Classification(sccs) Sunid Description a.1.1 46458 Globin-like a.1.2 46548 alpha-helical ferredoxin a.100.1 48179 6-phosphogluconate dehydrogenase C-terminal domain-like a.102.1 48208 Six-hairpin glycosidases a.102.2 48225 Seven-hairpin glycosidases a.102.3 48230 Chondroitin AC/alginate lyase a.102.4 48239 Terpenoid cyclases/Protein prenyltransferases a.102.6 158745 LanC-like a.103.1 48256 Citrate synthase a.104.1 48264 Cytochrome P450 a.108.1 48300 Ribosomal protein L7/12, oligomerisation (N-terminal) domain a.11.1 47027 Acyl-CoA binding protein a.11.2 47031 Second domain of FERM a.111.1 48317 Acid phosphatase/Vanadium-dependent haloperoxidase a.113.1 48334 DNA repair protein MutS, domain III a.114.1 48340 Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain a.116.1 48350 GTPase activation domain, GAP a.117.1 48366 Ras GEF a.118.1 48371 ARM repeat a.118.11 48479 Cytochrome c oxidase subunit E a.118.13 69103 Arp2/3 complex 16 kDa subunit ARPC5 a.118.17 74788 Cullin repeat-like a.118.18 81901 HCP-like a.118.19 101420 C-terminal domain of Ku80 a.118.22 100909 IP3 receptor type 1 binding core, domain 2 a.118.23 140856 USP8 N-terminal domain-like a.118.24 140860 Pseudo ankyrin repeat-like a.118.25 140864 TROVE domain-like a.118.3 48425 Sec7 domain a.118.4 48431 Lipovitellin-phosvitin complex, superhelical domain a.118.6 48439 Protein prenylyltransferase a.118.7 48445 14-3-3 protein a.118.8 48452 TPR-like a.118.9 48464 ENTH/VHS domain a.119.1 48484 Lipoxigenase a.12.1 47040 Kix domain of CBP (creb binding protein) a.121.1 48498 Tetracyclin repressor-like, C-terminal domain a.123.1 48508 Nuclear receptor ligand-binding domain a.126.1 48552 Serum albumin-like a.127.1 48557 L-aspartase-like a.128.1 48576 Terpenoid synthases a.129.1 48592 GroEL equatorial domain-like a.13.1 47045 RAP domain-like a.130.1 48600 Chorismate mutase II a.132.1 48613 Heme oxygenase-like a.133.1 48619 Phospholipase A2, PLA2 a.135.1 48652 Tetraspanin a.137.10 101494 Stathmin a.137.3 48670 Transducin (heterotrimeric G protein), gamma chain a.137.5 48678 Moesin tail domain a.137.8 48690 Epsilon subunit of mitochondrial F1F0-ATP synthase a.138.1 48695 Multiheme cytochromes a.14.1 47050 VHP, Villin headpiece domain a.140.1 63451 LEM domain a.140.2 68906 SAP domain a.140.5 116768 DNA-binding domain of EIN3-like a.140.6 158230 PRP4-like a.141.1 63501 Frizzled cysteine-rich domain a.143.1 63562 RPB6/omega subunit-like a.144.1 63570 PABC (PABP) domain a.144.2 74731 Ribosomal protein L20 a.146.1 63600 Telomeric repeat binding factor (TRF) dimerisation domain a.148.1 69060 Arp2/3 complex 21 kDa subunit ARPC3 a.149.1 69065 RNase III domain-like a.15.1 47055 TAF(II)230 TBP-binding fragment a.153.1 69125 Nuclear receptor coactivator interlocking domain a.156.1 46946 S13-like H2TH domain a.157.1 81382 Skp1 dimerisation domain-like a.158.1 81383 F-box domain a.159.1 81601 Protein serine/threonine phosphatase 2C, C-terminal domain a.159.2 81698 FF domain a.16.1 47060 S15/NS1 RNA-binding domain a.160.1 81631 PAP/OAS1 substrate-binding domain a.163.1 81778 Crustacean CHH/MIH/GIH neurohormone a.165.1 81790 Myosin phosphatase inhibitor 17kDa protein, CPI-17 a.166.1 81822 RuBisCo LSMT C-terminal, substrate-binding domain a.169.1 81837 BEACH domain a.17.1 47072 Cysteine alpha-hairpin motif a.170.1 81872 BRCA2 helical domain a.171.1 81878 BRCA2 tower domain a.173.1 81891 Poly A polymerase C-terminal region-like a.174.1 81923 Double Clp-N motif a.177.1 88946 Sigma2 domain of RNA polymerase sigma factors a.182.1 89095 GatB/YqeY motif a.183.1 89124 Nop domain a.187.1 101224 HAND domain of the nucleosome remodeling ATPase ISWI a.188.1 101233 PWI domain a.189.1 101238 XPC-binding domain a.192.1 101278 N-terminal domain of adenylylcyclase associated protein, CAP a.194.1 101288 L27 domain a.2.10 46604 Epsilon subunit of F1F0-ATP synthase C-terminal domain a.2.11 46609 Fe,Mn superoxide dismutase (SOD), N-terminal domain a.2.15 140102 ISY1 domain-like a.2.16 140106 Calcyclin-binding protein-like a.2.17 140111 Endosomal sorting complex assembly domain a.2.2 46561 Ribosomal protein L29 (L29p) a.2.3 46565 Chaperone J-domain a.2.5 46579 Prefoldin a.2.6 46585 HR1 repeat a.2.7 46589 tRNA-binding arm a.2.8 46596 Eukaryotic DNA topoisomerase I, dispensable insert domain a.20.1 47090 PGBD-like a.203.1 101353 Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) a.204.1 101386 all-alpha NTP pyrophosphatases a.205.1 101391 Hsp90 co-chaperone CDC37 a.207.1 101447 Formin homology 2 domain (FH2 domain) a.208.1 101473 DhaL-like a.209.1 101478 ADP-ribosylglycohydrolase a.21.1 47095 HMG-box a.211.1 109604 HD-domain/PDEase-like a.212.1 109640 KRAB domain (Kruppel-associated box) a.215.1 109880 A middle domain of Talin 1 a.216.1 109885 I/LWEQ domain a.217.1 109905 Surp module (SWAP domain) a.218.1 109910 YgfY-like a.22.1 47113 Histone-fold a.221.1 109925 Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain a.222.1 109993 VPS9 domain a.223.1 109998 Triger factor/SurA peptide-binding domain-like a.224.1 110004 Glycolipid transfer protein, GLTP a.227.1 110019 ERO1-like a.228.1 110035 GDNF receptor-like a.23.4 47157 Mitochondrial import receptor subunit Tom20 a.235.1 117018 ATP-dependent DNA ligase DNA-binding domain a.238.1 103657 BAR/IMD domain-like a.24.1 47162 Apolipoprotein a.24.10 47226 Histidine-containing phosphotransfer domain, HPT domain a.24.13 47364 Domain of the SRP/SRP receptor G-proteins a.24.14 68993 FAT domain of focal adhesion kinase a.24.15 69000 FAD-dependent thiol oxidase a.24.18 101112 Oxygen-evolving enhancer protein 3, a.24.23 109775 Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain a.24.24 109779 Domain from hypothetical 2610208m17rik protein a.24.25 116878 TrmE connector domain a.24.28 140427 VPS28 C-terminal domain-like a.24.7 47212 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) a.24.8 47216 Proteasome activator a.24.9 47220 alpha-catenin/vinculin-like a.240.1 140383 BSD domain-like a.242.1 140586 Dcp2 domain-like a.245.1 140612 EB1 dimerisation domain-like a.25.1 47240 Ferritin-like a.25.3 140453 EsxAB