Enzyme Commission (EC): With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

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Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology
Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
UniProtKB KeyWords (KW) Ontology
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
CTD Diseases (CD) Ontology
CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
CTD Chemicals (CC) Ontology
CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).

Root: EC Hierarchy (from IntEnz release 70)

Superfamily

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Cytochrome P450	0	Direct
Heme oxygenase-like	0.0000000000002492	Direct
Bacterial luciferase-like	0.000000000004322	Direct
Acyl-CoA dehydrogenase C-terminal domain-like	0.00004028	Direct
Acyl-CoA dehydrogenase NM domain-like	0.0001859	Direct
Dimeric alpha+beta barrel	0.01478	Inherited
Flavoproteins	1	Inherited
Riboflavin synthase domain-like	1	Inherited
FAD/NAD(P)-binding domain	1	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	1	Inherited
Nitric oxide (NO) synthase oxygenase domain	1	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Bacterial luciferase (alkanal monooxygenase)	0	Direct
Eukaryotic type heme oxygenase	0	Direct
Cytochrome P450	0	Direct
Flavodoxin-related	0.0000000000001717	Direct
Ssud-like monoxygenases	0.00000000004333	Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0.002175	Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0.008636	Inherited
PG130-like	0.08109	Inherited
NADPH-cytochrome p450 reductase-like	1	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	1	Inherited
Nitric oxide (NO) synthase oxygenase domain	1	Inherited
FAD/NAD-linked reductases, N-terminal and central domains	1	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

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Supra-domain (Single)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Cytochrome P450	0	Direct
Heme oxygenase-like	0.0000000000001774	Direct
Bacterial luciferase-like	0.000000000003113	Direct
Acyl-CoA dehydrogenase C-terminal domain-like	0.00003221	Direct
Acyl-CoA dehydrogenase NM domain-like	0.0001507	Direct
Dimeric alpha+beta barrel	0.01257	Inherited
Riboflavin synthase domain-like	1	Inherited
Flavoproteins	1	Inherited
FAD/NAD(P)-binding domain	1	Inherited
Nitric oxide (NO) synthase oxygenase domain	1	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	1	Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Duplex) in N- to C-terminal order

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48264,52218 48264 - Cytochrome P450 52218 - Flavoproteins	0	Direct
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0.00003221	Direct
52218,63380 52218 - Flavoproteins 63380 - Riboflavin synthase domain-like	0.1196	Inherited
51905,51905 51905 - FAD/NAD(P)-binding domain 51905 - FAD/NAD(P)-binding domain	1	Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Triple) in N- to C-terminal order

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48264,52218,63380 48264 - Cytochrome P450 52218 - Flavoproteins 63380 - Riboflavin synthase domain-like	0	Direct