HD-domain/PDEase-like superfamily

DO

Disease Ontology (DO)

	DO term	FDR (all)	SDDO (four levels)	Annotation (direct or inherited)
Disease Ontology (DO)	leukemia	0.06729	--	Inherited
Disease Ontology (DO)	immune system cancer	0.1222	--	Inherited
Disease Ontology (DO)	disease of cellular proliferation	1	--	Inherited
Disease Ontology (DO)	cancer	1	--	Inherited
Disease Ontology (DO)	organ system cancer	0.689	Least Informative	Inherited
Disease Ontology (DO)	hematologic cancer	0.1187	Moderately Informative	Inherited
Disease Ontology (DO)	lymphoblastic leukemia	0.001203	Informative	Inherited
Disease Ontology (DO)	chronic lymphocytic leukemia	0.00002434	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

HP

Human Phenotype (HP)

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Glucose intolerance	0.00003247	--	Direct
Phenotypic Abnormality (PA)	Abnormal glucose homeostasis	0.0003371	--	Direct
Phenotypic Abnormality (PA)	Hypogonadism	0.0004588	--	Direct
Phenotypic Abnormality (PA)	Abnormal homeostasis	0.02815	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.03069	--	Inherited
Phenotypic Abnormality (PA)	Puberty and gonadal disorders	0.09634	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.1906	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.202	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the endocrine system	0.01672	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of reproductive system physiology	0.02758	Informative	Inherited
Phenotypic Abnormality (PA)	Diabetes mellitus	0.00002732	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

MP

Mouse Phenotype (MP)

	MP term	FDR (all)	SDMP (four levels)	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased retinal photoreceptor cell number	0.0004035	--	Direct
Mammalian Phenotype (MP)	retinal photoreceptor degeneration	0.0005953	--	Direct
Mammalian Phenotype (MP)	abnormal retinal photoreceptor layer morphology	0.006107	--	Inherited
Mammalian Phenotype (MP)	abnormal retinal layer morphology	0.05596	--	Inherited
Mammalian Phenotype (MP)	decreased neuron number	0.06343	--	Inherited
Mammalian Phenotype (MP)	neurodegeneration	0.07113	--	Inherited
Mammalian Phenotype (MP)	abnormal retina morphology	0.1502	--	Inherited
Mammalian Phenotype (MP)	abnormal ocular fundus morphology	0.154	--	Inherited
Mammalian Phenotype (MP)	abnormal somatic sensory system morphology	0.1686	--	Inherited
Mammalian Phenotype (MP)	abnormal posterior eye segment morphology	0.2045	--	Inherited
Mammalian Phenotype (MP)	vision/eye phenotype	0.3699	--	Inherited
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.7725	--	Inherited
Mammalian Phenotype (MP)	nervous system phenotype	0.5442	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.2842	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal eye morphology	0.3201	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal neuron morphology	0.395	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal retinal neuronal layer morphology	0.0318	Informative	Inherited
Mammalian Phenotype (MP)	abnormal sensory neuron morphology	0.08301	Informative	Inherited
Mammalian Phenotype (MP)	abnormal neuron number	0.09741	Informative	Inherited
Mammalian Phenotype (MP)	abnormal retinal photoreceptor morphology	0.005474	Highly Informative	Inherited
Mammalian Phenotype (MP)	decreased sensory neuron number	0.007123	Highly Informative	Inherited
Mammalian Phenotype (MP)	neuron degeneration	0.03976	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	--	Direct
Worm Phenotype (WP)	lethal	0	--	Direct
Worm Phenotype (WP)	fertility variant	0	--	Direct
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	organ system physiology variant	0	--	Direct
Worm Phenotype (WP)	reproductive system physiology variant	0	--	Direct
Worm Phenotype (WP)	maternal sterile	0	--	Direct
Worm Phenotype (WP)	hermaphrodite sterile	0	--	Direct
Worm Phenotype (WP)	embryonic development variant	0	--	Direct
Worm Phenotype (WP)	hermaphrodite fertility variant	0	--	Direct
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	--	Direct
Worm Phenotype (WP)	fertility reduced	0	--	Direct
Worm Phenotype (WP)	thermosensory behavior variant	0.00000007123	--	Direct
Worm Phenotype (WP)	behavior variant	0.05182	--	Inherited
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.4076	--	Inherited
Worm Phenotype (WP)	organism physiology variant	0.4236	--	Inherited
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	sterile	1	--	Inherited
Worm Phenotype (WP)	organism environmental stimulus response variant	0.03587	Least Informative	Inherited
Worm Phenotype (WP)	organism behavior variant	0.05019	Least Informative	Inherited
Worm Phenotype (WP)	organism stress response variant	0.1453	Moderately Informative	Inherited
Worm Phenotype (WP)	organism temperature response variant	0.00001135	Informative	Direct
Worm Phenotype (WP)	thermotaxis variant	0.00000002026	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