dimer-like a.25.4 140459 PE/PPE dimer-like a.252.1 140718 Mediator hinge subcomplex-like a.256.1 140741 RUN domain-like a.26.1 47266 4-helical cytokines a.264.1 140924 Duffy binding domain-like a.265.1 140931 Fic-like a.266.1 140959 Indolic compounds 2,3-dioxygenase-like a.268.1 140984 PTPA-like a.269.1 140990 FtsH protease domain-like a.27.1 47323 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases a.271.1 158235 SOCS box-like a.273.1 158457 Orange domain-like a.274.1 158472 HAMP domain-like a.277.1 158553 TAFH domain-like a.278.1 158573 GINS helical bundle-like a.28.1 47336 ACP-like a.28.3 47353 Retrovirus capsid dimerization domain-like a.289.1 158702 Sec63 N-terminal domain-like a.29.10 140482 MAST3 pre-PK domain-like a.29.12 140490 Nqo1C-terminal domain-like a.29.2 47370 Bromodomain a.29.3 47203 Acyl-CoA dehydrogenase C-terminal domain-like a.29.5 69012 alpha-ketoacid dehydrogenase kinase, N-terminal domain a.29.6 101148 Plant invertase/pectin methylesterase inhibitor a.29.7 101152 Mob1/phocein a.3.1 46626 Cytochrome c a.30.2 47384 Homodimeric domain of signal transducing histidine kinase a.31.1 47391 Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit a.32.1 47396 Transcription factor IIA (TFIIA), alpha-helical domain a.34.2 100957 Dimerization cofactor of HNF-1 alpha a.34.4 109805 Phenylalanine zipper a.35.1 47413 lambda repressor-like DNA-binding domains a.36.1 47446 Signal peptide-binding domain a.37.1 47454 A DNA-binding domain in eukaryotic transcription factors a.38.1 47459 HLH, helix-loop-helix DNA-binding domain a.39.1 47473 EF-hand a.39.2 47565 Insect pheromone/odorant-binding proteins a.4.1 46689 Homeodomain-like a.4.10 46919 N-terminal Zn binding domain of HIV integrase a.4.11 46924 RNA polymerase subunit RPB10 a.4.12 48295 TrpR-like a.4.13 88659 Sigma3 and sigma4 domains of RNA polymerase sigma factors a.4.15 116820 Rps17e-like a.4.2 46767 Methylated DNA-protein cysteine methyltransferase, C-terminal domain a.4.3 46774 ARID-like a.4.5 46785 Winged helix DNA-binding domain a.4.6 46894 C-terminal effector domain of the bipartite response regulators a.4.7 46906 Ribosomal protein L11, C-terminal domain a.4.8 46911 Ribosomal protein S18 a.4.9 46915 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 a.40.1 47576 Calponin-homology domain, CH-domain a.40.3 116907 Hook domain a.41.1 47587 Domain of poly(ADP-ribose) polymerase a.42.1 47592 SWIB/MDM2 domain a.43.1 47598 Ribbon-helix-helix a.45.1 47616 GST C-terminal domain-like a.46.1 47644 Methionine synthase domain a.46.2 47648 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain a.47.1 47655 STAT a.47.2 47661 t-snare proteins a.47.4 109843 CAPPD, an extracellular domain of amyloid beta A4 protein a.48.1 47668 N-terminal domain of cbl (N-cbl) a.48.2 47672 Transferrin receptor-like dimerisation domain a.48.3 47676 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 a.48.4 140576 HIV integrase-binding domain a.5.10 109736 FGAM synthase PurL, linker domain a.5.2 46934 UBA-like a.5.3 46938 CRAL/TRIO N-terminal domain a.5.4 46942 Elongation factor TFIIS domain 2 a.5.7 89000 post-HMGL domain-like a.5.8 109728 Hypothetical protein AF0491, middle domain a.50.1 47686 Anaphylotoxins (complement system) a.51.1 47694 Cytochrome c oxidase subunit h a.52.1 47699 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin a.53.1 47719 p53 tetramerization domain a.55.1 47729 IHF-like DNA-binding proteins a.56.1 47741 CO dehydrogenase ISP C-domain like a.59.1 47762 PAH2 domain a.6.1 46955 Putative DNA-binding domain a.60.1 47769 SAM/Pointed domain a.60.12 81585 PsbU/PolX domain-like a.60.14 116742 eIF2alpha middle domain-like a.60.2 47781 RuvA domain 2-like a.60.3 47789 C-terminal domain of RNA polymerase alpha subunit a.60.4 47794 Rad51 N-terminal domain-like a.60.5 47798 Barrier-to-autointegration factor, BAF a.60.6 47802 DNA polymerase beta, N-terminal domain-like a.60.7 47807 5' to 3' exonuclease, C-terminal subdomain a.60.8 47819 HRDC-like a.60.9 47823 lambda integrase-like, N-terminal domain a.61.1 47836 Retroviral matrix proteins a.64.1 47862 Saposin a.65.1 47874 Annexin a.66.1 47895 Transducin (alpha subunit), insertion domain a.68.1 47912 Wiscott-Aldrich syndrome protein, WASP, C-terminal domain a.69.1 47917 C-terminal domain of alpha and beta subunits of F1 ATP synthase a.69.2 47923 Ypt/Rab-GAP domain of gyp1p a.7.1 46966 Spectrin repeat a.7.14 116846 MIT domain a.7.3 46977 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain a.7.4 46984 Smac/diablo a.7.7 63491 BAG domain a.7.8 89009 GAT-like domain a.70.1 47928 N-terminal domain of the delta subunit of the F1F0-ATP synthase a.71.1 47933 ERP29 C domain-like a.71.2 81811 Helical domain of Sec23/24 a.72.1 47938 Functional domain of the splicing factor Prp18 a.73.1 47943 Retrovirus capsid protein, N-terminal core domain a.74.1 47954 Cyclin-like a.75.1 47973 Ribosomal protein S7 a.77.1 47986 DEATH domain a.78.1 48008 GntR ligand-binding domain-like a.79.1 48013 NusB-like a.8.3 88688 Families 57/38 glycoside transferase middle domain a.8.4 100934 Heat shock protein 70kD (HSP70), C-terminal subdomain a.80.1 48019 post-AAA+ oligomerization domain-like a.83.1 48034 Guanido kinase N-terminal domain a.85.1 48050 Hemocyanin, N-terminal domain a.86.1 48056 Di-copper centre-containing domain a.87.1 48065 DBL homology domain (DH-domain) a.9.1 47005 Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex a.90.1 48092 Transcription factor STAT-4 N-domain a.91.1 48097 Regulator of G-protein signaling, RGS a.92.1 48108 Carbamoyl phosphate synthetase, large subunit connection domain a.93.1 48113 Heme-dependent peroxidases a.94.1 48140 Ribosomal protein L19 (L19e) a.96.1 48150 DNA-glycosylase a.97.1 48163 An anticodon-binding domain of class I aminoacyl-tRNA synthetases a.98.1 48168 R1 subunit of ribonucleotide reductase, N-terminal domain a.99.1 48173 Cryptochrome/photolyase FAD-binding domain b.1.1 48726 Immunoglobulin b.1.10 49348 Clathrin adaptor appendage domain b.1.11 49354 PapD-like b.1.12 49363 Purple acid phosphatase, N-terminal domain b.1.15 69179 Integrin