP)enlarged spleen0.0004501Highly InformativeDirect
Mammalian Phenotype (MP)increased mature B cell number0.0009952Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.01282Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01449Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.3689Least InformativeInherited
Worm Phenotype (WP)cell division variant0.004796Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.008016Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.01161Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.02298Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.3059Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.8909Moderately InformativeInherited
Worm Phenotype (WP)cell number increased0.0000001019InformativeDirect
Worm Phenotype (WP)RNA expression variant0.01373InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.0202InformativeInherited
Worm Phenotype (WP)ectopic expression transgene0.0000001156Highly InformativeDirect
Worm Phenotype (WP)intestinal development variant0.0001336Highly InformativeDirect
Worm Phenotype (WP)slow embryonic development0.0002538Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.0125Highly InformativeInherited
Worm Phenotype (WP)epithelial development variant0.01889Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.3173Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.009826Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.001756InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.00002356Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.000000000008446Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.05112Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Acting on ATP; involved in cellular and subcellular movement0.006535InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a CCCH zinc finger domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]