YP

Yeast Phenotype (YP)

	YP term	FDR (all)	SDYP (four levels)	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	--	Direct
Yeast Phenotype (YP)	stress resistance	0	--	Direct
Yeast Phenotype (YP)	resistance to chemicals	0	Least Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FP

Fly Phenotype (FP)

	FP term	FDR (all)	SDFP (four levels)	Annotation (direct or inherited)
Fly Phenotype (FP)	viable	0	Least Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FA

Fly Anatomy (FA)

	FA term	FDR (all)	SDFA (four levels)	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	--	Direct
Fly Anatomy (FA)	anatomical structure	1	--	Inherited
Fly Anatomy (FA)	material anatomical entity	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

ZA

Zebrafish Anatomy (ZA)

	ZA term	FDR (all)	SDZA (four levels)	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical group	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical structure	1	--	Inherited
Zebrafish Anatomy (ZA)	multi-tissue structure	0	Least Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	--	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

AP

Arabidopsis Plant Ontology (AP)

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	--	Direct
Plant ANatomical entity (PAN)	shoot system	0	--	Direct
Plant ANatomical entity (PAN)	portion of plant tissue	0	--	Direct
Plant ANatomical entity (PAN)	collective plant structure	0	--	Direct
Plant ANatomical entity (PAN)	root syncytium cell	0.00000000000003541	--	Direct
Plant ANatomical entity (PAN)	ground tissue cell	0.000000003347	--	Direct
Plant ANatomical entity (PAN)	vascular system	0.000001692	--	Direct
Plant ANatomical entity (PAN)	stele	0.000003422	--	Direct
Plant ANatomical entity (PAN)	root vascular system	0.007146	--	Inherited
Plant ANatomical entity (PAN)	cardinal organ part	0.1431	--	Inherited
Plant ANatomical entity (PAN)	root	0.384	--	Inherited
Plant ANatomical entity (PAN)	plant axis	0.4168	--	Inherited
Plant ANatomical entity (PAN)	plant organ	0.6494	--	Inherited
Plant ANatomical entity (PAN)	multi-tissue plant structure	0.6692	--	Inherited
Plant ANatomical entity (PAN)	plant structure	1	--	Inherited
Plant ANatomical entity (PAN)	collective plant organ structure	1	--	Inherited
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0.1436	Least Informative	Inherited
Plant ANatomical entity (PAN)	whole plant	0.2722	Least Informative	Inherited
Plant ANatomical entity (PAN)	root system	0.4044	Least Informative	Inherited
Plant ANatomical entity (PAN)	portion of ground tissue	0.00002324	Informative	Direct
Plant ANatomical entity (PAN)	fruit	0.0004237	Informative	Direct
Plant ANatomical entity (PAN)	root stele	0.000002639	Highly Informative	Direct

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	corolla development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	flowering stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	flower development stage	1	--	Inherited
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

	EC term	FDR (all)	SDEC (four levels)	Annotation (direct or inherited)
Enzyme Commission (EC)	Miscellaneous	0	--	Direct
Enzyme Commission (EC)	GTP diphosphokinase	0	--	Direct
Enzyme Commission (EC)	[Protein-PII] uridylyltransferase	0	--	Direct
Enzyme Commission (EC)	Acting on ester bonds	0	--	Direct
Enzyme Commission (EC)	5'-deoxynucleotidase	0	--	Direct
Enzyme Commission (EC)	3',5'-cyclic-GMP phosphodiesterase	0	--	Direct
Enzyme Commission (EC)	Triphosphoric monoester hydrolases	0	--	Direct
Enzyme Commission (EC)	Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase	0	--	Direct
Enzyme Commission (EC)	Guanosine-5'-triphosphate,3'-diphosphate diphosphatase	0	--	Direct
Enzyme Commission (EC)	Ligases forming aminoacyl-tRNA and related compounds	0	--	Direct
Enzyme Commission (EC)	Glycine--tRNA ligase	0	--	Direct
Enzyme Commission (EC)	3',5'-cyclic-nucleotide phosphodiesterase	0.000000002645	--	Direct
Enzyme Commission (EC)	3',5'-cyclic-AMP phosphodiesterase	0.000001661	--	Direct
Enzyme Commission (EC)	tRNA (cytidine(56)-2'-O)-methyltransferase	0.0000488	--	Direct
Enzyme Commission (EC)	Exopolyphosphatase	0.0001241	--	Direct
Enzyme Commission (EC)	Transferases	1	--	Inherited
Enzyme Commission (EC)	Methyltransferases	1	--	Inherited
Enzyme Commission (EC)	Hydrolases	2.574e-16	Least Informative	Direct
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.000000008509	Least Informative	Direct
Enzyme Commission (EC)	Oxidoreductases	1	Least Informative	Inherited
Enzyme Commission (EC)	Nucleotidyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Ligases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on acid anhydrides	0.2032	Moderately Informative	Inherited
Enzyme Commission (EC)	Transferring one-carbon groups	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Phosphoric monoester hydrolases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	Informative	Direct
Enzyme Commission (EC)	In phosphorus-containing anhydrides	0	Informative	Direct
Enzyme Commission (EC)	Forming carbon-oxygen bonds	0	Informative	Direct
Enzyme Commission (EC)	Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated	0.000000105	Informative	Direct
Enzyme Commission (EC)	Diphosphotransferases	0	Highly Informative	Direct
Enzyme Commission (EC)	Diphosphoric monoester hydrolases	0	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