domains b.1.16 74853 Lamin A/C globular tail domain b.1.18 81296 E set domains b.1.2 49265 Fibronectin type III b.1.22 101546 ASF1-like b.1.27 141072 CalX-like b.1.3 49299 PKD domain b.1.4 49303 beta-Galactosidase/glucuronidase domain b.1.5 49309 Transglutaminase, two C-terminal domains b.1.6 49313 Cadherin-like b.1.8 49329 Cu,Zn superoxide dismutase-like b.102.1 63877 Methuselah ectodomain b.103.1 63882 MoeA N-terminal region -like b.104.1 63887 P-domain of calnexin/calreticulin b.105.1 69189 Penicillin-binding protein associated domain b.106.1 69279 Phage tail proteins b.11.1 49695 gamma-Crystallin-like b.113.1 81624 N-terminal domain of MutM-like DNA repair proteins b.117.1 82051 Obg GTP-binding protein N-terminal domain b.118.1 82153 FAS1 domain b.119.1 82215 C-terminal autoproteolytic domain of nucleoporin nup98 b.12.1 49723 Lipase/lipooxygenase domain (PLAT/LH2 domain) b.121.1 49742 PHM/PNGase F b.121.3 69203 Nucleoplasmin-like core domain b.121.4 88633 Positive stranded ssRNA viruses b.122.1 88697 PUA domain-like b.124.1 89360 HesB-like domain b.125.1 89392 Prokaryotic lipoproteins and lipoprotein localization factors b.130.1 100920 Heat shock protein 70kD (HSP70), peptide-binding domain b.131.1 100939 SPOC domain-like b.132.1 101576 Supernatant protein factor (SPF), C-terminal domain b.139.1 101801 Surface presentation of antigens (SPOA) b.14.1 49758 Calpain large subunit, middle domain (domain III) b.142.1 101936 DNA-binding pseudobarrel domain b.143.1 101941 NAC domain b.145.1 102031 AXH domain b.146.1 110111 Ctag/Cox11 b.15.1 49764 HSP20-like chaperones b.152.1 117143 Flagellar hook protein flgE b.153.1 56037 PheT/TilS domain b.155.1 141091 L21p-like b.160.1 141523 L,D-transpeptidase catalytic domain-like b.162.1 141562 At5g01610-like b.165.1 141673 MOSC N-terminal domain-like b.168.1 141734 HisI-like b.17.1 49777 PEBP-like b.18.1 49785 Galactose-binding domain-like b.19.1 49818 Viral protein domain b.2.2 49384 Carbohydrate-binding domain b.2.3 49401 Bacterial adhesins b.2.4 49410 Alpha-macroglobulin receptor domain b.2.5 49417 p53-like transcription factors b.2.7 49447 Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor b.2.8 81995 beta-sandwich domain of Sec23/24 b.2.9 110083 Peptidylarginine deiminase Pad4, middle domain b.22.1 49842 TNF-like b.23.1 49854 Spermadhesin, CUB domain b.25.1 49870 Osmotin, thaumatin-like protein b.26.1 49879 SMAD/FHA domain b.29.1 49899 Concanavalin A-like lectins/glucanases b.3.1 49452 Starch-binding domain-like b.3.2 49464 Carboxypeptidase regulatory domain-like b.3.3 49468 VHL b.3.4 49472 Transthyretin (synonym: prealbumin) b.3.6 49482 Aromatic compound dioxygenase b.30.2 49998 Amine oxidase catalytic domain b.30.5 74650 Galactose mutarotase-like b.33.1 50022 ISP domain b.34.10 74924 Cap-Gly domain b.34.13 54160 Chromo domain-like b.34.14 101690 PAZ domain b.34.19 159034 Mib/herc2 domain-like b.34.2 50044 SH3-domain b.34.21 159042 Plus3-like b.34.3 50084 Myosin S1 fragment, N-terminal domain b.34.5 50104 Translation proteins SH3-like domain b.34.6 50118 Cell growth inhibitor/plasmid maintenance toxic component b.34.7 50122 DNA-binding domain of retroviral integrase b.34.8 63433 Fumarylacetoacetate hydrolase, FAH, N-terminal domain b.34.9 63748 Tudor/PWWP/MBT b.35.1 50129 GroES-like b.36.1 50156 PDZ domain-like b.38.1 50182 Sm-like ribonucleoproteins b.39.1 50193 Ribosomal protein L14 b.4.1 49493 HSP40/DnaJ peptide-binding domain b.40.16 159141 HIN-2000 domain-like b.40.3 50242 TIMP-like b.40.4 50249 Nucleic acid-binding proteins b.40.5 50324 Inorganic pyrophosphatase b.40.6 50331 MOP-like b.40.7 50341 CheW-like b.41.1 50346 PRC-barrel domain b.42.1 50353 Cytokine b.42.2 50370 Ricin B-like lectins b.42.4 50386 STI-like b.42.5 50405 Actin-crosslinking proteins b.42.6 82109 MIR domain b.42.7 110217 DNA-binding protein LAG-1 (CSL) b.42.8 110221 AbfB domain b.43.3 50447 Translation proteins b.43.4 63380 Riboflavin synthase domain-like b.43.5 82114 Riboflavin kinase-like b.44.1 50465 EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain b.44.2 101790 Aminomethyltransferase beta-barrel domain b.45.1 50475 FMN-binding split barrel b.46.1 50486 FMT C-terminal domain-like b.47.1 50494 Trypsin-like serine proteases b.49.1 50615 N-terminal domain of alpha and beta subunits of F1 ATP synthase b.49.2 50621 Alanine racemase C-terminal domain-like b.49.3 101821 Aminopeptidase/glucanase lid domain b.50.1 50630 Acid proteases b.51.1 50677 ValRS/IleRS/LeuRS editing domain b.52.1 50685 Barwin-like endoglucanases b.52.2 50692 ADC-like b.53.1 50715 Ribosomal protein L25-like b.54.1 50723 Core binding factor beta, CBF b.55.1 50729 PH domain-like b.56.1 50784 Transcription factor IIA (TFIIA), beta-barrel domain b.58.1 50800 PK beta-barrel domain-like b.59.1 50809 XRCC4, N-terminal domain b.6.1 49503 Cupredoxins b.60.1 50814 Lipocalins b.61.5 75001 Dipeptidyl peptidase I (cathepsin C), exclusion domain b.62.1 50891 Cyclophilin-like b.63.1 50904 Oncogene products b.64.1 50911 Mannose 6-phosphate receptor domain b.65.1 50916 Rap30/74 interaction domains b.66.1 50923 Hemopexin-like domain b.67.2 75005 Arabinanase/levansucrase/invertase b.67.3 101887 Apyrase b.68.1 50939 Sialidases b.68.10 101904 GyrA/ParC C-terminal domain-like b.68.11 117281 Kelch motif b.68.2 50952 Soluble quinoprotein glucose dehydrogenase b.68.5 63825 YWTD domain b.68.6 63829 Calcium-dependent phosphotriesterase b.68.9 101898 NHL repeat b.69.1 50965 Galactose oxidase, central domain b.69.11 101908 Putative isomerase YbhE b.69.12 101912 Sema domain b.69.13 110296 Oligoxyloglucan reducing end-specific cellobiohydrolase b.69.14 117289 Nucleoporin domain b.69.2 50969 YVTN repeat-like/Quinoprotein amine dehydrogenase b.69.4 50978 WD40 repeat-like b.69.5 50985 RCC1/BLIP-II b.69.6 50989 Clathrin heavy-chain terminal domain b.69.7 50993 Peptidase/esterase 'gauge' domain b.69.8 69318 Integrin alpha N-terminal domain b.69.9 69322 Tricorn protease domain 2 b.7.1 49562 C2 domain (Calcium/lipid-binding domain, CaLB) b.7.3 49590 PHL pollen allergen b.70.1 50998 Quinoprotein alcohol dehydrogenase-like b.70.3 82171 DPP6 N-terminal domain-like b.71.1 51011 Glycosyl hydrolase domain b.72.1 51045 WW domain b.72.2 51055 Carbohydrate binding domain b.72.3 101931 Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain b.73.1 51064 Head domain of nucleotide exchange factor GrpE b.74.1 51069 Carbonic anhydrase b.76.2 82185 Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain b.77.3 51101 Mannose-binding lectins b.78.1 51110 alpha-D-mannose-specific plant lectins b.8.1 49599 TRAF domain-like b.80.1 51126 Pectin lyase-like b.80.4 69336 Alpha subunit of glutamate synthase, C-terminal domain b.80.5 69340 C-terminal domain of adenylylcyclase associated protein b.80.8 141571 Pentapeptide repeat-like b.81.1 51161 Trimeric LpxA-like enzymes b.82.1 51182 RmlC-like cupins b.82.2 51197 Clavaminate synthase-like b.82.3 51206 cAMP-binding domain-like b.82.4 51215 Regulatory protein AraC b.82.6 63862 Thiamin pyrophosphokinase, substrate-binding domain b.82.7 81653 Calcium ATPase, transduction domain A b.84.1 51230 Single hybrid motif b.84.2 51246 Rudiment single hybrid motif b.84.4 110324 Ribosomal L27 protein-like b.85.4 51283 dUTPase-like b.85.6 63867 MoeA C-terminal domain-like b.85.7 82199 SET domain b.86.1 51294 Hedgehog/intein (Hint) domain b.87.1 51306 LexA/Signal peptidase b.88.1 51316 Mss4-like b.92.1 51338 Composite domain of metallo-dependent hydrolases b.93.1 51344 Epsilon subunit of F1F0-ATP synthase N-terminal domain b.96.1 63712 Nicotinic receptor ligand binding domain-like b.98.1 63737 Leukotriene A4 hydrolase N-terminal domain c.1.1 51351 Triosephosphate isomerase (TIM) c.1.10 51569 Aldolase c.1.11 51604 Enolase C-terminal domain-like c.1.12 51621 Phosphoenolpyruvate/pyruvate domain c.1.13 51645 Malate synthase G c.1.14 51649 RuBisCo, C-terminal domain c.1.15 51658 Xylose isomerase-like c.1.16 51679 Bacterial luciferase-like c.1.17 51690 Nicotinate/Quinolinate PRTase C-terminal domain-like c.1.18 51695 PLC-like phosphodiesterases c.1.19 51703 Cobalamin (vitamin B12)-dependent enzymes c.1.2 51366 Ribulose-phoshate binding barrel c.1.20 51713 tRNA-guanine transglycosylase c.1.21 51717 Dihydropteroate synthetase-like c.1.22 51726 UROD/MetE-like c.1.23 51730 FAD-linked oxidoreductase c.1.26 82282 Homocysteine S-methyltransferase c.1.28 102114 Radical SAM enzymes c.1.3 51391 Thiamin phosphate synthase c.1.33 141868 EAL domain-like c.1.4 51395 FMN-linked oxidoreductases c.1.5 51412 Inosine monophosphate dehydrogenase (IMPDH) c.1.6 51419 PLP-binding barrel c.1.7 51430 NAD(P)-linked oxidoreductase c.1.8 51445 (Trans)glycosidases c.1.9 51556 Metallo-dependent hydrolases c.10.1 52047 RNI-like c.10.2 52058 L domain-like c.10.3 52075 Outer arm dynein light chain 1 c.100.1 63999 Thiamin pyrophosphokinase, catalytic domain c.101.1 64005 Undecaprenyl diphosphate synthase c.103.1 64076 MTH938-like c.108.1 56784 HAD-like c.109.1 68923 PEP carboxykinase N-terminal domain c.111.1 69572 Activating enzymes of the ubiquitin-like proteins c.112.1 69593 Glycerol-3-phosphate (1)-acyltransferase c.113.1 69618 HemD-like c.114.1 75169 DsrEFH-like c.116.1 75217 alpha/beta knot c.117.1 75304 Amidase signature (AS) enzymes c.118.1 82544 GckA/TtuD-like c.119.1 82549 DAK1/DegV-like c.12.1 52080 Ribosomal proteins L15p and L18e c.120.1 88723 PIN domain-like c.123.1 89796 CoA-transferase family III (CaiB/BaiF) c.124.1 100950 NagB/RpiA/CoA transferase-like c.13.1 52087 CRAL/TRIO domain c.13.2 52091 SpoIIaa-like c.133.1 102546 RbsD-like c.134.1 102588 LmbE-like c.14.1 52096 ClpP/crotonase c.142.1 142019 Nqo1 FMN-binding domain-like c.144.1 142695 RibA-like c.149.1 159468 AtpF-like c.15.1 52113 BRCT domain c.17.1 52129 Caspase-like c.18.1 52141 Uracil-DNA glycosylase-like c.19.1 52151 FabD/lysophospholipase-like c.2.1 51735 NAD(P)-binding Rossmann-fold domains c.20.1 52156 Initiation factor IF2/eIF5b, domain 3 c.21.1 52161 Ribosomal protein L13 c.22.1 52166 Ribosomal protein L4 c.23.1 52172 CheY-like c.23.10 52266 SGNH hydrolase c.23.11 52279 Beta-D-glucan exohydrolase, C-terminal domain c.23.12 52283 Formate/glycerate dehydrogenase catalytic domain-like c.23.14 52309 N-(deoxy)ribosyltransferase-like c.23.15 52313 Ribosomal protein S2 c.23.16 52317 Class I glutamine amidotransferase-like c.23.2 52200 Toll/Interleukin receptor TIR domain c.23.4 52210 Succinyl-CoA synthetase domains c.23.5 52218 Flavoproteins c.23.6 52242 Cobalamin (vitamin B12)-binding domain c.23.8 52255 N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) c.24.1 52335 Methylglyoxal synthase-like c.25.1 52343 Ferredoxin reductase-like, C-terminal NADP-linked domain c.26.1 52374 Nucleotidylyl transferase c.26.2 52402 Adenine nucleotide alpha hydrolases-like c.26.3 52413 UDP-glucose/GDP-mannose dehydrogenase C-terminal domain c.27.1 52418 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain c.28.1 52425 Cryptochrome/photolyase, N-terminal domain c.3.1 51905 FAD/NAD(P)-binding domain c.30.1 52440 PreATP-grasp domain c.31.1 52467 DHS-like NAD/FAD-binding domain c.32.1 52490 Tubulin nucleotide-binding domain-like c.33.1 52499 Isochorismatase-like hydrolases c.34.1 52507 Homo-oligomeric flavin-containing Cys decarboxylases, HFCD c.36.1 52518 Thiamin diphosphate-binding fold (THDP-binding) c.37.1 52540 P-loop containing nucleoside triphosphate hydrolases c.39.1 52733 Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) c.4.1 51971 Nucleotide-binding domain c.40.1 52738 Methylesterase CheB, C-terminal domain c.41.1 52743 Subtilisin-like c.42.1 52768 Arginase/deacetylase c.43.1 52777 CoA-dependent acyltransferases c.44.1 52788 Phosphotyrosine protein phosphatases I c.44.2 52794 PTS system IIB component-like c.45.1 52799 (Phosphotyrosine protein) phosphatases II c.46.1 52821 Rhodanese/Cell cycle control phosphatase c.47.1 52833 Thioredoxin-like c.48.1 52922 TK C-terminal domain-like c.49.1 52935 PK C-terminal domain-like c.49.2 52943 ATP synthase (F1-ATPase), gamma subunit c.5.1 51984 MurCD N-terminal domain c.50.1 52949 Macro domain-like c.51.1 52954 Class II aaRS ABD-related c.51.4 52972 ITPase-like c.52.1 52980 