KW

UniProtKB KeyWords (KW)

	KW term	FDR (all)	SDKW (four levels)	Annotation (direct or inherited)
Molecular function	Hydrolase	0	Least Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

	CC term	FDR (all)	SDCC (four levels)	Annotation (direct or inherited)
CTD Chemicals (CC)	trequinsin	0	--	Direct
CTD Chemicals (CC)	Roflumilast	0	--	Direct
CTD Chemicals (CC)	L-826,141	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds, 1-Ring	0	--	Direct
CTD Chemicals (CC)	Hydrocarbons	0	--	Direct
CTD Chemicals (CC)	Hydrocarbons, Aromatic	0	--	Direct
CTD Chemicals (CC)	Hydrocarbons, Cyclic	0	--	Direct
CTD Chemicals (CC)	Organic Chemicals	0	--	Direct
CTD Chemicals (CC)	Cyclopropanes	0.00000000000001821	--	Direct
CTD Chemicals (CC)	PF-04254644	0.00000000000002366	--	Direct
CTD Chemicals (CC)	Cilomilast	0.0000000000543	--	Direct
CTD Chemicals (CC)	NVP ABE171	0.0000000000543	--	Direct
CTD Chemicals (CC)	E 4021	0.0000000007859	--	Direct
CTD Chemicals (CC)	Ribonucleotides	0.000001574	--	Direct
CTD Chemicals (CC)	Isoquinolines	0.000003697	--	Direct
CTD Chemicals (CC)	Oxadiazoles	0.00001119	--	Direct
CTD Chemicals (CC)	Purine Nucleotides	0.00001385	--	Direct
CTD Chemicals (CC)	Quinolines	0.0004579	--	Direct
CTD Chemicals (CC)	Benzamides	0.0005932	--	Direct
CTD Chemicals (CC)	Cycloparaffins	0.02313	--	Inherited
CTD Chemicals (CC)	Hydrocarbons, Alicyclic	0.03368	--	Inherited
CTD Chemicals (CC)	Nucleic Acids, Nucleotides, and Nucleosides	0.05123	--	Inherited
CTD Chemicals (CC)	Polycyclic Compounds	0.09402	--	Inherited
CTD Chemicals (CC)	Carboxylic Acids	0.4669	--	Inherited
CTD Chemicals (CC)	Benzene Derivatives	0.4737	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, 2-Ring	0.7721	--	Inherited
CTD Chemicals (CC)	Cyclohexanes	0.8693	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, Fused-Ring	1	--	Inherited
CTD Chemicals (CC)	Acids, Carbocyclic	0.01979	Least Informative	Inherited
CTD Chemicals (CC)	Pyrimidines	0.05475	Least Informative	Inherited
CTD Chemicals (CC)	Amines	0.1113	Least Informative	Inherited
CTD Chemicals (CC)	Amides	0.1597	Least Informative	Inherited
CTD Chemicals (CC)	Macrocyclic Compounds	0.2998	Least Informative	Inherited
CTD Chemicals (CC)	Azoles	0.4575	Least Informative	Inherited
CTD Chemicals (CC)	Nucleotides	0.00003361	Moderately Informative	Direct
CTD Chemicals (CC)	Pyridines	0.0001768	Moderately Informative	Direct
CTD Chemicals (CC)	Purines	0.01848	Moderately Informative	Inherited
CTD Chemicals (CC)	Benzoates	0.03993	Moderately Informative	Inherited
CTD Chemicals (CC)	Piperidines	0.08755	Moderately Informative	Inherited
CTD Chemicals (CC)	Aminopyridines	0.00008732	Informative	Direct
CTD Chemicals (CC)	Cyclohexanecarboxylic Acids	0.0003098	Informative	Direct
CTD Chemicals (CC)	Oxazoles	0.001855	Informative	Inherited
CTD Chemicals (CC)	Nitriles	0.0358	Informative	Inherited
CTD Chemicals (CC)	Quinazolines	0.04258	Informative	Inherited
CTD Chemicals (CC)	Tetrahydroisoquinolines	0.0000000000001015	Highly Informative	Direct
CTD Chemicals (CC)	Dipyridamole	0.000000000116	Highly Informative	Direct
CTD Chemicals (CC)	Naphthyridines	0.0000007649	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips

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HD-domain/PDEase-like superfamily