Restriction endonuclease-like c.52.2 53032 tRNA-intron endonuclease catalytic domain-like c.52.3 53036 Eukaryotic RPB5 N-terminal domain c.53.2 53056 beta-carbonic anhydrase, cab c.55.1 53067 Actin-like ATPase domain c.55.2 53092 Creatinase/prolidase N-terminal domain c.55.3 53098 Ribonuclease H-like c.55.4 53137 Translational machinery components c.55.6 53150 DNA repair protein MutS, domain II c.55.7 53155 Methylated DNA-protein cysteine methyltransferase domain c.56.2 53167 Purine and uridine phosphorylases c.56.5 53187 Zn-dependent exopeptidases c.56.8 159659 Cgl1923-like c.57.1 53218 Molybdenum cofactor biosynthesis proteins c.58.1 53223 Aminoacid dehydrogenase-like, N-terminal domain c.59.1 53244 MurD-like peptide ligases, peptide-binding domain c.6.2 88713 Glycoside hydrolase/deacetylase c.6.3 89550 PHP domain-like c.60.1 53254 Phosphoglycerate mutase-like c.61.1 53271 PRTase-like c.62.1 53300 vWA-like c.64.1 53323 Pyruvate-ferredoxin oxidoreductase, PFOR, domain III c.65.1 53328 Formyltransferase c.66.1 53335 S-adenosyl-L-methionine-dependent methyltransferases c.67.1 53383 PLP-dependent transferases c.68.1 53448 Nucleotide-diphospho-sugar transferases c.69.1 53474 alpha/beta-Hydrolases c.7.1 51998 PFL-like glycyl radical enzymes c.70.1 53590 Nucleoside hydrolase c.71.1 53597 Dihydrofolate reductase-like c.72.1 53613 Ribokinase-like c.72.2 53623 MurD-like peptide ligases, catalytic domain c.72.3 102645 CoaB-like c.73.1 53633 Carbamate kinase-like c.74.1 53639 AraD/HMP-PK domain-like c.76.1 53649 Alkaline phosphatase-like c.77.1 53659 Isocitrate/Isopropylmalate dehydrogenase-like c.78.1 53671 Aspartate/ornithine carbamoyltransferase c.79.1 53686 Tryptophan synthase beta subunit-like PLP-dependent enzymes c.8.1 52009 Phosphohistidine domain c.8.2 52016 LeuD/IlvD-like c.8.3 52021 Carbamoyl phosphate synthetase, small subunit N-terminal domain c.8.4 52025 PA domain c.8.5 52029 GroEL apical domain-like c.8.8 102198 Putative cyclase c.80.1 53697 SIS domain c.81.1 53706 Formate dehydrogenase/DMSO reductase, domains 1-3 c.82.1 53720 ALDH-like c.83.1 53732 Aconitase iron-sulfur domain c.84.1 53738 Phosphoglucomutase, first 3 domains c.86.1 53748 Phosphoglycerate kinase c.87.1 53756 UDP-Glycosyltransferase/glycogen phosphorylase c.88.1 53774 Glutaminase/Asparaginase c.89.1 53784 Phosphofructokinase c.9.2 52042 Ribosomal protein L32e c.90.1 53790 Tetrapyrrole methylase c.91.1 53795 PEP carboxykinase-like c.92.1 53800 Chelatase c.92.2 53807 Helical backbone metal receptor c.93.1 53822 Periplasmic binding protein-like I c.94.1 53850 Periplasmic binding protein-like II c.95.1 53901 Thiolase-like c.96.1 53920 Fe-only hydrogenase c.97.1 53927 Cytidine deaminase-like c.97.3 102712 JAB1/MPN domain c.98.1 63418 MurE/MurF N-terminal domain d.10.1 54171 DNA-binding domain d.100.1 55658 L9 N-domain-like d.101.1 55666 Ribonuclease PH domain 2-like d.102.1 55671 Regulatory factor Nef d.104.1 55681 Class II aaRS and biotin synthetases d.105.1 55711 Subdomain of clathrin and coatomer appendage domain d.106.1 55718 SCP-like d.107.1 55724 Mog1p/PsbP-like d.108.1 55729 Acyl-CoA N-acyltransferases (Nat) d.109.1 55753 Actin depolymerizing proteins d.109.2 82754 C-terminal, gelsolin-like domain of Sec23/24 d.110.1 55770 Profilin (actin-binding protein) d.110.2 55781 GAF domain-like d.110.3 55785 PYP-like sensor domain (PAS domain) d.110.4 64356 SNARE-like d.110.6 103190 Sensory domain-like d.110.7 103196 Roadblock/LC7 domain d.111.1 55797 PR-1-like d.112.1 55804 Phoshotransferase/anion transport protein d.113.1 55811 Nudix d.114.1 55816 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain d.115.1 55821 YrdC/RibB d.116.1 55826 YbaK/ProRS associated domain d.117.1 55831 Thymidylate synthase/dCMP hydroxymethylase d.118.1 55846 N-acetylmuramoyl-L-alanine amidase-like d.12.1 54189 Ribosomal proteins S24e, L23 and L15e d.120.1 55856 Cytochrome b5-like heme/steroid binding domain d.122.1 55874 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase d.124.1 55895 Ribonuclease Rh-like d.125.1 55904 Ornithine decarboxylase C-terminal domain d.126.1 55909 Pentein d.127.1 55920 Creatinase/aminopeptidase d.128.1 55931 Glutamine synthetase/guanido kinase d.129.1 55945 TATA-box binding protein-like d.129.2 55957 Phosphoglucomutase, C-terminal domain d.129.3 55961 Bet v1-like d.129.6 103243 KA1-like d.13.1 54197 HIT-like d.130.1 55973 S-adenosylmethionine synthetase d.131.1 55979 DNA clamp d.133.1 56003 Molybdenum cofactor-binding domain d.134.1 56014 Nitrite and sulphite reductase 4Fe-4S domain-like d.135.1 56019 The spindle assembly checkpoint protein mad2 d.136.1 56024 Phospholipase D/nuclease d.139.1 56042 PurM C-terminal domain-like d.14.1 54211 Ribosomal protein S5 domain 2-like d.140.1 56047 Ribosomal protein S8 d.141.1 56053 Ribosomal protein L6 d.142.1 56059 Glutathione synthetase ATP-binding domain-like d.142.2 56091 DNA ligase/mRNA capping enzyme, catalytic domain d.143.1 56104 SAICAR synthase-like d.144.1 56112 Protein kinase-like (PK-like) d.145.1 56176 FAD-binding/transporter-associated domain-like d.148.1 56204 Hect, E3 ligase catalytic domain d.15.1 54236 Ubiquitin-like d.15.10 81271 TGS-like d.15.11 89837 Doublecortin (DC) d.15.13 142984 Nqo1 middle domain-like d.15.2 54277 CAD & PB1 domains d.15.3 54285 MoaD/ThiS d.15.4 54292 2Fe-2S ferredoxin-like d.15.8 54364 Translation initiation factor IF3, N-terminal domain d.15.9 54368 Glutamine synthetase, N-terminal domain d.150.1 56214 4'-phosphopantetheinyl transferase d.151.1 56219 DNase I-like d.153.1 56235 N-terminal nucleophile aminohydrolases (Ntn hydrolases) d.156.1 56276 S-adenosylmethionine decarboxylase d.157.1 56281 Metallo-hydrolase/oxidoreductase d.159.1 56300 Metallo-dependent phosphatases d.16.1 54373 FAD-linked reductases, C-terminal domain d.160.1 56317 Carbon-nitrogen hydrolase d.161.1 56322 ADC synthase d.162.1 56327 LDH C-terminal domain-like d.163.1 56349 DNA breaking-rejoining enzymes d.164.1 56366 SMAD MH1 domain d.165.1 56371 Ribosome inactivating proteins (RIP) d.166.1 56399 ADP-ribosylation d.167.1 56420 Peptide deformylase d.168.1 56425 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain d.169.1 56436 C-type lectin-like d.17.1 54403 Cystatin/monellin d.17.2 54416 Amine oxidase N-terminal region d.17.4 54427 NTF2-like d.170.1 56487 SRCR-like d.170.2 56491 A heparin-binding domain d.171.1 56496 Fibrinogen C-terminal domain-like d.172.1 56502 gp120 core d.173.1 56507 Methionine synthase activation domain-like d.174.1 56512 Nitric oxide (NO) synthase oxygenase domain d.175.1 56519 Penicillin binding protein dimerisation domain d.176.1 56524 Oxidoreductase molybdopterin-binding domain d.177.1 56529 FAH d.178.1 56534 Aromatic aminoacid monoxygenases, catalytic and oligomerization domains d.179.1 56542 Substrate-binding domain of HMG-CoA reductase d.18.1 54447 ssDNA-binding transcriptional regulator domain d.181.1 56553 Insert subdomain of RNA polymerase alpha subunit d.184.1 56568 Non-globular alpha+beta subunits of globular proteins d.185.1 63411 LuxS/MPP-like metallohydrolase d.188.1 64263 Prokaryotic ribosomal protein L17 d.189.1 64268 PX domain d.19.1 54452 MHC antigen-recognition domain d.198.2 69645 Arp2/3 complex subunits d.2.1 53955 Lysozyme-like d.20.1 54495 UBC-like d.200.1 69687 Integrin beta tail domain d.201.1 69695 SRP19 d.203.1 69721 DsrC, the gamma subunit of dissimilatory sulfite reductase d.209.1 69848 LCCL domain d.21.1 54506 Diaminopimelate epimerase-like d.210.1 69864 Argininosuccinate synthetase, C-terminal domain d.211.1 48403 Ankyrin repeat d.211.2 75399 Plakin repeat d.212.1 74653 TolA/TonB C-terminal domain d.215.1 75553 Smc hinge domain d.217.1 63763 SAND domain-like d.218.1 81301 Nucleotidyltransferase d.219.1 81606 PP2C-like d.22.1 54511 GFP-like d.220.1 81660 Metal cation-transporting ATPase, ATP-binding domain N d.223.1 82615 Polo-box domain d.224.1 82649 SufE/NifU d.225.1 82714 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains d.226.1 82771 GIY-YIG endonuclease d.23.1 54518 Tubby C-terminal domain-like d.230.1 88798 N-terminal, heterodimerisation domain of RBP7 (RpoE) d.230.3 89811 Amyloid beta a4 protein copper binding domain (domain 2) d.235.1 89895 FYSH domain d.239.1 90073 GCM domain d.24.1 54523 Pili subunits d.240.1 100879 Lesion bypass DNA polymerase (Y-family), little finger domain d.241.1 100966 Translation initiation factor 2 beta, aIF2beta, N-terminal domain d.248.1 102886 Coproporphyrinogen III oxidase d.25.1 54529 Mitochondrial glycoprotein MAM33-like d.250.1 103025 Folate-binding domain d.258.1 103263 Chorismate synthase, AroC d.26.1 54534 FKBP-like d.26.3 54556 Chitinase insertion domain d.260.1 103359 Suppressor of Fused, N-terminal domain d.261.1 103365 Hypothetical protein PH1602 d.264.1 56747 Prim-pol domain d.265.1 55120 Pseudouridine synthase d.267.1 110836 Hypothetical protein SAV1430 d.268.1 110849 ParB/Sulfiredoxin d.269.1 110857 Gamma-glutamyl cyclotransferase-like d.27.1 54565 Ribosomal protein S16 d.270.1 110921 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain d.271.1 110942 HSP90 C-terminal domain d.272.1 111006 Dystroglycan, domain 2 d.278.1 111126 Ligand-binding domain in the NO signalling and Golgi transport d.28.1 54570 Ribosomal protein S19 d.284.1 82697 PurS-like d.286.1 116726 TrkA C-terminal domain-like d.288.1 117773 GTF2I-like repeat d.289.1 117839 WWE domain d.29.1 54575 Ribosomal protein L31e d.290.1 117856 AF0104/ALDC/Ptd012-like d.292.1 118116 DNA mismatch repair protein MutL d.294.1 142877 EndoU-like d.297.1 142921 WGR domain-like d.298.1 143011 RelE-like d.3.1 54001 Cysteine proteinases d.301.1 143034 L35p-like d.305.1 143113 NAP-like d.306.1 143120 YefM-like d.307.1 143243 Nqo5-like d.308.1 143437 THUMP domain-like d.31.1 54585 Cdc48 domain 2-like d.314.1 143503 PUG domain-like d.32.1 54593 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase d.322.1 143724 PHP14-like d.324.1 143791 DUSP-like d.325.1 143800 L28p-like d.328.1 143865 CorA soluble domain-like d.332.1 143885 RGC domain-like d.334.1 143975 IlvD/EDD N-terminal domain-like d.338.1 144000 Oxysterol-binding protein-like d.34.1 54616 DNA-binding domain of Mlu1-box binding protein MBP1 d.344.1 160059 PriA/YqbF domain d.345.1 160088 NRDP1 C-terminal domain-like d.353.1 160219 AMPKBI-like d.355.1 160374 RplX-like d.36.1 54626 Chalcone isomerase d.37.1 54631 CBS-domain pair d.370.1 160696 BTG domain-like d.379.1 160897 Taf5 N-terminal domain-like d.38.1 54637 Thioesterase/thiol ester dehydrase-isomerase d.381.1 160909 ATP12-like d.39.1 54648 DLC d.4.1 54060 His-Me finger endonucleases d.40.1 54654 CI-2 family of serine protease inhibitors d.41.1 54665 CO dehydrogenase molybdoprotein N-domain-like d.41.2 54675 Nicotinate/Quinolinate PRTase N-terminal domain-like d.41.4 54686 Ribosomal protein L16p/L10e d.41.5 54690 Molybdopterin synthase subunit MoaE d.42.1 54695 POZ domain d.43.1 54713 Elongation factor Ts (EF-Ts), dimerisation domain d.43.2 117892 Band 7/SPFH domain d.44.1 54719 Fe,Mn superoxide dismutase (SOD), C-terminal domain d.45.1 54736 ClpS-like d.47.1 54747 Ribosomal L11/L12e N-terminal domain d.48.1 54752 RecA protein, C-terminal domain d.49.1 54762 Signal recognition particle alu RNA binding heterodimer, SRP9/14 d.5.1 54076 RNase A-like d.50.1 54768 dsRNA-binding domain-like d.50.2 54782 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain d.50.4 110916 Peptidyl-tRNA hydrolase domain-like d.51.1 54791 Eukaryotic type KH-domain (KH-domain type I) d.52.10 160246 EspE N-terminal domain-like d.52.2 54810 GMP synthetase C-terminal dimerisation domain d.52.3 54814 Prokaryotic type KH domain (KH-domain type II) d.52.8 117916 Fe-S cluster assembly (FSCA) domain-like d.52.9 160240 Cation efflux protein cytoplasmic domain-like d.53.1 54821 Ribosomal protein S3 C-terminal domain d.54.1 54826 Enolase N-terminal domain-like d.55.1 54843 Ribosomal protein L22 d.56.1 54849 GroEL-intermediate domain like d.58.1 54862 4Fe-4S ferredoxins d.58.10 54975 Acylphosphatase/BLUF domain-like d.58.11 54980 EF-G C-terminal domain-like d.58.12 54984 eEF-1beta-like d.58.13 54991 Anticodon-binding domain of PheRS d.58.14 54995 Ribosomal protein S6 d.58.15 54999 Ribosomal protein S10 d.58.16 55003 PAP/Archaeal CCA-adding enzyme, C-terminal domain d.58.17 55008 HMA, heavy metal-associated domain d.58.18 55021 ACT-like d.58.19 55031 Bacterial exopeptidase dimerisation domain d.58.20 55035 NAD-binding domain of HMG-CoA reductase d.58.21 55040 Molybdenum cofactor biosynthesis protein C, MoaC d.58.22 55044 TRADD, N-terminal domain d.58.23 55048 Probable ACP-binding domain of malonyl-CoA ACP transacylase d.58.26 55060 GHMP Kinase, C-terminal domain d.58.28 55068 Peptide methionine sulfoxide reductase d.58.29 55073 Nucleotide cyclase d.58.3 54897 Protease propeptides/inhibitors d.58.30 55083 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK d.58.32 55103 FAD-linked oxidases, C-terminal domain d.58.36 55124 Nitrite/Sulfite reductase N-terminal domain-like d.58.4 54909 Dimeric alpha+beta barrel d.58.40 75445 D-ribose-5-phosphate isomerase (RpiA), lid domain d.58.41 82671 SEA domain d.58.44 82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains d.58.5 54913 GlnB-like d.58.51 110993 eIF-2-alpha, C-terminal domain d.58.6 54919 Nucleoside diphosphate kinase, NDK d.58.62 160369 Ribosomal protein L10-like d.58.7 54928 RNA-binding domain, RBD d.58.9 54966 RuBisCO, large subunit, small (N-terminal) domain d.59.1 55129 Ribosomal protein L30p/L7e d.6.1 54098 Prion-like d.60.1 55136 Probable bacterial effector-binding domain d.61.1 55144 LigT-like d.63.1 55154 CYTH-like phosphatases d.64.1 55159 eIF1-like d.65.1 55166 Hedgehog/DD-peptidase d.66.1 55174 Alpha-L RNA-binding motif d.67.1 55186 ThrRS/AlaRS common domain d.67.2 55190 Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain d.67.3 55194 Ribosome recycling factor, RRF d.68.1 55200 Translation initiation factor IF3, C-terminal domain d.68.2 55205 EPT/RTPC-like d.68.4 75471 YhbY-like d.68.7 82708 R3H domain d.7.1 54106 LysM domain d.73.1 55239 RuBisCO, small subunit d.74.1 55248 PCD-like d.74.3 55257 RBP11-like subunits of RNA polymerase d.74.4 55261 GAD domain-like d.75.2 55271 DNA repair protein MutS, domain I d.76.1 55277 GYF domain d.76.2 160481 BRK domain-like d.77.1 55282 RL5-like d.78.1 55287 RPB5-like RNA polymerase subunit d.79.2 55307 Tubulin C-terminal domain-like d.79.3 55315 L30e-like d.79.4 55326 PurM N-terminal domain-like d.79.7 103088 OmpA-like d.80.1 55331 Tautomerase/MIF d.81.1 55347 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain d.81.2 143548 Serine metabolism enzymes domain d.81.4 160527 V-type ATPase subunit E-like d.82.2 55387 Frataxin/Nqo15-like d.82.4 143575 GAS2 domain-like d.83.1 55394 Bactericidal permeability-increasing protein, BPI d.83.2 103111 Activator of Hsp90 ATPase, Aha1 d.86.1 55418 eIF4e-like d.87.1 55424 FAD/NAD-linked reductases, dimerisation (C-terminal) domain d.87.2 55447 CO dehydrogenase flavoprotein C-terminal domain-like d.88.1 55455 SRF-like d.89.1 55464 Origin of replication-binding domain, RBD-like d.9.1 54117 Interleukin 8-like chemokines d.90.1 55469 FMN-dependent nitroreductase-like d.91.1 55481 N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 d.92.1 55486 Metalloproteases ("zincins"), catalytic domain d.92.2 55545 beta-N-acetylhexosaminidase-like domain d.93.1 55550 SH2 domain d.94.1 55594 HPr-like d.95.1 55604 Glucose permease domain IIB d.95.2 55608 Homing endonucleases d.96.1 55620 Tetrahydrobiopterin biosynthesis enzymes-like d.97.1 55637 Cell cycle regulatory proteins e.1.1 56574 Serpins e.10.1 56712 Prokaryotic type I DNA topoisomerase e.11.1 56719 Type II DNA topoisomerase e.12.1 56726 DNA topoisomerase IV, alpha subunit e.13.1 56731 DNA primase core e.15.1 56741 Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment e.17.1 56752 D-aminoacid aminotransferase-like PLP-dependent enzymes e.18.1 56762 HydB/Nqo4-like e.19.1 56770 HydA/Nqo6-like e.22.1 56796 Dehydroquinate synthase-like e.23.1 56801 Acetyl-CoA synthetase-like e.24.1 56808 Ribosomal protein L1 e.25.1 56815 Sec1/munc18-like (SM) proteins e.29.1 64484 beta and beta-prime subunits of DNA dependent RNA-polymerase e.3.1 56601 beta-lactamase/transpeptidase-like e.32.1 64518 Phase 1 flagellin e.37.1 75615 Siroheme synthase middle domains-like e.38.1 75620 Release factor e.40.1 75632 Cullin homology domain e.43.1 90096 Subunits of heterodimeric actin filament capping protein Capz e.5.1 56634 Heme-dependent catalase-like e.52.1 111331 NAD kinase/diacylglycerol kinase-like e.55.1 111347 Rap/Ran-GAP e.57.1 118203 Vacuolar ATP synthase subunit C e.6.1 56645 Acyl-CoA dehydrogenase NM domain-like e.63.1 144074 E2F-DP heterodimerization region e.7.1 56655 Carbohydrate phosphatase e.8.1 56672 DNA/RNA polymerases f.1.4 56854 Bcl-2 inhibitors of programmed cell death f.13.1 81321 Family A G protein-coupled receptor-like f.14.1 81324 Voltage-gated potassium channels f.15.1 81327 Small-conductance potassium channel f.17.1 81333 F1F0 ATP synthase subunit C f.17.2 81464 Cytochrome c oxidase subunit II-like, transmembrane region f.17.3 144083 Magnesium transport protein CorA, transmembrane region f.18.1 81336 F1F0 ATP synthase subunit A f.19.1 81338 Aquaporin-like f.20.1 81340 Clc chloride channel f.21.1 81342 Transmembrane di-heme cytochromes f.21.2 81343 Fumarate reductase respiratory complex transmembrane subunits f.22.1 81345 ABC transporter involved in vitamin B12 uptake, BtuC f.23.1 81406 Mitochondrial cytochrome c oxidase subunit IV f.23.11 81496 Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor f.23.12 81502 ISP transmembrane anchor f.23.13 81508 Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) f.23.14 81514 Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) f.23.2 81411 Mitochondrial cytochrome c oxidase subunit VIa f.23.21 81573 F1F0 ATP synthase subunit B, membrane domain f.23.28 103456 Preprotein translocase SecE subunit f.23.30 103464 Oligosaccharyltransferase subunit ost4p f.23.4 81419 Mitochondrial cytochrome c oxidase subunit VIIa f.23.6 81427 Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) f.23.7 81431 Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) f.24.1 81442 Cytochrome c oxidase subunit I-like f.25.1 81452 Cytochrome c oxidase subunit III-like f.26.1 81483 Bacterial photosystem II reaction centre, L and M subunits f.27.1 81524 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) f.28.1 81531 Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) f.29.1 81558 Photosystem I subunits PsaA/PsaB f.32.1 81648 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) f.33.1 81665 Calcium ATPase, transmembrane domain M f.35.1 82866 Multidrug efflux transporter AcrB transmembrane domain f.36.1 90112 Neurotransmitter-gated ion-channel transmembrane pore f.37.1 90123 ABC transporter transmembrane region f.38.1 103473 MFS general substrate transporter f.39.1 103481 Multidrug resistance efflux transporter EmrE f.4.1 56925 OMPA-like f.4.3 56935 Porins f.4.5 103515 Autotransporter f.40.1 103486 V-type ATP synthase subunit C f.41.1 103491 Preprotein translocase SecY subunit f.42.1 103506 Mitochondrial carrier f.43.1 103511 Chlorophyll a-b binding protein f.44.1 111352 Ammonium transporter f.45.1 111357 Mitochondrial ATP synthase coupling factor 6 f.46.1 111369 HlyD-like secretion proteins f.49.1 118215 Proton glutamate symport protein f.5.1 56954 Outer membrane efflux proteins (OEP) f.50.1 118220 Connexin43 f.51.1 144091 Rhomboid-like f.52.1 161060 ATP synthase B chain-like f.53.1 161065 ATP synthase D chain-like f.54.1 161070 SNF-like f.55.1 161077 Photosystem II antenna protein-like f.56.1 161084 MAPEG domain-like f.57.1 161093 MgtE membrane domain-like f.58.1 161098 MetI-like f.59.1 161111 Cation efflux protein transmembrane domain-like f.7.1 56968 Lipovitellin-phosvitin complex; beta-sheet shell regions g.1.1 56994 Insulin-like g.10.1 57414 Hairpin loop containing domain-like g.12.1 57424 LDL receptor-like module g.14.1 57440 Kringle-like g.16.1 57492 Trefoil g.16.2 103575 Plexin repeat g.17.1 57501 Cystine-knot cytokines g.18.1 57535 Complement control module/SCR domain g.20.1 57552 Blood coagulation inhibitor (disintegrin) g.22.1 57567 Serine protease inhibitors g.23.1 57581 TB module/8-cys domain g.24.1 57586 TNF receptor-like g.25.1 57593 Heparin-binding domain from vascular endothelial growth factor g.27.1 57603 FnI-like domain g.28.1 57610 Thyroglobulin type-1 domain g.3.1 57016 Plant lectins/antimicrobial peptides g.3.11 57196 EGF/Laminin g.3.14 57256 Elafin-like g.3.16 57277 Granulin repeat g.3.17 64546 Satiety factor CART (cocaine and amphetamine regulated transcript) g.3.3 57038 Cyclotides g.3.5 57055 Agouti-related protein g.3.6 57059 omega toxin-like g.3.7 57095 Scorpion toxin-like g.3.8 57180 Cellulose-binding domain g.3.9 57184 Growth factor receptor domain g.31.1 57625 Invertebrate chitin-binding proteins g.32.1 57630 GLA-domain g.34.1 57647 HIV-1 VPU cytoplasmic domain g.37.1 57667 beta-beta-alpha zinc fingers g.38.1 57701 Zn2/Cys6 DNA-binding domain g.39.1 57716 Glucocorticoid receptor-like (DNA-binding domain) g.40.1 57756 Retrovirus zinc finger-like domains g.41.1 57770 Methionyl-tRNA synthetase (MetRS), Zn-domain g.41.10 82919 Zn-finger domain of Sec23/24 g.41.11 90209 Ran binding protein zinc finger-like g.41.17 144217 CSL zinc finger g.41.2 57774 Microbial and mitochondrial ADK, insert "zinc finger" domain g.41.3 57783 Zinc beta-ribbon g.41.4 57798 Casein kinase II beta subunit g.41.5 57802 Rubredoxin-like g.41.8 57829 Zn-binding ribosomal proteins g.41.9 63393 RNA polymerase subunits g.42.1 57840 Ribosomal protein L36 g.43.1 57845 B-box zinc-binding domain g.44.1 57850 RING/U-box g.45.1 57863 ArfGap/RecO-like zinc finger g.46.1 57868 Metallothionein g.47.1 57879 Zinc domain conserved in yeast copper-regulated transcription factors g.49.1 57889 Cysteine-rich domain g.5.1 57288 Midkine g.50.1 57903 FYVE/PHD zinc finger g.52.1 57924 Inhibitor of apoptosis (IAP) repeat g.53.1 57933 TAZ domain g.54.1 57938 DnaJ/Hsp40 cysteine-rich domain g.59.1 75689 Zinc-binding domain of translation initiation factor 2 beta g.60.1 82895 TSP-1 type 1 repeat g.62.1 82927 Cysteine-rich DNA binding domain, (DM domain) g.64.1 90188 Somatomedin B domain g.65.1 90193 Notch domain g.66.1 90229 CCCH zinc finger g.67.1 90234 Zinc finger domain of DNA polymerase-alpha g.68.1 100895 Kazal-type serine protease inhibitors g.7.1 57302 Snake toxin-like g.72.1 103612 SBT domain g.73.1 103637 CCHHC domain g.75.1 103647 TSP type-3 repeat g.76.1 111418 Hormone receptor domain g.78.1 111430 YAP1 redox domain g.79.1 118290 WRKY DNA-binding domain g.8.1 57362 BPTI-like g.80.1 118310 AN1-like Zinc finger g.83.1 144122 Tim10-like g.85.1 144232 HIT/MYND zinc finger-like g.9.1 57392 Defensin-like h.1.1 57944 Triple coiled coil domain of C-type lectins h.1.11 58022 XRCC4, C-terminal oligomerization domain h.1.12 58026 Delta-sleep-inducing peptide immunoreactive peptide h.1.15 58038 SNARE fusion complex h.1.18 58050 N-terminal coiled coil domain from apc h.1.2 57953 Trimerization domain of TRAF h.1.20 64593 Intermediate filament protein, coiled coil region h.1.22 75704 Mitotic arrest deficient-like 1, Mad1 h.1.25 90250 Troponin coil-coiled subunits h.1.26 90257 Myosin rod fragments h.1.27 103652 G protein-binding domain h.1.28 111469 Geminin coiled-coil domain h.1.29 118370 Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain h.1.3 57959 Leucine zipper domain h.1.31 144270 Eferin C-derminal domain-like h.1.34 161256 RILP dimerisation region h.1.5 57997 Tropomyosin h.1.6 58002 Chicken cartilage matrix protein h.1.7 58006 Assembly domain of cartilage oligomeric matrix protein h.1.8 58010 Fibrinogen coiled-coil and central regions h.1.9 58014 Coiled-coil domain of nucleotide exchange factor GrpE h.3.2 58069 Virus ectodomain h.4.10 69989 C-terminal domain of PLC-beta h.4.12 75712 Rad50 coiled-coil Zn hook h.4.13 82931 Tumor suppressor gene product Apc h.4.16 111479 Fzo-like conserved region h.4.17 144292 occludin/ELL-like h.4.2 58091 Clostridium neurotoxins, "coiled-coil" domain h.4.5 58104 Methyl-accepting chemotaxis protein (MCP) signaling domain h.4.8 64602 F1 ATPase inhibitor, IF1, C-terminal domain h.5.1 58113 Apolipoprotein A-I h.6.1 82936 Apolipoprotein A-II h.7.1 118375 Synuclein